Research

Publications

Below you can find a list of our published research.

9618 results

Cited 29 times since 2008 (1.7 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 15, Issue 3, 16 3 2008, Pages 442-455 Cardiac neuronal imaging: application in the evaluation of cardiac disease. Henneman MM, Bengel FM, van der Wall EE, Knuuti J, Bax JJ

Abstract

Cited 313 times since 2008 (18 per year) source: EuropePMC

Circulation, Volume 117, Issue 16, 14 2 2008, Pages 2051-2060 Role of left ventricular stiffness in heart failure with normal ejection fraction. Westermann D, Kasner M, Steendijk P, Spillmann F, Riad A, Weitmann K, Hoffmann W, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C

Background: Increased left ventricular stiffness is a distinct finding in patients who have heart failure with normal ejection fraction (HFNEF). To elucidate how diastolic dysfunction contributes to heart failure symptomatology during exercise, we conducted a study using an invasive pressure-volume loop approach and measured cardiac function at rest and during atrial pacing and handgrip exercise. Methods and results: Patients with HFNEF (n=70) and patients without heart failure symptoms (n=20) w... Abstract

Cited 50 times since 2008 (2.9 per year) source: EuropePMC

The Journal of allergy and clinical immunology, Volume 121, Issue 5, 11 2 2008, Pages 1196-1202 Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ

Background: Smooth muscle content is increased within the airway wall in patients with asthma and is likely to play a role in airway hyperresponsiveness. However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly. Objective: We examined the expression of contractile and structural proteins of smooth muscle cells, as well as extracellular matrix proteins, in bronchial biopsies of patients with asthma, and r... Abstract

Cited 24 times since 2008 (1.4 per year) source: EuropePMC

Diabetes care, Volume 31, Issue 7, 8 2 2008, Pages 1442-1444 Assessment of aortic pulse wave velocity and cardiac diastolic function in subjects with and without the metabolic syndrome: HDL cholesterol is independently associated with cardiovascular function. Roes SD, Alizadeh Dehnavi R, Westenberg JJ, Lamb HJ, Mertens BJ, Tamsma JT, de Roos A

Objective: To evaluate the influence of lipid and glucose metabolism in the metabolic syndrome on aortic pulse wave velocity (PWV) and left ventricular (LV) diastolic function using magnetic resonance imaging (MRI). Research design and methods: Aortic PWV and LV diastolic function were assessed using MRI in 16 subjects with the metabolic syndrome and 16 subjects without the metabolic syndrome matched for age, waist circumference, and blood pressure. The groups were compared using the unpaired t... Abstract

Cited 54 times since 2008 (3.1 per year) source: EuropePMC

Journal of inherited metabolic disease, Volume 31, Issue 3, 4 1 2008, Pages 337-349 'Non-neuronopathic' Gaucher disease reconsidered. Prevalence of neurological manifestations in a Dutch cohort of type I Gaucher disease patients and a systematic review of the literature. Biegstraaten M, van Schaik IN, Aerts JM, Hollak CE

Gaucher disease is a lysosomal storage disorder, which is classically divided into three types. Type I Gaucher disease is differentiated from types II and III disease by the absence of nervous system involvement. However, an increasing number of reports has emerged on neurological manifestations in patients with type I Gaucher disease. Whether a strict division in three different phenotypes is still valid has been the subject of debate. The main objective of this study was to provide scientific... Abstract

Cited 43 times since 2008 (2.5 per year) source: EuropePMC

Circulation research, Volume 102, Issue 9, 3 1 2008, Pages 1046-1056 Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q

We have recently demonstrated that stem cell antigen 1-positive (Sca-1(+)) progenitors exist in the vascular adventitia of apolipoprotein E-deficient (apoE(-/-)) mice and contribute to smooth muscle cell (SMC) accumulation in vein graft atherosclerosis. Using a combined proteomic and metabolomic approach, we now characterize these local progenitors, which participate in the formation of native atherosclerotic lesions in chow-fed apoE(-/-) mice. Unlike Sca-1(+) progenitors from embryonic stem cel... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

EJIFCC, Volume 19, Issue 1, 3 1 2008, Pages 42-47 6. Dose Adjustments Based on Pharmacogenetics of CYP450 Enzymes. van Schaik RH

Abstract

Cited 17 times since 2008 (1 per year) source: EuropePMC

Journal of virology, Volume 82, Issue 12, 2 1 2008, Pages 5693-5702 The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency. Lindner SE, Zeller K, Schepers A, Sugden B

