Research

Publications

Below you can find a list of our published research.

8853 results

Nursing in critical care, Volume 30, Issue 5, 1 1 2025, Pages e70141 Investigation of Fluorescent Concretisation Intervention on Intensive Care Nurses' Hand Hygiene Training According to the Kirkpatrick Model: A Cluster Randomised Controlled Study. Yılmaz H, Ayhan D, Yılmaz D, Özen Y

Background: The predominant fomite responsible for the transmission of healthcare-associated infections via the hands of healthcare professionals is ineffective handwashing within critical care. Aim: The fundamental aim was to evaluate the impact of fluorescent concretisation intervention on handwashing efficiency, skill performance, duration scores and educational programmes on hand hygiene (HH). A secondary aim was to determine the level of HH knowledge in intensive care nurses. Study design:... Abstract

PharmacoEconomics, 23 4 2025 Cost-Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn's Disease. Versteegh MM, Huygens SA, Bermejo I, Grimm S, Pierik M, Römkens T, van Schaik F, Wahab P

The clinical pathway for patients with moderate-to-severe Crohn's disease (CD) typically includes sequential pharmacologic treatment as well as surgery, but positioning of different therapies within these sequences remains challenging. Cost-utility analysis rarely captures these sequences and does not incorporate registry data on long-term effectiveness. In this study, we aim to overcome these limitations. We developed an individual state transition model with four health states (active dis... Abstract

International journal of stroke : official journal of the International Stroke Society, 22 4 2025, Pages 17474930251372371 Interaction of CYP2C19 with the effect of clopidogrel in secondary prevention of major ischemic events: systematic review and meta-analysis. Kremers F, van den Biggelaar J, Lingsma HF, van Schaik R, Roozenbeek B, Dippel D

Clopidogrel may be a less effective antiplatelet agent for secondary prevention after cardiovascular events in carriers of the CYP2C19 Loss of Function (LoF) allele. Randomized controlled trials (RCTs) of clopidogrel in patients with known CYP2C19 carrier status have provided inconsistent results. This meta-analysis aims to pool evidence on the effect of different antiplatelet strategies on outcomes according to CYP2C19 LoF status. We conducted a systematic review and meta-analysis of RCTs to ev... Abstract

Pediatric allergy, immunology, and pulmonology, 21 3 2025 A Rare Clinical Course in Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: Lung Involvement. Yılmaz D, Emeksiz ZŞ, İclal G, Bilgiç I, Mısırlıoğlu ED

Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction characterized by skin rash, fever, eosinophilia, and multi-organ involvement. Although pulmonary complications are uncommon, they can significantly impact prognosis. Case Presentation: Here, we present a 6-year-old male with antibiotic-induced DRESS syndrome complicated by pleural effusion and pneumonitis. The patient was treated successfully with s... Abstract

Scientific reports, Volume 15, Issue 1, 21 3 2025, Pages 30672 Metagenomic analysis and genomic characterization of enterovirus A76 and Norovirus GI.6[P11] co-infection in a patient with acute gastroenteritis in Thailand. Chuchaona W, Izquierdo-Lara RW, Schapendonk CME, Khongwichit S, Koopmans MPG, de Graaf M, Poovorawan Y

Acute gastroenteritis (AGE) remains a significant global health concern, with noroviruses among the most prevalent viral pathogens. However, other enteric viruses also contribute substantially to the public health burden. This study provides the first molecular characterization of a co-infection involving a rarely reported enterovirus A76 (EV-A76) and a norovirus GI.6[P11] in a patient from Thailand. Metagenomic sequencing successfully identified complete viral genomes, revealing unique genetic... Abstract

JACC. Basic to translational science, Volume 10, Issue 9, 21 3 2025, Pages 101359 Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells. Reilly NA, Mulder JWCM, Dekkers KF, Kuipers TB, van Vark-van der Zee LC, Mulder MT, Roeters van Lennep JE, Jukema JW, Heijmans BT

Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atherosclerotic plaques. This cross-sectional study examined transcriptomic differences in T cells among patients with varying triglyceride levels via RNA sequencing. We analyzed CD4+ and CD8+ T cells from 49 participants, including those with primary (genetic) and secondar... Abstract

Molecular therapy : the journal of the American Society of Gene Therapy, 20 3 2025, Pages S1525-0016(25)00656-2 In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease. Ibel A, Bhardwaj R, Yilmaz DE, Kong S, Wendlinger S, Cordero C, Papaioannou D, Papazian M, Schönauer R, Meng Q, Eckardt KU, Hassan F, Volpe I, Klämbt V, Halbritter J, Fedeles S, Krappitz M, Kaminski MM

Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder, affecting over 10 million individuals worldwide. Cystic expansion typically progresses to kidney failure and also involves the liver with limited treatment options. Pathogenic variants in PKD1 or PKD2 account for 85-90% of cases. Genetic re-expression of Pkd1 or Pkd2 has been shown to partially reverse key characteristics of the disease phenotype in mice. Despite advancements in understanding the... Abstract

