6382 results
Giornale italiano di cardiologia (2006),
Volume 26, Issue 12 Suppl. 1, 1 1 2025, Pages e1-e108
[2025 ESC/EACTS Guidelines for the management of valvular heart disease].
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
Volume 39, Issue 12, 1 1 2025, Pages 2028-2029
Reading the palms: Palmar hyperlinearity and type 2 biomarkers as early predictors of atopic dermatitis onset in infancy?
Vroman F, de Graaf M
Abstract
Communications biology,
Volume 8, Issue 1, 26 4 2025, Pages 1684
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling.
Muntjewerff EM, Epremidze D, Nezhyva M, Kal S, Rohm TV, Tang K, Singh K, Espes D, Jati S, Bootsma M, Mannaa AM, Ikebuchi H, Nilsson AM, Rajasekaran M, Andrén PE, Jansson ET, Mahata SK, Christoffersson G
Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the roles of these peptides in pancreatic endocrine function, morphology, neurotransmitter dynamics, and systemic glucose homeostasis. CST-KO mice displayed impaired insulin secretion in vivo (but not ex vivo), disru...
Abstract
JAMA cardiology,
26 4 2025
Interventions for Tricuspid Regurgitation.
Praz F, Angellotti D, Ajmone Marsan N, Butler J
Abstract
BMC primary care,
25 4 2025
Navigating chest pain online: who uses health information and what actions follow?
van Dijkman ED, de Boer YK, de Hollander EL, Numans ME, Siebelink HJ, Bonten TN
Abstract
Consciousness and cognition,
Volume 137, 17 3 2025, Pages 103964
Disentangling perceptual from non-perceptual expectation biases in short-term memory.
Koopmans JG, Thorat S, Quek GL, Peelen MV
There is debate about how many items can be represented in visual consciousness at once. Evidence against the view that visual consciousness consists of many detailed items has come from a study using the partial-report paradigm. De Gardelle et al. (2009) showed that rotated letters shown in non-cued (i.e., unattended) parts of a briefly presented letter array are sometimes illusorily perceived as upright. Presumably, the expectation that letters are generally seen upright modulated a rotated le...
Abstract
JACC. Clinical electrophysiology,
13 2 2025, Pages S2405-500X(25)00824-2
Characterizing Sustained Arrhythmias in Patients With Arrhythmic Mitral Valve Prolapse: Insights From the SAVE-MVP collaboration.
Sabbag A, Ajmone-Marsan N, Ezzeddine F, Ascione G, Guicciardi NA, Baudinaud P, Beinart R, Ben Kilani M, Bergonti M, Bhardwaj PK, Boveda S, Czimbalmos C, Cristin L, Conte G, Del Carpio F, Delling F, de Riva M, Deharo JC, Escande W, Font J, Foltran D, Guerra F, Guenancia C, Haugaa KH, Haddad C, Hermida A, Huttin O, Jacon P, Krebsová A, Laredo M, Lim HS, López-Santi P, Maury P, Mansourati J, Milman A, Mazor E, Nagy A, Przybylski A, Saba M, Sohns C, Sticherling C, Siontis KC, Ter Bekke RMA, Tixier R, Acha MR, Richard-Vitton R, Winkel BG, Ollitrault P, Aabel EW
Background: Arrhythmic mitral valve prolapse (AMVP) is a cause of sustained ventricular tachyarrhythmias (VAs) and sudden cardiac death (SCD), but the arrhythmias remain only partially understood. Objectives: In this worldwide collaboration, this study aimed to characterize the VAs occurring in AMVP patients, explore factors associated with various types of sustained VA, and describe common triggering mechanisms. Methods: In this multicenter retrospective cohort study, we collected patients with...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 13 2 2025, Pages D8782
[Cognitive bias in surgery: correctable failure or inevitably human?]
Hamming JF, Adriaanse MA
A review in the Annals of Surgery addressed the role of cognitive bias and heuristics in creating surgical complications and death. Bias and heuristics in decision making is not new, but the fact that surgeons and clinicians in general are influenced by them is apparently still noteworthy. The idea that clinicians act purely rational or should persists. But doctors are not computers. Nevertheless interventions aiming at improving behaviour of clinicians is based on the assumption that more knowl...
Abstract
International journal of cardiology,
Volume 444, 11 2 2025, Pages 134023
Sex differences in plaque burden and outcomes in symptomatic patients with suspected coronary artery disease.
Molnar D, Knuuti J, Bax JJ, Saraste A, Maaniitty T
Background: Sex-related differences in coronary artery disease (CAD) burden and outcomes are increasingly recognized but not fully understood, particularly when assessed using advanced imaging techniques. Objectives: To investigate sex differences in coronary plaque characteristics and their association with long-term cardiovascular outcomes in symptomatic patients undergoing coronary computed tomography angiography (CTA). Methods: A total of 2271 symptomatic patients without prior obstructive C...
