6429 results
JACC. Heart failure,
9 2 2026, Pages 102897
Clinical Impact of Device-Based Multisensory Monitoring in Heart Failure: A Propensity-Matched Study From the Netherlands.
Aslan U, Zwaenepoel BAC, Kirchhof B, Mertens BJA, Feijen M, van Erven L, Tops LF, Jukema JW, Egorova AD, Beeres SLMA
Abstract
Musculoskeletal science & practice,
Volume 82, 8 2 2026, Pages 103497
Effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice (SIX-Shoulder Study): A randomized controlled trial.
Versloot AHC, Schiphof D, Ottenheijm RPG, van der Windt DA, de Graaf M, van Ochten JM, Bindels PJE, Koes BW, Runhaar J
Background: Guidelines recommend a corticosteroid injection or exercise therapy for shoulder pain in primary care, but long-term comparative studies are lacking. Objective: To examine the effectiveness of a corticosteroid injection versus physiotherapist-led exercise therapy over 12 months in patients with shoulder pain presenting in primary care. Design: A pragmatic randomized controlled trial. Methods: Patients with a new episode of shoulder pain were included and randomly allocated to a corti...
Abstract
The American journal of emergency medicine,
Volume 101, 8 2 2026, Pages 159-165
Evaluation of patients admitted to the pediatric emergency departments due to suicide attempts: A multicenter study from Türkiye.
Yigit H, Birbilen AZ, Akbaba B, Demirel C, Çiçek A, Berksoy E, Mutlu B, Vatansever G, Tekin D, Bilen S, Yılmaz HL, Gökulu G, Tunç A, Akansu İ, Ulusoy E, Yılmaz D, Duman M, Fidancı İ, Taşar MA, Doğan M, Göktuğ A, Besli GE, Er A, Apa H, Demir Ş, Çağlar A, Bodur İ, Tuygun N, Gökay SS, Çınıçev Ş, Çağlar AA, Güleryüz OD, Okay B, Bayraktar S, Yavşan Z, Özdemir İ, Tekeli A, Özdel ZGE, Ödek Ç, Eser Ö, Güven Ş, Yıldız LA, Kurt F, Akça H, Karacan CD, Özkaya AK, Doğan YE, Bedir S, Seçilmiş Y, Kendir ÖT, Erkek N, Gültekingil A, Soydan E, Demirel Ö, Çilingiroğlu AÖ, Şık N, Nurhan E, Cebeci SO, Yalçın GA, Balcı ÖÖ, Anıl M, Ülgen BT, Alp EE, Tekşam Ö
Background: Suicide is a major cause of morbidity and mortality in adolescents and is increasingly recognized among younger children. Pediatric emergency departments (EDs) are critical points for the identification and management of suicide attempts. This study aimed to evaluate the demographic and clinical characteristics, methods, and temporal trends of suicide attempts among children and adolescents presenting to pediatric EDs in Türkiye. Methods: We conducted a retrospective, multicenter stu...
Abstract
Heart rhythm,
7 1 2026, Pages S1547-5271(26)00019-6
Effectiveness of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease: A Meta-Analysis of Biventricular and Conduction System Pacing Outcomes.
Zwaenepoel BAC, Neijenhuis RML, Veldtman G, Blom NA, Jukema JW, Jongbloed MRM, Schoones JW, Beeres SLMA, Egorova AD
Background: Adult congenital heart disease (ACHD) patients often develop heart failure (HF). Cardiac resynchronization therapy (CRT) may provide benefit, but evidence is limited to observational studies and guidelines are extrapolated from acquired HF. Objectives: To systematically evaluate the effects of CRT in ACHD, including both biventricular (BiV) and conduction system pacing (CSP) strategies, on electrocardiographic, functional, and clinical outcomes. Methods: We conducted a systematic rev...
Abstract
eLife,
Volume 14, 7 1 2026, Pages RP107072
Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics.
