Cited 25 times since 2011 (1.8 per year) source: EuropePMC Therapeutic drug monitoring, Volume 33, Issue 3, 1 1 2011, Pages 369-371 CYP3A5 genotype is not related to the intrapatient variability of tacrolimus clearance. Pashaee N, Bouamar R, Hesselink DA, Roodnat JI, van Schaik RH, Weimar W, van Gelder T
Background
The risk of long-term chronic allograft nephropathy and graft loss after kidney transplantation is increased in patients with a high intrapatient variability of tacrolimus (Tac) clearance.
Methods
To test whether this intrapatient variability is associated with an individual's CYP3A5 genotype, we measured the intrapatient variability in Tac clearance in a cohort of 208 kidney transplant recipients treated with Tac and mycophenolate mofetil.
Results
Tac dose requirement was significantly higher in patients expressing CYP3A5. However, intraindividual variability of Tac clearance was not related to CYP3A5 genotype.
Conclusions
Intraindividual variability in Tac clearance is not related to CYP3A5 genotype. Other factors, including patient adherence, may explain the variability in Tac clearance within an individual patient over time.
