Research

Publications

Below you can find a list of our published research.

9618 results

Cited 29 times since 2009 (1.8 per year) source: EuropePMC

Acta physiologica (Oxford, England), Volume 198, Issue 1, 6 1 2009, Pages 37-46 Single-beat estimation of the left ventricular end-systolic pressure-volume relationship in patients with heart failure. ten Brinke EA, Klautz RJ, Verwey HF, van der Wall EE, Dion RA, Steendijk P

Aim: The end-systolic pressure-volume relationship (ESPVR) constructed from multiple pressure-volume (PV) loops acquired during load intervention is an established method to asses left ventricular (LV) contractility. We tested the accuracy of simplified single-beat (SB) ESPVR estimation in patients with severe heart failure. Methods: Nineteen heart failure patients (NYHA III-IV) scheduled for surgical ventricular restoration and/or restrictive mitral annuloplasty and 12 patients with normal LV f... Abstract

Cited 215 times since 2009 (13.5 per year) source: EuropePMC

Journal of human evolution, Volume 57, Issue 4, 3 1 2009, Pages 392-400 The Expensive Brain: a framework for explaining evolutionary changes in brain size. Isler K, van Schaik CP

To explain variation in relative brain size among homoiothermic vertebrates, we propose the Expensive Brain hypothesis as a unifying explanatory framework. It claims that the costs of a relatively large brain must be met by any combination of increased total energy turnover or reduced energy allocation to another expensive function such as digestion, locomotion, or production (growth and reproduction). Focusing on the energetic costs of brain enlargement, a comparative analysis of the largest ma... Abstract

Cited 83 times since 2009 (5.2 per year) source: EuropePMC

American heart journal, Volume 158, Issue 3, 1 1 2009, Pages 327-334.e4 The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale. TRA*CER Executive and Steering Committees

Background: The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA*CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design: TRA*CER is a prospect... Abstract

Cited 33 times since 2009 (2.1 per year) source: EuropePMC

The Journal of bone and joint surgery. British volume, Volume 91, Issue 9, 1 1 2009, Pages 1134-1141 Ceramic-on-metal bearings in total hip replacement: whole blood metal ion levels and analysis of retrieved components. Isaac GH, Brockett C, Breckon A, van der Jagt D, Williams S, Hardaker C, Fisher J, Schepers A

This study reports on ceramic-on-metal (CoM) bearings in total hip replacement. Whole blood metal ion levels were measured. The median increase in chromium and cobalt at 12 months was 0.08 microg/1 and 0.22 microg/1, respectively, in CoM bearings. Comparable values for metal-on-metal (MoM) were 0.48 microg/1 and 0.32 microg/1. The chromium levels were significantly lower in CoM than in MoM bearings (p = 0.02). The cobalt levels were lower, but the difference was not significant. Examination of t... Abstract

Cited 47 times since 2009 (2.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 14, 1 1 2009, Pages 1317-1325 Effects of cardiac resynchronization therapy on left ventricular twist. Bertini M, Marsan NA, Delgado V, van Bommel RJ, Nucifora G, Borleffs CJ, Boriani G, Biffi M, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Objectives: This study explored the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) twist, particularly in relation to LV lead position. Background: LV twist is emerging as a comprehensive index of LV function. Methods: Eighty heart failure patients were included. Two-dimensional echocardiography was performed at baseline, immediately after CRT, and at 6-month follow-up. Speckle-tracking analysis was applied to assess LV twist. The LV lead was placed preferably in a (... Abstract

Cited 52 times since 2009 (3.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 14, 1 1 2009, Pages 1238-1245 Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention. Regieli JJ, Jukema JW, Doevendans PA, Zwinderman AH, Kastelein JJ, Grobbee DE, van der Graaf Y

Objectives: We investigated the effects of paraoxonase (PON)-1 variants on long-term clinical outcome in patients with coronary artery disease (CAD). Background: PON-1 is a potential therapeutic target to further reduce cardiovascular risk because it is a detoxifying esterase with antioxidant properties. The PON-1 knockout models result in higher susceptibility to atherosclerosis, and PON activity contributes to cardiovascular risk in humans. Human gene variants determine PON activity; however,... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Optics express, Volume 17, Issue 19, 1 1 2009, Pages 16969-16979 Detection and characterization of carbon contamination on EUV multilayer mirrors. Chen J, Louis E, Lee CJ, Wormeester H, Kunze R, Schmidt H, Schneider D, Moors R, van Schaik W, Lubomska M, Bijkerk F