Epstein-Barr virus (EBV) replicates its genome as a licensed plasmid in latently infected cells. Although replication of this plasmid is essential for EBV latent infection, its synthesis still fails for 16% of the templates in S phase. In order to understand these failures, we sought to determine whether the affinity of the initiator protein (EBNA1) for its binding sites in the origin affects the efficiency of plasmid replication. We have answered this question by using several engineered origin... Abstract

Cited 7 times since 2008 (0.4 per year) source: EuropePMC

Circulation research, Volume 102, Issue 7, 1 1 2008, Pages 749-751 Pitx2: a challenging teenager. Poelmann RE, Jongbloed MR, Gittenberger-de Groot AC

Abstract

Cited 54 times since 2008 (3.1 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 1, Issue 2, 1 1 2008, Pages 192-201 Stent malapposition after sirolimus-eluting and bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: acute and 9-month intravascular ultrasound results of the MISSION! intervention study. van der Hoeven BL, Liem SS, Dijkstra J, Bergheanu SC, Putter H, Antoni ML, Atsma DE, Bootsma M, Zeppenfeld K, Jukema JW, Schalij MJ

Objectives: Acute and late stent malapposition (SM) after bare-metal stents (BMS) and sirolimus-eluting stents (SES) in ST-segment elevation myocardial infarction patients were studied. Background: Stent thrombosis may be caused by SM after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction patients. Methods: Post-procedure and follow-up intravascular ultrasound data were available in 184 out of 310 patients (60%; 104 SES, 80 BMS) included in the MISSION! In... Abstract

Cited 94 times since 2008 (5.4 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 1, Issue 2, 1 1 2008, Pages 176-182 Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis. Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Reiber JH, Schalij MJ, Wijns W, Bax JJ

Objectives: The purpose of this study was to perform a head-to-head comparison of plaque observations with multislice computed tomography (MSCT) to virtual histology intravascular ultrasound (VH IVUS). Background: The VH IVUS allows in vivo coronary plaque characterization with high spatial resolution. Noninvasively, plaques may be evaluated with MSCT, but limited data are available. Methods: A total of 50 patients underwent 64-slice MSCT followed by VH IVUS. The Agatston score was evaluated on... Abstract

Cited 32 times since 2008 (1.8 per year) source: EuropePMC

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, Volume 15, Issue 2, 1 1 2008, Pages 140-144 Exercise training increases oxygen uptake efficiency slope in chronic heart failure. Gademan MG, Swenne CA, Verwey HF, van de Vooren H, Haest JC, van Exel HJ, Lucas CM, Cleuren GV, Schalij MJ, van der Wall EE

Background and aim: The oxygen uptake efficiency slope (OUES) is a novel measure of cardiopulmonary reserve. OUES is measured during an exercise test, but it is independent of the maximally achieved exercise intensity. It has a higher prognostic value in chronic heart failure (CHF) than other exercise test-derived variables such as(Equation is included in full-text article.)or(Equation is included in full-text article.)slope. Exercise training improves(Equation is included in full-text article.)... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Minerva cardioangiologica, Volume 56, Issue 2, 1 1 2008, Pages 227-235 Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE

Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (New York Heart Association [NYHA] class III or IV, depressed left ventricular [LV] ejection fraction, and prolonged QRS duration) result in at least 30% of the selected patients with no response to CRT. Recent studies with echocardiography have shown that the presence of LV dyssynchrony is an important predictor for response to CRT. However, the r... Abstract

Cited 33 times since 2008 (1.9 per year) source: EuropePMC

The Netherlands journal of medicine, Volume 66, Issue 4, 1 1 2008, Pages 169-174 Clinical practice guideline for cardiovascular risk management in the Netherlands. Smulders YM, Burgers JS, Scheltens T, van Hout BA, Wiersma T, Simoons ML, Guideline development group for the Dutch guideline for multidisciplinary cardiovascular risk management

Abstract

Cited 12 times since 2008 (0.7 per year) source: EuropePMC

The Journal of general virology, Volume 89, Issue Pt 4, 1 1 2008, Pages 975-983 Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses. de Graaf M, Herfst S, Schrauwen EJA, Choi Y, van den Hoogen BG, Osterhaus ADME, Fouchier RAM

