6128 results
Journal of diabetes and its complications,
Volume 34, Issue 9, 15 3 2020, Pages 107623
Skin disorders indicating peripheral arterial occlusive disease and chronic venous insufficiency in organ transplant recipients.
Buntinx M, Lavrijsen APM, de Fijter JW, Reinders MEJ, Schepers A, Bouwes Bavinck JN
Background: Peripheral arterial occlusive disease (PAOD) and chronic venous insufficiency (CVI) in organ transplant recipients (OTR) can lead to harmful outcomes. We made an inventory of cutaneous manifestations of PAOD and CVI in OTR in relation with diabetes and other potential risk factors. Methods: A prospective study in a single center was performed. OTR (n = 112) were included at the outpatient clinic to investigate clinical signs of PAOD and CVI. The most commonly associated risk factors...
Abstract
Cited 6 times since 2020 (1.3 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 21, Issue 10, 15 3 2020, Pages E3508
Myostatin Inhibits Vascular Smooth Muscle Cell Proliferation and Local 14q32 microRNA Expression, But Not Systemic Inflammation or Restenosis.
Goossens EAC, de Vries MR, Jukema JW, Quax PHA, Nossent AY
Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32 microRNAs by binding the 14q32 locus. Direct inhibition of 14q32 microRNA miR-495-3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSMC) proliferation and local inflammation. Here, we aimed to investigate the effects of myostatin in a mouse model for postinterventional restenosis. In VSMCs in vitro, myostatin led...
Abstract
Cited 33 times since 2020 (6.9 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 106, Issue 18, 13 2 2020, Pages 1438-1444
Global longitudinal strain: clinical use and prognostic implications in contemporary practice.
Abou R, van der Bijl P, Bax JJ, Delgado V
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 128, 13 2 2020, Pages 84-91
Characteristics and Prognosis of Patients With Nonvalvular Atrial Fibrillation and Significant Valvular Heart Disease Referred for Electrical Cardioversion.
Vo NM, Leung M, van Rosendael PJ, Goedemans L, van Wijngaarden SE, Prihadi EA, van der Bijl P, Ajmone Marsan N, Delgado V, Bax JJ
Valvular atrial fibrillation (AF) is defined as AF in the presence of mitral stenosis or mechanical valve prosthesis. However, there are patients with AF who have significant native valvular heart disease (VHD) others than mitral stenosis that are classified as nonvalvular AF. The characteristics and prognostic implications of these entities have not been extensively studied. Of 1,885 AF patients referred for electrical cardioversion (64 ± 13years, 71% male), 171 (9.1%) had valvular AF (any grad...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 6, Issue 9, 12 2 2020, Pages 1073-1085
RV Tissue Heterogeneity on CT: A Novel Tool to Identify the VT Substrate in ARVC.
Venlet J, Tao Q, de Graaf MA, Glashan CA, de Riva Silva M, van der Geest RJ, Scholte AJ, Piers SRD, Zeppenfeld K
Objectives: This study sought to evaluate whether right ventricular (RV) tissue heterogeneity on computed tomography (CT): 1) is associated with conduction delay in arrhythmogenic right ventricular cardiomyopathy (ARVC); and 2) distinguishes patients with ARVC from those with exercise-induced arrhythmogenic remodeling (EIAR) and control individuals. Background: ARVC is characterized by fibrofatty replacement, related to conduction delay and ventricular tachycardias. Distinguishing ARVC from acqu...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
SAGE open medical case reports,
Volume 8, 8 2 2020, Pages 2050313X20918989
A novel approach to resolve severe mediastinal and subcutaneous emphysema occurring in Pneumocystis jirovecii pneumonia using vacuum-assisted closure therapy.
Bouwmeester NH, Kieft H, Shahin GM, Nierich AP
A 50-year-old human immunodeficiency virus positive patient who was diagnosed with Pneumocystis jirovecii pneumonia developed severe subcutaneous and mediastinal emphysema, which was progressive despite low pressure mechanical ventilation. Infraclavicular skin incisions and vacuum-assisted closure therapy were used to resolve the emphysema. The subcutaneous emphysema decreased significantly, and after 1 week the vacuum-assisted closure therapy was ended successfully. This technique has previousl...
Abstract
Cited 12 times since 2020 (2.5 per year)
source: EuropePMC
PloS one,
Volume 15, Issue 5, 6 1 2020, Pages e0232573
Automatic segmentation of multiple cardiovascular structures from cardiac computed tomography angiography images using deep learning.
Baskaran L, Al'Aref SJ, Maliakal G, Lee BC, Xu Z, Choi JW, Lee SE, Sung JM, Lin FY, Dunham S, Mosadegh B, Kim YJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Shin S, Choi JH, Chinnaiyan K, Hadamitzky M, Conte E, Andreini D, Pontone G, Budoff MJ, Leipsic JA, Raff GL, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Bax JJ, Chang HJ, Min JK, Shaw LJ
Objectives: To develop, demonstrate and evaluate an automated deep learning method for multiple cardiovascular structure segmentation. Background: Segmentation of cardiovascular images is resource-intensive. We design an automated deep learning method for the segmentation of multiple structures from Coronary Computed Tomography Angiography (CCTA) images. Methods: Images from a multicenter registry of patients that underwent clinically-indicated CCTA were used. The proximal ascending and descendi...
