Research

Publications

Below you can find a list of our published research.

9618 results

Cited 54 times since 2008 (3.1 per year) source: EuropePMC

Pharmacogenetics and genomics, Volume 18, Issue 4, 1 1 2008, Pages 299-305 Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration. Aarnoudse AJ, Dieleman JP, Visser LE, Arp PP, van der Heiden IP, van Schaik RH, Molokhia M, Hofman A, Uitterlinden AG, Stricker BH

Background and objective: Digoxin is a known substrate of ATP-binding cassette B1 (ABCB1/MDR1). The results of studies on the association between ABCB1 polymorphisms and digoxin kinetics, however, remain contradictory. Almost all studies were small and involved only single dose kinetics. The goal of this study was to establish ABCB1 genotype effect on digoxin blood concentrations in a large cohort of chronic digoxin users in a general Dutch European population. Methods: Digoxin users were identi... Abstract

Cited 4 times since 2008 (0.2 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 7, Issue 3, 28 4 2008, Pages 517-518 Early atrial septal defect surgery due to a bronchogenic cyst causing congestive heart failure by left atrium compression. Mosquera VX, Rijlaarsdam M, Filippini L, Hazekamp MG

We report on an uncommon case of a 10-month-old patient who required early surgical closure of an ostium secumdum atrial septal defect due to the concomitant presence of a big subcarinal bronchogenic cyst compressing the left atrium and, therefore, increasing the left-to-right shunt. It led to refractory congestive heart failure symptoms, establishing thereby an earlier indication of surgical treatment. Abstract

Cited 7 times since 2008 (0.4 per year) source: EuropePMC

BMC psychiatry, Volume 8, 25 4 2008, Pages 18 Treatment of chronically depressed patients: a multisite randomized controlled trial testing the effectiveness of 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) for chronic depressions versus usual secondary care. Wiersma JE, van Schaik DJ, van Oppen P, McCullough JP, Schoevers RA, Dekker JJ, Blom MB, Maas K, Smit JH, Penninx BW, Beekman AT

Background: 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) is a form of psychotherapy specifically developed for patients with chronic depression. In a study in the U.S., remarkable favorable effects of CBASP have been demonstrated. However, no other studies have as yet replicated these findings and CBASP has not been tested outside the United States. This protocol describes a randomized controlled trial on the effectiveness of CBASP in the Netherlands. Methods/design:... Abstract

Cited 21 times since 2008 (1.2 per year) source: EuropePMC

Journal of neuroimmunology, Volume 195, Issue 1-2, 20 3 2008, Pages 164-170 B and T cell imbalances in CSF of patients with Hu-antibody associated PNS. de Graaf M, de Beukelaar J, Bergsma J, Kraan J, van den Bent M, Klimek M, van Norden Y, Kusuma A, Smitt PS, Gratama JW

In paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (approximately 20x) and relative (approximately 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolut... Abstract

Cited 52 times since 2008 (3 per year) source: EuropePMC

Circulation, Volume 117, Issue 12, 10 2 2008, Pages 1508-1517 Epicardium-derived cells in development of annulus fibrosis and persistence of accessory pathways. Kolditz DP, Wijffels MC, Blom NA, van der Laarse A, Hahurij ND, Lie-Venema H, Markwald RR, Poelmann RE, Schalij MJ, Gittenberger-de Groot AC

Background: The developmental mechanisms underlying the persistence of myocardial accessory atrioventricular pathways (APs) that bypass the annulus fibrosis are mainly unknown. In the present study, we investigated the role of epicardium-derived cells (EPDCs) in annulus fibrosis formation and the occurrence of APs. Methods and results: EPDC migration was mechanically inhibited by in ovo microsurgery in quail embryos. In ovo ECGs were recorded in wild-type (n=12) and EPDC-inhibited (n=12) hearts... Abstract

Cited 11 times since 2008 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 8, 4 1 2008, Pages 1179-1184 Effects of percutaneous transluminal septal myocardial ablation for obstructive hypertrophic cardiomyopathy on systolic and diastolic left ventricular function assessed by pressure-volume loops. Meliga E, Steendijk P, Valgimigli M, Ten Cate FJ, Serruys PW

The aim of the present study was to determine the long-term effects of percutaneous transluminal septal myocardial ablation (PTSMA) on systolic and diastolic left ventricular (LV) functions in patients with obstructive hypertrophic cardiomyopathy (HC). Ten consecutive patients with symptomatic HC despite optimal medical treatment were referred for PTSMA at our center. LV systolic and diastolic functions were assessed by online LV pressure-volume loops obtained by conductance catheter at baseline... Abstract

