Research

Publications

Below you can find a list of our published research.

6173 results

Family practice, Volume 42, Issue 2, 1 1 2025, Pages cmae050 Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment. Versloot AHC, Veldwijk J, Ottenheijm RPG, de Graaf M, van der Windt DA, Koes BW, Runhaar J, Schiphof D

Background: Shoulder pain is common amongst adults, but little is known about patients' preferences. Objective: The aim of this study was to determine patients' preferences for treatment options offered for shoulder pain in primary care. Methods: A discrete choice experiment was used to investigate these preferences. Adults with shoulder pain were asked to make 12 choices between two treatment options, or to opt-out. The attributes of the 12 treatment options were presented as varying... Abstract

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Volume 36, Issue 2, 1 1 2025, Pages e70040 Ocular surface disease in pediatric patients with moderate-to-severe atopic dermatitis. van der Rijst LP, Veldhuis N, van der Kamp S, Achten RE, van Luijk CM, Voskuil-Kerkhof ESM, Haeck IM, de Bruin-Weller MS, de Graaf M

Abstract

Health education research, Volume 40, Issue 2, 1 1 2025, Pages cyaf001 Implementation of a complex eHealth intervention by a public-private partnership in clinical practice: a qualitative multicentre analysis using CFIR. IJzerman RVH, van der Vaart R, Breeman LD, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR

Complex eHealth interventions-featuring multiple components within dynamic systems-are used for healthcare improvement. Public-private partnerships (PPPs), combining resources, expertise, and technology, are crucial in this context. Yet, integrating these interventions into practice remains challenging. This study identifies barriers and facilitators affecting implementation of the BENEFIT programme, a complex eHealth intervention targeting cardiovascular disease patients, by PPP within practice... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 67, Issue 2, 1 1 2025, Pages ezae442 Perioperative extracorporeal membrane oxygenation in neonates with transposition of the great arteries: 15 years of experience. Weeda JA, Van Der Palen RLF, Bunker-Wiersma HE, Koers L, Van Es E, Hazekamp MG, Te Pas AB, Roeleveld PP

Objectives: Extracorporeal membrane oxygenation (ECMO) can act as a bridge to recovery in both pre- and postoperative patients with transposition of the great arteries (TGA). However, literature on its use in these patients is scarce. Methods: Retrospective single-centre cohort study encompassing all TGA patients who received ECMO between January 2009 and March 2024. Results: Twenty-two neonates received ECMO during the study period, with an overall median age and weight at time of ECMO cannulat... Abstract

Molecular biology reports, Volume 52, Issue 1, 31 5 2025, Pages 180 Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19. Yilmaz E, Yilmaz D, Yildiz CG, Cacan E

Background: SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junct... Abstract

Open heart, Volume 12, Issue 1, 30 5 2025, Pages e003009 Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure. Neijenhuis RML, Nederend M, van Groningen AE, Jongbloed MRM, Vliegen HW, Jukema JW, Kiès P, Egorova AD

Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan. Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academi... Abstract

Clinical and translational radiation oncology, Volume 52, 29 5 2025, Pages 100927 Effect of FLASH proton therapy on primary bronchial epithelial cell organoids. Kuipers ME, van Liefferinge F, van der Wal E, Rovituso M, Slats AM, Hiemstra PS, Van Doorn-Wink KCJ

Purpose: The effects of conventional (CONV) and FLASH proton therapy on primary bronchial epithelial cell (PBEC) organoids from individuals with chronic obstructive pulmonary disease (COPD) were investigated. The primary objective was to compare the effect of FLASH and CONV on COPD PBEC organoids with a focus on DNA damage, organoid formation, and gene expression. Methods: PBECs were obtained from six COPD donors, cultured as three-dimensional (3D) organoids and exposed to 2 and 8 Gy CONV and FL... Abstract

Cited 1 times since 2025 (4.5 per year) source: EuropePMC

Journal of clinical medicine, Volume 14, Issue 3, 28 4 2025, Pages 859 From Survival to Recovery: Understanding the Life Impact of an Acute Aortic Dissection Through Activity, Sleep, and Quality of Life. Bacour N, Grewal S, Theijsse RT, Klautz RJM, Grewal N

