Research

Publications

Below you can find a list of our published research.

6883 results

Cited 22 times since 2015 (2.4 per year) source: EuropePMC

Heart rhythm, Volume 13, Issue 4, 8 2 2015, Pages 905-912 Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus. Ten Sande JN, Postema PG, Boekholdt SM, Tan HL, van der Heijden JF, de Groot NM, Volders PG, Zeppenfeld K, Boersma LV, Nannenberg EA, Christiaans I, Wilde AA

Background: Familial idiopathic ventricular fibrillation (IVF) is a severe disease entity and is notoriously difficult to manage because there are no clinical risk indicators for premature cardiac arrest. Previously, we identified a link between familial IVF and a risk haplotype on chromosome 7q36 (involving the arrhythmia gene DPP6). Objective: The purpose of this study was to expand our knowledge of familial IVF and to discuss its (extended) clinical characteristics. Methods: We studied 601 fa... Abstract

Cited 20 times since 2015 (2.2 per year) source: EuropePMC

Tuberculosis (Edinburgh, Scotland), Volume 97, 8 2 2015, Pages 163-171 KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults. Boer MC, van Meijgaarden KE, Goletti D, Vanini V, Prins C, Ottenhoff TH, Joosten SA

In cancer and chronic infectious diseases, immune checkpoint-blockade of inhibitory receptors can enhance T-cell immunity. In tuberculosis (TB), a chronic infectious disease, prolonged antigen exposure can potentially drive terminal T-cell differentiation towards functional 'exhaustion': in human TB T-cells express PD-1 (programmed cell death protein-1) and CTLA-4 (cytotoxic T-lymphocyte-associated protein-4). However, in murine TB not PD-1 but rather killer cell lectin-like receptor s... Abstract

Cited 6 times since 2015 (0.6 per year) source: EuropePMC

International journal of surgery case reports, Volume 19, 7 1 2015, Pages 8-10 Traumatic rupture of a Meckel's diverticulum due to blunt abdominal trauma in a soccer game: A case report. Tummers WS, van der Vorst JR, Swank DJ

Introduction: a Meckel's diverticulum is one of the most common congenital anomalies of the digestive tract. The reported lifetime complication rate is 4%, mostly due to hemorrhage, obstruction, perforation or inflammation. A symptomatic Meckel's diverticulum due to rupture after blunt abdominal trauma is very rare. We believe this case report is the first reporting a rupture of a Meckel's diverticulum after a low velocity blunt abdominal trauma and outlining the importance of a t... Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 6, 2 1 2015, Pages 1510-1513 One-stop-shop cardiac CT: 3D fusion of CT coronary anatomy and myocardial perfusion for guiding revascularization in complex multivessel disease. van Rosendael AR, Dimitriu-Leen AC, Montero-Cabezas JM, Bax JJ, Kroft LJ, Scholte AJ

Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Circulation, Volume 132, Issue 23, 1 1 2015, Pages e375 Letter Regarding Article, "MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization". Welten SM, Quax PH, Nossent AY

Abstract

Cited 16 times since 2015 (1.7 per year) source: Scopus

Behavior research methods, Volume 47, Issue 4, 1 1 2015, Pages 1356-1364 Algorithm-supported visual error correction (AVEC) of heart rate measurements in dogs, Canis lupus familiaris. Schöberl I, Kortekaas K, Schöberl FF, Kotrschal K

Dog heart rate (HR) is characterized by a respiratory sinus arrhythmia, and therefore makes an automatic algorithm for error correction of HR measurements hard to apply. Here, we present a new method of error correction for HR data collected with the Polar system, including (1) visual inspection of the data, (2) a standardized way to decide with the aid of an algorithm whether or not a value is an outlier (i.e., "error"), and (3) the subsequent removal of this error from the data set.... Abstract

Cited 4 times since 2015 (0.4 per year) source: EuropePMC

RMD open, Volume 1, Issue 1, 1 1 2015, Pages e000113 A prediction model for progressive disease in systemic sclerosis. Meijs J, Schouffoer AA, Ajmone Marsan N, Stijnen T, Putter H, Ninaber MK, Huizinga TW, de Vries-Bouwstra JK

