6125 results
Circulation. Arrhythmia and electrophysiology,
20 3 2025, Pages e013099
Characteristics of Patients With the Arrhythmogenic Mitral Valve Prolapse Syndrome and Sudden Cardiac Arrest and Sustained Ventricular Arrhythmias.
Chakrabarti A, Giudicessi JR, Ezzeddine FM, Delling FN, Dixit S, Lee YJ, Muser D, Magnani S, Van Wijngaarden A, Ajmone Marsan N, Miller MA, Gandhi J, Trivieri MG, Font J, Martins R, McCaffrey JA, Santangeli P, Marchlinski FE, Chapagain H, Mathew D, Kancharla K, Syed FF, Abid A, Cerbin L, Tzou WS, Garg L, Della Rocca DG, Natale A, Mohanty S, Sheldon SH, Kuo L, Haugaa KH, Aabel EW, Enriquez A, Maeda S, Deshmukh A, Ghannam M, Bogun FM, Ackerman MJ, Liang JJ
Patients with arrhythmogenic mitral valve prolapse syndrome are at increased risk for life-threatening ventricular arrhythmias, but studies have been limited by small sample sizes. We sought to assemble an international arrhythmogenic mitral valve prolapse syndrome registry to delineate the clinical, imaging, and treatment characteristics of patients with arrhythmogenic mitral valve prolapse syndrome who survived sudden cardiac arrest (SCA) or had sustained ventricular tachycardia (VT) or ventri...
Abstract
Digital health,
Volume 11, 19 3 2025, Pages 20552076241288724
Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers.
van den Brink WJ, Oosterman JE, Smid DJ, de Vries HJ, Atsma DE, Overeem S, Wopereis S
Digital biomarkers are quantifiable and objective indicators of a person's physiological function, behavioral state or treatment response, that can be captured using connected sensor technologies such as wearable devices and mobile apps. We envision that continuous and 24-h monitoring of the underlying physiological and behavioral processes through digital biomarkers can enhance early diagnostics, disease management, and self-care of cardiometabolic diseases. Cardiometabolic diseases, which...
Abstract
Aorta (Stamford, Conn.),
17 3 2025
The TRAIN Health Awareness Clinical Trial: Baseline Findings and Cardiovascular Risk Management in Aortic Dissection Patients.
Bacour N, Grewal S, Tirpan AU, Theijse R, Erp OV, Klautz RJM, Sakalihasan N, Hultgren R, Grewal N
Background/objective: Acute Type A aortic dissection (ATAAD) is a life-threatening condition requiring timely surgical intervention. Despite successful surgery, postoperative outcomes are frequently suboptimal due to the high frequency of cardiovascular risk factors. This study examines baseline cardiovascular risk factors in a population of ATAAD patients in the Netherlands. Additionally, this study outlines the protocol for a randomized controlled trial, designed to improve postoperative mana...
Abstract
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland,
17 3 2025, Pages S1479-666X(25)00026-5
Surgeon personality diversity across generations and subspecialties.
Sier VQ, Schmitz RF, Wertenbroek RWAM, Schepers A, van der Vorst JR, SUPER Collaborators
Traditional exploration of surgical professionals' personality traits focuses on general characteristics at the domain-level of the five-factor model. Personality has been related to clinically-relevant areas such as clinical decision-making and team effectiveness, yet there is limited insight in the personality of surgeons at the facet-level of the Big Five. Here, we performed a large-scale study examining domain- and facet-variations of personality in four surgical generations and subspec...
Abstract
The Journal of thoracic and cardiovascular surgery,
17 3 2025, Pages S0022-5223(25)00120-5
Valve sparing aortic root replacement in bicuspid aortic valves, the reimplantation technique: A multicenter study.
Arabkhani B, Boodhwani M, De Paulis R, Chen EP, Koolbergen D, Mastrobuoni S, Aphram G, Salica A, Jahanyar J, El Khoury G, de Kerchove L
Reported outcome in patients with bicuspid aortic valves(BAV) undergoing valve-sparing root replacement(VSRR) is scarce. This study aims to evaluate outcomes in patients with BAV, utilizing the reimplantation (David)technique. Consecutive adult patients, with BAV, aortic root aneurysm and/or valve insufficiency(AI) undergoing VSRR(reimplantation)), were included, from 5 centers experienced in reimplantation-procedure. Patients were subcategorized into 2 groups with different primary indications...