Background/Objectives: An acute aortic dissection (AAD) is a cardiovascular emergency with high mortality rates if left untreated. Survival has increased due to improvements in diagnosis and therapy. However, during their recovery, survivors frequently encounter major social, psychological, and physical challenges. This study aimed to evaluate the recovery experience of AAD survivors in The Netherlands. Insights on sleep quality, physical activity, and quality of life were collected from a uniqu... Abstract

Journal of the European Academy of Dermatology and Venereology : JEADV, 22 4 2025 Increasing dosing intervals for biologics in atopic dermatitis-why, who, when and how? Jacobson ME, Boesjes CM, de Bruin-Weller MS, de Graaf M, Morimoto RY, Simpson EL

Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care. Here, we rev... Abstract

Vascular medicine (London, England), 21 3 2025, Pages 1358863X241309326 Prognostic performance of bedside tests for predicting ulcer healing and wound healing after minor amputation in patients prone to medial arterial calcification: A systematic review. Willems SA, Nieuwstraten JA, Schepers A, van Schaik J, van den Hoven P, van der Vorst JR, Hamming JF, Brouwers JJ

Foot ulceration is a significant and growing health problem worldwide, particularly due to rises in diabetes mellitus (DM) and peripheral artery disease. The prediction of ulcer healing remains a major challenge. In patients with foot ulcers, medial arterial calcification (MAC) can be present as a result of concomitant DM or chronic kidney disease and is a prognostic factor for unfavorable outcome. This systematic review aimed to evaluate the prognostic reliability of bedside tests to predict ul... Abstract

Open heart, Volume 12, Issue 1, 21 3 2025, Pages e003055 Prognostic role of con-/discordant coronary flow reserve and microvascular resistance in coronary microvascular disease: a systematic review and network meta-analysis. Al-Gully J, Oliveri F, Forouzanfar JP, Montero-Cabezas JM, Jukema JW, den Haan MC, Al Amri I, Bingen BO

Background: Coronary microvascular disease (CMD) is defined as impaired coronary flow reserve (CFR) and/or increased microvascular resistance (MR) without significant epicardial coronary stenosis. This definition allows for discordant CFR and MR values within patients with CMD. The aim of this meta-analysis is to characterise the prognostic value and pathophysiological backgrounds of CFR and MR con-/discordance. Methods: A systematic search (PROSPERO CRD42024573004) identified studies determinin... Abstract

International journal of cardiology, Volume 423, 21 3 2025, Pages 132996 Intravascular lithotripsy in calcified left main coronary artery: Procedural success and 1-year clinical outcomes. Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) has an excellent efficacy and safety profile in the treatment of calcified coronary lesions during percutaneous coronary intervention (PCI). However, data regarding its use on left main (LM) lesions are still limited. Objective: We aimed to analyze the technical success and 1-year clinical outcomes in calcified LM lesions treated with IVL. Methods: Patients who underwent IVL from the ongoing prospective BENELUX registry were eligible for inclusion. Pat... Abstract

Cited 1 times since 2025 (4.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 33, Issue 3, 20 3 2025, Pages 93-102 Symptomatic early coronary graft failure in bypass surgery patients: incidence, predictors and clinical impact. van Oort MJH, Al Amri I, de Weger A, Regeer MV, Jukema JW, Mertens BJA, Montero-Cabezas JM

Objectives: Coronary graft failure (CGF) may occur early after coronary bypass graft surgery (CABG). The study aimed to identify clinical and perioperative risk factors and to evaluate the long-term clinical impact of symptomatic early CGF. Methods: Patients who underwent clinically indicated coronary angiography (CAG) prior to post-CABG discharge between 2012 and 2022 were included. Symptomatic early CGF was defined as a dysfunctional coronary graft, evaluated on clinically indicated CAG, cause... Abstract

Rheumatology advances in practice, Volume 9, Issue 1, 20 3 2025, Pages rkaf010 Anti-citrullinated protein antibody detection by hemagglutination. Kruis I, Kumari J, van der Heijden A, Weijn A, Vree Egberts W, Peeters IR, van Herwaarden N, Salden M, Pruijn GJM

