9618 results
Cited 37 times since 2009 (2.3 per year)
source: EuropePMC
PloS one,
Volume 4, Issue 8, 27 4 2009, Pages e6809
Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.
Birjmohun RS, Vergeer M, Stroes ES, Sandhu MS, Ricketts SL, Tanck MW, Wareham NJ, Jukema JW, Kastelein JJ, Khaw KT, Boekholdt SM
Background: Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospe...
Abstract
Cited 12 times since 2009 (0.8 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 19, 27 4 2009, Pages 2304-2307
Three-dimensional speckle tracking echocardiography: a novel approach in the assessment of left ventricular volume and function?
Flu WJ, van Kuijk JP, Bax JJ, Gorcsan J, Poldermans D
Abstract
Cited 369 times since 2009 (23.1 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 22, 27 4 2009, Pages 2769-2812
Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery.
Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery, European Society of Cardiology (ESC), Poldermans D, Bax JJ, Boersma E, De Hert S, Eeckhout E, Fowkes G, Gorenek B, Hennerici MG, Iung B, Kelm M, Kjeldsen KP, Kristensen SD, Lopez-Sendon J, Pelosi P, Philippe F, Pierard L, Ponikowski P, Schmid JP, Sellevold OF, Sicari R, Van den Berghe G, Vermassen F
Abstract
Cited 21 times since 2009 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 95, Issue 23, 25 4 2009, Pages 1931-1936
Aortic elasticity and size are associated with aortic regurgitation and left ventricular dysfunction in tetralogy of Fallot after pulmonary valve replacement.
Grotenhuis HB, Ottenkamp J, de Bruijn L, Westenberg JJ, Vliegen HW, Kroft LJ, de Roos A
Background: Aortic wall pathology and concomitant aortic dilatation have been described in tetralogy of Fallot (TOF) patients, which may negatively affect aortic valve and left ventricular systolic function. Objective: To assess aortic dimensions, aortic elasticity, aortic valve competence and biventricular function in repaired TOF patients after pulmonary valve replacement (PVR) using magnetic resonance imaging (MRI). Methods: MRI was performed in 16 patients with TOF after PVR (10 male; mean a...
Abstract
Cited 49 times since 2009 (3.1 per year)
source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology,
Volume 116, Issue 12, 13 2 2009, Pages 1593-1601
Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect.
Yap SC, Drenthen W, Meijboom FJ, Moons P, Mulder BJ, Vliegen HW, van Dijk AP, Jaddoe VW, Steegers EA, Roos-Hesselink JW, Pieper PG, ZAHARA investigators
Objective: To compare the risks of complications during pregnancy in women with repaired and unrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. Design: A retrospective multicentre study. Setting: Tertiary centres in the Netherlands and Belgium. Population: Women with ASD without associated complex cardiac lesions. Methods: Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 m...
Abstract
Cited 19 times since 2009 (1.2 per year)
source: EuropePMC
Circulation,
Volume 120, Issue 8, 10 2 2009, Pages 669-676
p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
van Tiel CM, Bonta PI, Rittersma SZ, Beijk MA, Bradley EJ, Klous AM, Koch KT, Baas F, Jukema JW, Pons D, Sampietro ML, Pannekoek H, de Winter RJ, de Vries CJ
Background: The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk stratification for in-stent restenosis. Methods and results: Three single nucleotide polymorphisms concerning the p27(kip1) gene (-838C>A, rs36228499; -79C>T, rs34330; +326G...
Abstract
Cited 67 times since 2009 (4.2 per year)
source: EuropePMC
Circulation. Heart failure,
Volume 2, Issue 6, 6 1 2009, Pages 643-653
A new direction for cardiac regeneration therapy: application of synergistically acting epicardium-derived cells and cardiomyocyte progenitor cells.
Winter EM, van Oorschot AA, Hogers B, van der Graaf LM, Doevendans PA, Poelmann RE, Atsma DE, Gittenberger-de Groot AC, Goumans MJ
Background: Adult human epicardium-derived cells (EPDCs), transplanted into the infarcted heart, are known to improve cardiac function, mainly through paracrine protection of the surrounding tissue. We hypothesized that this effect might be further improved if these supportive EPDCs were combined with cells that could possibly supply the ischemic heart with new cardiomyocytes. Therefore, we transplanted EPDCs together with cardiomyocyte progenitor cells that can generate mature cardiomyocytes in...