Cited 28 times since 2008 (1.6 per year) source: EuropePMC

Molecular therapy : the journal of the American Society of Gene Therapy, Volume 16, Issue 4, 4 1 2008, Pages 741-748 Genetic complementation of human muscle cells via directed stem cell fusion. Gonçalves MA, Swildens J, Holkers M, Narain A, van Nierop GP, van de Watering MJ, Knaän-Shanzer S, de Vries AA

Duchenne muscular dystrophy (DMD) is caused by mutations in the X chromosome-linked DMD gene, which encodes the sarcolemma-stabilizing protein-dystrophin. Initial attempts at DMD therapy deployed muscle progenitor cells from healthy donors. The utilization of these cells is, however, hampered by their immunogenicity, while those from DMD patients are scarce and display limited ex vivo replication. Nonmuscle cells with myogenic capacity may offer valuable alternatives especially if, to allow auto... Abstract

Cited 20 times since 2008 (1.1 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 2, 4 1 2008, Pages 417-423 Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity. Alizadeh Dehnavi R, de Roos A, Rabelink TJ, van Pelt J, Wensink MJ, Romijn JA, Tamsma JT

Background: Visceral obesity (VO) is associated with an increased risk of cardiovascular disease. Elevated C-reactive protein (CRP) levels are associated with VO and cardiovascular disease. After exploring the relation between CRP and VO, we aimed to evaluate the VO independent relation between CRP and carotid atherosclerosis. Methods and results: The prevalence of inflammation was evaluated in 439 male subjects with VO without type 2 diabetes and manifest cardiovascular disease. Waist circumfer... Abstract

Cited 36 times since 2008 (2.1 per year) source: EuropePMC

TheScientificWorldJournal, Volume 8, 3 1 2008, Pages 239-269 Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis. Jongbloed MR, Mahtab EA, Blom NA, Schalij MJ, Gittenberger-de Groot AC

The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties than the surrounding working myocardium, which can be observed on a histological level, as well as by the expression patterns of several immunohistological and molecular markers. In recent years, many markers have been studied that have helped to el... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

Vascular, Volume 16, Issue 2, 1 1 2008, Pages 116-119 Inflammatory aneurysm of the common iliac artery mimicking appendicitis. Mieog JS, Stoot JH, Bosch JJ, Koning OH, Hamming JF

Isolated inflammatory aneurysm of the common iliac artery is a rare condition. Previously reported cases presented with urologic complications owing to entrapment of the ureter in the perianeurysmal fibrosis. We report a case of a healthy young man who presented with acute abdominal pain in the right lower quadrant without urologic complications mimicking acute appendicitis. The pain was caused by an isolated inflammatory aneurysm of the right common iliac artery measuring 4 cm in diameter. Thre... Abstract

Annals of surgery, Volume 247, Issue 3, 1 1 2008, Pages 555; author reply 555-6 Re: Laparoscopic Versus Open Appendectomy in Children: A Meta-analysis. Aziz MI, van der Burg BL, Hamming JF

Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 1, Issue 2, 1 1 2008, Pages 190-199 Invasive versus noninvasive evaluation of coronary artery disease. Schuijf JD, van Werkhoven JM, Pundziute G, Jukema JW, Decramer I, Stokkel MP, Dibbets-Schneider P, Schalij MJ, Reiber JH, van der Wall EE, Wijns W, Bax JJ

Objectives: We sought to compare the diagnostic information obtained from noninvasive characterization of coronary artery disease by using multidetector computed tomography (MDCT) and myocardial perfusion imaging (MPI) and to compare findings with the use of invasive coronary angiography and intravascular ultrasound (IVUS). Background: Preliminary comparisons have suggested that abnormal myocardial perfusion studies correlate well with significant luminal stenosis on MDCT coronary angiography. H... Abstract

Cited 96 times since 2008 (5.5 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 237, Issue 3, 1 1 2008, Pages 847-857 Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC

Epicardium and epicardium-derived cells have been shown to be necessary for myocardial differentiation. To elucidate the function of podoplanin in epicardial development and myocardial differentiation, we analyzed podoplanin knockout mouse embryos between embryonic day (E) 9.5 and E15.5 using immunohistochemical differentiation markers, morphometry, and three-dimensional reconstructions. Podoplanin null mice have an increased embryonic lethality, possibly of cardiac origin. Our study reveals imp... Abstract