In this paper, we detect and characterize the carbon contamination layers that are formed during the illumination of extreme ultraviolet (EUV) multilayer mirrors. The EUV induced carbon layers were characterized ex situ using spectroscopic ellipsometry (SE) and laser generated surface acoustic waves (LG-SAW). We show that both LG-SAW and SE are very sensitive for measuring carbon layers, even in the presence of the highly heterogeneous structure of the multilayer. SE has better overall sensitivi... Abstract

Cited 57 times since 2009 (3.6 per year) source: EuropePMC

Pharmacoepidemiology and drug safety, Volume 18, Issue 9, 1 1 2009, Pages 770-777 Miglustat (Zavesca) in type 1 Gaucher disease: 5-year results of a post-authorisation safety surveillance programme. Hollak CE, Hughes D, van Schaik IN, Schwierin B, Bembi B

Purpose: Miglustat (Zavesca) is an orally-available substrate reduction therapy (SRT) for treatment of mild-to-moderate type 1 Gaucher disease (GD1) in adult patients unsuitable for enzyme replacement therapy (ERT). Miglustat has not been evaluated in children with GD1, and is not used during pregnancy and breast-feeding. A non-interventional, prospective, web-based safety surveillance programme was initiated at the time of the European launch of miglustat in 2003, and is ongoing. We report the... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

Journal of rehabilitation medicine, Volume 41, Issue 9, 1 1 2009, Pages 746-750 Limited upper limb functioning has impact on restrictions in participation and autonomy of patients with hereditary motor and sensory neuropathy 1a. Videler AJ, Beelen A, van Schaik IN, de Visser M, Nollet F

Objective: To evaluate upper limb functioning, restrictions on participation and the independent contribution of upper and lower limb disability to participation in hereditary motor and sensory neuropathy 1a. Design: Descriptive cross-sectional study. Subjects: Forty-nine patients with hereditary motor and sensory neuropathy 1a. Methods: Perceived upper limb functioning was evaluated using the Michigan Hand Outcomes Questionnaire and participation restrictions with the Impact on Participation an... Abstract

Cited 20 times since 2009 (1.3 per year) source: EuropePMC

Tissue engineering. Part B, Reviews, Volume 15, Issue 3, 1 1 2009, Pages 307-317 Translating autologous heart valve tissue engineering from bench to bed. Hjortnaes J, Bouten CV, Van Herwerden LA, Gründeman PF, Kluin J

Tissue engineering is currently being actively investigated to ascertain if it can offer an alternative to prosthetic aortic heart valves that may overcome the current limitations of prosthetic aortic heart valves while at the same time conferring the advantages of a living autologous structure, such as biocompatibility, the capacity to grow, repair, and remodel. In vitro studies have shown tissue-engineered heart valves to have adequate structural and functional properties, indicating a promisi... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Pediatric neurology, Volume 41, Issue 3, 1 1 2009, Pages 179-182 Cerebrospinal fluid nitric oxide levels in subacute sclerosing panencephalitis. Yilmaz D, Yüksel D, Senbil N, Eminzade S, Kilinç K, Anlar B, Gürer Y

Oxidative damage plays a role in neurodegenerative diseases. Levels of cerebrospinal fluid nitrite and nitrate levels (oxidation products that provide an indirect estimation of nitric oxide) were investigated in relation to clinical and laboratory features in subacute sclerosing panencephalitis (n = 47) and age-matched control (n = 43) groups. Significantly decreased levels of nitrite (median, 4.91 micromol/L) and nitrate (median, 6.14 micromol/L) were found in the patients. Nitrite and nitrate... Abstract

Cited 7 times since 2009 (0.4 per year) source: EuropePMC

Expert review of cardiovascular therapy, Volume 7, Issue 9, 1 1 2009, Pages 1117-1122 Opportunities in pulmonary valve replacement. Oosterhof T, Hazekamp MG, Mulder BJ

Pulmonary regurgitation is the most important residual lesion after initial surgical correction for pulmonary (sub)valvular stenosis in the early life of patients with tetralogy of Fallot or isolated pulmonary stenosis. Symptomatic or asymptomatic patients with severe right ventricular dilatation due to pulmonary regurgitation may benefit from pulmonary valve replacement. Surgery is ideally performed before the right ventricle becomes irreversibly damaged as a result of longstanding volume overl... Abstract

Cited 12 times since 2009 (0.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 95, Issue 18, 1 1 2009, Pages 1538-1546 Percutaneous aortic valve therapy: clinical experience and the role of multi-modality imaging. Tops LF, Delgado V, van der Kley F, Bax JJ

