7494 results
Nederlands tijdschrift voor geneeskunde,
Volume 169, 18 3 2025, Pages D8577
[The role of clinical practice guidelines in the assessment by the disciplinary board].
Weller FS, van Bodegom-Vos L, Repping S, Hamming JF
Objective: To examine how often disciplinary complaints against physicians are upheld explicitly on the grounds of deviation from clinical practice guidelines. Design: Retrospective document analysis of publicly available medical disciplinary rulings in the Netherlands between January 1, 2019, and December 31, 2023. Methods: We analysed rulings from the official Dutch disciplinary law database (tuchtrecht.nl). All upheld complaints were reviewed to determine whether the disciplinary board explic...
Abstract
JACC. Case reports,
10 2 2025, Pages 106227
Severe Aortic Stenosis and Dual Valve Vegetations: An Uncommon Presentation of Primary Antiphospholipid Syndrome.
van der Woude SFS, Valentijn FA, Antoni ML, Huisman SJ, van Vliet M
Background: Primary antiphospholipid syndrome (PAPS) may cause thromboembolic events and valvular heart disease. Case summary: A 42-year-old woman with a history of pre-eclampsia, epilepsy, and thrombocytopenia presented with acute chest pain and shortness of breath. Investigations revealed vegetation on both the aortic and mitral valves, severe aortic stenosis, and a non-ST-segment elevation myocardial infarction. Autoimmune testing confirmed antiphospholipid antibodies, which led to a diagnosi...
Abstract
Scientific reports,
10 2 2025
Sex-based differences in biomarker trajectories in acute coronary syndrome patients from the BIOMArCS study.
Gärtner C, Haaf MET, Akkerhuis KM, Oemrawsingh RM, van Schaik RH, de Rijke YB, Kardys I, Appelman Y, Boersma E
Acute coronary syndrome (ACS) presents sex-based differences in pathophysiology. Variations in biomarker patterns post-ACS, reflecting myocardial injury, vascular inflammation, and remodeling, may indicate critical differences in cardiovascular disease mechanisms and outcomes. We analyzed biomarker patterns in 787 patients (22% females) from the BIOMArCS study, all without re-ACS during the study period. We tracked levels of hs-cTnT, NT-proBNP, hs-CRP, GDF-15, and additional biomarkers in a subc...
Abstract
Allergy,
9 2 2025
Drug Survival in Atopic Dermatitis: Comparison of Biologics and JAK Inhibitors in the BioDay Registry.
van der Gang LF, Boesjes CM, Zuithoff NPA, Haeck I, Bacoş-Cosma O, Loman L, Atash K, Harbers V, Stadhouders S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynski A, Christoffers WA, Garritsen FM, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, Galimont-Collen AFS, Schuttelaar MA, de Graaf M, de Bruin-Weller MS
Abstract
The New England journal of medicine,
9 2 2025
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults.
Casey JD, Seitz KP, Driver BE, Gibbs KW, Ginde AA, Trent SA, Russell DW, Muhs AL, Prekker ME, Gaillard JP, Resnick-Ault D, Stewart LJ, Whitson MR, DeMasi SC, Robinson AE, Palakshappa JA, Aggarwal NR, Brainard JC, Douin DJ, Marvi TK, Scott BK, Alber SM, Lyle C, Gandotra S, Van Schaik GW, Lacy AJ, Sherlin KC, Erickson HL, Cain JM, Redman B, Beach LL, Gould B, McIntosh J, Lewis AA, Lloyd BD, Israel TL, Imhoff B, Wang L, Spicer AB, Churpek MM, Rice TW, Self WH, Han JH, Semler MW, RSI Investigators and the Pragmatic Critical Care Research Group
Background: For critically ill adults undergoing tracheal intubation, observational studies suggest that the use of etomidate to induce anesthesia may increase the risk of death. Whether the use of ketamine rather than etomidate decreases the risk of death is uncertain. Methods: In a randomized trial conducted in 14 emergency departments and intensive care units in the United States, we randomly assigned critically ill adults who were undergoing tracheal intubation to receive ketamine or etomida...
Abstract
European heart journal. Cardiovascular Imaging,
8 2 2025, Pages jeaf336
Pitfalls and Solutions in the Imaging Follow-up of Valvular Heart Disease Devices.
Ternacle J, Turgeon PY, Hahn RT, Marsan NA, Pibarot P
Doppler-echocardiography is the primary imaging modality for the evaluation and follow-up of valvular heart devices. This article highlights the unique pitfalls associated with these devices, including imaging challenges and flow dynamics, which often push echocardiography to its limits. The use of a multimodality imaging approach including cardiac computed tomography (CT) and magnetic resonance, and positron emission tomography-CT is recommended to confirm the diagnosis of prosthetic valve dysf...
Abstract
Expert opinion on biological therapy,
7 1 2025, Pages 1-22
Current treatment landscape of atopic dermatitis focusing on real-world evidence of dupilumab treatment.
