AATD test aanbevelingen

Testing is recommended in the following settings (type A recommendation):

1. Symptomatic adults with persistent obstruction on pulmonary function testing, with:
       a. Emphysema
       b. COPD
       c. Asthma where there is incompletely reversible airflow obstruction after aggressive treatment with bronchodilators
   
   
2. Asymptomatic individuals with persistent obstruction on pulmonary function testing with identifiable risk factors, including:
      a. Cigarette smoking
      b. Occupational exposure
   
   
3. Individuals with unexplained liver disease, including newborns, children and adults (particularly the elderly)
   
   
4. Adults with necrotising panniculitis
   
   
5. Adults and adolescents with a sibling with α1-AT homozygosity, i.e. the PiZZ genotype (asymptomatic individuals who may be at high risk of having the genetic predisposition for developing α1-AT deficiency)