6287 results
Scientific reports,
Volume 15, Issue 1, 21 3 2025, Pages 30672
Metagenomic analysis and genomic characterization of enterovirus A76 and Norovirus GI.6[P11] co-infection in a patient with acute gastroenteritis in Thailand.
Chuchaona W, Izquierdo-Lara RW, Schapendonk CME, Khongwichit S, Koopmans MPG, de Graaf M, Poovorawan Y
Acute gastroenteritis (AGE) remains a significant global health concern, with noroviruses among the most prevalent viral pathogens. However, other enteric viruses also contribute substantially to the public health burden. This study provides the first molecular characterization of a co-infection involving a rarely reported enterovirus A76 (EV-A76) and a norovirus GI.6[P11] in a patient from Thailand. Metagenomic sequencing successfully identified complete viral genomes, revealing unique genetic...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 9, 21 3 2025, Pages 101359
Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells.
Reilly NA, Mulder JWCM, Dekkers KF, Kuipers TB, van Vark-van der Zee LC, Mulder MT, Roeters van Lennep JE, Jukema JW, Heijmans BT
Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atherosclerotic plaques. This cross-sectional study examined transcriptomic differences in T cells among patients with varying triglyceride levels via RNA sequencing. We analyzed CD4+ and CD8+ T cells from 49 participants, including those with primary (genetic) and secondar...
Abstract
American journal of physiology. Renal physiology,
18 3 2025
The impact of chronic kidney disease on arteriovenous fistula remodelling: studies in a murine model of Autosomal Dominant Polycystic Kidney Disease.
Laboyrie S, Peters DJM, Bijkerk R, de Winter EP, Duijs JM, de Klerk JA, de Vries MR, Rotmans JI
The arteriovenous fistula (AVF) is the gold standard for hemodialysis vascular access, although inadequate vascular remodelling and intimal hyperplasia pose a major limitation. It is essential to study this in a clinically relevant model. We utilised an autosomal dominant polycystic kidney disease (ADPKD) model, the most common hereditary cause of chronic kidney disease (CKD), to study the effect of CKD on AVFs. Jugular-carotid AVFs were created in adult B6OlaPkd1nl/nl (ADPKD) mice and B6OlaPkd1...
Abstract
The American journal of cardiology,
16 3 2025, Pages S0002-9149(25)00477-1
Diagnosis and Treatment of Unrecognized Spontaneous Coronary Artery Dissection in Young Women Presenting with an Acute Coronary Syndrome.
Al-Gully J, Montero-Cabezas JM, Eikenboom J, den Exter PL, van der Kley F, Wouter Jukema J, Bingen BO, Al Amri I
Spontaneous Coronary Artery Dissection (SCAD) is often overlooked as a cause of Acute Coronary Syndrome (ACS), particularly in young women. SCAD requires distinct management, underscoring the importance of its timely and accurate diagnosis for effective treatment. This study aims to evaluate the frequency of SCAD underdiagnosis in young women with ACS and pinpoints potential SCAD indicators. All consecutive women ≤55 years with ACS who underwent coronary angiography (CAG) at our tertiary center...
Abstract
JACC. Advances,
Volume 4, Issue 9, 13 2 2025, Pages 102063
Ventricular Tachycardia Predicts All-Cause Mortality and Nonsudden Cardiac Death in Nonischemic Cardiomyopathy.
Omara S, Jensen TN, Koeber L, Thune JJ, Pehrson S, Mertens B, Tedrow UB, Hindricks G, Ebert M, Carbucicchio C, Berruezo A, Vaseghi M, Shivkumar K, Deneke T, Wijnmaalen AP, Stevenson WG, Nielsen JC, Zeppenfeld K
Background: Patients with nonischemic cardiomyopathies (NICMs) are at a risk for end-stage heart failure and death from ventricular arrhythmias. Implanted defibrillators (ICDs) protect against sudden arrhythmic death, but several studies suggest that ventricular arrhythmias are associated with worse outcomes despite ICDs. Objectives: This study evaluated the relationship of ventricular tachycardia (VT) with total mortality and nonsudden cardiovascular death (NSCVD) in NICM patients with ICDs enr...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 225, 13 2 2025, Pages 112097
Investigation of structural and radiation shielding properties of natural granite, clay, natural cement, and quartz supplied from Hakkâri region.
