Cited 15 times since 2011 (1 per year) source: EuropePMC American journal of obstetrics and gynecology, Volume 204, Issue 5, 23 4 2011, Pages 396.e1-396.e14 Perinatal risk indicators for long-term neurological morbidity among preterm neonates. Teune MJ, van Wassenaer AG, van Dommelen P, Mol BW, Opmeer BC, Dutch POPS-19 Collaborative Study Group
Objective
Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age.
Study design
Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap.
Results
Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively).
Conclusion
In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity.