Abstract
Cited 47 times since 2009 (2.9 per year)
source: EuropePMC
Proceedings. Biological sciences,
Volume 276, Issue 1673, 5 1 2009, Pages 3689-3694
Tool use in wild orang-utans modifies sound production: A functionally deceptive innovation?
Hardus ME, Lameira AR, Van Schaik CP, Wich SA
Culture has long been assumed to be uniquely human but recent studies, in particular on great apes, have suggested that cultures also occur in non-human primates. The most apparent cultural behaviours in great apes involve tools in the subsistence context where they are clearly functional to obtain valued food. On the other hand, tool-use to modify acoustic communication has been reported only once and its function has not been investigated. Thus, the question whether this is an adaptive behavio...
Abstract
Cited 92 times since 2009 (5.7 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 2, Issue 5, 5 1 2009, Pages 548-554
Predicting ventricular arrhythmias in patients with ischemic heart disease: clinical application of the ECG-derived QRS-T angle.
Borleffs CJ, Scherptong RW, Man SC, van Welsenes GH, Bax JJ, van Erven L, Swenne CA, Schalij MJ
Background: In patients with primary prevention implantable cardioverter-defibrillators (ICDs), the incidence of life-threatening ventricular arrhythmias resulting in ICD therapy is relatively low, prompting for better risk stratification. The aim of this study was to assess the value of the QRS-T angle for prediction of ICD therapy and mortality in primary prevention patients with ischemic heart disease. Methods and results: ICD patients (n=412, 361 men; age, 63+/-11 years) with ischemic heart...
Abstract
Cited 156 times since 2009 (9.7 per year)
source: EuropePMC
Journal of neurology,
Volume 257, Issue 1, 4 1 2009, Pages 85-90
Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
Trompet S, van Vliet P, de Craen AJ, Jolles J, Buckley BM, Murphy MB, Ford I, Macfarlane PW, Sattar N, Packard CJ, Stott DJ, Shepherd J, Bollen EL, Blauw GJ, Jukema JW, Westendorp RG
Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in t...
Abstract
Cited 66 times since 2009 (4.1 per year)
source: EuropePMC
Infection and immunity,
Volume 77, Issue 10, 3 1 2009, Pages 4437-4445
The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence.
van Schaik W, Château A, Dillies MA, Coppée JY, Sonenshein AL, Fouet A
In gram-positive bacteria, CodY is an important regulator of genes whose expression changes upon nutrient limitation and acts as a repressor of virulence gene expression in some pathogenic species. Here, we report the role of CodY in Bacillus anthracis, the etiologic agent of anthrax. Disruption of codY completely abolished virulence in a toxinogenic, noncapsulated strain, indicating that the activity of CodY is required for full virulence of B. anthracis. Global transcriptome analysis of a codY...
Abstract
Cited 30 times since 2009 (1.9 per year)
source: EuropePMC
Nucleic acids research,
Volume 37, Issue 17, 3 1 2009, Pages 5725-5736
Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease.
van Nierop GP, de Vries AA, Holkers M, Vrijsen KR, Gonçalves MA
Homologous recombination (HR) is a highly accurate mechanism of DNA repair that can be exploited for homology-directed gene targeting. Since in most cell types HR occurs very infrequently (approximately 10(-6) to 10(-8)), its practical application has been largely restricted to specific experimental systems that allow selection of the few cells that become genetically modified. HR-mediated gene targeting has nonetheless revolutionized genetics by greatly facilitating the analysis of mammalian ge...
Abstract
Cited 18 times since 2009 (1.1 per year)
source: EuropePMC
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Volume 24, Issue 3-4, 3 1 2009, Pages 201-210
Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.
Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A
Background: We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins. Methods: Rats were treated with MCT in low dose (30 mg/kg, MCT30, n=10) to induce compensated RV hypertrophy, in high dose (80 mg/kg, MCT80, n=11) to...
Abstract
Cited 12 times since 2009 (0.7 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 2, 1 1 2009, Pages 202-208
Intima media thickness of the common carotid artery in vascular surgery patients: a predictor of postoperative cardiovascular events.
Flu WJ, van Kuijk JP, Hoeks SE, Kuiper R, Schouten O, Goei D, Winkel T, van Gestel YR, Verhagen HJ, Bax JJ, Poldermans D
Background: Cardiovascular (CV) complications are the leading cause of morbidity and mortality in vascular surgery patients. The Revised Cardiac Risk (RCR) index, identifying cardiac risk factors, is commonly used for preoperative risk stratification. However, a more direct marker of the underlying atherosclerotic disease, such as the common carotid artery intimamedia thickness (CCA-IMT) may be of predictive value as well. The current study evaluated the prognostic value of the CCA-IMT for posto...