Abstract
Open heart,
Volume 12, Issue 1, 17 3 2025, Pages e002846
Clinical use and impact of mechanical circulatory support for myocardial infarction-related cardiogenic shock in the Netherlands: a registry-based propensity-matched analysis.
Bogerd M, Griffioen AM, Bunge JJH, Peters EJ, Ten Berg S, Timmermans MJC, Kraaijeveld AO, Lipsic E, Otterspoor LC, Bleeker G, Montero-Cabezas JM, Sjauw KD, Meuwissen M, Dubois EA, van Geuns RM, Henriques JPS, PCI Registration Committee of the Netherlands Heart Registration
Background: Despite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes. Methods: This real-world, multicentre registry included CS patients undergoing percutaneous coronary intervention between 2017 and 2021 in 14 Dutch hospitals. The impact on clinical outcomes was analysed aft...
Abstract
European journal of preventive cardiology,
8 2 2025, Pages zwaf067
Apolipoprotein C3 and risk of cardiovascular events and death in patients on optimized statin treatment after recent acute coronary syndrome.
Schwartz GG, Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Ruhaak LR, Stevanovic I, Cobbaert CM, Steg PG
Aims: Apolipoprotein (Apo) C3 has been associated with incident coronary heart disease and major adverse cardiovascular events (MACE). Whether ApoC3 levels predict risk in patients with acute coronary syndrome (ACS) on optimized statin treatment is unknown. Methods: ApoC3 was measured by mass spectrometry at baseline (n=11,956) and after 4 months' treatment (M4; n=11 176) with alirocumab or placebo in the ODYSSEY OUTCOMES trial. Patients with fasting triglycerides >400 mg/dL were exclude...
Abstract
Environmental monitoring and assessment,
Volume 197, Issue 3, 7 1 2025, Pages 252
Investigating the effects of local climate zones on land surface temperature using spectral indices via linear regression model: a seasonal study of Sapanca Lake.
Isinkaralar O, Yeboah E, Isinkaralar K, Sarfo I, Öztürk S, Yilmaz D, Bojago E
The formation of urban heat islands is a widespread issue in cities. However, the impact of spectral indices on land surface temperature (LST) with various urban forms, climates, and functions has not been sufficiently examined. Currently, the prevalent method for analyzing complex urban areas is the classification of local climate zones (LCZs). In this study, we aim to explore the urban thermal environment by utilizing GIS-based spatial analyses and statistical methods. We also examine LCZs and...
Abstract
Diabetes care,
6 1 2025, Pages dc242110
Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial.
Schwartz GG, Szarek M, Jukema JW, Cobbaert CM, Reijnders E, Bittner VA, Schwertfeger M, Bhatt DL, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Steg PG
Objective: Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. Research design and methods: In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA-insulin resistance [HOMA-IR]) and...
Abstract
Interdisciplinary cardiovascular and thoracic surgery,
6 1 2025, Pages ivaf009
Survival outcomes after surgery for type-a aortic dissection: a contemporary Dutch nationwide registry study.
Timmermans PT, Velders BJJ, Groenwold RHH, Vos RJ, Roefs MM, Braun J, Klautz RJM, Mecozzi G, Hjortnaes J
Objectives: To describe the nationwide survival outcomes after surgery for type-A dissection (TAAD). Methods: All patients who underwent surgery for TAAD in the Netherlands between 2018 and 2021 were identified in the Netherlands Heart Registration (NHR) database. The NHR data were linked to lifelong survival data from Statistics Netherlands (98% match). Time trends for in-hospital and mid-term mortality were described, and age- and sex-adjusted regression analysis was performed. The cause and l...
Abstract
The Pediatric infectious disease journal,
5 1 2025
Is Rhinovirus More Aggressive in Children This Season?
Özdem Alataş Ş, Elvan Tüz A, Kuş S, Aslan Saritaş Ü, Koçar S, Yilmaz D
Abstract
European heart journal. Cardiovascular Imaging,
4 1 2025, Pages jeaf045
The Reversibility of Cardiac Damage After Transcatheter Aortic Valve Implantation and Short-Term Outcomes in a Real-World Setting.
