7971 results
Cited 99 times since 2016 (11.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 68, Issue 9, 1 1 2016, Pages 934-945
Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.
van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, Zabaneh D, van Setten J, Isgum I, Galesloot TE, Arpegård J, Amouyel P, Trompet S, Waldenberger M, Dörr M, Magnusson PK, Giedraitis V, Larsson A, Morris AP, Felix JF, Morrison AC, Franceschini N, Bis JC, Kavousi M, O'Donnell C, Drenos F, Tragante V, Munroe PB, Malik R, Dichgans M, Worrall BB, Erdmann J, Nelson CP, Samani NJ, Schunkert H, Marchini J, Patel RS, Hingorani AD, Lind L, Pedersen NL, de Graaf J, Kiemeney LA, Baumeister SE, Franco OH, Hofman A, Uitterlinden AG, Koenig W, Meisinger C, Peters A, Thorand B, Jukema JW, Eriksen BO, Toft I, Wilsgaard T, Onland-Moret NC, van der Schouw YT, Debette S, Kumari M, Svensson P, van der Harst P, Kivimaki M, Keating BJ, Sattar N, Dehghan A, Reiner AP, Ingelsson E, den Ruijter HM, de Bakker PI, Pasterkamp G, Ärnlöv J, Holmes MV, Asselbergs FW
Background: Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. Objectives: The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population. Methods: We incorpor...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 118, Issue 8, 29 5 2016, Pages 1217-1224
Long-Term Echocardiographic Outcome in Super-Responders to Cardiac Resynchronization Therapy and the Association With Mortality and Defibrillator Therapy.
van der Heijden AC, Höke U, Thijssen J, Willem Borleffs CJ, Wolterbeek R, Schalij MJ, van Erven L
Super-response to cardiac resynchronization therapy (CRT) is associated with significant left ventricular (LV) reverse remodeling and improved clinical outcome. The study aimed to: (1) evaluate whether LV reverse remodeling remains sustained during long-term follow-up in super-responders and (2) analyze the association between the course of LV reverse remodeling and ventricular arrhythmias. Of all, primary prevention super-responders to CRT were selected. Super-response was defined as LV end-sys...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 23, Issue 6, 29 5 2016, Pages 1399-1410
Diagnostic and prognostic roles of echocardiography and cardiac magnetic resonance.
Delgado V, Bucciarelli-Ducci C, Bax JJ
Accurate prediction of sudden cardiac death due to ventricular arrhythmia remains challenging. Left ventricular ejection fraction has shown an association with increased risk of ventricular arrhythmias and is included in the recommendations for implantable cardioverter defibrillator as primary prevention. However, left ventricular ejection fraction may be normal in a large number of patients who are at risk of ventricular arrhythmias. Echocardiography remains the imaging technique of first choic...
Abstract
Cited 30 times since 2016 (3.4 per year)
source: EuropePMC
Scientific reports,
Volume 6, 27 4 2016, Pages 30439
Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model.
Wong C, Bezhaeva T, Rothuizen TC, Metselaar JM, de Vries MR, Verbeek FP, Vahrmeijer AL, Wezel A, van Zonneveld AJ, Rabelink TJ, Quax PH, Rotmans JI
Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulat...
Abstract
Cited 19 times since 2016 (2.1 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 102, Issue 6, 22 4 2016, Pages 1981-1987
Effect of Aortic Valve Replacement on Aortic Root Dilatation Rate in Patients With Bicuspid and Tricuspid Aortic Valves.
Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Background: It remains unclear whether aortic valve replacement (AVR) has an effect on the aortic root dilatation rate in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). The present study evaluated the pre- and postoperative annual aortic root dilatation rates in BAV and TAV. Methods: A total of 93 patients (67 ± 11 years; 71% men) who underwent AVR between 2003 and 2013 and had at least 2 pre- and postoperative echocardiographic studies 1 year or more apart were incl...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
Cancer epidemiology,
Volume 44, 21 3 2016, Pages 5-15
Quantitative and qualitative assessment of real world data comparative effectiveness research of systemic therapies in lung oncology: A systematic review.
Peters BJM, Janssen VEMT, Schramel FM, van de Garde EMW
Introduction: The growing interest in comparative effectiveness research (CER) based on data from routine clinical practice also extends towards lung oncology. Although CER studies using real world data (RWD) have the potential to assist clinical decision-making, concerns about the quality and validity of studies with observational data subsist. The primary objective of the present study is to assess the current status of observational CER in the field of lung oncology, both quantitatively as qu...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
Nuklearmedizin. Nuclear medicine,
Volume 55, Issue 5, 20 3 2016, Pages 196-202
Sex differences in absolute myocardial perfusion. Non-invasive H2(15)O-PET in young healthy adults.
