Kidney international, Volume 109, Issue 1, 1 1 2026, Pages 37-40 Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling. Baker AH, de Vries MR
Single-cell transcriptomics of arteriovenous fistulas reveal that failure is likely driven less by smooth muscle proliferation than by continuous inflammation, endothelial dysfunction, and fibroblast-driven fibrosis. These insights reframe current knowledge and highlight mechanistic pathways as to where future therapies could be targeted to improve arteriovenous fistula maturation kinetics and associated patency rates.
