6205 results
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
19 3 2025
Efficacy and Safety of Intravascular Lithotripsy in the Management of Underexpanded Stents: A Systematic Review and Meta-Analysis.
Sagris M, Soulaidopoulos S, Papanikolaou A, Ktenopoulos N, van Oort MJH, Montero-Cabezas JM, Patsourakos N, Honton B, Tousoulis D, Tsioufis K
Background: Stent underexpansion significantly heightens the risk of major adverse cardiac events (MACE), and available treatment options for this condition remain limited. Intravascular Lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, emerges as a promising tool for underexpanded stents. Aims: This study examines the overall efficacy and safety of IVL, an until-now off-label modality, in the management of underexpanded stents....
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
15 3 2025
Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum.
van der Rijst LP, Knol EF, Zuithoff NPA, den Hartog Jager CF, van Wijk F, de Bruin-Weller MS, de Graaf M
Objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods: Twenty paediatric AD patients (
Abstract
Heart & lung : the journal of critical care,
Volume 73, 12 2 2025, Pages 108-113
Intravascular lithotripsy and temporary mechanical circulatory support for the treatment of heavily calcified coronary artery disease: insights from the BENELUX-IVL registry.
Oliveri F, Merino I, van Oort MJH, Al Amri I, Bingen BO, Arslan F, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Kley F, Jukema JW, Montero-Cabezas J
Background: Intravascular lithotripsy (IVL) is increasingly utilized for the treatment of heavily calcified coronary lesions. However its use in conjunction with temporary mechanical circulatory support (tMCS) remains underexplored. Objective: This study aims to evaluate the current use of tMCS and IVL for the treatment of heavily calcified coronary lesions. Method: From the BENELUX-IVL prospective registry, patients who underwent IVL during PCI and required tMCS during the procedure were select...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
12 2 2025, Pages ezaf161
Sex difference in aortic root replacement with a stentless bioprosthesis.
Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J
Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centers were included. Survival analyses were performed using the Kaplan-Meier method or Aahlen-Johansen with death as competing risk as relevant. Results were quantified using uni- a...
Abstract
The Science of the total environment,
Volume 980, 3 1 2025, Pages 179386
Towards a European sustainable beneficiation of rare earth elements bearing minerals: a review.
Gajendra N, Yilmaz D, Vila MC, de Lurdes Dinis M, Levei EA, Török AI, Avsar D, Kladis A, Preveniou A, Hansen AM, Aaen SB, Ferrando-Climent L
This review explores the multifaceted aspects of sustainable extraction of rare earth elements (REEs) bearing minerals within Europe, stressing the exploitation of local deposits, that together with the integration of cleaner and greener approaches (including circular economy approaches) might help to reduce dependency on imports and contribute to a greener economy. The mineralogical characteristics and distribution of REEs in European deposits are examined, alongside current and emerging benefi...
Abstract
Journal of the American College of Cardiology,
Volume 85, Issue 17, 1 1 2025, Pages 1695-1705
Proactive Mapping and Preventive Ablation Reduce Defibrillator Implantation Rates in Tetralogy of Fallot.
Kimura Y, Wallet J, Brouwer C, Bokma JP, Bertels RA, Jongbloed MRM, Hazekamp MG, Blom NA, Zeppenfeld K
Background: In patients with repaired tetralogy of Fallot (rTOF) and spontaneous ventricular tachycardia (VT), transection of slow-conducting anatomical isthmus (SCAI) by ablation results in excellent long-term VT-free survival. In patients without prior VT, proactive electroanatomical mapping and preventive SCAI ablation may impact patient selection for primary prevention implantable cardioverter-defibrillator (ICD) implantation. Objectives: The purpose of this study was to evaluate long-term o...
Abstract
Brain : a journal of neurology,
Volume 148, Issue 5, 1 1 2025, Pages 1531-1539
N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski LE, Reichenbach K, Roediger L, Corlett P, Sterzer P
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the...
Abstract
ASAIO journal (American Society for Artificial Internal Organs : 1992),
29 5 2025
Bridging Therapy and Risk of Bleeding and Thrombosis in Continuous-Flow Left Ventricular Assist Device Patients: A Quasi-Experimental Study.
