9618 results
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 6, Issue 14, 1 1 2020, Pages 1794-1796
Automated Functional Substrate Mapping: Further Hurdles to Be Cleared.
Zeppenfeld K, Porta-Sánchez A
Abstract
Huisarts en wetenschap,
Volume 63, Issue 12, 30 5 2020, Pages 27-32
E-health bij poliklinische follow-up van myocardinfarctpatiënten.
Treskes R, van Winden L, van Keulen N, van der Velde E, Beeres S, Atsma D, Schalij MJ
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Current cardiology reports,
Volume 23, Issue 1, 27 4 2020, Pages 4
Cardiac Sympathetic Innervation Imaging with PET Radiotracers.
van der Bijl P, Knuuti J, Delgado V, Bax JJ
Purpose of review: The present article reviews the pathophysiology of cardiac sympathetic denervation, the principles of positron emission tomography (PET) imaging of the sympathetic innervation of the heart and its potential clinical role, based on current and expected future evidence. Recent findings: Imaging of cardiac sympathetic denervation can be performed with radiolabeled noradrenaline analogues, e.g., 11C-hydroxyephedrine. A greater burden of sympathetic denervation carries prognostic s...
Abstract
Cited 14 times since 2020 (3 per year)
source: EuropePMC
Journal of diabetes and its complications,
Volume 35, Issue 2, 26 4 2020, Pages 107810
Prevalence of ECG abnormalities in people with type 2 diabetes: The Hoorn Diabetes Care System cohort.
Harms PP, van der Heijden AA, Rutters F, Tan HL, Beulens JWJ, Nijpels G, Elders P, ESCAPE-NET
Aims: The American Diabetes Association, and the joint European Society of Cardiology and European Association for the Study of Diabetes guidelines recommend a resting ECG in people with type 2 diabetes with hypertension or suspected cardiovascular disease (CVD). However, knowledge on the prevalence of ECG abnormalities is incomplete. We aimed to analyse the prevalence of ECG abnormalities and their cross-sectional associations with cardiovascular risk factors in people with type 2 diabetes. Met...
Abstract
Cited 5 times since 2020 (1.1 per year)
source: Scopus
Animals : an open access journal from MDPI,
Volume 10, Issue 12, 26 4 2020, Pages E2214
Social Context Influences Resting Physiology in Dogs.
Kortekaas K, Kotrschal K
Domestication has affected the social life of dogs. They seem to be less dependent on their pack members than wolves, potentially causing dogs to be more alert towards their environment, especially when resting. Such a response has been found in dogs resting alone compared to wolves in the same situation. However, as this may be influenced by social context, we compared alertness (i.e., degree of activation along the sleep-wake continuum-measured via cardiac parameters) of pack-living and enclos...
Abstract
Cited 56 times since 2020 (11.8 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 4, 25 4 2020, Pages 854-866
Neo-LVOT and Transcatheter Mitral Valve Replacement: Expert Recommendations.
Reid A, Ben Zekry S, Turaga M, Tarazi S, Bax JJ, Wang DD, Piazza N, Bapat VN, Ihdayhid AR, Cavalcante JL, Blanke P, Leipsic J
With the advent of transcatheter mitral valve replacement (TMVR), the concept of the neo-left ventricular outflow tract (LVOT) was introduced and remains an essential component of treatment planning. This paper describes the LVOT anatomy and provides a step-by-step computed tomography methodology to segment and measure the neo-LVOT while discussing the current evidence and outstanding challenges. It also discusses the technical and hemodynamic factors that play a major role in assessing the neo-...
Abstract
Cited 17 times since 2020 (3.6 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 87, Issue 4, 24 4 2020, Pages 1918-1929
Monitoring the tacrolimus concentration in peripheral blood mononuclear cells of kidney transplant recipients.