Objective: To develop a model that assesses the risk for progressive disease in patients with systemic sclerosis (SSc) over the short term, in order to guide clinical management. Methods: Baseline characteristics and 1 year follow-up results of 163 patients with SSc referred to a multidisciplinary healthcare programme were evaluated. Progressive disease was defined as: death, ≥10% decrease in forced vital capacity, ≥15% decrease in diffusing capacity for carbon monoxide, ≥10% decrease in body we... Abstract

Cited 49 times since 2015 (5.3 per year) source: EuropePMC

Revista espanola de cardiologia (English ed.), Volume 68, Issue 12, 1 1 2015, Pages 1125 2015 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S

Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 22, Issue 6, 1 1 2015, Pages 1171-1178 Multimodality imaging: Bird's eye view from The European Society of Cardiology Congress 2015 London, August 29-September 2, 2015. Bax JJ, Delgado V, Achenbach S, Sechtem U, Knuuti J

Abstract

Journal of the American College of Cardiology, Volume 66, Issue 22, 1 1 2015, Pages 2576-2577 Reply: Elimination of All Inducible Ventricular Tachycardias as the Endpoint for Ablation. Yokokawa M, Kim HM, Baser K, Stevenson W, Nagashima K, Della Bella P, Vergara P, Hindricks G, Arya A, Zeppenfeld K, de Riva Silva M, Daoud EG, Kumar S, Kuck KH, Tilz R, Mathew S, Ghanbari H, Latchamsetty R, Morady F, Bogun F

Abstract

Cited 24 times since 2015 (2.6 per year) source: EuropePMC

American heart journal, Volume 173, 1 1 2015, Pages 77-85 Rationale and design of POPular-TAVI: antiPlatelet therapy fOr Patients undergoing Transcatheter Aortic Valve Implantation. Nijenhuis VJ, Bennaghmouch N, Hassell M, Baan J, van Kuijk JP, Agostoni P, van 't Hof A, Kievit PC, Veenstra L, van der Harst P, van den Heuvel AF, den Heijer P, Kelder JC, Deneer VH, van der Kley F, Onorati F, Collet JP, Maisano F, Latib A, Huber K, Stella PR, Ten Berg JM

Background: Despite improving experience and techniques, ischemic and bleeding complications after transcatheter aortic valve implantation (TAVI) remain prevalent and impair survival. Current guidelines recommend the temporary addition of clopidogrel in the initial period after TAVI to prevent thromboembolic events. However, explorative studies suggest that this is associated with a higher rate of major bleeding without a decrease in thromboembolic complications. Methods: The POPular TAVI trial... Abstract

Cited 19 times since 2015 (2 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 27, Issue 1, 25 4 2015, Pages 80-87 VT Recurrence After Ablation: Incomplete Ablation or Disease Progression? A Multicentric European Study. Berte B, Sacher F, Venlet J, Andreu D, Mahida S, Aldhoon B, DE Potter T, Sarkozy A, Tavernier R, Andronache M, Deneke T, Kautzner J, Berruezo A, Cochet H, Zeppenfeld K, Jaïs P

Aim: To determine whether ventricular tachycardia (VT) recurrences in arrhythmogenic RV cardiomyopathy (ARVC) and nonischemic cardiomyopathy (NICM) are related to incomplete ablation or disease progression. Methods: ARVC and NICM patients with two substrate maps of the same diseased ventricle with an interprocedural delay of ≥12 months were included. Disease progression was defined as ≥1 factor: scar area progression (PROG, +5%), ventricular remodeling (dilatation [+25 mL] or decreased ejection... Abstract

European journal of preventive cardiology, Volume 23, Issue 11, 24 4 2015, Pages 1195-1201 Advantages and disadvantages of unstructured cardiovascular risk factor screening for follow-up in primary care. de Boer AW, de Mutsert R, den Heijer M, Rosendaal FR, Jukema JW, Blom JW, Numans ME, NEO study group

