Research

Publications

Below you can find a list of our published research.

8821 results

Cited 7 times since 2008 (0.4 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 4, Issue 3, 1 1 2008, Pages 318-323 Characterisation of the "vulnerable" coronary plaque by multi-detector computed tomography: a correlative study with intravascular ultrasound-derived radiofrequency analysis of plaque composition. Sarno G, Vanhoenacker P, Decramer I, Schuijf JD, Pundziute G, Margolis P, Gupta S, Bax JJ, Wijns W

Aims: To assess plaque characteristics by multi-detector computed tomography angiography in patients with known coronary artery disease and to compare these findings with those obtained with intravascular ultrasound-derived radiofrequency analysis of plaque composition. Methods and results: By computed tomography, lesions were classified on the basis of Hounsfield Units as non-calcified, calcified, or mixed. By intravascular ultrasound-derived radiofrequency analysis, plaques were classified acc... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Ugeskrift for laeger, Volume 170, Issue 45, 1 1 2008, Pages 3637-3639 [Myocardial perfusion scintigraphy. Exact and cost-effective coronary disease imaging--secondary publication]. Hesse B, Petersen CL, Marcassa C, Bax JJ, Bengel F, Reyes E, Underwood R

Mortality rates due to coronary arterial disease (CAD) have declined as result of improved prevention, diagnosis and management, but CAD remains the leading cause of death. Myocardial perfusion scintigraphy (MPS) provides a cost-effective tool for early detection of CAD in symptomatic individuals and can stratify patients according to risk of cardiac events. MPS also provides valuable information to assist clinical decision-making. A large body of evidence supports the current applications of MP... Abstract

Cited 343 times since 2008 (21 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 52, Issue 22, 1 1 2008, Pages 1793-1799 Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. Rijzewijk LJ, van der Meer RW, Smit JW, Diamant M, Bax JJ, Hammer S, Romijn JA, de Roos A, Lamb HJ

Objectives: The purpose of this study was to compare myocardial triglyceride content and function between patients with uncomplicated type 2 diabetes mellitus (T2DM) and healthy subjects within the same range of age and body mass index (BMI), and to study the associations between myocardial triglyceride content and function. Background: T2DM is a major risk factor for cardiovascular disease. Increasing evidence is emerging that lipid oversupply to cardiomyocytes plays a role in the development o... Abstract

Cited 17 times since 2008 (1 per year) source: EuropePMC

Echocardiography (Mount Kisco, N.Y.), Volume 25, Issue 10, 1 1 2008, Pages 1186-1194 Left ventricular mechanical dyssynchrony as assessed by phase analysis of ECG-gated SPECT myocardial perfusion imaging. Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE

Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (NYHA class III or IV, depressed left ventricular (LV) ejection fraction, and prolonged QRS duration) result in at least 30% of the selected patients with no response to CRT. Recent studies with tissue Doppler imaging (TDI) have shown that the presence of LV dyssynchrony is an important predictor for response to CRT. Phase analysis has been develop... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

The European respiratory journal, Volume 32, Issue 5, 1 1 2008, Pages 1135-1137 The secret life of steroids in asthma. Sterk PJ, Yick CY, Slats AM

Abstract

Cited 44 times since 2008 (2.7 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 31, Issue 11, 1 1 2008, Pages 1475-1499 Noninvasive imaging in cardiac resynchronization therapy--part 1: selection of patients. Ypenburg C, Westenberg JJ, Bleeker GB, VAN de Veire N, Marsan NA, Henneman MM, van der Wall EE, Schalij MJ, Abraham TP, Barold SS, Bax JJ

Cardiac resynchronization therapy (CRT) is an established therapy for patients with advanced heart failure, depressed left ventricular function, and wide QRS complex. However, individual response varies, and a substantial amount of patients do not respond to CRT. Recent studies observed that assessment of inter- and particularly intraventricular dyssynchrony may allow identification of potential responders to CRT. In addition, presence of scar tissue and venous anatomy may play a role in the sel... Abstract

Cited 5 times since 2008 (0.3 per year) source: EuropePMC

Cytometry. Part A : the journal of the International Society for Analytical Cytology, Volume 73, Issue 11, 1 1 2008, Pages 1079-1085 Contamination of synthetic HuD protein spanning peptide pools with a CMV-encoded peptide. de Graaf MT, de Beukelaar JW, Burgers PC, Luider TM, Kraan J, Smitt PA, Gratama JW