Boesjes CM, van der Gang LF, Achten RE, Bakker DS, van der Rijst LP, Dekkers CC, van Wijk F, Haeck IM, de Bruin-Weller MS, de Graaf M
Introduction: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder and has a considerable impact on patients' quality of life. Dupilumab, the first biologic approved for moderate-to-severe AD, is a human monoclonal antibody targeting the interleukin (IL)-4 receptor α, thereby blocking both IL-4 and IL-13 signaling, key drivers of type 2 inflammation in AD. Its introduction has marked a paradigm shift in the management of AD and paved the way for future therapies. As real...
Abstract
ESMO open,
Volume 10, Issue 12, 5 1 2025, Pages 105923
Pathological complete response and survival after neoadjuvant chemotherapy in patients with stage I TNBC: a registry-based study.
de Graaf M, Gielen RCAM, Balduzzi S, Siesling S, Linn SC, Kok M
Background: Pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is a strong prognostic factor in patients with early-stage triple-negative breast cancer (TNBC). One-third of all patients with early-stage TNBC have stage I disease. Chemotherapy is recommended for most patients with stage I TNBC with an increasing use in the neoadjuvant setting supported by recent guidelines. However, little is known on the chemotherapy benefit for stage I TNBC, in particular the likelihood...
Abstract
JAC-antimicrobial resistance,
Volume 7, Issue 6, 5 1 2025, Pages dlaf229
Increasing trend in fusidic acid resistance among MRSA isolates in the Netherlands, 2016-23.
Velthuis F, Nauta IM, Altorf-van der Kuil W, Notermans DW, Zwittink RD, Schoffelen AF, de Greeff SC, Infectious Diseases Surveillance Information System–Antimicrobial Resistance (ISIS–AR) Study Group
Objectives: Recently, several MRSA community outbreaks occurred in the Netherlands, including one caused by an impetigo-causing MRSA strain resistant to fusidic acid. Since fusidic acid and flucloxacillin are the main treatment options for impetigo, increasing resistance limits treatment possibilities. We examined trends in fusidic acid resistance percentages among MRSA isolates in the Netherlands. Materials and methods: Data on routine bacteriological cultures between 2016 and 2023 from 30 labo...
Abstract
United European gastroenterology journal,
5 1 2025
Filgotinib Is an Effective and Safe Treatment Option for Difficult-To-Treat Ulcerative Colitis: Real-World Evidence of the Dutch Initiative on Crohn and Colitis (ICC) Registry.
Naber MR, van der Meulen AE, Voorneveld PW, Veltkamp SHC, van Bodegraven AA, Bodelier A, Mujagic Z, Pierik M, Verleye LMM, Duijvestein M, Bouwknegt DG, Visschedijk MC, Srivastava N, West RL, Oldenburg B, Löwenberg M, van Schaik FDM, Dutch ICC Registry
Background: Filgotinib is a preferential Janus kinase 1 (JAK-1) inhibitor registered for the treatment of ulcerative colitis (UC). Real-world effectiveness of filgotinib, especially for difficult-to-treat (DTT, failure of ≥ 2 prior advanced therapies) patients, has been scarcely reported. Objective: This study aimed to assess the effectiveness and safety of filgotinib for UC patients in routine care. Methods: The Dutch ICC registry enrolled UC patients initiating filgotinib and prospectively eva...
Abstract
Circulation. Cardiovascular imaging,
4 1 2025, Pages e018862
Global Longitudinal Strain for Prognostic Staging in Wild-Type Transthyretin Cardiac Amyloidosis.
Debonnaire P, L'Hoyes W, Donal E, Verheyen N, Vervloet D, Dujardin K, Pouleur AC, Dulgheru R, Sarli Issa V, Droogmans S, Jurcut R, Regeer M, Dupont M, Bondue A, Timmermans P, Bohyn A, Christiaen E, Wyseure N, Bezard M, Zach D, Schwegel N, Knapen R, Buytaert L, de Marneffe N, Adam R, Ajmone Marsan N, Tavernier R, Buysschaert I, Trenson S
Background: A formal prognostic staging system in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), based on echocardiographic imaging, is lacking. We evaluated the prognostic performance of global longitudinal strain (GLS) staging in a large ATTRwt-CM patient cohort, including under tafamidis treatment and relative to National Amyloidosis Center (NAC) biomarker staging. Methods: A multicentric, international ATTRwt-CM patient cohort with baseline GLS (distribution quartiles), evaluate...
Abstract
Journal of the American Heart Association,
3 1 2025, Pages e046283
Anrep Effect in the Right Ventricle: Evidence From Systolic Duration Analysis.
Reil JC, Sequeira V, Wink J, Federspiel JM, Reil GH, Steendijk P
Abstract
Annals of hepatology,
3 1 2025, Pages 102170
Genetic risk factors for MASLD/MASH and cardiovascular disease in elderly individuals.
