Clinical and experimental rheumatology, Volume 14 Suppl 15, 1 1 1996, Pages S27-30 In vitro investigation of immunoglobulin treatment mechanisms in autoimmune diseases. Brand A, Vuist WM, Van Schaik IN, Vermeulen M
High doses of immunoglobulins (IVIG) may have beneficial effects in patients with autoimmune diseases. In this review several different mechanisms of action are discussed. These mechanisms include effects on the effector phase of the immune response, on the initial steps of the immune response and on the mixed lymphocytic reaction.