Kabamakli E, Yalcin S, Aktas B, Yilmaz D
This study aims to investigate the physical, structural, and radiation shielding properties of four rock types commonly used in natural cement, including clay, granite, and quartz originating from the Hakkâri region of Turkey. Structural characterization was performed using ICP-MS, XRD, and FT-IR analyses. At the same time, radiation shielding effectiveness was determined through measurements of mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), mea...
Abstract
Acta dermato-venereologica,
Volume 105, 12 2 2025, Pages adv44209
Topical Steroid Withdrawal: Perspectives of Dutch Healthcare Professionals.
Vroman F, Schimmel CS, Van der Rijst LP, De Graaf M, De Bruin-Weller M, Kemperman PMJH, Hijnen DJ, Haeck IM
Topical steroid withdrawal (TSW) is a highly controversial condition, typically reported following prolonged and/or frequent use of topical corticosteroids. Despite growing public awareness, knowledge of topical steroid withdrawal remains limited. Therefore, this study aimed to explore the perspectives of Dutch healthcare professionals (HCPs) on topical steroid withdrawal. A web-based survey was conducted among 168 Dutch HCPs. The results show that erythema (64.1%) and a burning sensation (60.3%...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
9 2 2025, Pages 102470
Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories.
Kero T, Knuuti J, Bär S, Bax JJ, Saraste A, Maaniitty T
Background: It is unclear whether coronary artery stenosis, plaque burden, and composition differ between major epicardial arteries supplying ischemic myocardial territories. Methods and results: We studied 837 symptomatic patients undergoing coronary computed tomography angiography (CTA) and 15O-water PET myocardial perfusion imaging for suspected obstructive coronary artery disease. Coronary CTA was analyzed using Artificial Intelligence-Guided Quantitative Computed Tomography (AI-QCT) to asse...
Abstract
Virchows Archiv : an international journal of pathology,
5 1 2025
Diagnosing the silent: the molecular landscape of non-functional parathyroid carcinoma.
Jentus MM, Corver WE, Snel M, van Haalen FM, van Wezel T, Ruano D, Kapiteijn E, Crobach S, Appelman-Dijkstra NM, Schepers A, Morreau H
Non-functional parathyroid carcinoma (NFPC) is an exceptionally rare malignancy, with approximately 50 cases reported since the parathyroid glands were first described in the late nineteenth century. Unlike functional parathyroid carcinomas (PC), which typically present with severe hyperparathyroidism (HPT) and are monitored via serum calcium and parathyroid hormone (PTH) levels, NFPC lacks biochemical markers and is monitored solely through imaging. In this study, we present two new cases of pr...
Abstract
The Journal of thoracic and cardiovascular surgery,
4 1 2025, Pages S0022-5223(25)00648-8
Personalized External Aortic Root Support, the Dutch Experience.
Kougioumtzoglou AM, Lam BCY, Bouma BJ, Groenink M, Scholte AJHA, Dolmaci OB, Corsmit OT, Pandey AK, de Blok ACJ, Noter SL, Austin C, Klautz RJM, Hazekamp MG, Koolbergen DR
Introduction: Patients with connective tissue disease and aortic root aneurysm are at risk of dissection and progression of the dilation. Standard treatment of aortic root aneurysm is either a total root replacement or valve-sparing root replacement. Both procedures have drawbacks such as the need for anticoagulation and long term exposure to the chance of reoperation or endocarditis. The ExoVasc® Personalized External Aortic Root Support (PEARS) is a perivascular stent, that has been introduced...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 8, 1 1 2025, Pages euaf136
Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram.
Hoogendoorn JC, Bosman LP, van der Heijden JF, Wilde AA, van den Berg MP, Yap SC, van Tintelen JP, Dooijes D, Te Riele ASJM, Zeppenfeld K
The task force criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly sensitive but lack specificity. Atypical RV involvement (aRVi) may indicate different underlying aetiologies and prognosis, requiring specific therapeutic interventions. We aimed to evaluate the role of the baseline 12-lead ECG for initial suspicion of aRVi. From the Netherlands Heart Institute Arrhythmogenic Cardiomyopathy (NHI-ACM) registry, patients were selected who (i) fulfilled TFC for defin...
Abstract
The journal of vascular access,
1 1 2025, Pages 11297298251350745
Cephalic vein dilatation at the elbow by preoperative supervised forearm exercise depends on adherence to therapy: Results from the randomized controlled single-blind PINCH trial.
