Research

Publications

Below you can find a list of our published research.

8892 results

Nursing in critical care, Volume 30, Issue 6, 1 1 2025, Pages e70191 Intensive Care and Operating Room Nurses' Knowledge Regarding Skin Tears. Yeşilyurt M, Yılmaz D

Background: Skin tears are a prevalent but often under-recognised type of injury in clinical settings, particularly affecting vulnerable patients in intensive care and surgical environments. Aim: The aim of this study was to determine the knowledge levels of nurses working in operating rooms and intensive care units regarding skin tears. Study design: This descriptive study was conducted between December 2024 and April 2025 with 81 intensive care and 76 operating room nurses at a training and re... Abstract

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 1: Multimodality imaging for the evaluation of patients with advanced heart failure. Aimo A, Tops LF, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Gal TB, Moura B

Heart failure (HF) represents a significant global health burden, with approximately 10% of patients progressing to advanced stages characterized by severe symptoms and recurrent hospitalizations despite conventional treatments such as guideline-directed medical therapy, devices, and surgery. This clinical consensus statement from the Heart Failure Association of the European Society of Cardiology discusses the applications of imaging modalities in patients with advanced HF. Transthoracic echoca... Abstract

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation. Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T

This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess... Abstract

Irish journal of medical science, 14 2 2025 Enhancing educator preparedness for type 1 diabetes: a theory-based intervention targeting knowledge and Self-efficacy in low-resource schools. Yılmaz DA, Dege G, Atasoy M

Background: Type 1 diabetes mellitus (T1DM) is an increasing concern among school-aged children, with more than 1.2 million affected globally. In low- and middle-income countries (LMICs), teachers often act as first responders to diabetes-related emergencies despite limited preparation. Structured education programs informed by behavioral theory may help strengthen both knowledge and applied competence among school staff. Aim: This study examined the short-term effects of a Bandura-based diabete... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 12 2 2025 Modification Procedures for Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry. Kladou E, Strepkos D, Alexandrou M, Mutlu D, Carvalho PEP, Sara JDS, Ser OS, Alaswad K, Basir MB, Khelimskii D, Jaffer FA, Rafeh NA, Chandwaney R, Cevik C, Ahmad Y, Mastrodemos O, Rangan BV, Jalli S, Voudris K, Sandoval Y, Nicholas Burke M, Brilakis ES, PROGRESS‐CTO Investigators

Background: CTO-ARC (Chronic Total Occlusion Academic Research Consortium) defines CTO modification procedures (previously called investment procedures) as intentional balloon dilatation (diameter ≥ 2.0 mm) of the entire CTO, including the proximal and distal caps and the CTO body. Aims: The aim of this study is to compare the outcomes of repeat CTO PCI between patients who underwent lesion modification during the initial failed procedure and those who did not. Methods: We analyzed the associati... Abstract

JMIR medical informatics, Volume 13, 10 2 2025, Pages e71994 Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study. van Velze VY, Burger HL, van der Steenhoven TJ, Al-Ers H, Goncalves LN, Eefting D, de Jong WJ, Smeets HJ, Welleweerd JCS, van der Vorst JR, Uchtmann S, Rissmann R, Hamming JF, Stergioulas L, van der Bogt KE

Background: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and severe outcomes, providing an ideal example for a comprehensive framework that encompasses all essential steps for implementing ML in a clinically relevant fashion. Objective: This paper aims to provide a framework for the proper use of ML algorithms t... Abstract

American journal of physiology. Heart and circulatory physiology, 10 2 2025 Bone Morphogenetic Protein 10: Clinical Correlates and Risk of Incident Atrial Fibrillation. Suthahar N, Yap SC, de Vries AAF, Damman K, Fabritz L, Bakker SJL, Gansevoort RT, Kirchhof P, Rienstra M, de Boer RA

Background: Bone morphogenetic protein-10 (BMP10), a protein predominantly secreted by atrial cardiomyocytes, has emerged as a promising biomarker in patients with atrial fibrillation (AF) and as a marker of atrial stress in patients with heart failure. Its clinical correlates in community-dwelling adults and its association with incident AF remain unexplored. Methods and Results: BMP10 was measured in 5883 participants from the PREVEND community-based cohort (mean age 53.6 years; 51.5% females)... Abstract

Journal of clinical microbiology, 9 2 2025, Pages e0027225 In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections. Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB

Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib... Abstract

Biological research for nursing, 8 2 2025, Pages 10998004251385121 Effect of Infant Massage in Neonates With Hyperbilirubinemia Receiving Phototherapy: A Systematic Review and Meta-Analysis. Erçelik ZE, Yilmaz DA

Most infants are diagnosed with hyperbilirubinemia in the first day of life. Although phototherapy is the most common treatment used in hyperbilirubinemia, different alternative therapies such as massage are also used. This systematic review and meta-analysis was designed to evaluate the effect of massage on serum bilirubin levels, defecation frequency, and length of hospital stay in neonates with hyperbilirubinemia receiving phototherapy. A review of randomized controlled trials published in En... Abstract

