Cited 4 times since 2004 (0.2 per year) source: EuropePMC European journal of heart failure, Volume 6, Issue 2, 1 1 2004, Pages 187-193 QT dispersion correlates to myocardial viability assessed by dobutamine stress echocardiography in patients with severely depressed left ventricular function due to coronary artery disease. Bountioukos M, Schinkel AF, Poldermans D, Rizzello V, Vourvouri EC, Krenning BJ, Biagini E, Roelandt JR, Bax JJ
Background
QT dispersion is prolonged in numerous cardiac diseases, representing a general repolarization abnormality.
Aim
To evaluate the influence of viable myocardium on QT dispersion in patients with severely depressed left ventricular (LV) function due to coronary artery disease.
Methods and results
103 patients with ischemic cardiomyopathy (LV ejection fraction [EF]: 25+/-6%) were studied. Patients underwent 12-lead electrocardiography to assess QT dispersion, and two-dimensional echocardiography to identify segmental dysfunction. Dobutamine stress echocardiography (DSE) was then performed to detect residual viability. Resting echo demonstrated 1260 dysfunctional segments; of these, 476 (38%) were viable. Substantial viability (> or =4 viable segments on DSE) was found in 62 (60%) patients. QT dispersion was lower in these patients, than in patients without viability (55+/-17 ms vs. 65+/-22 ms, P=0.012). Viable segments negatively correlated to QT dispersion (r=-0.333, P=0.001). In contrast, there was no correlation between LVEF and QT dispersion (r=-0.001, P=NS).
Conclusions
There is a negative correlation between QT dispersion and the number of viable segments assessed by DSE. Patients with severely depressed LV function and a low QT dispersion probably have a substantial amount of viable tissue. Conversely, when QT dispersion is high, the likelihood of substantial viability is reduced.
