6275 results
Virchows Archiv : an international journal of pathology,
5 1 2025
Diagnosing the silent: the molecular landscape of non-functional parathyroid carcinoma.
Jentus MM, Corver WE, Snel M, van Haalen FM, van Wezel T, Ruano D, Kapiteijn E, Crobach S, Appelman-Dijkstra NM, Schepers A, Morreau H
Non-functional parathyroid carcinoma (NFPC) is an exceptionally rare malignancy, with approximately 50 cases reported since the parathyroid glands were first described in the late nineteenth century. Unlike functional parathyroid carcinomas (PC), which typically present with severe hyperparathyroidism (HPT) and are monitored via serum calcium and parathyroid hormone (PTH) levels, NFPC lacks biochemical markers and is monitored solely through imaging. In this study, we present two new cases of pr...
Abstract
The Journal of thoracic and cardiovascular surgery,
4 1 2025, Pages S0022-5223(25)00648-8
Personalized External Aortic Root Support, the Dutch Experience.
Kougioumtzoglou AM, Lam BCY, Bouma BJ, Groenink M, Scholte AJHA, Dolmaci OB, Corsmit OT, Pandey AK, de Blok ACJ, Noter SL, Austin C, Klautz RJM, Hazekamp MG, Koolbergen DR
Introduction: Patients with connective tissue disease and aortic root aneurysm are at risk of dissection and progression of the dilation. Standard treatment of aortic root aneurysm is either a total root replacement or valve-sparing root replacement. Both procedures have drawbacks such as the need for anticoagulation and long term exposure to the chance of reoperation or endocarditis. The ExoVasc® Personalized External Aortic Root Support (PEARS) is a perivascular stent, that has been introduced...
Abstract
The journal of vascular access,
1 1 2025, Pages 11297298251350745
Cephalic vein dilatation at the elbow by preoperative supervised forearm exercise depends on adherence to therapy: Results from the randomized controlled single-blind PINCH trial.
Wilschut ED, de Winter EP, Bos EJ, de Vries MR, Putter H, van der Steenhoven TJ, Eefting D, Hamming JF, Rotmans JI, van der Bogt KEA
Background: Maturation failure may be as high as 30%-60% of arteriovenous fistulas (AVF). Forearm exercise postoperatively has shown potential in increasing blood vessel size in patients with end-stage renal disease and may promote maturation of AVFs. Little evidence exists on the impact of pre-operative forearm exercises on the increase of vascular diameters. Aim of this study was to evaluate the effect of supervised forearm exercises on vascular diameters and AVF maturation. Methods: The PINCH...
Abstract
European heart journal,
1 1 2025, Pages ehaf480
Heart failure with reduced ejection fraction and ventricular secondary mitral regurgitation: a holistic approach.
Adamo M, Pagnesi M, Ajmone Marsan N, Bauersachs J, Hausleiter J, Zieroth S, Metra M
Optimal management of patients with heart failure with reduced ejection fraction (HFrEF) and secondary mitral regurgitation (SMR) requires the integration of multiple competencies with the interplay of guideline-directed medical therapy (GDMT) for HFrEF, devices, namely cardiac resynchronization therapy (CRT), when indicated, and mitral transcatheter edge-to-edge repair (M-TEER). Both GDMT and CRT can reduce SMR severity. However, GDMT may not be tolerated in patients with HFrEF who develop hypo...
Abstract
The Journal of asthma : official journal of the Association for the Care of Asthma,
31 5 2025, Pages 1-7
Inhaled muscarinic antagonists during pregnancy in women with asthma: case series from a Dutch prospective observational cohort study.
Kathiravetpillai N, van Buul AR, Ezinga M, Koehorst-Ter Huurne K, Van Nederveen-Bendien SA
Introduction: A large proportion of women with asthma experience worsening of asthma during pregnancy. Well-controlled asthma during pregnancy decreases the risk of maternal and fetal complications. Long-acting muscarinic antagonists (LAMAs) are part of treatment guidelines for poorly controlled asthma. There are no clinical safety data available on LAMA and short-acting muscarinic antagonists (SAMAs) use in pregnancy.Objective: The aim was to evaluate asthma control and pregnancy outcomes in pr...
Abstract
The Journal of dermatological treatment,
Volume 36, Issue 1, 30 5 2025, Pages 2539282
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry.