Camilleri E, Roovers RPW, Janssen E, Krommenhoek JF, Klok FA, Palmen M, Jukema JW, van Rein N, Tops LF
Bridging with low-molecular-weight heparin (LMWH) is recommended in continuous-flow left ventricular assist device (CF-LVAD) patients during subtherapeutic international normalized ratios (INRs). We aimed to assess the risk of adverse events during bridging in patients implanted at Leiden University Medical Center between 2010 and 2024. Incidence rates and hazard ratios of major bleeding, thromboembolic events, neurologic complications, and death with 95% confidence intervals (95% CI) were estim...
Abstract
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society,
29 5 2025, Pages 14574969251336863
Sex differences as a catalyst for the next step in surgeon personality research.
Sier JA, van der Vorst JR, Sier VQ
Abstract
The Pediatric infectious disease journal,
28 4 2025
Listeria Meningitis in Pediatric Patient with Associated Pneumonia Presenting with Refractory Status Epilepticus: Expanding the Clinical Spectrum of an Underrecognized Entity.
Kuş S, Alataş ŞÖ, Tüz AE, Dündar NO, Durak F, Yilmaz D
Abstract
Revista espanola de cardiologia (English ed.),
25 4 2025, Pages S1885-5857(25)00122-7
Prognostic benefit of percutaneous revascularization for chronic total coronary occlusions. Paradoxes and contradictions in an endless debate.
Jurado-Román A, Montero-Cabezas JM
Abstract
European journal of heart failure,
25 4 2025
Heart failure in patients with a systemic right ventricle: A multicentre study with long-term follow-up.
Ansari Ramandi MM, Budts W, Roos-Hesselink JW, Helbing WA, Egorova AD, Bouma BJ, Duijnhouwer A, van Kimmenade R, Sieswerda GT, Konings TC, Wagenaar LJ, Ubachs JFA, Berger RMF, Hoendermis ES, Voors AA, van Melle JP
Aims: Adult patients with transposition of the great arteries (TGA) and an systemic right ventricle (sRV) are at risk for heart failure (HF). In this study, we investigated risk factors for HF hospitalization and developed a novel risk stratification tool to optimize risk prediction for clinical practice. Methods and results: In this international multicentre study, 522 patients with TGA and an sRV, without history of HF hospitalization, were followed retrospectively for a median of 17.9 years (...
Abstract
Cited 1 times since 2025 (12.3 per year)
source: EuropePMC
eLife,
Volume 13, 25 4 2025, Pages RP99116
Major nuclear locales define nuclear genome organization and function beyond A and B compartments.
Gholamalamdari O, van Schaik T, Wang Y, Kumar P, Zhang L, Zhang Y, Gonzalez GAH, Vouzas AE, Zhao PA, Gilbert DM, Ma J, van Steensel B, Belmont AS
Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here, we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nuclear locales: the nuclear lamina, nuclear speckles, and nucleoli. Although gene expression correlates mostly with nuclear speckle proximity, DNA replication timing correlates with proximity to multip...
Abstract
Journal of thoracic disease,
Volume 17, Issue 4, 25 4 2025, Pages 2194-2205
Early versus late chest tube removal after surgery for primary spontaneous pneumothorax-a systematic review and meta-analysis.
van Steenwijk QCA, Spaans LN, Braun J, Dijkgraaf MGW, van den Broek FJC
Background: The optimal timing of postoperative chest tube removal remains disputable. Traditionally, chest tubes are left in place for several days for adequate pleurodesis and recurrence prevention after surgery for primary spontaneous pneumothorax (PSP). Currently, early tube removal, defined as immediate removal upon cessation of air leakage, is increasingly practiced. This study aimed to evaluate the safety of early chest tube removal in terms of recurrence in these patients. Methods: MEDLI...
Abstract
Cardiology and therapy,
Volume 14, Issue 2, 23 4 2025, Pages 219-230
Defibrillation Threshold Testing After ICD Implantation in Patients with Chronic Kidney Disease.
