6417 results
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
27 4 2025, Pages 15266028251397339
A 15-Year Single-Center Experience Treating Complex Aortic Aneurysms: Transitioning From Open to Complex Endovascular Repair.
Warmerdam BWCM, Hjortnaes J, Driessen AHG, Eefting D, Hamming JF, Klautz RJM, Van der Meer RW, Van Rijswijk CSP, Van der Vorst JR, van Schaik J
Introduction: This is a descriptive study analyzing all surgically treated complex aneurysm patients in a tertiary referral center, during a 15-year time period in which complex endovascular aortic repair (complex EVAR) was introduced alongside open surgical repair (OSR). The goal was to present the real-world clinical profiles and surgical outcomes of complex (thoraco-)abdominal aneurysm patients, based on the current decision-making process. Methods: Patients undergoing OSR and complex EVAR be...
Abstract
Molecular biology of the cell,
24 4 2025, Pages mbcE24090405T
The RhoGEF Trio regulates the formation of tensile linear endothelial junctions to improve barrier function.
van Rijssel J, Sluiter TJ, van der Krogt JMA, Bart CI, Zhang J, de Vries AAF, van Alphen FPJ, Janssen H, van den Biggelaar M, Wubbolts RW, Quax PHA, de Vries MR, van Buul JD
The vascular endothelium serves as a selectively permeable barrier, tightly regulating transendothelial transport of small molecules, macromolecules, and immune cells. In the context of cardiovascular and inflammatory pathologies, the integrity of this barrier is often markedly compromised, contributing to tissue dysfunction, multi-organ failure, and, ultimately, mortality. Therapeutic strategies aimed at mitigating endothelial barrier dysfunction primarily focus on enhancing the stability of en...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
24 4 2025, Pages euaf324
Management of patients with atrial tachycardia: A clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS) and the Association for European Paediatric and Congenital Cardiology (AEPC).
Meyer C, Kahle AK, Dagres N, Derval N, Dewland TA, Drago F, Eckardt L, Frontera A, Gerstenfeld EP, Hardy C, Jais P, Kalman J, Kistler PM, Martin C, Pürerfellner H, Takigawa M, Wong T, Zeppenfeld K
Atrial tachycardias (AT) represent an increasingly recognized cause of morbidity and mortality. Over the past decade the mechanistic understanding and therapeutic concepts guiding AT treatment have undergone rapid progress. Catheter ablation has become the most effective therapy for maintaining sinus rhythm in patients with regular AT, while mapping and ablation concepts and technologies have improved significantly. Accordingly, international cardiac electrophysiology professional societies aime...
Abstract
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
20 3 2025, Pages S1198-743X(25)00618-4
CefiderocolFinder: a tool for detecting genetic adaptations implicated in cefiderocol resistance.
van den Brand B, Notermans DW, Verkaik NJ, Lansu S, Rossen JWA, Hendrickx APA, Dutch CPE surveillance study group, van Arkel ALE, Leversteijn-van Hall MA, van den Bijllaardt W, van Mansfeld R, van Dijk K, Zwart B, Diederen BMW, Berkhout H, Ott A, Waar K, Ang W, da Silva J, Vlek ALM, Stohr JJJM, Bode LGM, Jansz A, Paltansing S, van Griethuysen AJ, Lo Ten Foe JR, van Trijp MJCA, Wong M, Muller AE, van der Linden MPM, van Rijn M, Debast SB, Kolwijck E, Al Naiemi N, Schulin T, Dinant S, van Mens SP, Melles DC, Stuart JWTC, Gruteke P, van Dam AP, Rahamat-Langendoen J, Maraha B, Sinnige JC, van der Vorm E, van Meer MPA, de Graaf M, de Jong E, Vainio SJ, Heikens E, Reijer MD, Dorigo-Zetsma JW, Troelstra A, Bathoorn E, de Vries J, van Dam DW, de Brauwer EIGB, Steingrover R, Oliveira Dos Santos C
Objectives: Cefiderocol is a novel last-resort cephalosporin antimicrobial increasingly used for difficult-to-treat infections by multidrug-resistant microorganisms (MDRO), and is effective against carbapenem-resistant Enterobacterales and Pseudomonas species. Multiple chromosomally encoded genetic determinants have been implicated in cefiderocol resistance, including mutations, deletions and/or frameshifts. However, identification of these determinants remains labour-intensive and time-consumin...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 18 3 2025, Pages D8577
[The role of clinical practice guidelines in the assessment by the disciplinary board].
