Research

Publications

Below you can find a list of our published research.

9549 results

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 40760 Explainable and likelihood aware AI framework for MRI-based pixel-level bladder tumour prediction. Khan M, de Groot AG, Cornel EB, van der Heijden AG, Siepel FJ

Bladder tumours (BTs) pose significant clinical challenges due to their high recurrence rates and risk of progression to invasive malignancies, which emphasises the need for early and accurate detection. Magnetic resonance imaging (MRI), with its superior soft tissue contrast, is a potential modality for BT detection. To analyse the MRI scans, artificial intelligence (AI) models are increasingly being leveraged. However, these models are often limited by a scarcity of annotated datasets, challen... Abstract

Communications medicine, Volume 5, Issue 1, 18 3 2025, Pages 472 Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events. van Eijs MJM, van der Wal MM, Klotškova HB, Dautzenberg NMM, Schuiveling M, Verheijden RJ, van Schaik FDM, Oldenburg B, Nierkens S, UNICIT Consortium, Suijkerbuijk KPM, van Wijk F

Background: High-dose steroids constitute the cornerstone of first-line treatment for immune-related adverse events (irAEs) associated with immune checkpoint inhibitors, but compromise antitumor immunity. A deeper understanding of irAEs and their response to steroids can improve management. Methods: Using a multi-omics approach, we investigated blood- and tissue-based correlates of steroid response, focusing on gastro-intestinal irAEs, in the largest cohort to date. Results: Here we show clear t... Abstract

Consciousness and cognition, Volume 137, 17 3 2025, Pages 103964 Disentangling perceptual from non-perceptual expectation biases in short-term memory. Koopmans JG, Thorat S, Quek GL, Peelen MV

There is debate about how many items can be represented in visual consciousness at once. Evidence against the view that visual consciousness consists of many detailed items has come from a study using the partial-report paradigm. De Gardelle et al. (2009) showed that rotated letters shown in non-cued (i.e., unattended) parts of a briefly presented letter array are sometimes illusorily perceived as upright. Presumably, the expectation that letters are generally seen upright modulated a rotated le... Abstract

Inflammatory bowel diseases, 17 3 2025, Pages izaf269 Bridging the Gap: From Clinic to Home in IBD Monitoring-Authors' Reply. Schuurman GS, van Schaik FDM

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JACC. Clinical electrophysiology, 13 2 2025, Pages S2405-500X(25)00824-2 Characterizing Sustained Arrhythmias in Patients With Arrhythmic Mitral Valve Prolapse: Insights From the SAVE-MVP collaboration. Sabbag A, Ajmone-Marsan N, Ezzeddine F, Ascione G, Guicciardi NA, Baudinaud P, Beinart R, Ben Kilani M, Bergonti M, Bhardwaj PK, Boveda S, Czimbalmos C, Cristin L, Conte G, Del Carpio F, Delling F, de Riva M, Deharo JC, Escande W, Font J, Foltran D, Guerra F, Guenancia C, Haugaa KH, Haddad C, Hermida A, Huttin O, Jacon P, Krebsová A, Laredo M, Lim HS, López-Santi P, Maury P, Mansourati J, Milman A, Mazor E, Nagy A, Przybylski A, Saba M, Sohns C, Sticherling C, Siontis KC, Ter Bekke RMA, Tixier R, Acha MR, Richard-Vitton R, Winkel BG, Ollitrault P, Aabel EW

Background: Arrhythmic mitral valve prolapse (AMVP) is a cause of sustained ventricular tachyarrhythmias (VAs) and sudden cardiac death (SCD), but the arrhythmias remain only partially understood. Objectives: In this worldwide collaboration, this study aimed to characterize the VAs occurring in AMVP patients, explore factors associated with various types of sustained VA, and describe common triggering mechanisms. Methods: In this multicenter retrospective cohort study, we collected patients with... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 169, 13 2 2025, Pages D8782 [Cognitive bias in surgery: correctable failure or inevitably human?] Hamming JF, Adriaanse MA

