6354 results
Journal of cellular and molecular medicine,
Volume 29, Issue 21, 1 1 2025, Pages e70933
Breaking (Light) Barriers: Photoacoustics in Atherosclerotic Diseases.
van Dijk K, de Vries MR
Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of tissues. By leveraging both endogenous absorbers, such as lipids and collagen, and exogenous contrast agents like nanoparticles and molecular dyes, PAI offers a comprehensive approach to characterising atherosclerosis. This review describes the technical principles underlying various PAI modalities an...
Abstract
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
31 5 2025, Pages 107789
Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology.
Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz RJM, Elefteriades J, Grewal N
Objective: Despite a voluminous literature on aortopathy, comparatively little attention has been paid to the lamellar architecture of the aortic wall, including the number and distribution of these layers. This study compares the lamellar organization of the developing aorta in individuals with a bicuspid (BAV) versus tricuspid aortic valve (TAV) and includes a literature review on aortic lamellae in mammals and adult humans. Methods: Non-dilated ascending aortic wall samples (n=83) were analyz...
Abstract
American heart journal,
31 5 2025, Pages 107296
Routine versus selective protamine administration to reduce bleeding after TAVI: Rationale and Design of the POPular ACE TAVI trial.
Overduin DC, van Ginkel DJ, Dubois C, Lesizza P, Broeze GM, Montero-Cabezas JM, Rosseel L, van der Kley F, van Nuland PJ, Smits TP, Hemelrijk KI, Aarts HM, Rensing BJWM, Timmers L, Swaans MJ, Sonker U, Veenstra L, van 't Hof AWJ, Peper J, Tijssen JGP, Delewi R, Vriesendorp PA, Ten Berg JM
Background: Unfractionated heparin is routinely used during transcatheter aortic valve implantation (TAVI) to reduce catheter thrombosis and thromboembolism. Protamine reverses the effect of heparin and may lower bleeding risk, but it can also trigger severe allergic reactions. Robust data on the safety and efficacy of routine protamine administration after TAVI is lacking. Methods: The 'Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter A...
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
31 5 2025, Pages S0894-7317(25)00608-X
Reply to "Optimizing clinical applicability of left atrial strain index in patients with heart failure with preserved ejection fraction".
Chua AP, Marsan NA
Abstract
Annals of vascular surgery,
31 5 2025, Pages S0890-5096(25)00695-8
Rupture risk of large abdominal aortic aneurysms: a scoping review.
Paping JHM, Bulder RMA, Lancaster E, Chang RW, Putter H, Hamming JF, Lindeman JH
Objectives: Abdominal Aortic Aneurysm (AAA) management is currently dictated by the 55 mm intervention threshold. Whilst it has been suggested that this intervention threshold is too conservative, the rupture risk of AAAs larger than 55 mm is discussed differently. This scoping review aims to critically summarize and review the available evidence with respect to the rupture risk of larger AAA. Methods: A quantitative and qualitative evaluation of the available literature on the rupture risk of l...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
30 5 2025, Pages euaf276
The Sidecar 2.0 (S-ICD Registry in European Paediatric and Young Adult Patients with Congenital Heart Defects 2.0): An Analysis of European S-ICD Clinical Practice and its Evolution in Paediatric Patients.
Silvetti MS, Bruyndonckx L, Waldmann V, Gebauer R, Környei L, Ksiazczyk T, Illikova V, Tavacova T, Noguer FR, Kwiatkowska J, Pazzano V, Wilkin M, Paech C, Fésüs G, Egorova AD, Wieniawski P, Gandara NR, Kempa M, Battipaglia I, Klehs S, Chalupka M, Maltret A, Knops RE, Janousek J, Blom NA, Lovecchio M, Valsecchi S, Drago F
Background: Subcutaneous implantable cardioverter-defibrillators (S-ICD) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. Objective: To evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices...
Abstract
JACC. Cardiovascular imaging,
30 5 2025, Pages S1936-878X(25)00549-2
Can Cardiac Computed Tomography Refine Prognosis in Tricuspid Regurgitation?
Ajmone Marsan N
Abstract
Science advances,
Volume 11, Issue 43, 24 4 2025, Pages eadx3794
The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.
In Het Panhuis W, Thiemann E, van Dijk DMAH, Been B, Jarrett KE, Meurs A, Kooijman S, Hovingh MV, Modder M, van Os BW, Sluiter TJ, Blomberg N, Pronk ACM, Afkir S, Streefland TCM, Lalai RA, Taveras MO, Zhang S, Adams TE, Terry LV, Turpin-Nolan SM, de Vries MR, Giera M, Rose-John S, Zelcer N, de Boer JF, de Aguiar Vallim TQ, Febbraio MA, Rensen PCN, Schönke M
The chimeric cytokine IC7Fc conveys the metabolic signaling properties of the glycoprotein 130 receptor cytokines interleukin-6 and ciliary neurotrophic factor via membrane-bound signaling. IC7Fc was previously shown to slow the progression of type 2 diabetes mellitus, and here, we demonstrate its effect on atherosclerotic development. In APOE*3-Leiden.CETP mice, an atherosclerosis-prone model with a humanized lipoprotein metabolism, IC7Fc markedly lowered plasma triglyceride and total cholester...