Human metapneumovirus (HMPV) and avian metapneumovirus (AMPV) have a similar genome organization and protein composition, but a different host range. AMPV subgroup C (AMPV-C) is more closely related to HMPV than other AMPVs. To investigate the specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses, a minireplicon system was generated for AMPV-C and used in combination with minireplicon systems for HMPV lineages A1 and B1. Viral RNA-like mol... Abstract

Cited 135 times since 2008 (7.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 51, Issue 16, 1 1 2008, Pages 1588-1596 Long-term prognosis of patients with peripheral arterial disease: a comparison in patients with coronary artery disease. Welten GM, Schouten O, Hoeks SE, Chonchol M, Vidakovic R, van Domburg RT, Bax JJ, van Sambeek MR, Poldermans D

Objectives: This study was designed to compare the long-term outcomes of patients with peripheral arterial disease (PAD) with a risk factor matched population of coronary artery disease (CAD) patients, but without PAD. Background: The PAD is considered to be a risk factor for adverse late outcome. Methods: A total of 2,730 PAD patients undergoing vascular surgery were categorized into groups: 1) carotid endarterectomy (n = 560); 2) elective abdominal aortic surgery (AAA) (n = 923); 3) acute AAA... Abstract

Cited 24 times since 2008 (1.4 per year) source: EuropePMC

Environmental science & technology, Volume 42, Issue 7, 1 1 2008, Pages 2367-2373 EXAFS study on the reactions between iron and fulvic acid in acid aqueous solutions. van Schaik JW, Persson I, Kleja DB, Gustafsson JP

Iron(III) competes with trace metals for binding sites on organic ligands. We used X-ray absorption fine structure (EXAFS) spectroscopy to determine the binding mode and oxidation state of iron in solutions initially containing only iron(III) and fulvic acid at pHs 2 and 4. EXAFS spectra were recorded at different times after sample preparation. Iron was octahedrally configured with inner-sphere Fe-O interactions at 1.98-2.10 A, depending on the oxidation state of iron. Iron(III) formed complexe... Abstract

Cited 93 times since 2008 (5.3 per year) source: EuropePMC

Pharmacogenetics and genomics, Volume 18, Issue 4, 1 1 2008, Pages 339-348 CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients. Hesselink DA, van Schaik RH, van Agteren M, de Fijter JW, Hartmann A, Zeier M, Budde K, Kuypers DR, Pisarski P, Le Meur Y, Mamelok RD, van Gelder T

Objective: Patients expressing the tacrolimus-metabolizing enzyme, cytochrome P450 (CYP) 3A5, require more tacrolimus to reach target concentrations. We studied the influence of the CYP3A5(*)3 allele, which results in the absence of CYP3A5 protein, on tacrolimus dose and exposure, as well as the incidence of biopsy-proven acute rejection (BPAR) after renal transplantation. Methods: A total of 136 patients participating in a prospective, randomized-controlled clinical trial with the primary aim o... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Minerva cardioangiologica, Volume 56, Issue 2, 1 1 2008, Pages 215-226 Multi-slice computed tomography coronary angiography: anatomic vs functional assessment in clinical practice. Van Werkhoven JM, Schuijf JD, Jukema JW, Van Der Wall EE, Bax JJ

Non-invasive imaging plays an increasingly important role in the diagnosis and risk stratification of coronary artery disease (CAD). Several techniques such as stress echocardiography and myocardial perfusion imaging have become available to assess cardiac function and myocardial perfusion. With the arrival of multi-slice computed tomography coronary angiography (CTA), non-invasive imaging of coronary anatomy has also become possible. Studies concerning the diagnostic accuracy have demonstrated... Abstract

Cited 11 times since 2008 (0.6 per year) source: EuropePMC

The Veterinary record, Volume 162, Issue 15, 1 1 2008, Pages 475-479 Subclinical hypocalcaemia in captive Asian elephants (Elephas maximus). van der Kolk JH, van Leeuwen JP, van den Belt AJ, van Schaik RH, Schaftenaar W

The hypothesis that hypocalcaemia may play a role in dystocia in captive Asian elephants (Elephas maximus) was investigated. The objectives of the study were to measure the total calcium concentration in elephant plasma; assess the changes in parameters of calcium metabolism during a feeding trial; investigate a possible relationship between calcium metabolism and dystocia; and assess bone mineralisation in captive Asian elephants in vivo. The following parameters were measured: total and ionise... Abstract