A review in the Annals of Surgery addressed the role of cognitive bias and heuristics in creating surgical complications and death. Bias and heuristics in decision making is not new, but the fact that surgeons and clinicians in general are influenced by them is apparently still noteworthy. The idea that clinicians act purely rational or should persists. But doctors are not computers. Nevertheless interventions aiming at improving behaviour of clinicians is based on the assumption that more knowl... Abstract

International journal of cardiology, Volume 444, 11 2 2025, Pages 134023 Sex differences in plaque burden and outcomes in symptomatic patients with suspected coronary artery disease. Molnar D, Knuuti J, Bax JJ, Saraste A, Maaniitty T

Background: Sex-related differences in coronary artery disease (CAD) burden and outcomes are increasingly recognized but not fully understood, particularly when assessed using advanced imaging techniques. Objectives: To investigate sex differences in coronary plaque characteristics and their association with long-term cardiovascular outcomes in symptomatic patients undergoing coronary computed tomography angiography (CTA). Methods: A total of 2271 symptomatic patients without prior obstructive C... Abstract

The Pediatric infectious disease journal, 11 2 2025 Pediatric Preseptal and Orbital Cellulitis: A Comparative Study of Clinical, Radiologic, and Laboratory Features. Şahin A, Tanriverdi Kaymaz C, Kara Aksay A, Pekçevik Y, Ekemen Keleş Y, Üstündağ G, Elvan Tüz A, Tasar S, Arslan Maden A, Karadağ Öncel E, Yilmaz D

Background: This study aimed to evaluate and compare the clinical, laboratory and radiologic characteristics, as well as treatment approaches, in pediatric patients diagnosed with preseptal and orbital cellulitis. Methods: This descriptive, retrospective, cross-sectional study included pediatric patients treated at a tertiary care center between January 2019 and December 2023. Demographic, clinical, etiologic, laboratory and radiologic data were analyzed. Results: Among 244 patients, 233 (95.5%)... Abstract

BJPsych open, Volume 11, Issue 6, 10 2 2025, Pages e271 Reducing functional dysconnectivity in people with schizophrenia spectrum disorders. Wunderlich S, Keeser D, Spaeth J, Yilmaz D, Maurus I, Alici C, Schmitt A, Falkai P, Stoecklein S, Roell L

Background: The dysconnection hypothesis of schizophrenia posits that widespread synaptic inefficiencies lead to altered macroscale brain connectivity, contributing to symptom severity and cognitive deficits in individuals with schizophrenia spectrum disorders (SSD). Emerging evidence suggests that physical exercise may help to ameliorate these connectivity abnormalities and associated clinical impairments. Aims: This study investigated whether reductions in functional dysconnectivity following... Abstract

NEJM evidence, 10 2 2025, Pages EVIDoa2500268 Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction. Van't Hof AWJ, Gibson CM, Rikken SAOF, Januzzi JL, Granger CB, van Beurden A, Rasoul S, Ruiters L, Vainer J, Verburg A, Arslan F, Jukema JW, Durieux M, Polad J, van Vliet R, van den Branden BJL, Magro M, Remkes W, Beelen J, Hermanides R, Tolsma R, Gosselink M, Vinereanu D, Chioncel V, van de Hoef TP, Boomars R, Arkenbout KE, van Houwelingen GK, Hengstman G, van de Wetering H, Pisters R, Kala P, Merkely B, Ecollan P, Lapostolle F, Giugliano RP, Welsh RC, Levy M, Arias-Mendoza A, Baron N, Cociorva D, Wittes J, Unger EF, Coller BS, Ten Berg JM, Montalescot G

Background: Zalunfiban is a glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor designed for subcutaneous administration on first medical contact with patients with suspected ST-segment elevation myocardial infarction (STEMI). Methods: An international, double-blind, placebo-controlled trial randomly assigned patients with STEMI in a 1:1:1 ratio to receive a single subcutaneous injection of zalunfiban (0.11 mg/kg or 0.13 mg/kg) or placebo. The primary efficacy end point was a hierarchical proporti... Abstract