Theel WB, de Jong VD, Grobbee DE, Jukema JW, Trompet S, Cabezas MC
Introduction and objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, MASH, are closely related to obesity and lifestyle. From previous studies, MASLD is also known for its strong genetic background. This study aimed to investigate the association between previously reported genetic polymorphisms of MASLD/MASH and clinical outcomes in an elderly Western European population. Patients and methods: We performed an analysis of 5,244 participants (mea...
Abstract
Cardiovascular diabetology,
Volume 24, Issue 1, 2 1 2025, Pages 453
Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.
Mäenpää M, Jukema RA, van Diemen P, Bär S, Raijmakers PG, Sprengers R, Driessen RS, Bax JJ, Knaapen P, Knuuti J, Danad I, Saraste A, Maaniitty T
Background: Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary computed tomography angiography (CTA) whereas positron emission tomography (PET) enables quantitative assessment of myocardial perfusion. We studied the prognostic implications of quantitatively measured coronary plaque burden and myocardial perfusion in diabetic vs. non-diabetic patients with suspe...
Abstract
Annals of vascular surgery,
2 1 2025, Pages S0890-5096(25)00855-6
Considerations with respect to elective Abdominal Aortic Aneurysm repair in older people.
Biemond MJ, Paping JHM, Bulder RMA, Hultgren R, Mooijaart SP, Hamming JF, Lindeman JH
Objectives: The epidemiology of abdominal aortic aneurysm (AAA) is changing, with progressively more older patients receiving repair. Advancing age associates with an increased procedural risk, but also with a decreasing life-time rupture risk. This national study aims to provide background information for decision-making in older people. Methods: National administrative data (Statistics Netherlands) was used to estimate time-varying trends in the age and sex distribution of patients that underw...
Abstract
Circulation. Arrhythmia and electrophysiology,
2 1 2025, Pages e014049
International Survey on Vein of Marshall Retrograde Ethanol Infusion.
De Becker B, Derval N, Amin R, El Haddad M, Pambrun T, Bouyer B, Francois C, De Smet M, Channan EM, Blankoff N, Krahnefeld O, Agdirlioglu T, Minois D, Andorin A, Bessiere F, Gardey K, Sesselberg HW, Leyton-Mange JS, Marchand H, Mariottini C, Miled M, Sebag FA, Lellouche N, Andronache M, Marchese P, Rossi A, Nesti M, Herzet JM, Rodríguez Manero M, Pavlović N, Anselme F, Chaumont C, Wijnmaalen AP, Piers SRD, Waktare JEP, Najm A, Almorad A, Sousa PA, Lepièce C, Badot D, Auquier N, Efremidis M, Lian E, Maslova V, Tavernier R, Duytschaever M, Le Polain de Waroux JB, Valderrabano M, Knecht S
Background: Retrograde ethanolization of the vein of Marshall (VOM) has been identified as an adjunct technique in the treatment of persistent atrial fibrillation (AF) and left atrial tachycardia, as stated in the last consensus statement on ablation of AF. However, there is a lack of high-volume data on the technique. Methods: Through the collection of data from worldwide centers, we performed this international survey that aims to analyze the safety and procedural characteristics of VOM ethano...
Abstract
Giornale italiano di cardiologia (2006),
Volume 26, Issue 12 Suppl. 1, 1 1 2025, Pages e1-e108
[2025 ESC/EACTS Guidelines for the management of valvular heart disease].
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
Volume 39, Issue 12, 1 1 2025, Pages 2028-2029
Reading the palms: Palmar hyperlinearity and type 2 biomarkers as early predictors of atopic dermatitis onset in infancy?
Vroman F, de Graaf M
Abstract
Circulation,
1 1 2025
Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes after Acute Coronary Syndrome.
Tsimikas S, Szarek M, Cobbaert CM, Romijn F, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Yuan C, Gong XM, Goodman SG, White HD, Witztum JL, Steg PG, Schwartz GG, ODYSSEY OUTCOMES investigators
Background: Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) reflect pro-inflammatory properties of Lp(a) (lipoprotein(a)). The effect of OxPL-apoB on major adverse cardiovascular events (MACE) in patients with acute coronary syndrome in recent the era is not known. Methods: OxPL-apoB levels and Lp(a) were measured in 11 630 participants before and 5185 participants 4 months after randomization to alirocumab or placebo in the ODYSSEY OUTCOMES trial. Proportional hazards models adjusted...
Abstract
Stem cell research,
Volume 90, 1 1 2025, Pages 103877
Generation of three induced pluripotent stem cell clones from a functional single ventricle patient carrying the BRAF c.1897 T > C variant.
Bos TA, Polyakova E, DeRuiter MC, Nühn E, Jongbloed MRM
Cardiofaciocutaneous syndrome is a genetic disorder characterized by congenital heart disease, developmental delays and ectodermal abnormalities. Cardiofaciocutaneous syndrome is caused by pathogenic variants in the genes of the RAS/MAPK pathway, particularly BRAF. However, the mechanism by which congenital heart defects arise in RASopathy patients is still poorly understood. Therefore, using non-integrating episomal vectors, we generated three hiPSC clones from peripheral blood mononuclear cell...
Abstract