JMIR cardio, Volume 9, 18 3 2025, Pages e56236 Adherence Patterns of Patients Using Remote Patient Management After Myocardial Infarction: Mixed Methods Persona Approach. Hondmann SM, Schrauwen L, Reijnders T, Stoop E, Evers AW, Visch VT, Atsma DE, Janssen VR

Remote patient management (RPM) using smartphone-enabled health monitoring devices (SHMDs) can be an effective, value-added part of cardiovascular care. However, cardiac patients' adherence to RPM is variable. Personas are fictional representations of users with common behaviors, needs, and motivation and can thereby help guide tailoring of interventions to be meaningful and possibly more effective. Personas can be used to understand the needs of the patient group and guide tailoring toward... Abstract

American journal of physiology. Renal physiology, 18 3 2025 The impact of chronic kidney disease on arteriovenous fistula remodelling: studies in a murine model of Autosomal Dominant Polycystic Kidney Disease. Laboyrie S, Peters DJM, Bijkerk R, de Winter EP, Duijs JM, de Klerk JA, de Vries MR, Rotmans JI

The arteriovenous fistula (AVF) is the gold standard for hemodialysis vascular access, although inadequate vascular remodelling and intimal hyperplasia pose a major limitation. It is essential to study this in a clinically relevant model. We utilised an autosomal dominant polycystic kidney disease (ADPKD) model, the most common hereditary cause of chronic kidney disease (CKD), to study the effect of CKD on AVFs. Jugular-carotid AVFs were created in adult B6OlaPkd1nl/nl (ADPKD) mice and B6OlaPkd1... Abstract

The American journal of cardiology, 16 3 2025, Pages S0002-9149(25)00477-1 Diagnosis and Treatment of Unrecognized Spontaneous Coronary Artery Dissection in Young Women Presenting with an Acute Coronary Syndrome. Al-Gully J, Montero-Cabezas JM, Eikenboom J, den Exter PL, van der Kley F, Wouter Jukema J, Bingen BO, Al Amri I

Spontaneous Coronary Artery Dissection (SCAD) is often overlooked as a cause of Acute Coronary Syndrome (ACS), particularly in young women. SCAD requires distinct management, underscoring the importance of its timely and accurate diagnosis for effective treatment. This study aims to evaluate the frequency of SCAD underdiagnosis in young women with ACS and pinpoints potential SCAD indicators. All consecutive women ≤55 years with ACS who underwent coronary angiography (CAG) at our tertiary center... Abstract

BMJ open, Volume 15, Issue 8, 16 3 2025, Pages e100002 Multiparametric MRI for local staging in patients with suspected muscle-invasive bladder cancer: study protocol for a multicentre, non-inferiority randomised controlled trial (the BladParadigm study). van Koeverden SW, van Hoogstraten LM, de Rooij M, van der Leest M, Grutters JP, BladParadigm study group, Kiemeney LA, van der Heijden AG

Introduction: Muscle-invasive bladder cancer (MIBC) is an aggressive type of cancer. About 50% of patients will die from the disease within 5 years despite radical treatment. This implies that in many patients, the disease has already spread at the time of radical treatment, even though imaging shows no signs of metastasis. We hypothesise that the standard local staging method, transurethral resection of the bladder tumour (TURBT), is partly responsible for tumour cell spread. Furthermore, TURBT... Abstract

Nature communications, Volume 16, Issue 1, 14 2 2025, Pages 7569 Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. Kiu R, Darby EM, Alcon-Giner C, Acuna-Gonzalez A, Camargo A, Lamberte LE, Phillips S, Sim K, Shaw AG, Clarke P, van Schaik W, Kroll JS, Hall LJ

Preterm infants ( Abstract

JACC. Advances, Volume 4, Issue 9, 13 2 2025, Pages 102063 Ventricular Tachycardia Predicts All-Cause Mortality and Nonsudden Cardiac Death in Nonischemic Cardiomyopathy. Omara S, Jensen TN, Koeber L, Thune JJ, Pehrson S, Mertens B, Tedrow UB, Hindricks G, Ebert M, Carbucicchio C, Berruezo A, Vaseghi M, Shivkumar K, Deneke T, Wijnmaalen AP, Stevenson WG, Nielsen JC, Zeppenfeld K

Background: Patients with nonischemic cardiomyopathies (NICMs) are at a risk for end-stage heart failure and death from ventricular arrhythmias. Implanted defibrillators (ICDs) protect against sudden arrhythmic death, but several studies suggest that ventricular arrhythmias are associated with worse outcomes despite ICDs. Objectives: This study evaluated the relationship of ventricular tachycardia (VT) with total mortality and nonsudden cardiovascular death (NSCVD) in NICM patients with ICDs enr... Abstract