Background: In contrast to structured, integrated risk assessment in primary care, unstructured risk factor screening outside primary care and corresponding recommendations to consult a general practitioner (GP) are often based on one abnormal value of a single risk factor. This study investigates the advantages and disadvantages of unstructured screening of blood pressure and cholesterol outside primary care. Methods: After the baseline visit of the Netherlands Epidemiology of Obesity study (po... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

European journal of preventive cardiology, Volume 23, Issue 10, 24 4 2015, Pages 1104-1113 Risk stratification and treatment effect of statins in secondary cardiovascular prevention in old age: Additive value of N-terminal pro-B-type natriuretic peptide. Poortvliet RK, van Peet PG, de Craen AJ, Mertens BJ, Mooijaart SP, Wijsman LW, Drewes YM, Ford I, Sattar N, Jukema JW, Stott DJ, de Ruijter W, Gussekloo J

Background: To date, no validated risk scores exist for prediction of recurrence risk or potential treatment effect for older people with a history of a cardiovascular event. Therefore, we assessed predictive values for recurrent cardiovascular disease of models with age and sex, traditional cardiovascular risk markers, and 'SMART risk score', all with and without addition of N-terminal pro-B-type natriuretic peptide (NT-proBNP). Treatment effect of pravastatin was assessed across low... Abstract

Cited 7 times since 2015 (0.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 102, Issue 2, 23 4 2015, Pages 107-113 Aortic valve prosthesis-patient mismatch and exercise capacity in adult patients with congenital heart disease. van Slooten YJ, van Melle JP, Freling HG, Bouma BJ, van Dijk AP, Jongbloed MR, Post MC, Sieswerda GT, Huis In 't Veld A, Ebels T, Voors AA, Pieper PG

Objectives: To report the prevalence of aortic valve prosthesis-patient mismatch (PPM) in an adult population with congenital heart disease (CHD) and its impact on exercise capacity. Adults with congenital heart disease (ACHD) with a history of aortic valve replacement may outgrow their prosthesis later in life. However, the prevalence and clinical consequences of aortic PPM in ACHD are presently unknown. Methods: From the national Dutch Congenital Corvitia (CONCOR) registry, we identified 207 A... Abstract

Cited 11 times since 2015 (1.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 17, Issue 11, 20 3 2015, Pages 1269-1278 Sustained favourable haemodynamics 1 year after TAVI: improvement in NYHA functional class related to improvement of left ventricular diastolic function. Muratori M, Fusini L, Tamborini G, Gripari P, Delgado V, Marsan NA, Ghulam Ali S, Barbier P, Bartorelli AL, Alamanni F, Pepi M

Aims: Despite expected improvement in left ventricular (LV) systolic and diastolic function after transcatheter aortic valve implantation (TAVI), the complex relationship between pre-existent LV systolic and diastolic function and changes in LV haemodynamics and clinical symptoms have been scarcely investigated. This study investigated the presence of pre-operative LV diastolic dysfunction and its improvement over time after TAVI alongside improvement in New York Heart Association (NYHA) class i... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

PloS one, Volume 10, Issue 11, 20 3 2015, Pages e0143079 Candidate Gene Analysis of Mortality in Dialysis Patients. Rothuizen TC, Ocak G, Verschuren JJ, Dekker FW, Rabelink TJ, Jukema JW, Rotmans JI

Background: Dialysis patients have high cardiovascular mortality risk. This study aimed to investigate the association between SNPs of genes involved in vascular processes and mortality in dialysis patients. Methods: Forty two SNPs in 25 genes involved in endothelial function, vascular remodeling, cell proliferation, inflammation, coagulation and calcium/phosphate metabolism were genotyped in 1330 incident dialysis patients. The effect of SNPs on 5-years cardiovascular and non-cardiovascular mor... Abstract