Abstract
Cited 13 times since 2020 (2.7 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 52, Issue 4, 6 1 2020, Pages 971-977
How to Measure the Aorta Using MRI: A Practical Guide.
van Hout MJ, Scholte AJ, Juffermans JF, Westenberg JJ, Zhong L, Zhou X, Schalla SM, Hope MD, Bremerich J, Kramer CM, Dewey M, Ordovas KG, Bluemke DA, Lamb HJ
Abstract
Cited 15 times since 2020 (3.1 per year)
source: EuropePMC
Allergy,
Volume 75, Issue 9, 5 1 2020, Pages 2376-2379
Two-year drug survival of dupilumab in a large cohort of difficult-to-treat adult atopic dermatitis patients compared to cyclosporine A and methotrexate: Results from the BioDay registry.
Spekhorst LS, Ariëns LFM, van der Schaft J, Bakker DS, Kamsteeg M, Oosting AJ, de Ridder I, Sloeserwij A, Romeijn GLE, de Graaf M, Haeck I, Thijs JL, Schuttelaar MLA, de Bruin-Weller MS
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 33, Issue 8, 4 1 2020, Pages 964-972
Correlates and Long-Term Implications of Left Ventricular Mechanical Dispersion by Two-Dimensional Speckle-Tracking Echocardiography in Patients with ST-Segment Elevation Myocardial Infarction.
Abou R, Goedemans L, van der Bijl P, Fortuni F, Prihadi EA, Mertens B, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Background: Left ventricular (LV) mechanical dispersion (LVMD), measured with speckle-tracking echocardiography (STE) after ST-segment elevation myocardial infarction (STEMI), has been proposed as a measurement of regional heterogeneity of myocardial contraction and may reflect changes in the myocardial structure (e.g., fibrosis or edema). Further insight into this parameter may aid in the risk stratification of STEMI patients. Methods: A total of 1,000 STEMI patients (77% male, 60 ± 12 years) t...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Pediatric cardiology,
Volume 41, Issue 5, 4 1 2020, Pages 1042-1050
Left and Right Ventricular Impairment Shortly After Correction of Tetralogy of Fallot.
Terol C, Kamphuis VP, Hazekamp MG, Blom NA, Ten Harkel ADJ
Surgical repair of Tetralogy of Fallot (ToF) is usually performed in the first months of life with low early postoperative mortality. During long-term follow-up, however, both right (RV) and left ventricular (LV) performances may deteriorate. Tissue Doppler imaging (TDI) and speckle tracking echocardiography (ST) can unmask a diminished RV and LV performance. The objective of the current study was to assess the cardiac performance before and shortly after corrective surgery in ToF patients using...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 1, 1 1 2020, Pages 48-55
Temporal changes in FFR<sub>CT</sub>-Guided Management of Coronary Artery Disease - Lessons from the ADVANCE Registry.
Nous F, Budde RPJ, Fairbairn TA, Akasaka T, Nørgaard BL, Berman DS, Raff G, Hurwitz-Koweek LM, Pontone G, Kawasaki T, Sand NPR, Jensen JM, Amano T, Poon M, Øvrehus KA, Sonck J, Rabbat MG, Mullen S, De Bruyne B, Rogers C, Matsuo H, Bax JJ, Leipsic J, Patel MR, Nieman K
Background: The ADVANCE registry is a large prospective study of outcomes and resource utilization in patients undergoing coronary computed tomography angiography (CCTA) and CT-based fractional flow reserve (FFRCT). As experience with new technologies and practices develops over time, we investigated temporal changes in the use of FFRCT within the ADVANCE registry. Methods: 5083 patients with coronary artery disease (CAD) on CCTA were prospectively enrolled in the ADVANCE registry and were divid...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 20, 1 1 2020, Pages 1915-1917
Left ventricular myocardial fibrosis: a marker of bad prognosis in symptomatic severe aortic stenosis.
Kong WKF, Bax JJ, Delgado V
Abstract
Cited 15 times since 2020 (3.1 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 20, 1 1 2020, Pages 1932-1940
Uncertainties and challenges in surgical and transcatheter tricuspid valve therapy: a state-of-the-art expert review.
Chang CC, Veen KM, Hahn RT, Bogers AJJC, Latib A, Oei FBS, Abdelghani M, Modolo R, Ho SY, Abdel-Wahab M, Fattouch K, Bosmans J, Caliskan K, Taramasso M, Serruys PW, Bax JJ, van Mieghem NMDA, Takkenberg JJM, Lurz P, Modine T, Soliman O
Tricuspid regurgitation (TR) is a frequent and complex problem, commonly combined with left-sided heart disease, such as mitral regurgitation. Significant TR is associated with increased mortality if left untreated or recurrent after therapy. Tricuspid regurgitation was historically often disregarded and remained undertreated. Surgery is currently the only Class I Guideline recommended therapy for TR, in the form of annuloplasty, leaflet repair, or valve replacement. As growing experience of tra...