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Volume 225, 13 2 2025, Pages 112097 Investigation of structural and radiation shielding properties of natural granite, clay, natural cement, and quartz supplied from Hakkâri region. Kabamakli E, Yalcin S, Aktas B, Yilmaz D

This study aims to investigate the physical, structural, and radiation shielding properties of four rock types commonly used in natural cement, including clay, granite, and quartz originating from the Hakkâri region of Turkey. Structural characterization was performed using ICP-MS, XRD, and FT-IR analyses. At the same time, radiation shielding effectiveness was determined through measurements of mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), mea... Abstract

Nature communications, Volume 16, Issue 1, 13 2 2025, Pages 7493 CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death. Arunima A, Niyakan S, Butler SM, Clark SD, Pinson A, Kwak D, Case EDR, Qian X, de Figueiredo P, van Schaik EJ, Samuel JE

Coxiella burnetii (Cb), the causative agent of Q fever, replicates within host macrophages by modulating immune responses through poorly understood mechanisms. Long non-coding RNAs (lncRNAs) are crucial yet underexplored regulators of inflammation, particularly in Cb pathogenesis. Employing a comparative transcriptomic analysis of THP-1 macrophages infected with 16 different microbes, we dissect a core set of immune-responsive lncRNAs such as MAILR, LINC01215, PACER, and MROCKI-common to human a... Abstract

Acta dermato-venereologica, Volume 105, 12 2 2025, Pages adv44209 Topical Steroid Withdrawal: Perspectives of Dutch Healthcare Professionals. Vroman F, Schimmel CS, Van der Rijst LP, De Graaf M, De Bruin-Weller M, Kemperman PMJH, Hijnen DJ, Haeck IM

Topical steroid withdrawal (TSW) is a highly controversial condition, typically reported following prolonged and/or frequent use of topical corticosteroids. Despite growing public awareness, knowledge of topical steroid withdrawal remains limited. Therefore, this study aimed to explore the perspectives of Dutch healthcare professionals (HCPs) on topical steroid withdrawal. A web-based survey was conducted among 168 Dutch HCPs. The results show that erythema (64.1%) and a burning sensation (60.3%... Abstract

BMC medical informatics and decision making, Volume 25, Issue 1, 12 2 2025, Pages 302 Applying text-mining to clinical notes: the identification of patient characteristics from electronic health records (EHRs). Ten Hoope S, Welvaars K, van Geijtenbeek K, Klok-Everaars M, van Schaik S, Karapinar-Çarkit F

Background: Clinical notes contain information on critical patient characteristics, which, if overlooked, could escalate the risk of adverse events as well as miscommunication between the healthcare professional and the patient. This study investigates the feasibility of employing text-mining to extract patient characteristics from Electronic Health Records (EHRs) and compares the effectiveness of text-mining against human intelligence for identifying four patient characteristics: language barri... Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 9 2 2025, Pages 102470 Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories. Kero T, Knuuti J, Bär S, Bax JJ, Saraste A, Maaniitty T

Background: It is unclear whether coronary artery stenosis, plaque burden, and composition differ between major epicardial arteries supplying ischemic myocardial territories. Methods and results: We studied 837 symptomatic patients undergoing coronary computed tomography angiography (CTA) and 15O-water PET myocardial perfusion imaging for suspected obstructive coronary artery disease. Coronary CTA was analyzed using Artificial Intelligence-Guided Quantitative Computed Tomography (AI-QCT) to asse... Abstract

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Volume 225, 8 2 2025, Pages 112089 Albedo parameter-based characterization of surface roughness in chemically etched zirconium samples. Yılmaz D, Pathman AF, Kalecik S, Kurucu Y, Demir L

In this study, we investigate the potential of gamma-ray albedo parameters as a non-contact and radiation-based technique to characterize surface roughness variations in zirconium foils subjected to chemical etching. Zirconium samples were etched in 20 % hydrofluoric acid (HF) for different durations (30, 60, 90, and 120 s), and their surface morphology was evaluated using profilometry and gamma spectrometry. Albedo parameters were derived from the intensities of Compton and coherent scattering... Abstract

Applied neuropsychology. Child, 6 1 2025, Pages 1-7 Cognitive function and inflammatory markers of survivors of MIS-C. Üstündağ G, Özyurt G, Elvan Tüz A, Argüz Çıldır D, Akman S, Kara Aksay A, Yılmaz D, Karadağ Öncel E

Background: Multisystem inflammatory syndrome in children (MIS-C) presents severe clinical challenges due to its severe outcomes and diagnostic complexities. Recent studies suggest cognitive functions may also be affected. This study evaluates cognitive functions in MIS-C survivors over 12 months and explores the relationship with inflammatory markers. Methods: This prospective observational cohort study included children diagnosed with MIS-C hospitalized in a tertiary pediatric care unit. Follo... Abstract