Timal RJ, Osman L, Rotmans JI, Bootsma M, Mertens B, Schalij MJ, Rabelink TJ, Jukema JW
Introduction: Routine defibrillation threshold (DFT) testing at the time of implantable cardioverter-defibrillator (ICD) implantation is no longer recommended because testing did not improve shock efficacy or reduce arrhythmic death. However, patients with severe chronic kidney disease (CKD) were not included in these trials and might benefit from DFT testing. International guidelines shed no light on the subject of the effect of kidney function on DFT testing in patients with CKD. Methods: In t...
Abstract
Journal of cardiothoracic and vascular anesthesia,
22 4 2025, Pages S1053-0770(25)00338-6
Effect of Bicuspid or Tricuspid Aortic Valve on Preoperative Coagulation in Patients Scheduled for Thoracic Aortic Surgery.
van Haeren MMT, Bozic C, Eberl S, Hollmann MW, Breel JS, Grewal N, Driessen AHG, Vlaar APJ, Müller MCA, Hermanns H
Objectives: This study aimed to analyze the impact of aortic valve morphology on preoperative coagulation status in patients undergoing elective thoracic aortic surgery. Preoperative ROTEM and conventional coagulation tests of patients with a bicuspid aortic valve (BAV) were compared to those with a tricuspid aortic valve (TAV). Design: An exploratory prospective observational study. Setting: Conducted in a single center. Participants: The study included 169 patients (63 BAV and 106 TAV). Interv...
Abstract
The international journal of cardiovascular imaging,
22 4 2025
Plaque burden improves the detection of ischemic CAD over stenosis from coronary computed tomography angiography.
Kero T, Bär S, Saraste A, Klén R, Bax JJ, Knuuti J, Maaniitty T
In symptomatic patients undergoing coronary CTA for suspected coronary artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value for the identification of ischemic CAD on a per patient level. We evaluated 2145 patients who underwent coronary CTA for suspected CAD with sequential selective downstream 15O-water positron emission tomography (PET) myocardial perfusion imaging. Coronary CTA scans were ana...
Abstract
Frontiers in pediatrics,
Volume 13, 22 4 2025, Pages 1511086
Current methods in the diagnosis of invasive meningococcal disease.
Ciftci E, Ocal D, Somer A, Tezer H, Yilmaz D, Bozkurt S, Dursun OU, Merter Ş, Dinleyici EC
Invasive meningococcal disease (IMD) remains a significant health concern due to its global distribution, potential for epidemic spread, unpredictable nature, rapid progression, and high mortality rates or permanent sequelae. The global elimination of meningococcal illness via immunization is a primary objective of the World Health Organization's strategy to defeat meningitis by 2030. Timely recognition of meningococcal infection and immediate, precise, and specific identification of Neisse...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 2, 18 3 2025, Pages rkae155
Improving efficiency of a rheumatology outpatient clinic through classification of newly referred patients.
Dijkstra S, de Man YA, Braaksma A, de Graaf M, Bernelot Moens HJ, Boucherie RJ
Objectives: Diagnosing a rheumatological disease in patients newly referred by their general practitioner requires assessment by a rheumatologist and often diagnostic tests. Ideally, these tests are performed prior to the patient's first consultation with the rheumatologist, aiming for quick diagnosis and fewer visits. We retrospectively studied whether a pre-first visit digital patient questionnaire can lead to fewer consultations and faster diagnosis. Methods: We applied machine learning-...
Abstract
JACC. Advances,
Volume 4, Issue 5, 18 3 2025, Pages 101728
Investigating the Anrep Effect in Hypertrophic Obstructive Cardiomyopathy With Invasive Pressure-Volume Analysis.
Reil JC, Sequeira V, Reil GH, Scholtz S, Rudolph V, Maack C, Serruys P, Steendijk P
Background: The Anrep effect, an adaptation enhancing left ventricular (LV) contractility in response to raised afterload, is hypothesized to influence hypertrophic cardiomyopathy pathophysiology. Objectives: This study investigated the activation and reversibility of the Anrep effect in obstructive hypertrophic cardiomyopathy (HOCM) patients undergoing percutaneous transluminal septal myocardial ablation (PTSMA) to relieve LV outflow tract obstruction. Methods: Invasive pressure-volume (PV) ana...
Abstract