Teplenin AS, Kudryashova NN, Majumder R, de Vries AAF, Panfilov AV, Pijnappels DA, De Coster T
Many biological processes emerge as frequency-dependent responses to trains of external stimuli. Heart rhythm disturbances, that is cardiac arrhythmias, are important examples as they are often triggered by specific patterns of preceding stimuli. In this study, we investigated how ectopic arrhythmias can be induced by external stimuli in cardiac tissue containing a localised area of depolarisation. Using optogenetic in vitro experiments and in silico modelling, we systematically explored the dyn...
Abstract
Pathology international,
5 1 2026
The Occurrence of Gene Fusions in Thyroid Lesions and the Relation With Chronic Lymphocytic Thyroiditis.
Jentus MM, van Wezel T, Ruano D, Snel M, Schepers A, Crobach S, Morreau H
Previously, we concluded that thyroid resections with multifocal, genetically distinct lesions more often showed florid chronic lymphocytic thyroiditis (CLT) than thyroids with clonally related multiple lesions. In this study, we characterized a consecutive cohort of thyroid lesions for molecular drivers and investigated the relationship between the molecular alteration type and florid CLT. Molecular diagnostic data from 414 patients (2016-2025) were retrospectively reviewed, including clinical...
Abstract
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
5 1 2026
Preoperative Extracorporeal Membrane Oxygenation in Children With Dextro-Transposition of the Great Arteries: Extracorporeal Life Support Organization Registry Study, 2000-2022.
Koers L, Thiagarajan RR, van der Palen RLF, Willems AMA, Liebenberg L, Rycus P, Hazekamp MG, Roeleveld PP
Objective: To describe those neonates with dextro-transposition of the great arteries (d-TGA) who undergo preoperative support with extracorporeal membrane oxygenation (ECMO) and to compare outcomes in those undergoing the arterial switch operation (ASO) on-ECMO vs. those who undergo ASO after weaning from ECMO. Design: Retrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry data, 2000-2022. Patients: Neonates aged up to 21 days with d-TGA supported by ECMO before...
Abstract
International journal of biometeorology,
Volume 70, Issue 1, 3 1 2026, Pages 8
Quantifying associations between local climate zones on land surface temperature: new insights from coastal areas of Italy.
Isinkaralar O, Isinkaralar K, Yilmaz D, Yeboah E, Sarfo I, Öztürk S
Coastal regions across Europe face rising sea levels and climate change-related extreme weather conditions such as more frequent and intense heat waves, floods, droughts, and storms. As climate change and rapid urbanization continue to pose significant challenges to the resilience of cities, knowledge from LCZ studies has the potential to generate targeted adaptation strategies that address the unique thermal performance characteristics of different urban areas. A range of physical characteristi...
Abstract
Kidney international,
Volume 109, Issue 1, 1 1 2026, Pages 37-40
Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling.
Baker AH, de Vries MR
Single-cell transcriptomics of arteriovenous fistulas reveal that failure is likely driven less by smooth muscle proliferation than by continuous inflammation, endothelial dysfunction, and fibroblast-driven fibrosis. These insights reframe current knowledge and highlight mechanistic pathways as to where future therapies could be targeted to improve arteriovenous fistula maturation kinetics and associated patency rates.
Abstract
JAMA cardiology,
Volume 11, Issue 1, 1 1 2026, Pages 5-6
Interventions for Tricuspid Regurgitation.
Praz F, Angellotti D, Ajmone Marsan N, Butler J
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 68, Issue 1, 1 1 2026, Pages ezaf461
Mitral Annular Disjunction: A Roadmap for the Surgeon.
Bonaros N, Gollmann-Tepeköylü C, Palmen M, Ajmone N, Delgado V, Garbi M, Mayr A, Pölzl L, Marin-Cuartas M, Ascione G, Azzola Guicciardi N, Troger F, Pereda D, Klautz R, De Bonis M, Borger MA, Perier P
Objectives: Mitral annular disjunction (MAD) is a structural abnormality of the mitral annulus fibrosus, associated with myxomatous leaflet degeneration, mitral valve prolapse (MVP), and ventricular arrhythmias. The combination of annular dilatation and abnormal annular motion increases mechanical stress on the mitral leaflets, triggering the degenerative process. Methods: This review summarizes the major pathophysiologic, diagnostic and therapeutic measures for the treatment of patients with MA...