Francke MI, Hesselink DA, Li Y, Koch BCP, de Wit LEA, van Schaik RHN, Yang L, Baan CC, van Gelder T, de Winter BCM
Aims: Tacrolimus is a critical dose drug and to avoid under- and overexposure, therapeutic drug monitoring is standard practice. However, rejection and drug-related toxicity occur despite whole-blood tacrolimus pre-dose concentrations ([Tac]blood ) being on target. Monitoring tacrolimus concentrations at the target site (within peripheral blood mononuclear cells; [Tac]cells ) may better correlate with drug-efficacy. The aim of this study was to (1) investigate the relationship between [Tac]blood...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: Scopus
Frontiers in psychology,
Volume 11, 24 4 2020, Pages 568199
Context-Specific Arousal During Resting in Wolves and Dogs: Effects of Domestication?
Jean-Joseph H, Kortekaas K, Range F, Kotrschal K
Due to domestication, dogs differ from wolves in the way they respond to their environment, including to humans. Selection for tameness and the associated changes to the autonomic nervous system (ANS) regulation have been proposed as the primary mechanisms of domestication. To test this idea, we compared two low-arousal states in equally raised and kept wolves and dogs: resting, a state close to being asleep, and inactive wakefulness, which together take up an important part in the time budgets...
Abstract
Cited 119 times since 2020 (25.1 per year)
source: EuropePMC
Nature genetics,
Volume 52, Issue 12, 23 4 2020, Pages 1314-1332
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E,
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P
Abstract
Cited 32 times since 2020 (6.8 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 1, 23 4 2020, Pages 566-576
Meta-analysis of echocardiographic quantification of left ventricular filling pressure.
Jones R, Varian F, Alabed S, Morris P, Rothman A, Swift AJ, Lewis N, Kyriacou A, Wild JM, Al-Mohammad A, Zhong L, Dastidar A, Storey RF, Swoboda PP, Bax JJ, Garg P
Aims: The clinical reliability of echocardiographic surrogate markers of left ventricular filling pressures (LVFPs) across different cardiovascular pathologies remains unanswered. The main objective was to evaluate the evidence of how effectively different echocardiographic indices estimate true LVFP. Methods and results: Design: this is a systematic review and meta-analysis. Data source: Scopus, PubMed and Embase. Eligibility criteria for selecting studies were those that used echocardiography...
Abstract
Cited 29 times since 2020 (6.1 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 112, Issue 4, 19 3 2020, Pages 1150-1159
Multiinstitutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer.
Gangadharan S, Sarkaria IN, Rice D, Murthy S, Braun J, Kucharczuk J, Predina J, Singhal S
Background: Intraoperative molecular imaging (IMI) may improve surgical outcomes during pulmonary resection for lung cancer. A multiinstitutional phase 2 IMI clinical trial was conducted using a near-infrared, folate receptor-targeted contrast agent for lung adenocarcinomas, OTL38. The primary goal was to determine whether OTL38 improved surgeons' ability to identify difficult to find nodules, occult cancers, and positive margins. Methods: Patients with lung nodules received OTL38 (0.025 mg...
Abstract
Cited 50 times since 2020 (10.5 per year)
source: EuropePMC
Frontiers in nutrition,
Volume 7, 19 3 2020, Pages 597600
The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19.
de Frel DL, Atsma DE, Pijl H, Seidell JC, Leenen PJM, Dik WA, van Rossum EFC
Background: COVID-19 is a global challenge to healthcare. Obesity is common in patients with COVID-19 and seems to aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors and the immune system, and propose societal interventions to enhance global immunity. Search Strategy and Selection Criteria: We performed three literature searches using the keywords (1) coronavirus AND comorbidities, (2) comorbidities AND immune system, and (3) lifes...
Abstract
Cited 44 times since 2020 (9.3 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 1, 18 3 2020, Pages 233-242
The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease.
