Cited 12 times since 2020 (2.3 per year) source: EuropePMC Pharmacogenomics, Volume 21, Issue 3, 1 1 2020, Pages 181-193 <i>OPRM1</i> and <i>COMT</i> polymorphisms: implications on postoperative acute, chronic and experimental pain after cardiac surgery. Matic M, Matic M, de Hoogd S, de Wildt SN, Tibboel D, Knibbe CA, van Schaik RH
Aim: Investigate the potential role of OPRM1 (mu-opioid receptor) and COMT (catechol-O-methyltransferase enzyme) polymorphisms in postoperative acute, chronic and experimental thermal pain. Methods: A secondary analysis of 125 adult cardiac surgery patients that were randomized between fentanyl and remifentanil during surgery and genotyped. Results: Patients in the fentanyl group with the COMT high-pain sensitivity haplotype required less postoperative morphine compared with the average-pain sensitivity haplotype (19.4 [16.5; 23.0] vs 34.6 [26.2; 41.4]; p = 0.00768), but not to the low-pain sensitivity group (30.1 [19.1; 37.7]; p = 0.13). No association was found between COMT haplotype and other pain outcomes or OPRM1 polymorphisms and the different pain modalities. Conclusion:COMT haplotype appears to explain part of the variability in acute postoperative pain in adult cardiac surgery patients.