Abstract

Cited 153 times since 2009 (9.6 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 30, Issue 3, 1 1 2009, Pages 521-526 Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI. Grotenhuis HB, Westenberg JJ, Steendijk P, van der Geest RJ, Ottenkamp J, Bax JJ, Jukema JW, de Roos A

Purpose: To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI. Materials and methods: PWV(MRI) was compared with PWV(INV) in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWV(MRI) was tested in 10 healthy volunteers who underwent repeated measuremen... Abstract

Cited 9 times since 2009 (0.6 per year) source: EuropePMC

Annals of vascular surgery, Volume 23, Issue 5, 1 1 2009, Pages 583-597 Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia. Flu HC, Lardenoye JH, Veen EJ, Aquarius AE, Van Berge Henegouwen DP, Hamming JF

Background: We assessed cardiac adverse events (AEs) after primary lower extremity arterial revascularization (LEAR) for critical lower limb ischemia (CLI) in order to evaluate the impact of cardiac AEs on the clinical outcome. We created an optimized care protocol concerning CLI patients' preoperative work-up as well as intra- and postoperative surveillance according to recent important literature and guidelines. Methods: We conducted a prospective analysis of clinical outcome after LEAR u... Abstract

Cited 184 times since 2009 (11.5 per year) source: EuropePMC

The New England journal of medicine, Volume 361, Issue 10, 1 1 2009, Pages 980-989 Fluvastatin and perioperative events in patients undergoing vascular surgery. Schouten O, Boersma E, Hoeks SE, Benner R, van Urk H, van Sambeek MR, Verhagen HJ, Khan NA, Dunkelgrun M, Bax JJ, Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group

Background: Adverse cardiac events are common after vascular surgery. We hypothesized that perioperative statin therapy would improve postoperative outcomes. Methods: In this double-blind, placebo-controlled trial, we randomly assigned patients who had not previously been treated with a statin to receive, in addition to a beta-blocker, either 80 mg of extended-release fluvastatin or placebo once daily before undergoing vascular surgery. Lipid, interleukin-6, and C-reactive protein levels were me... Abstract

Cited 86 times since 2009 (5.4 per year) source: EuropePMC

Trends in microbiology, Volume 17, Issue 9, 31 5 2009, Pages 423-430 LPxTG surface proteins of enterococci. Hendrickx AP, Willems RJ, Bonten MJ, van Schaik W

Enterococci have become an important cause of nosocomial infections since the late 1980s. Several surface proteins have been implicated in contributing to infections caused by Enterococcus faecalis and Enterococcus faecium. Understanding the in vivo function of enterococcal surface proteins, particularly their role in directing interactions with the host during infection, is essential to explain the success of enterococci as nosocomial pathogens. Here we review current knowledge of enterococcal... Abstract

Cited 133 times since 2009 (8.3 per year) source: EuropePMC

European heart journal, Volume 30, Issue 20, 30 5 2009, Pages 2470-2477 Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis. van Bommel RJ, Bax JJ, Abraham WT, Chung ES, Pires LA, Tavazzi L, Zimetbaum PJ, Gerritse B, Kristiansen N, Ghio S

Aims: Predictors of Response to Cardiac Resynchronization Therapy (CRT) (PROSPECT) was the first large-scale, multicentre clinical trial that evaluated the ability of several echocardiographic measures of mechanical dyssynchrony to predict response to CRT. Since response to CRT may be defined as a spectrum and likely influenced by many factors, this sub-analysis aimed to investigate the relationship between baseline characteristics and measures of response to CRT. Methods and results: A total of... Abstract

Cited 20 times since 2009 (1.3 per year) source: EuropePMC

International journal of cardiology, Volume 147, Issue 1, 28 4 2009, Pages 52-57 Can we use the end systolic volume index to monitor intrinsic right ventricular function after repair of tetralogy of Fallot? Uebing A, Fischer G, Schlangen J, Apitz C, Steendijk P, Kramer HH

Background: After tetralogy of Fallot (ToF) repair the right ventricle (RV) is commonly exposed to abnormal volume load resulting from pulmonary regurgitation (PR) leading to progressive RV dilatation. The objective of this study was to assess the relationship between RV volumes, especially the end systolic volume index (ESVi), and RV contractility in patients after ToF repair and significant PR and to determine whether RV dilatation reflects intrinsic RV dysfunction in these patients. Methods:... Abstract

Cited 141 times since 2009 (8.8 per year) source: EuropePMC

The Biochemical journal, Volume 422, Issue 3, 27 4 2009, Pages 443-453 Human Ccr4-Not complexes contain variable deadenylase subunits. Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT

The Ccr4-Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4-Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity. In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least fou... Abstract