Jin HY, Weir-McCall JR, Leipsic JA, Son JW, Sellers SL, Shao M, Blanke P, Ahmadi A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araujo Goncalves P, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Chinnaiyan K, Raff G, Al-Mallah MH, Lin FY, Min JK, Sung JM, Lee SE, Chang HJ
Objectives: The aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease. Background: Coronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in respo...
Abstract
Cited 19 times since 2020 (4 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 9, Issue 23, 16 3 2020, Pages e017094
Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.
Bruijn LE, van den Akker BEWM, van Rhijn CM, Hamming JF, Lindeman JHN
Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as "fibroblasts," "myofibroblasts," "smooth muscle cells," "fibrocytes," "mesangial cells," and "pericytes." However, a discriminative marker-based subclassification has to date not been established. Methods and Results As a fir...
Abstract
Cited 7 times since 2020 (1.5 per year)
source: EuropePMC
American journal of physiology. Renal physiology,
Volume 320, Issue 1, 16 3 2020, Pages F17-F30
Connexin43 is differentially distributed within renal vasculature and mediates profibrotic differentiation in medullary fibroblasts.
Xu Y, Hu J, Yilmaz DE, Bachmann S
Connexins (Cxs) form gap junctions for intercellular exchange of inorganic ions and messenger molecules. In the kidney, Cxs play essential roles within its compartments, but data on the precise cellular localization and cell type-related function of their isoforms are scarce. We tested whether Cx43 distribution is restricted to vascular and interstitial cells and whether medullary fibroblasts express Cx43 to coordinate profibrotic signaling. Confocal immunofluorescence techniques, ultrastructura...
Abstract
Cited 14 times since 2020 (2.9 per year)
source: EuropePMC
Biomaterials,
Volume 268, 14 2 2020, Pages 120498
Fibronectin-functionalization of 3D collagen networks supports immune tolerance and inflammation suppression in human monocyte-derived macrophages.
Logie C, van Schaik T, Pompe T, Pietsch K
The extracellular matrix (ECM) is dynamically reorganized during wound healing. Concomitantly, recruited monocytes differentiate into macrophages. However, the role of the wound's ECM during this transition remain to be fully understood. Fibronectin is a multifunctional glycoprotein present in early wound ECM with a potential immunomodulatory role during monocyte-to-macrophage differentiation. Hence, to investigate the impact of fibronectin during this differentiation step, 3D fibrillar col...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Drug metabolism and personalized therapy,
Volume 35, Issue 4, 13 2 2020
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients.
Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN
Abstract
Drug metabolism and personalized therapy,
13 2 2020
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients.
Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN
Abstract
Cited 174 times since 2020 (36.5 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 18, Issue 4, 13 2 2020, Pages 291-304
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging.
Ng ACT, Delgado V, Borlaug BA, Bax JJ
Diabesity is a term used to describe the combined adverse health effects of obesity and diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an important public health issue. Projections estimate a sixfold increase in the number of adults with obesity in 40 years and an increase in the number of individuals with diabetes to 642 million by 2040. Increased adiposity is the strongest risk factor for developing diabetes. Early detection of the effects of diabesity on the...
Abstract
Cited 10 times since 2020 (2.1 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 164, Issue 3, 12 2 2020, Pages 822-829.e6
Why the categorization of indexed effective orifice area is not justified for the classification of prosthesis-patient mismatch.
Vriesendorp MD, Deeb GM, Reardon MJ, Kiaii B, Bapat V, Labrousse L, Rao V, Sabik JF, Gearhart E, Klautz RJM
Objectives: Although the impact of prosthesis-patient mismatch (PPM) on survival has been widely studied, there has been little debate about whether the current definition of PPM truly reflects hemodynamic obstruction. This study aimed to validate the categorization of indexed effective orifice area (EOAi) for the classification of PPM. Methods: In total, 2171 patients who underwent aortic valve replacement with a surgical stented bioprosthesis in 5 trials (CoreValve US High-Risk, SURTAVI [Surgi...
Abstract