To detect HuD-specific T cells in patients with Hu-antibody associated paraneoplastic neurological syndromes (Hu-PNS), we used short-term stimulation assays with HuD protein spanning peptide pools (PSPP) with purities of at least 70% and found reproducible false-positive CD8+ T-cell responses in three of 127 individuals (two healthy controls and one Hu-PNS patient), which all shared HLA-A*2402 and HLA-B*1801. After testing the 15-mer peptides of the HuD antigen separately, we discovered that the... Abstract

Cited 10 times since 2008 (0.6 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 10 Suppl 3, 1 1 2008, Pages iii73-9 Predicting response to CRT. The value of two- and three-dimensional echocardiography. Marsan NA, Breithardt OA, Delgado V, Bertini M, Tops LF

Recently, it has been suggested that a direct assessment of left ventricular (LV) mechanical dyssynchrony may improve the selection of candidates to cardiac resynchronization therapy (CRT). In fact, when the established clinical and electrocardiographic selection criteria are applied, response to CRT may vary widely and up to one-third of the patients fail to benefit from CRT. Echocardiography has been extensively applied to assess LV dyssynchrony and to predict favourable response to CRT, using... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Archives of internal medicine, Volume 168, Issue 21, 1 1 2008, Pages 2383 Statins and blood pressure. Trompet S, Jukema JW, Ford I, Shepherd J, Gussekloo J, Buckley BM, Westendorp RG, de Craen AJ

Abstract

Cited 16 times since 2008 (1 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 10 Suppl 3, 1 1 2008, Pages iii101-5 Is nuclear imaging a viable alternative technique to assess dyssynchrony? Chen J, Bax JJ, Henneman MM, Boogers MJ, Garcia EV

Cardiac resynchronization therapy (CRT) has shown benefits in patients with end-stage heart failure (HF) (NYHA class III or IV), depressed left ventricular (LV) ejection fraction, and prolonged QRS duration (>120 ms). However, at least 30% of the patients who meet the above criteria show no response to CRT. It has shown with echocardiography that the presence of LV mechanical dyssynchrony is an important predictor for response to CRT. However, echocardiography requires expertise to produce re... Abstract

Cited 126 times since 2008 (7.7 per year) source: EuropePMC

Annals of neurology, Volume 64, Issue 5, 1 1 2008, Pages 514-522 Randomized, controlled trial of miglustat in Gaucher's disease type 3. Schiffmann R, Fitzgibbon EJ, Harris C, DeVile C, Davies EH, Abel L, van Schaik IN, Benko W, Timmons M, Ries M, Vellodi A

Objective: To evaluate the efficacy and safety of miglustat, concomitant with enzyme replacement therapy (ERT), in patients with Gaucher's disease type 3 (GD3). Methods: This 24-month, phase II, open-label clinical trial of miglustat in GD3 was conducted in two phases. During the initial 12 months, patients were randomized 2:1 to receive miglustat or "no miglustat treatment." The randomized phase was followed by an optional 12-month extension phase in which all patients received m... Abstract

Cited 84 times since 2008 (5.1 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 21, Issue 11, 1 1 2008, Pages 1244-1250 Relation between global left ventricular longitudinal strain assessed with novel automated function imaging and biplane left ventricular ejection fraction in patients with coronary artery disease. Delgado V, Mollema SA, Ypenburg C, Tops LF, van der Wall EE, Schalij MJ, Bax JJ

Objective: Automated function imaging (AFI) is a novel algorithm based on speckle-tracking imaging that can be used for assessment of global longitudinal strain of the left ventricle. The purpose of this study was to evaluate the relation between global longitudinal peak systolic strain average (GLPSS Avg) assessed by AFI and left ventricular ejection fraction (LVEF). Methods: The study population consisted of 222 consecutive patients with coronary artery disease (99 patients with acute ST-segme... Abstract

Cited 65 times since 2008 (4 per year) source: EuropePMC

European heart journal, Volume 29, Issue 22, 28 4 2008, Pages 2792-2799 CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction. Regieli JJ, Jukema JW, Grobbee DE, Kastelein JJ, Kuivenhoven JA, Zwinderman AH, van der Graaf Y, Bots ML, Doevendans PA

Aims: Inhibition of cholesteryl ester transfer protein (CETP) increases HDL-cholesterol. However, its combination with statins may increase mortality by factors incompletely understood. We previously observed that patients with intrinsically low CETP levels (carriers of the TaqIB-B2 allele) may have less benefit from statin therapy, and here tested this pharmacogenetic hypothesis on long-term outcomes. Methods and results: We performed a 10-year follow-up analysis in 812 coronary artery disease... Abstract

Cited 39 times since 2008 (2.4 per year) source: EuropePMC

International journal of epidemiology, Volume 38, Issue 1, 24 4 2008, Pages 253-261 Adipocytokines and risk of stroke in older people: a nested case-control study. Stott DJ, Welsh P, Rumley A, Robertson M, Ford I, Sattar N, Westendorp RG, Jukema JW, Cobbe SM, Lowe GD