Wilschut ED, de Winter EP, Bos EJ, de Vries MR, Putter H, van der Steenhoven TJ, Eefting D, Hamming JF, Rotmans JI, van der Bogt KEA
Background: Maturation failure may be as high as 30%-60% of arteriovenous fistulas (AVF). Forearm exercise postoperatively has shown potential in increasing blood vessel size in patients with end-stage renal disease and may promote maturation of AVFs. Little evidence exists on the impact of pre-operative forearm exercises on the increase of vascular diameters. Aim of this study was to evaluate the effect of supervised forearm exercises on vascular diameters and AVF maturation. Methods: The PINCH...
Abstract
European heart journal,
1 1 2025, Pages ehaf480
Heart failure with reduced ejection fraction and ventricular secondary mitral regurgitation: a holistic approach.
Adamo M, Pagnesi M, Ajmone Marsan N, Bauersachs J, Hausleiter J, Zieroth S, Metra M
Optimal management of patients with heart failure with reduced ejection fraction (HFrEF) and secondary mitral regurgitation (SMR) requires the integration of multiple competencies with the interplay of guideline-directed medical therapy (GDMT) for HFrEF, devices, namely cardiac resynchronization therapy (CRT), when indicated, and mitral transcatheter edge-to-edge repair (M-TEER). Both GDMT and CRT can reduce SMR severity. However, GDMT may not be tolerated in patients with HFrEF who develop hypo...
Abstract
Cited 2 times since 2025 (27.1 per year)
source: EuropePMC
European heart journal. Quality of care & clinical outcomes,
Volume 11, Issue 5, 1 1 2025, Pages 691-697
Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings.
Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis
European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician...
Abstract
The Journal of asthma : official journal of the Association for the Care of Asthma,
31 5 2025, Pages 1-7
Inhaled muscarinic antagonists during pregnancy in women with asthma: case series from a Dutch prospective observational cohort study.
Kathiravetpillai N, van Buul AR, Ezinga M, Koehorst-Ter Huurne K, Van Nederveen-Bendien SA
Introduction: A large proportion of women with asthma experience worsening of asthma during pregnancy. Well-controlled asthma during pregnancy decreases the risk of maternal and fetal complications. Long-acting muscarinic antagonists (LAMAs) are part of treatment guidelines for poorly controlled asthma. There are no clinical safety data available on LAMA and short-acting muscarinic antagonists (SAMAs) use in pregnancy.Objective: The aim was to evaluate asthma control and pregnancy outcomes in pr...
Abstract
The Journal of dermatological treatment,
Volume 36, Issue 1, 30 5 2025, Pages 2539282
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry.
Vroman F, van der Rijst LP, Bacoş-Cosma OI, Zuithoff NPA, Kamsteeg M, van Lumig PPM, Loman L, Schuttelaar MLA, de Bruin-Weller MS, de Graaf M
Purpose: Upadacitinib is approved for treating moderate-to-severe atopic dermatitis (AD) aged ≥12 years. We evaluated upadacitinib's effectiveness and safety in AD adolescents in daily practice. Materials and methods: Fifteen adolescent AD patients from the BioDay registry, treated with upadacitinib 15 mg once daily were evaluated at baseline and after 4, 8, 16, and 28 weeks. Effectiveness was assessed using Eczema Area and Severity Index (EASI) score and Investigator Global Assessment (IGA...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 8, 29 5 2025, Pages 101323
CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR
Atherosclerotic vein graft failure still presents a major problem. T-cells have been identified as one of the most abundant immune cell subset in atherosclerotic plaques. Their role, however, remains only partly understood. Using a murine vein graft model for advanced, unstable atherosclerotic lesions, we find that T-cells accumulate over time in atherosclerotic vein grafts, and appear to be activated rapidly after engraftment, demonstrated by increased expression of CD137 on plaque T-cells. Tar...
Abstract
European heart journal,
25 4 2025, Pages ehaf456
Arrhythmia ablation in patients with congenital heart disease: challenges and opportunities in using complex spectrum data to guide individual care.
Kimura Y, Zeppenfeld K
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
25 4 2025, Pages S0894-7317(25)00396-7
Left Atrial Strain Index in Patients with Heart Failure with Preserved Ejection Fraction.
Chua APA, Weerts J, Achten A, Nabeta T, Sarrazyn C, Lopez-Santi P, Mourmans SGJ, Su JL, Bax JJ, Knackstedt C, van Empel VPM, Ajmone-Marsan N
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 8, 25 4 2025, Pages e013150
Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
Jungen C, Chen HS, Wijnmaalen AP, Dibbets-Schneider P, Meretta A, Piers SR, Kimura Y, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Mertens BJA, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown. Methods: Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent progr...
Abstract