Vroman F, van der Rijst LP, Bacoş-Cosma OI, Zuithoff NPA, Kamsteeg M, van Lumig PPM, Loman L, Schuttelaar MLA, de Bruin-Weller MS, de Graaf M
Purpose: Upadacitinib is approved for treating moderate-to-severe atopic dermatitis (AD) aged ≥12 years. We evaluated upadacitinib's effectiveness and safety in AD adolescents in daily practice. Materials and methods: Fifteen adolescent AD patients from the BioDay registry, treated with upadacitinib 15 mg once daily were evaluated at baseline and after 4, 8, 16, and 28 weeks. Effectiveness was assessed using Eczema Area and Severity Index (EASI) score and Investigator Global Assessment (IGA...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 8, 29 5 2025, Pages 101323
CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR
Atherosclerotic vein graft failure still presents a major problem. T-cells have been identified as one of the most abundant immune cell subset in atherosclerotic plaques. Their role, however, remains only partly understood. Using a murine vein graft model for advanced, unstable atherosclerotic lesions, we find that T-cells accumulate over time in atherosclerotic vein grafts, and appear to be activated rapidly after engraftment, demonstrated by increased expression of CD137 on plaque T-cells. Tar...
Abstract
European heart journal,
25 4 2025, Pages ehaf456
Arrhythmia ablation in patients with congenital heart disease: challenges and opportunities in using complex spectrum data to guide individual care.
Kimura Y, Zeppenfeld K
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
25 4 2025, Pages S0894-7317(25)00396-7
Left Atrial Strain Index in Patients with Heart Failure with Preserved Ejection Fraction.
Chua APA, Weerts J, Achten A, Nabeta T, Sarrazyn C, Lopez-Santi P, Mourmans SGJ, Su JL, Bax JJ, Knackstedt C, van Empel VPM, Ajmone-Marsan N
Abstract
Circulation. Arrhythmia and electrophysiology,
25 4 2025, Pages e013150
Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
Jungen C, Chen HS, Wijnmaalen AP, Dibbets-Schneider P, Meretta A, Piers SR, Kimura Y, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Mertens BJA, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown. Methods: Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent progr...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 24 4 2025, Pages 1649558
Editorial: New trends in vascular biology 2024.
Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M
Abstract
The American journal of cardiology,
22 4 2025, Pages S0002-9149(25)00421-7
Procedural and Clinical Outcomes of Coronary Intravascular Lithotripsy in Patients With Impaired Renal Function: A Multicenter Retrospective Study.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Chronic kidney disease (CKD) is a prevalent comorbidity in patients undergoing percutaneous coronary intervention (PCI), yet its impact on outcomes following intravascular lithotripsy (IVL) remains insufficiently studied. This study evaluated procedural and long-term outcomes of IVL-assisted PCI in patients with renal insufficiency compared to those with normal renal function. From the BENELUX-IVL registry (May 2019-September 2024), 558 patients were included in a retrospective multicenter analy...
Abstract
Cited 2 times since 2025 (28.4 per year)
source: EuropePMC
Nature medicine,
21 3 2025
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, G
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry...
Abstract
Open heart,
Volume 12, Issue 2, 21 3 2025, Pages e003445
Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure.
Neijenhuis RM, Regeer MV, Walker NL, Mertens BJ, Hunter A, Kiès P, Swan L, Vliegen HW, MacDonald ST, Zemrak F, Zaidi AN, Cedars AM, Jongbloed MR, Jukema JW, Veldtman GR, Egorova AD
Background: Systemic right ventricle (sRV) patients are at an increased risk of developing heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) could be a valuable treatment option. This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i. Methods: Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 15, 17 3 2025, Pages e040868
Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse: Prevalence, Predictors, and Association With Outcomes.
Topilsky Y, Essayagh B, Benfari G, Le Tourneau T, Antoine C, Grigioni F, Roussel JC, Bax JJ, Marsan NA, van Wijngaarden A, Tribouilloy C, Loewenstein I, Hochstadt A, Thapa P, Michelena HI, Enriquez-Sarano M
Background: Left ventricular (LV) end-systolic enlargement in severe degenerative mitral-regurgitation (MR) is a class I surgical trigger. Whether it occurs disproportionately to less-than-severe MR due to mitral valve prolapse and is associated with mortality are unknown. We aimed to analyze prevalence and association with survival of disproportionate LV enlargement in less-than-severe MR. Methods: A multicenter cohort international study enrolled 2848 consecutive patients (52% women, 69±16 yea...
