Cited 11 times since 2012 (0.8 per year) source: EuropePMC Current pharmaceutical biotechnology, Volume 13, Issue 4, 1 1 2012, Pages 498-503 Translational optical imaging in diagnosis and treatment of cancer. Keereweer S, Hutteman M, Kerrebijn JD, van de Velde CJ, Vahrmeijer AL, Löwik CW
In cancer imaging, many different modalities are used that each have their specific features, leading to the combined use of different techniques for the detection, staging and treatment evaluation of cancer. Optical imaging using near-infrared fluorescence light is a new imaging modality that has recently emerged in the field of cancer imaging. After extensive preclinical research, the first steps of translation to the clinical practice are currently being made. In this article, we discuss the preclinical and clinical results of near-infrared optical imaging for non-invasive detection and classification of tumors, therapy monitoring, sentinel lymph node procedures, and image-guided cancer surgery. Widespread availability of imaging systems and optical contrast agents will enable larger studies on their clinical benefit and can help establish a definitive role in clinical practice.
