Cited 21 times since 2016 (2.3 per year) source: EuropePMC Pharmacogenomics, Volume 17, Issue 14, 17 3 2016, Pages 1483-1490 Polymorphisms in SLCO1B1 and UGT1A1 are associated with sorafenib-induced toxicity. Bins S, Lenting A, El Bouazzaoui S, van Doorn L, Oomen-de Hoop E, Eskens FA, van Schaik RH, Mathijssen RH
Aim
Sorafenib-treated patients display a substantial variation in the incidence of toxicity. We aimed to investigate the association of genetic polymorphisms with observed toxicity on sorafenib.
Patients & methods
We genotyped 114 patients that were treated with sorafenib at the Erasmus MC Cancer Institute, the Netherlands, for SLCO1B1, SLCO1B3, ABCC2, ABCG2, UGT1A1 and UGT1A9.
Results
The UGT1A1 (rs8175347) polymorphism was associated with hyperbilirubinemia and treatment interruption. Polymorphisms in SLCO1B1 (rs2306283, rs4149056) were associated with diarrhea and thrombocytopenia, respectively. None of the investigated polymorphisms was associated with overall or progression-free survival in hepatocellular cancer patients.
Conclusion
Polymorphisms in SLCO1B1 and UGT1A1 are associated with several different sorafenib side effects.