Cited 65 times since 2008 (3.7 per year) source: EuropePMC

Diabetic medicine : a journal of the British Diabetic Association, Volume 25, Issue 3, 1 1 2008, Pages 277-281 Sulphonylurea therapy improves cognition in a patient with the V59M KCNJ11 mutation. Slingerland AS, Hurkx W, Noordam K, Flanagan SE, Jukema JW, Meiners LC, Bruining GJ, Hattersley AT, Hadders-Algra M

Background: KCNJ11 mutations are a common cause of diabetes diagnosed in the first 6 months of life, and approximately 25% of patients have neurological features. Sulphonylureas have been shown to improve glycaemic control and also motor function, but the impact on cognitive function has not been extensively addressed previously. Methods: The patient had a low birth weight and was found to have diabetes at the age of 2 days. The patient was treated with insulin from diagnosis. The child also had... Abstract

Cited 25 times since 2008 (1.4 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 31, Issue 3, 1 1 2008, Pages 358-374 Ablation of ventricular tachycardia in patients with structural heart disease. Zeppenfeld K, Stevenson WG

Catheter ablation is an important therapeutic option for controlling recurrent ventricular arrhythmias in patients with heart disease. Although implantable defibrillators are generally first line therapy in this patient population, a substantial number of patients require additional therapy with either antiarrhythmic drugs, ablation, or both. Studies of mapping and ablation have produced further insights into pathophysiologic mechanisms of these arrhythmias, which are now well characterized. The... Abstract

Cited 339 times since 2008 (19.4 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 21, Issue 3, 1 1 2008, Pages 191-213 Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting--a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society. Gorcsan J, Abraham T, Agler DA, Bax JJ, Derumeaux G, Grimm RA, Martin R, Steinberg JS, Sutton MS, Yu CM, American Society of Echocardiography Dyssynchrony Writing Group, American Society of Echocardiography Dyssynchrony Writing Group, Heart Rhythm Society

Echocardiography plays an evolving and important role in the care of heart failure patients treated with biventricular pacing, or cardiac resynchronization therapy (CRT). Numerous recent published reports have utilized echocardiographic techniques to potentially aide in patient selection for CRT prior to implantation and to optimized device settings afterwards. However, no ideal approach has yet been found. This consensus report evaluates the contemporary applications of echocardiography for CRT... Abstract

Cited 19 times since 2008 (1.1 per year) source: EuropePMC

IEEE transactions on biomedical circuits and systems, Volume 2, Issue 1, 1 1 2008, Pages 30-43 An active 2-d silicon cochlea. Hamilton TJ, Jin C, van Schaik A, Tapson J

In this paper, we present an analog integrated circuit design for an active 2-D cochlea and measurement results from a fabricated chip. The design includes a quality factor control loop that incorporates some of the nonlinear behavior exhibited in the real cochlea. This control loop varies the gain and the frequency selectivity of each cochlear resonator based on the amplitude of the input signal. Abstract

Cited 26 times since 2008 (1.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 3, 1 1 2008, Pages 255-257 CT angiography: an alternative to nuclear perfusion imaging? Schuijf JD, Bax JJ

Abstract

Cited 29 times since 2008 (1.7 per year) source: EuropePMC

World journal of gastroenterology, Volume 14, Issue 10, 1 1 2008, Pages 1633-1635 Melanoma of the rectum: a rare entity. van Schaik PM, Ernst MF, Meijer HA, Bosscha K

A 41-year-old man presented with a 6-mo history of changed defecation and rectal bleeding. A 3-cm polypoid tumor of the lower rectum was found at rectosigmoidoscopy, which proved to be a leiomyosarcoma upon biopsy. Dissemination studies did not show any metastases. He was underwent to an abdomino-perineal resection (APR). Histopathology of the specimen showed a melanoma (S-100 stain positive). Two years after the resection, metastases in the abdomen and right lung were found. He died one and hal... Abstract

Cited 48 times since 2008 (2.7 per year) source: EuropePMC

American journal of hematology, Volume 83, Issue 3, 1 1 2008, Pages 200-202 UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J

The purpose of the study was to determine if UDP-glucuronosyltransferase (UGT) 2B7 allelic variants encoding for UGT2B7, primary enzyme responsible for morphine glucuronidation contribute to the variability in the hepatic clearance of morphine in sickle cell disease (SCD). Twenty-four hour PK study of morphine and UGT2B7 variants genotyping was performed in 20 SCD patients in a steady state of health. Presence of the -840G allele (GG and GA) was associated with lower morphine metabolites/morphin... Abstract