Cited 1 times since 2014 (0.1 per year) source: EuropePMC Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, Volume 199, 5 1 2014, Pages 23-29 Effects of fly ash and boric acid on Y2O3-stabilized tetragonal ZrO2 dispersed with MgAl2O4: An experimental study on rat subcutaneous tissue. Ergun G, Guru M, Egilmez F, Cekic-Nagas I, Yilmaz D
The aim of this study was to evaluate the subcutaneous tissue reaction around zirconia-based materials. Forty-eight male Wistar Albino rats were used in this study. Disk-shaped (1mm height and 5mm diameter) samples composed of 67% spinel (MgAl2O4), 27% tetragonal zirconia polycrystal, 4% (m/m) fly ash and 2% (m/m) boric acid were inserted into dorsal muscles of rats. After 1, 4, 8 and 16 weeks, the animals were sacrificed and zirconia materials were removed with the surrounding tissue. Tissue sections were made with a microtome and then stained with hematoxylin and eosin. Sections were evaluated for the intensity of inflammation. Additionally, the somatic and visceral lymph nodes were evaluated. Data were submitted to one-way analysis of variance (ANOVA) and Tukey HSD tests at a significant level of p < 0.05. There were statistically significant differences between mean inflammatory scores in different experimental periods (p <0.05). In addition, the inflammatory reaction decreased over time. The tested materials had no damaging effect on the rat lymph nodes and did not have a toxic action on the internal organs. Therefore, zirconia polycrystal tested in the present study may offer a promising treatment alternative after further mechanical and biological studies are performed.