Abstract
American heart journal,
15 3 2025, Pages S0002-8703(25)00218-2
Design and rationale of the HARTc 2.0 trial: a multicentre randomized controlled study on the impact of point-of-care hs-cTnI testing in prehospital ACS triage on diagnosis and cost-effectiveness.
van der Lande ACMH, Diederiks NM, de Koning ER, Bosch J, Romijn FPHTM, van der Loo WPM, van den Akker-van Marle ME, Dehnavi RA, Tietge WJ, Mertens BJA, Jukema JW, Cobbaert CM, Schalij MJ, Boogers MJ
Introduction: Chest pain accounts for ∼10% of emergency department visits, though most cases are not ACS, underscoring the need for effective prehospital triage. The HARTc 2.0 study evaluates the modified HEART score incorporating point-of-care (POC) high-sensitivity cardiac troponin I (hs-cTnI) capillary fingerprick testing with sex-specific cut-offs to improve ACS risk stratification. The randomized controlled trial (RCT) compares a prehospital triage strategy using this modified HEART score a...
Abstract
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
12 2 2025, Pages S1078-5884(25)00678-1
Factors Influencing Vascular Surgeons' Compliance with Elective Repair Guidelines for Abdominal Aortic Aneurysm: A Qualitative Study.
Brust M, van Gestel LC, Vriens PWHE, Hamming JF, Adriaanse MA, Lindeman JH
Objective: Despite guideline recommendations to delay elective abdominal aortic aneurysm (AAA) repair until the diameter exceeds the intervention threshold, a notable proportion of repairs occur earlier. This study aimed to explore factors influencing vascular surgeons' compliance with the intervention threshold regarding AAA repair, adopting a behavioural science perspective. Methods: This qualitative study employed semi-structured interviews with vascular surgeons. Twelve vascular surgeon...
Abstract
Cited 1 times since 2025 (9.7 per year)
source: EuropePMC
Royal Society open science,
Volume 12, Issue 7, 9 2 2025, Pages 241754
An integrated baseline assessment of reef-associated sharks around Saba (Dutch Caribbean), combining three methods: stereo-BRUVs, telemetry and citizen science.
Leurs G, de Graaf M, Hassell-Knijff D, Izioka LAK, van Looijengoed W, Meijer Zu Schlochtern MP, Bervoets T, Nagelkerke LAJ, Winter HV
The Exclusive Economic Zone of Saba (Dutch Windward Islands) has been designated Yarari Marine Mammal and Shark Sanctuary. However, to effectively conserve sharks, a baseline on their diversity and spatiotemporal distribution is required. We used three methods: telemetry, stereo-baited remote underwater video systems (stereo-BRUVs) and a citizen science program to study reef-associated sharks, mainly Caribbean reef sharks (Carcharhinus perezi) and nurse sharks (Ginglymostoma cirratum) around Sab...
Abstract
Heart (British Cardiac Society),
8 2 2025, Pages heartjnl-2025-326162
Representativeness of surgical controls in aortic valve replacement trials: comparison with routine surgical cohorts.
Tomsic A, Velders BJJ, Kawczynski MJ, Schoones JW, Klautz RJM, Palmen M, Sardari Nia P, Owais T, Girdauskas E, Heuts S
Background: Randomised controlled trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have significantly influenced treatment guidelines for aortic stenosis, expanding the use of TAVI into lower risk populations. However, the patients enrolled in the SAVR arms of these trials may differ from those typically undergoing SAVR in routine clinical practice. This study aims to critically assess the representativeness of SAVR patients in t...
Abstract
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland,
8 2 2025, Pages S1479-666X(25)00123-4
Bridging generational gaps in Surgery: A narrative review on values, well-being, and training preferences.
Huizing F, Sier VQ, Sark AD, Snijders HS, van der Vorst JR, Schmitz RF, Schepers A, Blok JJ, Future Surgeon Initiative
Background and purpose: Intergenerational differences in surgery create both challenges and opportunities. While differening perspectives and expectations may deter younger generations from pursuing surgical careers, it is crucial to balance these with the core values that define the surgical profession. This narrative review was conducted to better understand how the profession needs to evolve. Methods: A structured literature search on generational changes in surgery was conducted using PubMed...
Abstract
