Cited 30 times since 2006 (1.6 per year) source: EuropePMC The Netherlands journal of medicine, Volume 64, Issue 5, 1 1 2006, Pages 160-162 Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. van der Padt A, van Schaik RH, Sonneveld P
Background
Extrapyramidal syndromes (EPS) are clinically relevant side effects of metoclopramide which are often not anticipated.
Patients and methods
Two patients who received metoclopramide developed an acute dystonic reaction. Symptoms disappeared after biperiden or trihexyphenidyl were given. Molecular analysis of the CYP2D6 gene was performed using a PCR-based method.
Results
Both patients were homozygous for inactive CYP2D6 alleles (CYP2D6*4/*4 and CYP2D6*4/*5), which are associated with slow drug metabolism.
Conclusion
Metoclopramide-induced acute dystonic reactions may occur in patients carrying a CYP2D6 genetic polymorphism.