Objectives: ACPAs play an important role in the classification of RA and can be detected by serological tests. Several ACPA detection assays are available for clinical use, which are all based on ELISA(-like) tests with citrullinated peptides (CCP2) or alternative citrullinated proteins/peptides. We aimed to facilitate ACPA detection in low-volume laboratories and resource-poor environments by developing a rapid and easy-to-perform test. Methods: We designed and generated an agglutination mediat... Abstract

Respiratory research, Volume 26, Issue 1, 18 3 2025, Pages 20 Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation. Kuipers ME, Ninaber DK, van Doorn-Wink KCJ, Slats AM, Hiemstra PS

Objective: Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. Since these effects are incompletely understood, the aim of the present study was to evaluate the effect of ionizing radiation (IR) on cultured well-differentiated primary bronchial epithelial cells (PBEC) with a focus on cytotoxicity, barrier formation, inflammation and epithelial progenitor function. Materials and methods:... Abstract

Brain : a journal of neurology, 16 3 2025, Pages awaf011 N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference. Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski LE, Reichenbach K, Rödiger L, Corlett P, Sterzer P

Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-Methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the... Abstract

Scientific reports, Volume 15, Issue 1, 16 3 2025, Pages 2180 Iron metabolism in a mouse model of hepatocellular carcinoma. Yilmaz D, Tharehalli U, Paganoni R, Knoop P, Gruber A, Chen Y, Dong R, Leithäuser F, Seufferlein T, Leopold K, Lechel A, Vujić Spasić M

Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. To investigate iron metabolism during liver carcinogenesis, we employed a model of chronic carbon tetrachloride injections in liver-specific p53-deficient mice to induce liver fibrosis, cirrhosis and subsequent carcinogenesis. A transcriptome analysis of liver c... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 105, Issue 4, 13 2 2025, Pages 951-958 Angiographic Characterization and Sex-Related Anatomical Differences of Atrial Coronary Arteries Anatomy-A Proposal of Systematic Classification. Marques-Antunes M, van Oort MJH, Oliveri F, Al Amri I, Bingen BO, Cruz-Ferreira R, Wouter Jukema J, Montero-Cabezas JM

Background: The coronary atrial circulation is the network of vessels that supply blood to the atria, originating from the left circumflex and right coronary arteries. Current descriptions of this arterial system are based on anatomical studies with a limited number of patients, predominantly male. In addition, there is a lack of consensus its angiographic nomenclature. Aims: This study aimed to evaluate the anatomical variations of coronary atrial branches (CAB) and investigate sex-related diff... Abstract

Heart rhythm, 13 2 2025, Pages S1547-5271(25)00022-0 Application of artificial intelligence to analyze data from randomized controlled trials: An example from DECAAF II. Mekhael M, Feng H, Akoum N, Sohns C, Sommer P, Mahnkopf C, Kholmovski E, Bax JJ, Sanders P, McGann C, Marchlinski F, Mansour M, Hindricks G, Wilber D, Calkins H, Jais P, Younes H, Assaf A, Noujaim C, Lim C, Huang C, Pandey A, Wazni O, Marrouche N

Background: Causal machine learning (ML) provides an efficient way of identifying heterogeneous treatment effect groups from hundreds of possible combinations, especially for randomized trial data. Objective: The aim of this paper is to illustrate the potential of applying causal ML on the DECAAF II trial data. We proposed a causal ML model to predict the treatment response heterogeneity. Methods: We applied causal tree learning to the DECAAF II trial data as an example of real applications, ide... Abstract

The American journal of cardiology, Volume 241, 11 2 2025, Pages 61-68 Arrhythmogenic Right Ventricular Cardiomyopathy: The Importance of Biventricular Strain in Risk-Stratification. Chua AP, Laenens D, Sarrazyn C, Lopez-Santi MP, Nabeta T, Myagmardorj R, Bootsma M, Barge-Schaapveld DQCM, Bax JJ, Marsan NA

Despite arrhythmogenic right ventricular cardiomyopathy (ARVC) being predominantly a right ventricular (RV) disease, concomitant left ventricular (LV) involvement has been recognized. ARVC is diagnosed by the RV-centric 2010 Task Force Criteria(TFC) using routine echocardiography, but previous studies have suggested that strain imaging may be more sensitive to detect RV and LV dysfunction. No data however are available regarding the additional value of combining biventricular strain for risk str... Abstract