Abstract
The Pediatric infectious disease journal,
11 2 2025
Pediatric Preseptal and Orbital Cellulitis: A Comparative Study of Clinical, Radiologic, and Laboratory Features.
Şahin A, Tanriverdi Kaymaz C, Kara Aksay A, Pekçevik Y, Ekemen Keleş Y, Üstündağ G, Elvan Tüz A, Tasar S, Arslan Maden A, Karadağ Öncel E, Yilmaz D
Background: This study aimed to evaluate and compare the clinical, laboratory and radiologic characteristics, as well as treatment approaches, in pediatric patients diagnosed with preseptal and orbital cellulitis. Methods: This descriptive, retrospective, cross-sectional study included pediatric patients treated at a tertiary care center between January 2019 and December 2023. Demographic, clinical, etiologic, laboratory and radiologic data were analyzed. Results: Among 244 patients, 233 (95.5%)...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 10 2 2025, Pages 1682714
Nordic consensus document on Evolut FX+ transcatheter aortic valve implantation: optimizing index implantation and longer-term outcomes.
Khokhar AA, Savontaus M, Al-Ani A, Terkselsen CJ, Bieliauskas G, van der Heijden A, Amin AAA, James S, Russell K, De Backer O
Transcatheter aortic valve replacement (TAVI) is an established treatment strategy for patients with severe symptomatic aortic stenosis (AS). Multiple landmark randomized controlled trials have consistently demonstrated the safety, efficacy, and longer-term durability of the CoreValve/Evolut (Medtronic, MN, USA) transcatheter aortic valve (TAV) platform in treating severe AS. These findings have supported the expansion of TAVI to younger patients with longer life expectancy, in whom an optimized...
Abstract
BJPsych open,
Volume 11, Issue 6, 10 2 2025, Pages e271
Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.
Wunderlich S, Keeser D, Spaeth J, Yilmaz D, Maurus I, Alici C, Schmitt A, Falkai P, Stoecklein S, Roell L
Background: The dysconnection hypothesis of schizophrenia posits that widespread synaptic inefficiencies lead to altered macroscale brain connectivity, contributing to symptom severity and cognitive deficits in individuals with schizophrenia spectrum disorders (SSD). Emerging evidence suggests that physical exercise may help to ameliorate these connectivity abnormalities and associated clinical impairments. Aims: This study investigated whether reductions in functional dysconnectivity following...
Abstract
Cited 1 times since 2025 (18.9 per year)
source: EuropePMC
NEJM evidence,
10 2 2025, Pages EVIDoa2500268
Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction.
Van't Hof AWJ, Gibson CM, Rikken SAOF, Januzzi JL, Granger CB, van Beurden A, Rasoul S, Ruiters L, Vainer J, Verburg A, Arslan F, Jukema JW, Durieux M, Polad J, van Vliet R, van den Branden BJL, Magro M, Remkes W, Beelen J, Hermanides R, Tolsma R, Gosselink M, Vinereanu D, Chioncel V, van de Hoef TP, Boomars R, Arkenbout KE, van Houwelingen GK, Hengstman G, van de Wetering H, Pisters R, Kala P, Merkely B, Ecollan P, Lapostolle F, Giugliano RP, Welsh RC, Levy M, Arias-Mendoza A, Baron N, Cociorva D, Wittes J, Unger EF, Coller BS, Ten Berg JM, Montalescot G
Background: Zalunfiban is a glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor designed for subcutaneous administration on first medical contact with patients with suspected ST-segment elevation myocardial infarction (STEMI). Methods: An international, double-blind, placebo-controlled trial randomly assigned patients with STEMI in a 1:1:1 ratio to receive a single subcutaneous injection of zalunfiban (0.11 mg/kg or 0.13 mg/kg) or placebo. The primary efficacy end point was a hierarchical proporti...
Abstract
Thrombosis research,
Volume 256, 9 2 2025, Pages 109533
Predicting clinically relevant bleeding in new-onset atrial fibrillation patients initiating oral anticoagulant therapy: External validation of the AF-BLEED score.