Range FT, Kies P, Schäfers KP, Breithardt G, Schober O, Wichter T, Schäfers MA
Aim: To investigate sex differences in myocardial perfusion especially in healthy individuals since former studies are rare and findings are controversial. Participants, methods: 26 subjects were enrolled: 16 healthy women (age: 34 ±7 years) were compared with 10 healthy men (age: 34 ± 3 years; p = ns). Myocardial blood flow (MBF) and coronary vascular resistance (CVR) were quantified at rest, during adenosine infusion and cold-pressor-testing, using positron emission tomography and radioactive-...
Abstract
Cited 15 times since 2016 (1.7 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 29, Issue 9, 19 3 2016, Pages 871-878
Prevalence and Correlates of Early Right Ventricular Dysfunction in Sarcoidosis and Its Association with Outcome.
Joyce E, Kamperidis V, Ninaber MK, Katsanos S, Debonnaire P, Schalij MJ, Taube C, Bax JJ, Delgado V, Ajmone Marsan N
Background: Right ventricular (RV) function has not been systematically assessed in sarcoidosis. The aim of this study was to assess the prevalence and associates of RV dysfunction in sarcoidosis using global longitudinal peak systolic strain (GLS). Furthermore, whether RV dysfunction was associated with clinical outcomes was investigated. Methods: A total of 88 patients with sarcoidosis (mean age, 54 ± 13 years; 51% men) without known sarcoid-related or other structural heart disease or alterna...
Abstract
Cited 5 times since 2016 (0.6 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 50, Issue 3, 19 3 2016, Pages 476-481
Valve-sparing root replacement in children.
Kluin J, Koolbergen DR, Sojak V, Hazekamp MG
Objectives: In children, words of caution have been raised about valve-sparing procedures especially regarding the valve-remodelling technique. This study reviewed our experience with the valve-sparing reimplantation technique in children. Methods: All consecutive paediatric (
Abstract
Cited 12 times since 2016 (1.4 per year)
source: EuropePMC
Congenital heart disease,
Volume 12, Issue 1, 18 3 2016, Pages 40-48
Comparative Evaluation of Flow Quantification across the Atrioventricular Valve in Patients with Functional Univentricular Heart after Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization.
She HL, Roest AA, Calkoen EE, van den Boogaard PJ, van der Geest RJ, Hazekamp MG, de Roos A, Westenberg JJ
Purpose: To evaluate the inflow pattern and flow quantification in patients with functional univentricular heart after Fontan's operation using 4D flow magnetic resonance imaging (MRI) with streamline visualization when compared with the conventional 2D flow approach. Method: Seven patients with functional univentricular heart after Fontan's operation and twenty-three healthy controls underwent 4D flow MRI. In two orthogonal two-chamber planes, streamline visualization was applied, and...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 32, Issue 10, 12 2 2016, Pages 1567-1575
Incidence of persistent renal dysfunction after contrast enhanced coronary CT angiography in patients with suspected coronary artery disease.
Maaniitty T, Stenström I, Uusitalo V, Ukkonen H, Kajander S, Bax JJ, Saraste A, Knuuti J
Contrast-induced nephropathy (CIN) is a potentially serious complication of contrast agents used in computed tomography angiography (CTA). The aim of this study was to evaluate whether persistent renal dysfunction occurs in patients undergoing coronary CTA for suspected stable coronary artery disease (CAD). From a cohort of 957 patients undergone coronary CTA, we identified 402 patients with plasma creatinine levels collected before and within 6 months after CTA. According to the definition of C...
Abstract
Cited 54 times since 2016 (6.1 per year)
source: EuropePMC
European journal of cancer (Oxford, England : 1990),
Volume 64, 11 2 2016, Pages 127-136
A five-gene expression signature to predict progression in T1G3 bladder cancer.
van der Heijden AG, Mengual L, Lozano JJ, Ingelmo-Torres M, Ribal MJ, Fernández PL, Oosterwijk E, Schalken JA, Alcaraz A, Witjes JA
Objective: The aim of this study was to analyze tumour gene expression profiles of progressive and non-progressive T1G3 bladder cancer (BC) patients to develop a gene expression signature to predict tumour progression. Methods: Retrospective, multicenter study of 96 T1G3 BC patients without carcinoma in situ (CIS) who underwent a transurethral resection. Formalin-fixed paraffin-embedded tissue samples were collected. Global gene expression patterns were analyzed in 21 selected samples from progr...
Abstract
International journal of cardiology,
Volume 221, 9 2 2016, Pages 682-687
Haptoglobin polymorphism in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and near-infrared spectroscopy in patients with coronary artery disease.