Abstract
Cell host & microbe,
Volume 34, Issue 1, 1 1 2026, Pages 103-115.e9
Molecular basis of 60 years of antigenic evolution of human influenza A(H3N2) virus neuraminidase.
Rosu ME, Westgeest KB, de Graaf M, Hauser BM, Tureli S, James S, Sinartio FF, Bestebroer TM, Lexmond P, Pronk MR, van der Vliet S, Skepner E, Spronken MIJ, Mühlemann B, Richard M, Jones TC, Smith DJ, Herfst S, Fouchier RAM
Human influenza A viruses escape antibody-mediated immunity through changes in the hemagglutinin (HA) and neuraminidase (NA) glycoproteins. HA antigenic evolution has been studied extensively, with more recent interest in NA due to its importance in influenza vaccine efficacy. Here, the antigenic properties of the NA of more than 300 A(H3N2) and A(H2N2) viruses isolated since 1957 were quantified with a NA inhibition enzyme-linked lectin assay and visualized using antigenic cartography, with fol...
Abstract
European heart journal. Cardiovascular Imaging,
29 5 2026, Pages jeaf372
Outcomes with Revascularization vs. Medical Therapy According to Plaque Burden from Coronary Computed Tomography Angiography.
Bär S, Knuuti J, Saraste A, Nurmohamed NS, Jukema RA, Klén R, Bax JJ, Knaapen P, Danad I, Maaniitty T
Aims: We aimed to investigate, whether plaque burden from coronary computed tomography angiography (CCTA) could be used to identify patients potentially benefitting from revascularization. Methods and results: We assessed consecutive patients undergoing CCTA and selective 15O-water perfusion positron emission tomography for evaluation of coronary artery disease (CAD) at two tertiary care centers in Finland and the Netherlands. Per-patient percent atheroma volume (PAV) and maximum per-vessel PAV...
Abstract
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
27 4 2025, Pages 15266028251397339
A 15-Year Single-Center Experience Treating Complex Aortic Aneurysms: Transitioning From Open to Complex Endovascular Repair.
Warmerdam BWCM, Hjortnaes J, Driessen AHG, Eefting D, Hamming JF, Klautz RJM, Van der Meer RW, Van Rijswijk CSP, Van der Vorst JR, van Schaik J
Introduction: This is a descriptive study analyzing all surgically treated complex aneurysm patients in a tertiary referral center, during a 15-year time period in which complex endovascular aortic repair (complex EVAR) was introduced alongside open surgical repair (OSR). The goal was to present the real-world clinical profiles and surgical outcomes of complex (thoraco-)abdominal aneurysm patients, based on the current decision-making process. Methods: Patients undergoing OSR and complex EVAR be...
Abstract
Molecular biology of the cell,
24 4 2025, Pages mbcE24090405T
The RhoGEF Trio regulates the formation of tensile linear endothelial junctions to improve barrier function.
van Rijssel J, Sluiter TJ, van der Krogt JMA, Bart CI, Zhang J, de Vries AAF, van Alphen FPJ, Janssen H, van den Biggelaar M, Wubbolts RW, Quax PHA, de Vries MR, van Buul JD
The vascular endothelium serves as a selectively permeable barrier, tightly regulating transendothelial transport of small molecules, macromolecules, and immune cells. In the context of cardiovascular and inflammatory pathologies, the integrity of this barrier is often markedly compromised, contributing to tissue dysfunction, multi-organ failure, and, ultimately, mortality. Therapeutic strategies aimed at mitigating endothelial barrier dysfunction primarily focus on enhancing the stability of en...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 18 3 2025, Pages D8577
[The role of clinical practice guidelines in the assessment by the disciplinary board].