Abstract
Cited 22 times since 2020 (4.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 5, 1 1 2020, Pages 479-488
Clinical risk factors and atherosclerotic plaque extent to define risk for major events in patients without obstructive coronary artery disease: the long-term coronary computed tomography angiography CONFIRM registry.
van Rosendael AR, Bax AM, Smit JM, van den Hoogen IJ, Ma X, Al'Aref S, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Peña JM, Lin FY, Shaw LJ, Min JK, Bax JJ
Aims: In patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent. Methods and results: Patients from the long-term CONFIRM registry without prior CAD and without obstructive (≥50%) stenosis were included. Within the groups of normal coronary computed tomography angiography (CCTA) (N = 1849) and non-obstructive CAD (N = 1698), the prognostic value of traditional clinical risk factors and atherosclerotic extent (segmen...
Abstract
Cited 8 times since 2020 (1.7 per year)
source: EuropePMC
JMIR research protocols,
Volume 9, Issue 5, 1 1 2020, Pages e17419
Improving Hand Hygiene Compliance in Nursing Homes: Protocol for a Cluster Randomized Controlled Trial (HANDSOME Study).
Teesing GR, Erasmus V, Petrignani M, Koopmans MPG, de Graaf M, Vos MC, Klaassen CHW, Verduijn-Leenman A, Schols JMGA, Richardus JH, Voeten HACM
Background: Hand hygiene compliance is considered the most (cost-)effective measure for preventing health care-associated infections. While hand hygiene interventions have frequently been implemented and assessed in hospitals, there is limited knowledge about hand hygiene compliance in other health care settings and which interventions and implementation methods are effective. Objective: This study aims to evaluate the effect of a multimodal intervention to increase hand hygiene compliance of nu...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 30, Issue 5, 1 1 2020, Pages 780-782
Intraoperative cryoablation in late pulmonary valve replacement for tetralogy of Fallot.
Nevvazhay T, Zeppenfeld K, Brouwer C, Hazekamp M
Ventricular tachyarrhythmia (VT) is a major cause of late morbidity and mortality in patients who underwent surgical repair of tetralogy of Fallot. The majority of VTs are monomorphic macro-reentrant VT (MVT) and depend on slow conducting areas of diseased myocardium bordered by unexcitable tissue (anatomical isthmuses). Myocardial fibrosis due to surgical incisions, patch material and valve annuli are typical boundaries of anatomical isthmuses (AI). The conducting myocardium between the pulmona...
Abstract
Cited 1048 times since 2020 (216.6 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 369, Issue 6499, 1 1 2020, Pages 50-54
SARS-CoV-2 productively infects human gut enterocytes.
Lamers MM, Beumer J, van der Vaart J, Knoops K, Puschhof J, Breugem TI, Ravelli RBG, Paul van Schayck J, Mykytyn AZ, Duimel HQ, van Donselaar E, Riesebosch S, Kuijpers HJH, Schipper D, van de Wetering WJ, de Graaf M, Koopmans M, Cuppen E, Peters PJ, Haagmans BL, Clevers H
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocyt...
Abstract
Cited 25 times since 2020 (5.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 75, Issue 18, 1 1 2020, Pages 2297-2308
Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes: The ODYSSEY OUTCOMES Trial.
Bhatt DL, Briggs AH, Reed SD, Annemans L, Szarek M, Bittner VA, Diaz R, Goodman SG, Harrington RA, Higuchi K, Joulain F, Jukema JW, Li QH, Mahaffey KW, Sanchez RJ, Roe MT, Lopes RD, White HD, Zeiher AM, Schwartz GG, Gabriel Steg P, ODYSSEY OUTCOMES Investigators
Background: Cholesterol reduction with proprotein convertase subtilisin-kexin type 9 inhibitors reduces ischemic events; however, the cost-effectiveness in statin-treated patients with recent acute coronary syndrome remains uncertain. Objectives: This study sought to determine whether further cholesterol reduction with alirocumab would be cost-effective in patients with a recent acute coronary syndrome on optimal statin therapy. Methods: A cost-effectiveness model leveraging patient-level data f...
Abstract
Cited 10 times since 2020 (2.1 per year)
source: EuropePMC
Nucleic acids research,
Volume 48, Issue 8, 1 1 2020, Pages 4161-4178
A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation.
Kochanova NY, Schauer T, Mathias GP, Lukacs A, Schmidt A, Flatley A, Schepers A, Thomae AW, Imhof A
During interphase centromeres often coalesce into a small number of chromocenters, which can be visualized as distinct, DAPI dense nuclear domains. Intact chromocenters play a major role in maintaining genome stability as they stabilize the transcriptionally silent state of repetitive DNA while ensuring centromere function. Despite its biological importance, relatively little is known about the molecular composition of the chromocenter or the processes that mediate chromocenter formation and mai...
Abstract
