Cited 11 times since 2016 (1.2 per year) source: EuropePMC Pharmacogenomics, Volume 17, Issue 13, 29 5 2016, Pages 1391-1403 Opioid treatment failure in cancer patients: the role of clinical and genetic factors. Oosten AW, Matic M, van Schaik RH, Look MP, Jongen JL, Mathijssen RH, van der Rijt CC
Aim
To identify clinical and genetic factors associated with outcome of opioid treatment.
Patients & methods
We performed an exploratory analysis in a cohort of 353 patients treated with fentanyl, morphine, oxycodone and/or hydromorphone for cancer-related pain, exploring selected clinical and pharmacogenetic factors for a correlation with treatment failure for all and per type of opioid.
Results
Use of adjuvant pain medication, intensity of pain at rest and age were associated with treatment failure in the various cohorts. Only the genetic variants rs12948783 (RHBDF2) and rs7016778 (OPRK1) correlated statistically significant in univariate, but not in multivariable analysis.
Conclusion
Several clinical and genetic factors were identified that warrant further study to clarify their role and use in opioid treatment.