Thrombosis research, Volume 256, 9 2 2025, Pages 109533 Predicting clinically relevant bleeding in new-onset atrial fibrillation patients initiating oral anticoagulant therapy: External validation of the AF-BLEED score. van der Horst SFB, Chu G, Seelig J, Trinks-Roerdink EM, Voorhout L, de Vries TAC, van Alem AP, Beukema RJ, Boersma LVA, Brouwer MA, Ten Cate H, Faber LM, de Groot JR, Gu YL, den Hartog FR, de Jong JSSG, de Jong Y, Kirchhof CJHJ, Kleijwegt FS, Klok FA, Kruip MJHA, Lenderink T, Luermans JG, Meeder JG, Otten AM, Pisters R, Pos L, Prins FJ, Römer TJ, Smeets F, Tahapary GJM, Theunissen LJHJ, Tieleman RG, Timmer SAJ, Tichelaar V, Trines SA, van der Voort P, Velthuis S, de Vrey EA, Walhout RJ, Hemels MEW, Rutten FH, Geersing GJ, Huisman MV

Background: Atrial fibrillation/flutter (AF/AFL) is associated with an increased stroke risk, for which oral anticoagulation (OAC) is often indicated. Bleeding risk assessment is crucial in these patients to mitigate bleeding complications, yet AF guidelines do not recommend the use of any bleeding risk score (e.g., HAS-BLED) due to concerns about predictive accuracy. The AF-adapted VTE-BLEED (AF-BLEED) score was developed to predict major bleeding (MB) post-OAC initiation. Aims: Evaluate the in... Abstract

FEMS microbiology reviews, 8 2 2025, Pages fuaf057 Resistance to last-resort antibiotics in enterococci. Lu Z, Mclnnes RS, Allen F, Gadar K, van Schaik W

The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The two most prominent species associated with humans, Enterococcus faecalis and Enterococcus faecium, have also emerged as prominent opportunistic pathogens causing a range of infections in hospitalised patients, including urinary tract infections, bloodstream infections and endocarditis. The rise of antibiotic resistance in enterococci undermines the eff... Abstract

The Journal of invasive cardiology, 7 1 2025 Vascular access and mortality outcomes: insights from the Percutaneous Coronary Interventions registry from the Netherlands Heart Registration. Karalis I, Timmermans MJ, Tuccillo A, Jukema JW, Derks L, Verbeek EC, Amoroso G, PCI Registration Committee of the Netherlands Heart Registration (NHR)

Objectives: While the transradial approach (TRA) is associated with fewer bleeding complications than the transfemoral approach (TFA), its effect on mortality outcomes in real-world clinical practice remains unclear. This study examines the relationship between vascular access site and mortality in patients undergoing percutaneous coronary intervention (PCI). Methods: This retrospective cohort study used prospectively collected data from the Netherlands Heart Registration, including 130,813 PCI... Abstract

Multiple sclerosis (Houndmills, Basingstoke, England), 6 1 2025, Pages 13524585251386217 Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis. Yang JH, Race J, Sumowski P, Jacques K, Fardad S, Fair A, Hazlett A, Lin J, Yilmaz D, Aaen G, Abrams A, Benson L, Casper TC, Chitnis T, Gorman M, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Barcellos LF, Waubant E, Graves JS

Background: Age is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) and telomere length (TL). It is unknown whether these markers report overlapping or distinct aging-related processes. Objectives: To determine the correlation between DNAm and TL aging markers. Methods: We conducted a cross-sectional case-control study within t... Abstract

Journal of the American Heart Association, Volume 14, Issue 22, 6 1 2025, Pages e040726 Prognostic Value of a Coronary Computed Tomography Angiography-Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging. Maaniitty T, Bär S, Nabeta T, Bax JJ, Saraste A, Knuuti J

Background: Artificial intelligence-guided quantitative computed tomography ischemia (AI-QCTischemia) is a novel machine-learning method for predicting myocardial ischemia from coronary computed tomography angiography (CCTA). This observational cohort study aimed to compare the long-term prognostic value of AI-QCTischemia with hybrid CCTA/positron emission tomography (PET) myocardial perfusion imaging in suspected coronary artery disease (CAD). Methods: Symptomatic patients with suspected CAD un... Abstract