Journal of cardiovascular computed tomography, 8 2 2025, Pages S1934-5925(25)00442-3 Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease. Nabeta T, Bär S, Maaniitty T, Kärpijoki H, Bax JJ, Saraste A, Knuuti J

Background: A novel artificial intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) comprises a machine-learned method using atherosclerosis and vascular morphology features from coronary computed tomography angiography (CCTA) images to predict myocardial ischemia. This study evaluates the diagnostic performance of AI-QCTischemia compared to standard CCTA interpretation in detecting myocardial ischemia. Methods and results: Patients with suspected coronary art... Abstract

Endocrine connections, Volume 14, Issue 10, 6 1 2025, Pages e250400 Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism. Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM

Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t... Abstract

Annals of vascular surgery, 6 1 2025, Pages S0890-5096(25)00655-7 Prediction of wound healing following amputation surgery based on near-infrared fluorescence with indocyanine green. Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group

Objectives: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound-healing complications within six weeks after lower-extremity amputation. Methods: In this dual-centre cohort study, patients undergoing minor (below-ankle) or major (above-ankle) amputations due to PAD or diabetes mellitus, with perfusion assessment performed using ICG NIR fluorescence imaging, were included. Fluorescence videos were recorded using st... Abstract

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2 1 2025 Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy. van Dijk SPJ, Maas CCHM, Alshangi A, van Driel MHE, Feitsma EA, van Kinschot CMJ, Lončar I, van Noord C, Koppert LB, Kruijff S, van Klaveren D, Verhoef C, Peeters RP, van Ginhoven TM, Hypoparathyroidism Study Group of the Thyroid Network

Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy. Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals. Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

Microbial genomics, Volume 11, Issue 10, 1 1 2025 The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant. McCallum GE, Ho SFS, Cummins EA, Wildsmith AJ, McInnes RS, Weigel C, Tong LYS, Quick J, van Schaik W, Moran RA

The laboratory contaminant strain Noodlococcus was named for its coccoid cells and unusual colony morphology, which resembled a pile of noodles. Along with laboratory characterisation and electron microscopy, we generated a complete Noodlococcus genome sequence using Illumina and Oxford Nanopore data. The genome consisted of a single, circular, 2,732,108 bp chromosome that shared 97.5% average nucleotide identity (ANI) with the Kocuria rhizophila type strain TA68. We identified genomic features... Abstract

Global change biology, Volume 31, Issue 10, 1 1 2025, Pages e70531 One Species Hibernates Shorter, the Other Longer: Rapid but Opposing Responses to Warming Climate in Two Sympatric Bat Species. Krivek G, Meier F, Grosche L, Kerth G, van Schaik J

The timing of hibernation represents a key seasonal transition in the annual cycle of hibernators, directly impacting their survival and reproductive success. Ongoing climate change affects many of the factors that influence hibernation phenology, such as weather patterns, food availability and the timing of mating and reproduction. The extent to which individuals should adjust their hibernation phenology in response is likely to vary between species, sexes and age classes. Consequently, long-te... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

BJA open, Volume 16, 29 5 2025, Pages 100485 The association between postoperative myocardial injury of unexplained aetiology after noncardiac surgery and sex and cancer on 1-yr survival: a retrospective, single-centre, observational cohort study. van Schaik EPC, Vernooij LM, Haddou Y, Grobben RB, van Klei WA, van Waes JAR

Background: The aetiology of postoperative myocardial injury (PMI) is often unexplained, and the effect of sex and cancer surgery on prognosis in patients with PMI is unknown. We aimed to estimate the proportion of patients developing PMI of unknown aetiology and compare their prognosis with those with explained PMI, and to investigate the interaction with sex and cancer surgery. Methods: This retrospective, single-centre, observational cohort study included patients aged ≥60 yr undergoing nonca... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 29 5 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Background and aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults, the present study evaluates the effectiveness in children. Methods: Retrospective multi-center study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD-sho... Abstract

Scientific reports, Volume 15, Issue 1, 26 4 2025, Pages 33000 Green synthesis of antimicrobial alginate/hydroxyethyl cellulose hydrogels crosslinked by Ca2+ and dual Ca2+/Mg2. Jahir Hussain FS, Ghosh S, Al Saadi HSO, Al-Sibani M, Al Amri IS, Al Harrasi A, Al Abri AM, Al-Hinai A, Al-Housni SK, Al-Hatmi AMS

Eco-friendly antimicrobial hydrogels derived from carbohydrate polymers are receiving significant attention for their sustainable and cost-effective properties. This study focuses on developing antimicrobial hydrogels based on alginate and hydroxyethyl cellulose (SA/HEC) using a green chemistry approach. The impact of bivalent metal ions on cross-linking efficiency and the hydrogels' physicochemical properties were analyzed, with hydrogels produced in various forms, such as beads, sponges,... Abstract