Abstract
Cited 183 times since 2009 (11.4 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 13, Issue 8A, 1 1 2009, Pages 1577-1585
Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis.
van Solingen C, Seghers L, Bijkerk R, Duijs JM, Roeten MK, van Oeveren-Rietdijk AM, Baelde HJ, Monge M, Vos JB, de Boer HC, Quax PH, Rabelink TJ, van Zonneveld AJ
MicroRNAs are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function and have been proposed to be involved in neovascularization. Previously, using an extensive cloning and sequencing approach, we identified miR-126 to be specifically and highly expressed in human endothelial cells (EC). Here, we demonstrate EC-specific expression of miR-126 in capillaries and the larger vessels in vivo. We therefore explored the potentia...
Abstract
Cited 255 times since 2009 (15.9 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 9, 1 1 2009, Pages 764-776
The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy.
Tops LF, Schalij MJ, Bax JJ
Cardiac pacing is the only effective treatment for patients with sick sinus syndrome and atrioventricular conduction disorders. In cardiac pacing, the endocardial pacing lead is typically positioned at the right ventricular (RV) apex. At the same time, there is increasing indirect evidence, derived from large pacing mode selection trials and observational studies, that conventional RV apical pacing may have detrimental effects on cardiac structure and left ventricular function, which are associa...
Abstract
Cited 3 times since 2009 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 57, Issue 4, 1 1 2009, Pages 415-441
Advanced applications of 3-dimensional echocardiography.
Ng AC, Delgado V, Bertini M, Nucifora G, Shanks M, Ajmone Marsan N, Holman E, Van De Veire NR, Leung DY, Bax JJ
Over the last few decades, advancements in ultrasound, electronic and computing technologies have permitted current second generation 3-dimensional (3D) echocardiography to display on-line 3D rendered images of the heart. Since various studies demonstrated its superiority over 2-dimensional echocardiography, there is growing enthusiasm to embrace this new 3D echocardiographic technology. With its increasing widespread clinical availability, 3D echocardiography is getting closer to routine clinic...
Abstract
Cited 11 times since 2009 (0.7 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 68, Issue 2, 1 1 2009, Pages 221-225
Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants.
Kwadijk-de Gijsel S, Bijl MJ, Visser LE, van Schaik RH, Hofman A, Vulto AG, van Gelder T, Ch Stricker BH
Aim: To study the effect of the CYP2D6*4 polymorphism on serum sodium concentration in users of antidepressants [selective serotonin reuptake inhibitors and tricyclic antidepressants (TCAs)]. Methods: In this population-based cohort study, all subjects in the Rotterdam Study were included who used an antidepressant at baseline and from whom a blood sample was available in which CYP2D6 genotype and serum sodium concentration could be determined (n= 76). Multivariate linear regression was used to...
Abstract
Cited 60 times since 2009 (3.7 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 19, Issue 8, 1 1 2009, Pages 626-634
Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism.
Sombogaard F, van Schaik RH, Mathot RA, Budde K, van der Werf M, Vulto AG, Weimar W, Glander P, Essioux L, van Gelder T
Objectives: The active metabolite of mycophenolate mofetil (MMF), mycophenolic acid, inhibits the activity of the target enzyme inosine monophosphate dehydrogenase (IMPDH). The aim of this study was to correlate eight different single nucleotide polymorphisms of the IMPDH type II gene to the activity of the IMPDH enzyme to explain between-patient differences in IMPDH activity. Methods and results: In a prospective study, we measured IMPDH activity, mycophenolic acid plasma concentrations, and ei...
Abstract
Cited 43 times since 2009 (2.7 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 32, Issue 8, 1 1 2009, Pages 1040-1049
Relevance of echocardiographic evaluation of right ventricular function in patients undergoing cardiac resynchronization therapy.
Scuteri L, Rordorf R, Marsan NA, Landolina M, Magrini G, Klersy C, Frattini F, Petracci B, Vicentini A, Campana C, Tavazzi L, Ghio S
Aims: Right ventricular (RV) dysfunction is a marker of poor prognosis in heart failure (HF) patients. It is still unclear whether RV function might influence response to cardiac resynchronization therapy (CRT). Methods: Forty-four consecutive patients with HF, large QRS, and either intraventricular or interventricular dyssynchrony underwent echocardiographic evaluation before, 1 month after, and 6 months after CRT. Response to CRT was considered in case of significant LV reverse remodeling, def...
Abstract
