Research

Publications

Below you can find a list of our published research.

6327 results

Journal of clinical microbiology, 9 2 2025, Pages e0027225 In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections. Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB

Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib... Abstract

Endocrine connections, Volume 14, Issue 10, 6 1 2025, Pages e250400 Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism. Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM

Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t... Abstract

Annals of vascular surgery, 6 1 2025, Pages S0890-5096(25)00655-7 Prediction of wound healing following amputation surgery based on near-infrared fluorescence with indocyanine green. Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group

Objectives: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound-healing complications within six weeks after lower-extremity amputation. Methods: In this dual-centre cohort study, patients undergoing minor (below-ankle) or major (above-ankle) amputations due to PAD or diabetes mellitus, with perfusion assessment performed using ICG NIR fluorescence imaging, were included. Fluorescence videos were recorded using st... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 29 5 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Background and aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults, the present study evaluates the effectiveness in children. Methods: Retrospective multi-center study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD-sho... Abstract

Arteriosclerosis, thrombosis, and vascular biology, 25 4 2025 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt P, Jukema JW, Ruhaak LR, Romijn F, Szarek M, Trompet S, Bhatt D, Bittner V, Diaz R, Fazio S, Stevanovic I, Goodman S, Harrington R, White H, Steg PG, Schwartz G, Cobbaert C

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 32618 (Cardiac) complexity needs interaction. De Coster T

The heart exemplifies a complex system where electrical, mechanical, and biochemical processes interact dynamically. Understanding cardiac complexity requires exploring these interactions across multiple levels, from cellular dynamics to organ-wide behavior. This collection examines key interactions in cardiology, including excitation-contraction coupling, arrhythmia quantification, electromechanical modeling, and imaging advances. By integrating mathematical, computational, and clinical perspec... Abstract

Applied and environmental microbiology, 19 3 2025, Pages e0082225 Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model. Leng J, Ferrandis-Vila M, Oldenkamp R, Mehat JW, Fivian-Hughes AS, Kumar Tiwari S, Van der Putten B, Trung Nguyen V, Bethe A, Clark J, Singh P, Semmler T, Schwarz S, Alvarez J, Hoa NT, Bootsma M, Menge C, Berens C, Schultsz C, Ritchie JM, La Ragione RM

The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken c... Abstract

American journal of clinical dermatology, 19 3 2025 Systemic Treatments in Moderate-to-Severe Atopic Dermatitis in Pediatric Patients up to 12 Years of Age: Real-World Treatment Outcomes from the PEDISTAD Registry. Paller AS, Marcoux D, Ramien M, Baselga E, Carvalho VO, Ardusso LRF, de Graaf M, Pasmans S, Toledo-Bahena M, Rubin C, Joyce JC, Lee LW, Gupta R, Adams B, Ardeleanu M, Zhang A

Background: Atopic dermatitis (AD), a chronic systemic disease, can cause intense skin itching and negatively impact sleep, mood, and quality of life (QoL) for patients and families. Methods: PEDISTAD is an ongoing, 10-year, observational registry describing disease characteristics, atopic comorbidities, and treatment patterns in pediatric patients (aged Abstract

Microbiology spectrum, Volume 13, Issue 10, 18 3 2025, Pages e0176225 Activity of HOCl-generating e-bandage with clinically available hydrogels against Staphylococcus aureus and Acinetobacter baumannii biofilms. Dagsuyu E, Kies P, Karau MJ, Patel R, Beyenal H

Biofilms hinder wound infection healing, making wound infections a healthcare challenge for which innovative treatments are needed. A 1.77 cm2 electrochemical bandage (e-bandage), which generates the biocide hypochlorous acid (HOCl), has shown promising anti-biofilm activity in vitro, ex vivo, and in vivo. The e-bandage is a three-electrode system operationalized by a hydrogel. In addition to providing a conductive electrolyte for the electrodes, the hydrogel provides a protective barrier for th... Abstract

Signal transduction and targeted therapy, Volume 10, Issue 1, 18 3 2025, Pages 311 Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction. Garoffolo G, Ferrari S, De Martino S, Pizzo E, Candino V, Curini L, Macrì F, Kruithof BPT, Mongelli A, Grillo M, Fanotti N, Fejzaj P, Casaburo M, Alanazi A, Marsan NA, Khaliel F, Alsulbud A, Agrifoglio M, Colombo GI, Chiesa M, Farsetti A, Gaetano C, Raucci A, Pesce M

Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatments to halt its progression are not yet available. We hypothesized that calcification of the human valve interstitial cells (VICs) is associated with cellular senescence and alterations in the epigenetic setup, like in arteries. To verify this hypothesis, we ex... Abstract

Annals of vascular surgery, 17 3 2025, Pages S0890-5096(25)00604-1 Diagnostic accuracy of elastic deformation for detecting high aneurysm sac pressure after endovascular aneurysm repair. van Rijn K, van Genderen OS, Putter H, Eiberg JP, van Wissen RC, Hamming JF, van Schaik J, van der Vorst JR

Objectives: Elastic deformation (ED) is a novel non-invasive follow-up modality after endovascular aortic repair (EVAR). ED is defined as the percentage of diameter change of the aneurysm sac after application of a controlled ultrasound transducer pressure. It is hypothesized that low aneurysm sac deformation indicates high sac pressure. The current study aims to determine the ideal cut-off value of ED and analyze the corresponding diagnostic accuracy. Methods: A prospective cohort study was per... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 17 3 2025 Radiofrequency ablation of supraventricular tachyarrhythmias in newborns and infants: why, when, and how? Palma A, Bertels RA, de Riva M, Zeppenfeld K, Blom NA

Supraventricular tachyarrhythmias (SVTs) in newborns and infants ( Abstract

Transfusion, 17 3 2025 Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients. van Hout FMA, Caram-Deelder C, Pors A, Middelburg RA, Klautz RJM, Rosseel PMJ, Helmerhorst HJF, van de Watering LMG, Kerkhoffs JL, Palmen M, van der Bom JG

Background: The changes in platelet structure and function arising from its collection and storage are collectively called "platelet storage lesion." In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis-generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017. Study design and methods: We explored whether longer storage duration of platelets is associate... Abstract

Innovations (Philadelphia, Pa.), 16 3 2025, Pages 15569845251367418 Application of Augmented Reality in Robot-Assisted Mitral Valve Repair Surgery: A Feasibility Study. Peek JJ, Hildebrandt K, Zhang X, Kharbanda RK, Oudeman MAP, Klautz RJM, Palmen M, Mahtab EAF

Objective: In mitral valve surgery, it is important to be aware of adjacent intraoperatively invisible anatomy, to avoid complications and enhance safety. In this feasibility study, we aimed to develop semi-automated intraoperative 3-dimensional (3D) augmented reality (3D-AR) overlays for robotic mitral valve repair. Methods: In 5 patients undergoing robot-assisted mitral valve repair, a 3D point cloud was generated, using intraoperatively recorded images from both eyes of the stereoscopic da Vi... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 21, Issue 18, 15 3 2025, Pages e1081-e1089 VARC-HBR criteria validation in TAVI patients on oral anticoagulation. Overduin DC, van Ginkel DJ, Bor WL, Kobari Y, Aarts HM, Dubois C, De Backer O, Rooijakkers MJP, Rosseel L, Veenstra L, van der Kley F, van Bergeijk KH, van Mieghem NM, Agostoni P, Voskuil M, Schotborgh CE, Ijsselmuiden AJJ, Van Heyden JAS, Hermanides RS, Barbato E, Mylotte D, Fabris E, Frambach P, Dujardin K, Ferdinande B, Peper J, Rensing BJWM, Timmers L, Swaans MJ, Brouwer J, Nijenhuis VJ, Adriaenssens T, Vriesendorp PA, Montero-Cabezas JM, Jattari HE, Halim J, Van den Branden BJL, Leonora R, Vanderheyden M, Lauterbach M, Wykrzykowska JJ, van 't Hof AWJ, van Royen N, Tijssen JGP, Delewi R, Ten Berg JM

Background: Bleeding remains a frequent complication after transcatheter aortic valve implantation (TAVI). Recently, the Valve Academic Research Consortium High Bleeding Risk (VARC-HBR) criteria were introduced to identify patients at (very) high risk of bleeding. Aims: This study aimed to evaluate the validity of the VARC-HBR criteria for predicting bleeding risk in TAVI patients and to compare its performance with other existing criteria. Methods: Data were obtained from the POPular PAUSE TAVI... Abstract

Interventional cardiology (London, England), Volume 20, 9 2 2025, Pages e23 Introduction to Pulmonary Embolism Treatment: An Evolving Paradigm. Montero-Cabezas JM

Abstract