Weller FS, van Bodegom-Vos L, Repping S, Hamming JF
Objective: To examine how often disciplinary complaints against physicians are upheld explicitly on the grounds of deviation from clinical practice guidelines. Design: Retrospective document analysis of publicly available medical disciplinary rulings in the Netherlands between January 1, 2019, and December 31, 2023. Methods: We analysed rulings from the official Dutch disciplinary law database (tuchtrecht.nl). All upheld complaints were reviewed to determine whether the disciplinary board explic...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
17 3 2025, Pages ezaf461
Mitral annular disjunction: a roadmap for the surgeon.
Bonaros N, Gollmann-Tepeköylü C, Palmen M, Ajmone N, Delgado V, Garbi M, Mayr A, Pölzl L, Marin-Cuartas M, Ascione G, Azzola Guicciardi N, Troger F, Pereda D, Klautz R, De Bonis M, Borger MA, Perier P
Objectives: Mitral annular disjunction (MAD) is a structural abnormality of the mitral annulus fibrosus, associated with myxomatous leaflet degeneration, mitral valve prolapse (MVP), and ventricular arrhythmias. The combination of annular dilatation and abnormal annular motion increases mechanical stress on the mitral leaflets, triggering the degenerative process. Methods: This review summarizes the major pathophysiologic, diagnostic and therapeutic measures for the treatment of patients with MA...
Abstract
Nature,
17 3 2025
An integrated view of the structure and function of the human 4D nucleome.
Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Andréa W, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepińska T, Chiliński M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park PJ, Alver BH, Schroeder AJ, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit AD, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F
The dynamic three-dimensional (3D) organization of the human genome (the 4D nucleome) is linked to genome function. Here we describe efforts by the 4D Nucleome Project1 to map and analyse the 4D nucleome in widely used H1 human embryonic stem cells and immortalized fibroblasts (HFFc6). We produced and integrated diverse genomic datasets of the 4D nucleome, each contributing unique observations, which enabled us to assemble extensive catalogues of more than 140,000 looping interactions per cell t...
Abstract
JACC. Advances,
Volume 5, Issue 1, 17 3 2025, Pages 102424
Activation of the Anrep Effect in Aortic Stenosis Pre-TAVR and Post-TAVR: An Echocardiographic Pressure-Volume Analysis.
Reil JC, Sequeira V, Lucas P, Tadros L, Reil GH, Federspiel JM, Scholtz S, Omran H, Steendijk P, Marquetand C, Scholtz W, Piper C, Rudolph T, Rudolph V
Background: In aortic stenosis (AS), chronic pressure overload of the left ventricle (LV) may sustain an intrinsic, afterload-dependent adaptive response known as the Anrep effect, characterized by increased myocardial contractility and prolonged systolic duration. Whether this response resolves following transcatheter aortic valve replacement (TAVR) remains unknown. Objectives: The objective of the study was to determine whether the Anrep is chronically activated in severe AS and acutely revers...
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 12, 17 3 2025, Pages 498
Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair.
