Cited 19 times since 2010 (1.2 per year) source: EuropePMC Journal of neuroimmunology, Volume 226, Issue 1-2, 12 2 2010, Pages 147-149 HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. de Graaf MT, de Beukelaar JW, Haasnoot GW, Levering WH, Rogemond V, Didelot A, Honnorat J, Gratama JW, Smitt PA
Background
Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS).
Objective
To identify genetic risk factors for Hu-PNS and investigate the role of T cells.
Methods
HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC).
Results
The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC.
Conclusions
This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.