Myagmardorj R, Fortuni F, Généreux P, Nabeta T, Stassen J, Galloo X, Meucci MC, Butcher S, van der Kley F, Cohen DJ, Clavel MA, Pibarot P, Leon MB, Regeer MV, Delgado V, Ajmone Marsan N, Bax JJ
This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI) and to investigate the prognostic value of cardiac damage stage evolution. Patients with severe AS undergoing TAVI were retrospectively analyzed. A 5-stage system based on the presence and extent of cardiac damage assessed by echocardiography was applied before and 6 months after TAVI. Multivariable Cox regression analyses were used to examine...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
4 1 2025
Increased Levels of Inflammatory Proteins, Including TARC/CCL17, in Skin of AD Patients During JAK Inhibitor Treatment.
Boesjes CM, van der Gang LF, Bakker DS, den Hartog Jager CF, de Graaf M, de Bruin-Weller MS, van Wijk F, Knol EF
Abstract
Journal of lipid research,
3 1 2025, Pages 100753
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis.
Inia JA, van Nieuwkoop-van Straalen A, Jukema JW, Rolin B, Staarup EM, Mogensen CK, Princen HMG, van den Hoek AM
Atherosclerosis is the major cause of cardiovascular disease. This study evaluated the effect of lipid lowering using a novel peptide inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) and a monoclonal antibody against angiopoietin-like 3 (evinacumab), either alone or in combination in APOE*3-Leiden.CETP mice fed a Western diet. Effects on body weight, plasma lipids, atherosclerotic lesion size, severity, composition and morphology were assessed. Treatment with PCSK9 inhibitory pep...
Abstract
European journal of endocrinology,
Volume 192, Issue 2, 1 1 2025, Pages S1-S14
The effect of first intervention on cardiac parameters in patients with acromegaly: a systematic review.
Huynh KA, Al-Gully J, Montero-Cabezas JM, Scheffers LE, Verstegen MJT, Biermasz NR, Coopmans EC
Objective: Cardiovascular disease in acromegaly patients remains a major cause of morbidity and all-cause mortality. This systematic review investigates the effect of the first growth hormone-lowering intervention on cardiac parameters. Design: Systematic review. Methods: Studies evaluating cardiac parameters following the first intervention in acromegaly published up to February, 25, 2022 were included in this systematic review. Risk of bias was assessed using a modified Newcastle-Ottawa Scale...
Abstract
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 36, Issue 2, 1 1 2025, Pages e70040
Ocular surface disease in pediatric patients with moderate-to-severe atopic dermatitis.
van der Rijst LP, Veldhuis N, van der Kamp S, Achten RE, van Luijk CM, Voskuil-Kerkhof ESM, Haeck IM, de Bruin-Weller MS, de Graaf M
Abstract
Health education research,
Volume 40, Issue 2, 1 1 2025, Pages cyaf001
Implementation of a complex eHealth intervention by a public-private partnership in clinical practice: a qualitative multicentre analysis using CFIR.
IJzerman RVH, van der Vaart R, Breeman LD, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Complex eHealth interventions-featuring multiple components within dynamic systems-are used for healthcare improvement. Public-private partnerships (PPPs), combining resources, expertise, and technology, are crucial in this context. Yet, integrating these interventions into practice remains challenging. This study identifies barriers and facilitators affecting implementation of the BENEFIT programme, a complex eHealth intervention targeting cardiovascular disease patients, by PPP within practice...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 2, 1 1 2025, Pages ezae442
Perioperative extracorporeal membrane oxygenation in neonates with transposition of the great arteries: 15 years of experience.
Weeda JA, Van Der Palen RLF, Bunker-Wiersma HE, Koers L, Van Es E, Hazekamp MG, Te Pas AB, Roeleveld PP
Objectives: Extracorporeal membrane oxygenation (ECMO) can act as a bridge to recovery in both pre- and postoperative patients with transposition of the great arteries (TGA). However, literature on its use in these patients is scarce. Methods: Retrospective single-centre cohort study encompassing all TGA patients who received ECMO between January 2009 and March 2024. Results: Twenty-two neonates received ECMO during the study period, with an overall median age and weight at time of ECMO cannulat...
Abstract
Molecular biology reports,
Volume 52, Issue 1, 31 5 2025, Pages 180
Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19.
Yilmaz E, Yilmaz D, Yildiz CG, Cacan E
SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junction, cell pr...
Abstract
Open heart,
Volume 12, Issue 1, 30 5 2025, Pages e003009
Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure.
Neijenhuis RML, Nederend M, van Groningen AE, Jongbloed MRM, Vliegen HW, Jukema JW, Kiès P, Egorova AD
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan. Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academi...
Abstract