van der Horst SFB, Chu G, Seelig J, Trinks-Roerdink EM, Voorhout L, de Vries TAC, van Alem AP, Beukema RJ, Boersma LVA, Brouwer MA, Ten Cate H, Faber LM, de Groot JR, Gu YL, den Hartog FR, de Jong JSSG, de Jong Y, Kirchhof CJHJ, Kleijwegt FS, Klok FA, Kruip MJHA, Lenderink T, Luermans JG, Meeder JG, Otten AM, Pisters R, Pos L, Prins FJ, Römer TJ, Smeets F, Tahapary GJM, Theunissen LJHJ, Tieleman RG, Timmer SAJ, Tichelaar V, Trines SA, van der Voort P, Velthuis S, de Vrey EA, Walhout RJ, Hemels MEW, Rutten FH, Geersing GJ, Huisman MV
Background: Atrial fibrillation/flutter (AF/AFL) is associated with an increased stroke risk, for which oral anticoagulation (OAC) is often indicated. Bleeding risk assessment is crucial in these patients to mitigate bleeding complications, yet AF guidelines do not recommend the use of any bleeding risk score (e.g., HAS-BLED) due to concerns about predictive accuracy. The AF-adapted VTE-BLEED (AF-BLEED) score was developed to predict major bleeding (MB) post-OAC initiation. Aims: Evaluate the in...
Abstract
The Journal of invasive cardiology,
7 1 2025
Vascular access and mortality outcomes: insights from the Percutaneous Coronary Interventions registry from the Netherlands Heart Registration.
Karalis I, Timmermans MJ, Tuccillo A, Jukema JW, Derks L, Verbeek EC, Amoroso G, PCI Registration Committee of the Netherlands Heart Registration (NHR)
Objectives: While the transradial approach (TRA) is associated with fewer bleeding complications than the transfemoral approach (TFA), its effect on mortality outcomes in real-world clinical practice remains unclear. This study examines the relationship between vascular access site and mortality in patients undergoing percutaneous coronary intervention (PCI). Methods: This retrospective cohort study used prospectively collected data from the Netherlands Heart Registration, including 130,813 PCI...
Abstract
Multiple sclerosis (Houndmills, Basingstoke, England),
6 1 2025, Pages 13524585251386217
Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.
Yang JH, Race J, Sumowski P, Jacques K, Fardad S, Fair A, Hazlett A, Lin J, Yilmaz D, Aaen G, Abrams A, Benson L, Casper TC, Chitnis T, Gorman M, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Barcellos LF, Waubant E, Graves JS
Background: Age is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) and telomere length (TL). It is unknown whether these markers report overlapping or distinct aging-related processes. Objectives: To determine the correlation between DNAm and TL aging markers. Methods: We conducted a cross-sectional case-control study within t...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 22, 6 1 2025, Pages e040726
Prognostic Value of a Coronary Computed Tomography Angiography-Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging.
Maaniitty T, Bär S, Nabeta T, Bax JJ, Saraste A, Knuuti J
Background: Artificial intelligence-guided quantitative computed tomography ischemia (AI-QCTischemia) is a novel machine-learning method for predicting myocardial ischemia from coronary computed tomography angiography (CCTA). This observational cohort study aimed to compare the long-term prognostic value of AI-QCTischemia with hybrid CCTA/positron emission tomography (PET) myocardial perfusion imaging in suspected coronary artery disease (CAD). Methods: Symptomatic patients with suspected CAD un...
Abstract
Journal of manipulative and physiological therapeutics,
5 1 2025, Pages S0161-4754(25)00063-6
Effectiveness of Thoracic Spine Manipulation for Upper Quadrant Musculoskeletal Disorders: A Systematic Review.
Thoomes EJ, Tilborghs G, Heneghan NR, Falla D, De Graaf M
Objective: Thoracic high-velocity low-amplitude thrust (Tx-HVLAT) manipulation is a form of conservative management recommended as an effective treatment option for patients with upper quadrant musculoskeletal disorders (UQMD). This systematic review aimed to update the current evidence on the effectiveness of Tx-HVLAT for patients with UQMD on pain, disability, and performance outcome measures. Methods: Electronic libraries of the Cochrane Controlled Trials Register, MEDLINE, EMBASE, CINAHL, PE...
Abstract
American heart journal,
Volume 292, 3 1 2025, Pages 107295
Evolocumab before percutaneous coronary intervention for acute myocardial infarction: Design of the AMUNDSEN trial.
Montalescot G, Bolognese L, Bartus S, Cequier-Fillat A, Thiele H, Mach F, Jukema JW, Ferrari E, Souteyrand G, Bouleti C, Range G, Chioccioli M, Picchi A, Batias-Moreau L, Esposito G, Braik N, Redjimi N, Duband B, Guedeney P, Zeitouni M, Brochard K, Silvain J, Vicaut E, AMUNDSEN investigators of the ACTION Study Group
Rationale: PCSK9 inhibitors are currently recommended as third-line therapy for post-myocardial infarction (MI) patients, added to high-dose statin, ezetimibe, and potentially bempedoic acid when the LDL-C target of
Abstract
Cited 23 times since 2025 (296.9 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 44, 1 1 2025, Pages 4635-4736
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