Background: Inflammation may play an important role in atherothrombosis and in promoting cerebral damage after stroke. We hypothesized that plasma adipocytokine concentrations would be associated with risk of stroke in older people. Methods: Nested case-control study from the Prospective Study of Pravastatin in the Elderly (PROSPER). Subjects were aged 70-82 years and followed up for a mean of 3.2 years: 266 incident stroke cases (179 confirmed as ischaemic) were compared with 532 controls match... Abstract

Cited 75 times since 2008 (4.6 per year) source: EuropePMC

The EMBO journal, Volume 27, Issue 22, 23 4 2008, Pages 3024-3035 RNA-dependent recruitment of the origin recognition complex. Norseen J, Thomae A, Sridharan V, Aiyar A, Schepers A, Lieberman PM

The origin recognition complex (ORC) has an important function in determining the initiation sites of DNA replication. In higher eukaryotes, ORC lacks sequence-specific DNA binding, and the mechanisms of ORC recruitment and origin determination are poorly understood. ORC is recruited with high efficiency to the Epstein-Barr virus origin of plasmid replication (OriP) through a complex mechanism involving interactions with the virus-encoded EBNA1 protein. We present evidence that ORC recruitment t... Abstract

Cited 36 times since 2008 (2.2 per year) source: EuropePMC

Radiology, Volume 249, Issue 3, 21 3 2008, Pages 801-809 Aortic elasticity and left ventricular function after arterial switch operation: MR imaging--initial experience. Grotenhuis HB, Ottenkamp J, Fontein D, Vliegen HW, Westenberg JJ, Kroft LJ, de Roos A

Purpose: To prospectively assess aortic dimensions, aortic elasticity, aortic valve competence, and left ventricular (LV) systolic function in patients after the arterial switch operation (ASO) by using magnetic resonance (MR) imaging. Materials and methods: Informed consent was obtained from all participants for this local ethics committee-approved study. Fifteen patients (11 male patients, four female patients; mean age, 16 years +/- 4 [standard deviation]; imaging performed 16.1 years after s... Abstract

Cited 21 times since 2008 (1.3 per year) source: EuropePMC

American journal of surgery, Volume 197, Issue 6, 17 3 2008, Pages 747-751 Wound complications at the groin after peripheral arterial surgery sparing the lymphatic tissue: a double-blind randomized clinical trial. Ploeg AJ, Lardenoye JW, Peeters MP, Hamming JF, Breslau PJ

Background: The groin incision after arterial reconstructive surgery is most likely at risk for infectious or lymphatic wound complications. Theoretically; sparing lymphatic tissue by a lateral approach to the femoral artery should minimize these. The aim of this study was to assess the incidence of wound complications after the lateral versus the direct approach of the common femoral artery. Methods: The study population included all patients who underwent an exploration of the common femoral a... Abstract

Cited 76 times since 2008 (4.6 per year) source: EuropePMC

American journal of epidemiology, Volume 168, Issue 11, 15 3 2008, Pages 1233-1246 Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Sagoo GS, Tatt I, Salanti G, Butterworth AS, Sarwar N, van Maarle M, Jukema JW, Wiman B, Kastelein JJ, Bennet AM, de Faire U, Danesh J, Higgins JP

Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid fractions and CHD risk in population-based cohort, case-control, and cross-sectional studies published by January 2007. Meta-analyses of 22,734 CHD cases and 50,177 controls in 89 association studies focused on the relations of the T-93G (rs1800590), D9N (rs1801177), G188E, N291S (rs268), PvuII (rs2... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 25, Issue 1, 15 3 2008, Pages 53-55 Gated SPECT in left bundle branch block: from improved diagnosis to improved treatment. van der Wall EE, Bax JJ, Jukema JW, Schalij MJ

Abstract

Cited 123 times since 2008 (7.5 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 12, 14 2 2008, Pages 1602-1607 Relation of epicardial adipose tissue to coronary atherosclerosis. Djaberi R, Schuijf JD, van Werkhoven JM, Nucifora G, Jukema JW, Bax JJ

Adipose tissue surrounding the coronary arteries has been suggested to induce development of atherosclerosis. We explored the relation between epicardial adipose tissue (EAT) volume and coronary atherosclerosis using multislice computed tomography. The study population consisted of 190 patients who had undergone multislice computed tomographic coronary angiography. Coronary artery calcium score was assessed. In addition, patients were classified as having (1) no atherosclerosis, (2) nonobstructi... Abstract