Cited 3 times since 2022 (1.1 per year) source: EuropePMC Current heart failure reports, Volume 19, Issue 5, 25 4 2022, Pages 255-266 Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure. Woudenberg T, Kruyt ND, Quax PHA, Nossent AY
Purpose of review
Small non-coding RNAs regulate gene expression and are highly implicated in heart failure. Recently, an additional level of post-transcriptional regulation has been identified, referred to as the epitranscriptome, which encompasses the body of post-transcriptional modifications that are placed on RNA molecules. In this review, we summarize the current knowledge on the small non-coding RNA epitranscriptome in heart failure.
Recent findings
With the rise of new methods to study RNA modifications, epitranscriptome research has begun to take flight. Over the past 3 years, the number of publications on the epitranscriptome in heart failure has significantly increased, and we expect many more highly relevant publications to come out over the next few years. Currently, at least six modifications on small non-coding RNAs have been investigated in heart failure-relevant studies, namely N6-adenosine, N5-cytosine and N7-guanosine methylation, 2'-O-ribose-methylation, adenosine-to-inosine editing, and isomiRs. Their potential role in heart failure is discussed.