Rolando M, Elmasry N, Gobbi F, Moreo A, Ajmone Marsan N, Carluccio E, Fortuni F
Mitral regurgitation (MR) is one of the most prevalent valvular disorders worldwide, with a growing burden driven by population aging and improved diagnostic capabilities. Understanding the mechanism of MR, whether primary, due to intrinsic valve abnormalities, or secondary, resulting from atrial or ventricular remodeling, is essential for optimal management. Echocardiography, particularly advanced modalities such as three-dimensional imaging and strain analysis, plays a central role in this pro...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
16 3 2025
Left atrial appendage occlusion vs standard of care in high stroke risk atrial fibrillation patients ineligible for anticoagulation: COMPARE-LAAO.
Aarnink EW, Huijboom MFM, van der Kley F, Folkeringa R, de Groot JR, van der Voort PH, Blaauw Y, Chaldoupi M, Stevenhagen J, Vlachojannis GJ, van Mieghem NM, Swaans MJ, van Dijk VF, Dijkgraaf MG, van Dijk EJ, Tijssen JGP, Boersma LVA
Introduction: The left atrial appendage is the dominant source of cardioembolic stroke in patients with atrial fibrillation (AF). Contemporary guidelines recommend considering left atrial appendage occlusion (LAAO) in AF patients contraindicated to oral anticoagulation therapy (OAC), but randomized controlled trial (RCT) data for this subpopulation are lacking. Methods: COMPARE LAAO was designed as an event-driven, multicenter, prospective, randomized, open, blinded endpoint (PROBE) trial that r...
Abstract
JACC. Advances,
Volume 5, Issue 1, 11 2 2025, Pages 102415
Prognostic Value of NT-proBNP in Patients Treated With Allogeneic Stem Cell Transplantation.
Polomski EAS, von dem Borne PA, Veelken H, Heemelaar JC, Jukema JW, Antoni ML
Background: As survival rates after allogeneic stem cell transplantation (alloSCT) continue to grow, cardiovascular disease is becoming a major complication after alloSCT. However, the prognostic value of cardiac biomarkers has not been widely investigated. Objectives: This study aims to investigate the association between baseline N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in patients treated with alloSCT and mortality. Methods: Patients who were referred for alloSCT between...
Abstract
JACC. Case reports,
10 2 2025, Pages 106227
Severe Aortic Stenosis and Dual Valve Vegetations: An Uncommon Presentation of Primary Antiphospholipid Syndrome.
van der Woude SFS, Valentijn FA, Antoni ML, Huisman SJ, van Vliet M
Background: Primary antiphospholipid syndrome (PAPS) may cause thromboembolic events and valvular heart disease. Case summary: A 42-year-old woman with a history of pre-eclampsia, epilepsy, and thrombocytopenia presented with acute chest pain and shortness of breath. Investigations revealed vegetation on both the aortic and mitral valves, severe aortic stenosis, and a non-ST-segment elevation myocardial infarction. Autoimmune testing confirmed antiphospholipid antibodies, which led to a diagnosi...
Abstract
Journal of cardiovascular medicine (Hagerstown, Md.),
Volume 26, Issue 12, 10 2 2025, Pages 703-711
Intravascular lithotripsy in eccentric and concentric coronary calcifications: a post-hoc analysis of the BENELUX-IVL registry.
Oliveri F, Van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has demonstrated excellent results in treating calcified coronary lesions. However, specific focus on different calcification patterns is still limited. The aim of our study was to evaluate the procedural and clinical outcomes of IVL in treating concentric vs. eccentric calcifications. Methods: The BENELUX-IVL prospective registry enrolled patients aged ≥18 years who underwent IVL. For this study, patients who underwent both IVL and intravascular ultra...
Abstract
Allergy,
9 2 2025
Drug Survival in Atopic Dermatitis: Comparison of Biologics and JAK Inhibitors in the BioDay Registry.
van der Gang LF, Boesjes CM, Zuithoff NPA, Haeck I, Bacoş-Cosma O, Loman L, Atash K, Harbers V, Stadhouders S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynski A, Christoffers WA, Garritsen FM, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, Galimont-Collen AFS, Schuttelaar MA, de Graaf M, de Bruin-Weller MS
Abstract
European heart journal. Cardiovascular Imaging,
8 2 2025, Pages jeaf336
Pitfalls and Solutions in the Imaging Follow-up of Valvular Heart Disease Devices.