Buljubasic N, Oemrawsingh RM, Smeets MB, Cheng JM, Regar E, van Geuns RJ, Serruys PW, Boersma E, Akkerhuis KM, Kardys I, Arslan F
Background: Conflicting results exist regarding the association between a common Haptoglobin (Hp) polymorphism and risk of coronary artery disease. We investigated the association of three functionally different anti-oxidant and anti-inflammatory Hp phenotypes (Hp1-1, Hp2-1, Hp2-2) with invasively measured degree and composition of coronary atherosclerosis as determined by intravascular ultrasound (-virtual histology) (IVUS(-VH)) as well as near-infrared spectroscopy (NIRS). Methods: Non-culprit...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
African journal of traditional, complementary, and alternative medicines : AJTCAM,
Volume 13, Issue 4, 3 1 2016, Pages 191-198
EFFECT OF HARVEST DATE AND STALK SECTION ON SELECTED STRENGTH CHARACTERISTICS OF TURKISH OREGANO (<i>Origanum onites</i> L).
Yilmaz D, Jasinskas A
Background: The time required to harvest plant crops is important to the plant properties. It is affected by design of the harvest equipment and the desire for high-quality products with low energy usage. Materials and methods: Strength characteristics of Origanum onites L., an important medicinal aromatic plant, harvested on 2, 9, 16 and 23 July, 2012-2014 (H1, H2, H3 and H4, respectively) were measured at the bottom and top sections of the stalk. Measurements included maximum force, bio-yield...
Abstract
Cited 82 times since 2016 (9.2 per year)
source: EuropePMC
Lab on a chip,
Volume 16, Issue 14, 1 1 2016, Pages 2644-2653
Engineering a perfusable 3D human liver platform from iPS cells.
Schepers A, Li C, Chhabra A, Seney BT, Bhatia S
In vitro models of human tissue are crucial to our ability to study human disease as well as develop safe and effective drug therapies. Models of single organs in static and microfluidic culture have been established and shown utility for modeling some aspects of health and disease; however, these systems lack multi-organ interactions that are critical to some aspects of drug metabolism and toxicity. Thus, as part of a consortium of researchers, we have developed a liver chip that meets the foll...
Abstract
Cited 54 times since 2016 (6.1 per year)
source: EuropePMC
Circulation,
Volume 134, Issue 3, 1 1 2016, Pages 212-221
Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects.
Smit RA, Trompet S, Sabayan B, le Cessie S, van der Grond J, van Buchem MA, de Craen AJ, Jukema JW
Background: Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. Methods: We investigated the association between LDL-C variability and 4 cognitive domains at month 30 in 4428 participants of PROSPER (PROspective Study of Pravastatin in the Elderly at Risk...
Abstract
Cited 5 times since 2016 (0.6 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 24, Issue 7, 1 1 2016, Pages 1096
Genome-wide association studies identify genetic loci for low von Willebrand factor levels.
van Loon J, Dehghan A, Weihong T, Trompet S, McArdle WL, Asselbergs FW, Chen MH, Lopez LM, Huffman JE, Leebeek FW, Basu S, Stott DJ, Rumley A, Gansevoort RT, Davies G, Wilson JJ, Witteman JC, Cao X, de Craen AJ, Bakker SJ, Psaty BM, Starr JM, Hofman A, Jukema JW, Deary IJ, Hayward C, van der Harst P, Lowe GD, Folsom AR, Strachan DP, Smith N, de Maat MP, O'Donnell C
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Journal of pediatric endocrinology & metabolism : JPEM,
Volume 29, Issue 7, 1 1 2016, Pages 783-788
Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children.
Sezer OB, Buluş D, Hızlı Ş, Andıran N, Yılmaz D, Ramadan SU
Background: Obesity is an important risk factor for non-alcoholic fatty liver disease. Few studies have evaluated the association between vitamin D and non-alcoholic fatty liver disease in obese children. Therefore, we conducted a study to examine the relationship of vitamin D levels and hepatosteatosis in obese children. Methods: One hundred and eleven children with obesity participated in this study. Hepatosteatosis was diagnosed and graded using ultrasonography in all patients. Study particip...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Archives of medical science : AMS,
Volume 12, Issue 4, 1 1 2016, Pages 697-703
Serum paraoxonase 1 activity in patients with iron deficiency anemia.
Okuturlar Y, Gedikbasi A, Akalin N, Gunaldi M, Yilmaz D, Mert M, Harmankaya O, Soylu A, Karakaya P, Kumbasar A
Introduction: In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy. Material and methods: In this study, 50 adult patients with IDA and 40 healthy subjects were enrolled. All patients were analyzed at the beginning and after treatment according to laboratory assessments. Results: Mean paraoxonase and arylesterase activities in the iron deficiency anemia group were signifi...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 7-8, 1 1 2016, Pages 441-446
Redesigning healthcare: The 2.4 billion euro question? : Connecting smart technology to improve outcome of patients.
Treskes RW, Van Der Velde ET, Atsma DE, Schalij MJ
Although it has been possible to transfer electrocardiograms via a phone line for more than 100 years, use of internet-based patient monitoring and communication systems in daily care is uncommon. Despite the introduction of numerous health-monitoring devices, and despite most patients having internet access, the implementation of individualised healthcare services is still limited. On the other hand, hospitals have invested heavily in massive information systems offering limited value for money...
Abstract