Weller FS, van Bodegom-Vos L, Repping S, Hamming JF
Objective: To examine how often disciplinary complaints against physicians are upheld explicitly on the grounds of deviation from clinical practice guidelines. Design: Retrospective document analysis of publicly available medical disciplinary rulings in the Netherlands between January 1, 2019, and December 31, 2023. Methods: We analysed rulings from the official Dutch disciplinary law database (tuchtrecht.nl). All upheld complaints were reviewed to determine whether the disciplinary board explic...
Abstract
Cited 2 times since 2025 (22.7 per year)
source: EuropePMC
Nature,
Volume 649, Issue 8097, 17 3 2025, Pages 759-776
An integrated view of the structure and function of the human 4D nucleome.
Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Andréa W, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepińska T, Chiliński M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park PJ, Alver BH, Schroeder AJ, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit AD, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F
The dynamic three-dimensional (3D) organization of the human genome (the 4D nucleome) is linked to genome function. Here we describe efforts by the 4D Nucleome Project1 to map and analyse the 4D nucleome in widely used H1 human embryonic stem cells and immortalized fibroblasts (HFFc6). We produced and integrated diverse genomic datasets of the 4D nucleome, each contributing unique observations, which enabled us to assemble extensive catalogues of more than 140,000 looping interactions per cell t...
Abstract
JACC. Advances,
Volume 5, Issue 1, 17 3 2025, Pages 102424
Activation of the Anrep Effect in Aortic Stenosis Pre-TAVR and Post-TAVR: An Echocardiographic Pressure-Volume Analysis.
Reil JC, Sequeira V, Lucas P, Tadros L, Reil GH, Federspiel JM, Scholtz S, Omran H, Steendijk P, Marquetand C, Scholtz W, Piper C, Rudolph T, Rudolph V
Background: In aortic stenosis (AS), chronic pressure overload of the left ventricle (LV) may sustain an intrinsic, afterload-dependent adaptive response known as the Anrep effect, characterized by increased myocardial contractility and prolonged systolic duration. Whether this response resolves following transcatheter aortic valve replacement (TAVR) remains unknown. Objectives: The objective of the study was to determine whether the Anrep is chronically activated in severe AS and acutely revers...
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 12, 17 3 2025, Pages 498
Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair.
Rolando M, Elmasry N, Gobbi F, Moreo A, Ajmone Marsan N, Carluccio E, Fortuni F
Mitral regurgitation (MR) is one of the most prevalent valvular disorders worldwide, with a growing burden driven by population aging and improved diagnostic capabilities. Understanding the mechanism of MR, whether primary, due to intrinsic valve abnormalities, or secondary, resulting from atrial or ventricular remodeling, is essential for optimal management. Echocardiography, particularly advanced modalities such as three-dimensional imaging and strain analysis, plays a central role in this pro...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 34, Issue 1, 16 3 2025, Pages 18-26
Left atrial appendage occlusion vs standard of care in high stroke risk atrial fibrillation patients ineligible for anticoagulation: COMPARE-LAAO.
Aarnink EW, Huijboom MFM, van der Kley F, Folkeringa R, de Groot JR, van der Voort PH, Blaauw Y, Chaldoupi M, Stevenhagen J, Vlachojannis GJ, van Mieghem NM, Swaans MJ, van Dijk VF, Dijkgraaf MG, van Dijk EJ, Tijssen JGP, Boersma LVA
Introduction: The left atrial appendage is the dominant source of cardioembolic stroke in patients with atrial fibrillation (AF). Contemporary guidelines recommend considering left atrial appendage occlusion (LAAO) in AF patients contraindicated to oral anticoagulation therapy (OAC), but randomized controlled trial (RCT) data for this subpopulation are lacking. Methods: COMPARE LAAO was designed as an event-driven, multicenter, prospective, randomized, open, blinded endpoint (PROBE) trial that r...
Abstract