Ternacle J, Turgeon PY, Hahn RT, Marsan NA, Pibarot P
Doppler-echocardiography is the primary imaging modality for the evaluation and follow-up of valvular heart devices. This article highlights the unique pitfalls associated with these devices, including imaging challenges and flow dynamics, which often push echocardiography to its limits. The use of a multimodality imaging approach including cardiac computed tomography (CT) and magnetic resonance, and positron emission tomography-CT is recommended to confirm the diagnosis of prosthetic valve dysf...
Abstract
ESMO open,
Volume 10, Issue 12, 5 1 2025, Pages 105923
Pathological complete response and survival after neoadjuvant chemotherapy in patients with stage I TNBC: a registry-based study.
de Graaf M, Gielen RCAM, Balduzzi S, Siesling S, Linn SC, Kok M
Background: Pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is a strong prognostic factor in patients with early-stage triple-negative breast cancer (TNBC). One-third of all patients with early-stage TNBC have stage I disease. Chemotherapy is recommended for most patients with stage I TNBC with an increasing use in the neoadjuvant setting supported by recent guidelines. However, little is known on the chemotherapy benefit for stage I TNBC, in particular the likelihood...
Abstract
Circulation. Cardiovascular imaging,
4 1 2025, Pages e018862
Global Longitudinal Strain for Prognostic Staging in Wild-Type Transthyretin Cardiac Amyloidosis.
Debonnaire P, L'Hoyes W, Donal E, Verheyen N, Vervloet D, Dujardin K, Pouleur AC, Dulgheru R, Sarli Issa V, Droogmans S, Jurcut R, Regeer M, Dupont M, Bondue A, Timmermans P, Bohyn A, Christiaen E, Wyseure N, Bezard M, Zach D, Schwegel N, Knapen R, Buytaert L, de Marneffe N, Adam R, Ajmone Marsan N, Tavernier R, Buysschaert I, Trenson S
Background: A formal prognostic staging system in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), based on echocardiographic imaging, is lacking. We evaluated the prognostic performance of global longitudinal strain (GLS) staging in a large ATTRwt-CM patient cohort, including under tafamidis treatment and relative to National Amyloidosis Center (NAC) biomarker staging. Methods: A multicentric, international ATTRwt-CM patient cohort with baseline GLS (distribution quartiles), evaluate...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 24, 3 1 2025, Pages e046283
Anrep Effect in the Right Ventricle: Evidence From Systolic Duration Analysis.
Reil JC, Sequeira V, Wink J, Federspiel JM, Reil GH, Steendijk P
Abstract
Annals of hepatology,
3 1 2025, Pages 102170
Genetic risk factors for MASLD/MASH and cardiovascular disease in elderly individuals.
Theel WB, de Jong VD, Grobbee DE, Jukema JW, Trompet S, Cabezas MC
Introduction and objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, MASH, are closely related to obesity and lifestyle. From previous studies, MASLD is also known for its strong genetic background. This study aimed to investigate the association between previously reported genetic polymorphisms of MASLD/MASH and clinical outcomes in an elderly Western European population. Patients and methods: We performed an analysis of 5,244 participants (mea...
Abstract
Cardiovascular diabetology,
Volume 24, Issue 1, 2 1 2025, Pages 453
Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.
Mäenpää M, Jukema RA, van Diemen P, Bär S, Raijmakers PG, Sprengers R, Driessen RS, Bax JJ, Knaapen P, Knuuti J, Danad I, Saraste A, Maaniitty T
Background: Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary computed tomography angiography (CTA) whereas positron emission tomography (PET) enables quantitative assessment of myocardial perfusion. We studied the prognostic implications of quantitatively measured coronary plaque burden and myocardial perfusion in diabetic vs. non-diabetic patients with suspe...
Abstract