Open heart, Volume 12, Issue 2, 5 1 2025, Pages e003630 Trends and risk factors of stroke and mortality after transcatheter aortic valve implantation in the Netherlands. van Putten SE, Hegeman RRMJJ, Timmers L, Overduin DC, Nieuwkerk PT, Peper J, Roefs MM, Sonker U, Rensing BJWM, Swaans MJ, Klautz RJM, Ten Berg J, Klein P, THI Registration Committee of the Netherlands Heart Registration

Background: Stroke after transcatheter aortic valve implantation (TAVI) is an infrequent but serious complication with important impact on morbidity and mortality. Contemporary real-world evidence on the risk factors of early stroke after TAVI is scarce. We aimed to evaluate the incidence, temporal trends and predictors of in-hospital stroke after TAVI and to assess its association with mortality. Methods: We conducted a retrospective, observational cohort study using data from the Netherlands H... Abstract

Journal of manipulative and physiological therapeutics, 5 1 2025, Pages S0161-4754(25)00063-6 Effectiveness of Thoracic Spine Manipulation for Upper Quadrant Musculoskeletal Disorders: A Systematic Review. Thoomes EJ, Tilborghs G, Heneghan NR, Falla D, De Graaf M

Objective: Thoracic high-velocity low-amplitude thrust (Tx-HVLAT) manipulation is a form of conservative management recommended as an effective treatment option for patients with upper quadrant musculoskeletal disorders (UQMD). This systematic review aimed to update the current evidence on the effectiveness of Tx-HVLAT for patients with UQMD on pain, disability, and performance outcome measures. Methods: Electronic libraries of the Cochrane Controlled Trials Register, MEDLINE, EMBASE, CINAHL, PE... Abstract

BMJ open, Volume 15, Issue 11, 4 1 2025, Pages e105053 Prevention of postamputation pain with targeted muscle reinnervation (PreventPAP trial): protocol for a national, multicentre, randomised, sham-controlled trial. Tendijck GAH, van Schaik J, Dijkman RR, Niesters M, van Zwet EW, van den Hout WB, Ploeg AJ, van Rijt WG, de Ruiter GCW, Coert JH, Duraku LS, Zuidam JM, van de Water W, Pondaag W, van der Krogt H, Groen JL, PreventPAP consortium

Introduction: In the Netherlands, approximately 2200 major amputations of the lower extremities are performed each year, the majority in vascular patients. Around 61% of these patients will develop postamputation pain (PAP). PAP is a severe, lifelong, disabling condition profoundly affecting quality of life. During amputations, the common practice is to cut the nerves without employing nerve-surgical techniques to prevent chronic pain due to neuroma formation. In recent years, targeted muscle re... Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 4 1 2025, Pages S1078-5884(25)01046-9 Role of Epidural Anaesthesia in Elective Open Abdominal Aortic Aneurysm Repair: Secondary Analysis of a Randomised Trial. Steunenberg TAH, Eberl S, Wiersema AM, Roosendaal LC, Hoebink M, Jongkind V, ACTION-1 Investigators

Objective: Using peri-operative epidural anaesthesia (PEA) during elective open abdominal aortic aneurysm (AAA) repair is debated by surgeons and anaesthesiologists. This study aimed to evaluate the clinical benefits and risks of PEA in patients undergoing elective open AAA repair. Methods: This exploratory post hoc analysis of the ACTION-1 trial (NCT04061798), a multicentre, international, single blinded, randomised controlled trial designed to compare heparinisation strategies during elective... Abstract

Open medicine (Warsaw, Poland), Volume 20, Issue 1, 4 1 2025, Pages 20251272 Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial. Yılmaz D, Güney BG

Objectives: The administration of subcutaneous low molecular weight heparin (LMWH) injections frequently causes injection pain, disrupting the comfort of patients. No studies were found evaluating the effect of the application of local vibration in the management of pain relating to subcutaneous LMWH injection. The aim of this study is to examine the effect on injection pain of the local vibration technique applied to the injection site during subcutaneous LMWH injection. Methods: The patients w... Abstract