Cited 4 times since 2015 (0.4 per year) source: EuropePMC

NPJ aging and mechanisms of disease, Volume 1, 12 2 2015, Pages 15011 Fine mapping the <i>CETP</i> region reveals a common intronic insertion associated to HDL-C. van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S, Manichaikul A, Brody JA, Feitosa MF, Duan Q, Schraut KE, Navarro P, van Vliet-Ostaptchouk JV, Zhu G, Mbarek H, Trompet S, Verweij N, Lyytikäinen LP, Deelen J, Nolte IM, van der Laan SW, Davies G, Vermeij-Verdoold AJ, van Oosterhout AA, Vergeer-Drop JM, Arking DE, Trochet H, Generation Scotland, Medina-Gomez C, Rivadeneira F, Uitterlinden AG, Dehghan A, Franco OH, Sijbrands EJ, Hofman A, White CC, Mychaleckyj JC, Peloso GM, Swertz MA, LifeLines Cohort Study, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Ford I, Buckley BM, de Craen AJ, Starr JM, Deary IJ, Pasterkamp G, Oldehinkel AJ, Snieder H, Slagboom PE, Nikus K, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT, van der Harst P, Jukema JW, Hottenga JJ, Boomsma DI, Whitfield JB, Montgomery G, Martin NG, CHARGE Lipids Working Group, Polasek O, Vitart V, Hayward C, Kolcic I, Wright AF, Rudan I, Joshi PK, Wilson JF, Lange LA, Wilson JG, Gudnason V, Harris TB, Morrison AC,

Background: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (CETP) gene. In this study, we investigate the association of CETP and HDL-C further to identify novel, independent CETP variants associated with HDL-C in humans. Methods: We performed a meta-analysis of HDL-C within the CETP region using 59,... Abstract

Cited 6 times since 2015 (0.6 per year) source: EuropePMC

Heart rhythm, Volume 13, Issue 2, 11 2 2015, Pages 504-510 Troponin levels after ICD implantation with and without defibrillation testing and their predictive value for outcomes: Insights from the SIMPLE trial. Vamos M, Healey JS, Wang J, Duray GZ, Connolly SJ, van Erven L, Vinolas X, Neuzner J, Glikson M, Hohnloser SH

Background: The Shockless IMPLant Evaluation trial randomized 2500 patients receiving a first implantable cardioverter-defibrillator (ICD)/cardiac resynchronization therapy-defibrillator device to have either defibrillation testing (DT) or no DT. It demonstrated that DT did not improve shock efficacy or reduce mortality. Objective: This prospective substudy evaluated the effect of DT on postoperative troponin levels and their predictive value for total and arrhythmic mortality. Methods: Troponin... Abstract

Cited 52 times since 2015 (5.6 per year) source: EuropePMC

Human molecular genetics, Volume 25, Issue 2, 10 2 2015, Pages 358-370 A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, Hottenga JJ, Trompet S, Müller-Nurasyid M, Zhao JH, Brody JA, Kleber ME, Guo X, Wang JJ, Auer PL, Attia JR, Yanek LR, Ahluwalia TS, Lahti J, Venturini C, Tanaka T, Bielak LF, Joshi PK, Rocanin-Arjo A, Kolcic I, Navarro P, Rose LM, Oldmeadow C, Riess H, Mazur J, Basu S, Goel A, Yang Q, Ghanbari M, Willemsen G, Rumley A, Fiorillo E, de Craen AJ, Grotevendt A, Scott R, Taylor KD, Delgado GE, Yao J, Kifley A, Kooperberg C, Qayyum R, Lopez LM, Berentzen TL, Räikkönen K, Mangino M, Bandinelli S, Peyser PA, Wild S, Trégouët DA, Wright AF, Marten J, Zemunik T, Morrison AC, Sennblad B, Tofler G, de Maat MP, de Geus EJ, Lowe GD, Zoledziewska M, Sattar N, Binder H, Völker U, Waldenberger M, Khaw KT, Mcknight B, Huang J, Jenny NS, Holliday EG, Qi L, Mcevoy MG, Becker DM, Starr JM, Sarin AP, Hysi PG, Hernandez DG, Jhun MA, Campbell H, Hamsten A, Rivadeneira F, Mcardle WL, Slagboom PE, Zeller T, Koenig W, Psat

Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on... Abstract