Abstract
Langenbeck's archives of surgery,
Volume 410, Issue 1, 23 4 2025, Pages 309
Cut from the same cloth? investigating the personality of interventional and surgical cardiovascular specialists.
Sier VQ, Verhagen MJ, Zegel M, Schmitz RF, van Rijswijk CSP, van Schaik J, Schmidt EJET, Hamming JF, Schepers A, Wijdh-den Hamer IJ, Burgmans MC, Hjortnaes J, van der Vorst JR, SUPER Consortium
Purpose: Considering that the treatment of patients with complex vascular disease requires multidisciplinary collaboration in teams and personality traits can impact team dynamics, we investigated the personality structures of vascular surgeons, cardiothoracic surgeons, and interventional radiologists using the validated big five model. Methods: A cross-sectional study utilizing the validated Big Five Inventory-2 (BFI-2) questionnaire. Corrected one-way analyses of variance were performed to com...
Abstract
European heart journal,
23 4 2025, Pages ehaf835
Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry.
Padalino MA, Constantine A, Bergonzoni E, Cao I, Horer J, Ono M, Staehler H, Sames-Dolzer E, Gierlinger G, Hazekamp M, Rijnberg FM, Galletti L, Butera G, Panebianco M, Meyns B, Van Puyvelde J, Yemets I, Bairamov E, Kansy A, Nosal M, Lenoir M, Angeli E, Careddu L, Martens T, Bove T, Napoleone CP, Lo Rito M, Giamberti A, Montanaro C, Marianeschi S, Agati S, Sarris GK, Protopapas E, Rocafort AG, Scrascia G, Meliota G, Vairo U, Michielon G, Gozzi A, Biffanti R, Castaldi B, Gregori D, Vedovelli L, Di Salvo G, Vida V, Dimopoulos K
Background and aims: The Fontan operation and its modifications have transformed the management of children with functional single ventricle physiology. While outcomes have improved, peri-operative complications remain common. This study aimed to assess early outcomes and complications following Fontan completion in a large international European cohort. Methods: The EuroFontan registry is a multicentre retrospective study involving 21 congenital heart disease and transplant centres across Europ...
Abstract
JACC. Advances,
Volume 4, Issue 11 Pt 1, 23 4 2025, Pages 102250
Drug-Coated Balloon After Intravascular Lithotripsy: Procedural and Clinical Outcome of the "Crack and Drug" Strategy.
Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas J
Background: Drug-eluting stents (DESs) after intravascular lithotripsy (IVL) have proven effective in calcified coronary lesions. However, evidence supporting drug-coated balloons (DCBs) after IVL remains limited. Objectives: We aimed to compare the technical success and 1-year clinical outcomes of IVL + DES vs IVL + DCB strategies for the treatment of balloon-crossable calcified coronary lesions. Methods: Patients undergoing percutaneous coronary intervention with IVL from the prospective BENEL...
Abstract
The American journal of cardiology,
22 4 2025, Pages S0002-9149(25)00656-3
Clinical and Technical Predictors of Adverse Cardiovascular Events Following Coronary Lithotripsy in the BENELUX-IVL Registry.
van Oort MJH, Phagu AAS, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Intravascular lithotripsy (IVL) has emerged as a viable treatment option for calcified coronary lesions. This study aimed to identify clinical and procedural factors associated with major adverse cardiovascular events (MACE) following IVL. This retrospective analysis included 583 patients (72.9±9 years, 74% male) treated with IVL for 612 lesions from the multicenter BENELUX-IVL registry (May 2019 - December 2024). Kaplan-Meier analysis was performed to evaluate survival probability. Binary logis...
Abstract
Heart (British Cardiac Society),
20 3 2025, Pages heartjnl-2025-326395
Ventricular arrhythmias during exercise in patients with mitral valve prolapse.
van Wijngaarden AL, de Riva M, Sabbag A, El-Am E, Essayagh B, Michelena HI, Rahme SJ, Medina Inojosa J, Enriquez-Sarano M, Bax JJ, Ajmone Marsan N
Background: Mitral valve prolapse (MVP) can be associated with ventricular arrhythmias (VA), but little is known about the relationship between VA and exercise in these patients. The aim of this study was to assess the occurrence and severity of VA during exercise tests in patients with MVP, and to explore the association between VA during exercise and the occurrence of arrhythmic events during follow-up. Methods: In this multicentre study, 375 patients with MVP (58 (48-69) years, 53% male) who...
