Cited 3 times since 2014 (0.3 per year) source: EuropePMC The Journal of clinical endocrinology and metabolism, Volume 99, Issue 10, 25 4 2014, Pages E2060-6 Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assay. Unal OK, Cinkilic N, Gul OO, Cander S, Vatan O, Ersoy C, Yilmaz D, Tuncel E
Context
Although patients with acromegaly may have an increased risk of developing several types of cancers, the degree of risk for malignancy in these patients is unresolved.
Objective
The present study aimed to investigate the potential genotoxic effects of acromegaly on the cell cycle in peripheral blood lymphocyte cultures.
Design
This was a single center, crossover, case-control study conducted on the acromegalic patients in Turkey.
Setting
The study was conducted in the outpatient clinic of a university hospital.
Patients
Seventy-one consecutively screened acromegalic patients and 56 controls participated in the study.
Intervention
Patients were included, regardless of the disease activity status and their treatment duration before the study.
Main outcome measures
The primary end point was the frequency of micronucleus (MN) in the peripheral blood lymphocyte cultures, and the secondary end point was its clinical correlations.
Results
The MN level was 3.82 ± 1.49 in the control group and 18.00 ± 6.13 in the acromegalic group (P < .01), whereas the nuclear division index (NDI) was 1.79 ± 0.12 in the control group and 1.68 ± 0.07 in the acromegalic group (P < .01). Neither MN nor NDI was correlated with age, GH, IGF-I, initial GH, initial IGF-I, duration of the remission period, and initial tumor size. Only the MN level was positively correlated with the duration of disease (r = 0.323, P = .014).
Conclusion
Our results indicated that acromegalic patients had genotoxic damage at a substantial level, and there was a positive correlation between the duration of disease and genotoxicity level.