Abstract
European heart journal,
17 3 2025, Pages ehaf791
Outcomes of moderate mixed aortic valve stenosis and regurgitation.
Lopez Santi P, Bernard J, Chua A, Laenens D, Powers A, Abdoun K, Velders BJJ, Sarrazyn C, Springhetti P, Zhang J, Amanullah MR, Ewe SH, Yiu KH, Palmen M, Hjortnaes J, Pibarot P, Clavel MA, Bax JJ, Ajmone Marsan N
Background and aims: There are limited data on mortality in patients with moderate mixed aortic valve disease (MAVD), defined as the combination of moderate aortic stenosis (AS) and moderate aortic regurgitation (AR). Consequently, current guidelines lack specific recommendations for aortic valve replacement (AVR) in this population. This study aims to compare survival between moderate MAVD and isolated severe AS or severe AR, and to evaluate the impact of symptoms or left ventricular ejection f...
Abstract
Revista da Associacao Medica Brasileira (1992),
Volume 71, Issue 9, 17 3 2025, Pages e20250355
Comparison of tension-free transvaginal tape and transobturator tape in terms of urinary incontinence and quality of life among Turkish women.
Karkin PÖ, Sezer G, Pişkin N, Yilmaz D
Objective: Urinary incontinence is more common in women than men; additionally, prevalence rises in elderly women. This study was conducted to compare the 10-year results of tension-free transvaginal tape and transobturator tape operations in terms of urinary incontinence and quality of life in women. Methods: Women who underwent transvaginal tape and transobturator tape operations in the urogynecology department at Istanbul Kanuni Sultan Süleyman Training and Research Hospital between January a...
Abstract
Intensive & critical care nursing,
Volume 92, 15 3 2025, Pages 104253
Important and feasible patient- and family-centered intensive care interventions: A Delphi study with stakeholders.
Tilburgs B, Bakker-Crommentuijn C, de Graaf M, van den Boogaard M
Background: Intensive care unit (ICU) admissions can be stressful for patients and family members. Patients may face discomfort, pain, delirium, immobility, and uncertainty about recovery, while family members often experience emotional strain, uncertainty and fatigue. Patient- and family-centered care (PFCC) is a guideline recommended approach to reduce ICU-burden for both patient and family members. However, which interventions are important and feasible for PFCC in the ICU is unknown. Objecti...
Abstract
European journal of preventive cardiology,
14 2 2025, Pages zwaf661
Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib.
Tardif JC, Pfeffer MA, Kouz S, Koenig W, Maggioni AP, McMurray JJV, Waters DD, Jukema JW, White HD, Heinonen T, Kallend D, Laghrissi-Thode F, Muroke V, Fortier A, Guertin MC, Dubé MP
Background: Acute coronary syndrome (ACS) survivors have heightened risk for subsequent cardiovascular events. Methods: All baseline characteristics collected in both the Dal-Outcomes and Dal-GenE trials were considered as potential risk markers. A prediction index for subsequent fatal and non-fatal myocardial infarction (MI) following ACS was developed using Cox proportional hazards modeling on data from Dal-Outcomes placebo patients (n=7086). This prediction index was then applied in all Dal-G...
Abstract
European journal of heart failure,
14 2 2025
Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 1: Multimodality imaging for the evaluation of patients with advanced heart failure.
Aimo A, Tops LF, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Gal TB, Moura B
Heart failure (HF) represents a significant global health burden, with approximately 10% of patients progressing to advanced stages characterized by severe symptoms and recurrent hospitalizations despite conventional treatments such as guideline-directed medical therapy, devices, and surgery. This clinical consensus statement from the Heart Failure Association of the European Society of Cardiology discusses the applications of imaging modalities in patients with advanced HF. Transthoracic echoca...
Abstract
European journal of heart failure,
14 2 2025
Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation.
Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T
This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess...
Abstract
Trends in cardiovascular medicine,
13 2 2025, Pages S1050-1738(25)00135-5
Controversies in valvular heart disease: insights from cardiac imaging.
van der Bijl P, Ajmone Marsan N, Bax JJ
Numerous controversies still exist in the diagnosis and management of valvular heart disease, for example, the benefit of treating moderate aortic stenosis (AS) or asymptomatic, severe AS and the appropriate selection criteria for transcatheter edge-to-edge mitral valve repair. While numerous imaging parameters have been linked to the risk of sudden cardiac death in mitral valve prolapse, their relative merits are unknown and this is a challenging population to risk-stratify. No large, randomize...
Abstract
