6190 results
Cited 40 times since 2015 (4.2 per year)
source: EuropePMC
Biomaterials,
Volume 75, 22 4 2015, Pages 82-90
Development and evaluation of in vivo tissue engineered blood vessels in a porcine model.
Rothuizen TC, Damanik FFR, Lavrijsen T, Visser MJT, Hamming JF, Lalai RA, Duijs JMGJ, van Zonneveld AJ, Hoefer IE, van Blitterswijk CA, Rabelink TJ, Moroni L, Rotmans JI
Background: There's a large clinical need for novel vascular grafts. Tissue engineered blood vessels (TEBVs) have great potential to improve the outcome of vascular grafting procedures. Here, we present a novel approach to generate autologous TEBV in vivo. Polymer rods were engineered and implanted, evoking an inflammatory response that culminates in encapsulation by a fibrocellular capsule. We hypothesized that, after extrusion of the rod, the fibrocellular capsule differentiates into an a...
Abstract
Cited 6 times since 2015 (0.6 per year)
source: EuropePMC
Scientific reports,
Volume 5, 21 3 2015, Pages 15187
Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation.
Bingen BO, Askar SF, Neshati Z, Feola I, Panfilov AV, de Vries AA, Pijnappels DA
Electrical cardioversion (ECV), a mainstay in atrial fibrillation (AF) treatment, is unsuccessful in up to 10-20% of patients. An important aspect of the remodeling process caused by AF is the constitutive activition of the atrium-specific acetylcholine-dependent potassium current (IK,ACh → IK,ACh-c), which is associated with ECV failure. This study investigated the role of IK,ACh-c in ECV failure and setting the atrial defibrillation threshold (aDFT) in optically mapped neonatal rat cardiomyocy...
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
Family practice,
Volume 32, Issue 6, 17 3 2015, Pages 646-651
Overweight can be used as a tool to guide case-finding for cardiovascular risk assessment.
de Boer AW, de Mutsert R, den Heijer M, Jukema JW, Rosendaal FR, Blom JW, Assendelft WJ, NEO study group
Background: In general practice, it is too time-consuming to invite all patients for cardiovascular risk assessment. Objective: To examine how many patients with an indication for treatment with cardiovascular medication can be identified by ad hoc case-finding when all patients with overweight/obesity are invited for risk assessment. Methods: A cross-sectional analysis of the baseline measurements of the Netherlands Epidemiology of Obesity study, a population-based prospective cohort study in 6...
Abstract
Cited 130 times since 2015 (13.6 per year)
source: EuropePMC
Cell reports,
Volume 13, Issue 4, 17 3 2015, Pages 733-745
Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function.
Birket MJ, Ribeiro MC, Kosmidis G, Ward D, Leitoguinho AR, van de Pol V, Dambrot C, Devalla HD, Davis RP, Mastroberardino PG, Atsma DE, Passier R, Mummery CL
Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate level of function to permit robust single-cell contractility measurements in a human induced pluripotent stem cell (hiPSC) model of hypertrophic cardiomyopathy (HCM). A simple screen revealed the collaborative effects of thyroid hormone, IGF-1 and the...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Trends in cardiovascular medicine,
Volume 26, Issue 4, 17 3 2015, Pages 348-360
Noninvasive imaging markers associated with sudden cardiac death.
van der Bijl P, Delgado V, Bax JJ
Sudden cardiac death (SCD) accounts for approximately 15-20% of all deaths worldwide. While the majority of SCDs occur in adults, children, and adults
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 55, Issue 3, 15 3 2015, Pages 504-512
Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis.
Yiu KH, Ninaber MK, Kroft LJ, Schouffoer AA, Stolk J, Scherer HU, Meijs J, de Vries-Bouwstra J, Tse HF, Delgado V, Bax JJ, Huizinga TW, Marsan NA
Objectives: Right ventricular (RV) dysfunction is of great prognostic value in patients with SSc. The aim of the present study was to assess in these patients the relationship between pulmonary fibrosis and elevated pulmonary pressure (PHT) with RV function. Methods: A total of 102 SSc patients who underwent thoracic CT and transthoracic echocardiography were included. Speckle tracking-derived RV free wall strain was used to assess RV function. Results: A total of 51 (50%) SSc patients did not h...
Abstract
Cited 34 times since 2015 (3.6 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 50, Issue 6, 9 2 2015, Pages 702-713
Editor's Choice - Pharmaceutical Management of Small Abdominal Aortic Aneurysms: A Systematic Review of the Clinical Evidence.
Kokje VB, Hamming JF, Lindeman JH
Background: Management of abdominal aortic aneurysms (AAAs) relies on surgical repair of larger AAAs. Consequently medical interventions inhibiting AAA progression could greatly reduce the need for surgical repair. A spectrum of pharmaceutical strategies has been reported, albeit conclusions often appear contradictory. Given the longstanding interest in pharmaceutical AAA stabilization, a systematic review of the available literature is relevant. Objectives: The aim is to provide an up to date s...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 11, 9 2 2015, Pages 1029-1031
The Descending Septal Artery: Description of This Infrequent Coronary Anatomical Variant in Three Different Clinical Scenarios.
Montero-Cabezas JM, Tohamy AM, Karalis I, Delgado V, Schalij MJ
Abstract
Cited 15 times since 2015 (1.6 per year)
source: EuropePMC
Stroke,
Volume 46, Issue 11, 8 2 2015, Pages 3048-3057
White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BF, Wolf C, Yang Q, Adams HH, Amouyel P, Beiser A, Buckley BM, Callisaya M, Chauhan G, de Craen AJ, Dufouil C, van Duijn CM, Ford I, Freudenberger P, Gottesman RF, Gudnason V, Heiss G, Hofman A, Lumley T, Martinez O, Mazoyer B, Moran C, Niessen WJ, Phan T, Psaty BM, Satizabal CL, Sattar N, Schilling S, Shibata DK, Slagboom PE, Smith A, Stott DJ, Taylor KD, Thomson R, Töglhofer AM, Tzourio C, van Buchem M, Wang J, Westendorp RG, Windham BG, Vernooij MW, Zijdenbos A, Beare R, Debette S, Ikram MA, Jukema JW, Launer LJ, Longstreth WT, Mosley TH, Seshadri S, Schmidt H, Schmidt R, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Background and purpose: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Methods: Heritability of WML progression was calculated in t...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Journal of periodontology,
Volume 87, Issue 2, 2 1 2015, Pages 193-202
Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical In Silico, Comparative In Vivo, and Explanatory In Vitro Models.
Gürsoy UK, Zeidán-Chuliá F, Yilmaz D, Özdemir V, Mäki-Petäys J, Neves de Oliveira BH, Firatli Y, Güncü GN, Caglayan F, Könönen E
Background: A deeper understanding of periodontitis pathophysiology is central to future development of novel biomarkers and therapeutics. The following is reported here: 1) an in silico network model of interactions among cell adhesion molecules and a network-focused microarray analysis of the corresponding genes in periodontitis; 2) analysis of secretions of adhesion molecules in gingival tissue samples from patients with periodontitis and healthy controls; and 3) effect of the human neutrophi...
Abstract
Cited 268 times since 2015 (27.9 per year)
source: EuropePMC
PLoS genetics,
Volume 11, Issue 10, 1 1 2015, Pages e1005378
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Sc
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of Europ...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Thrombosis and haemostasis,
Volume 115, Issue 2, 1 1 2015, Pages 353-360
Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention.
Rutten B, Roest M, McClellan EA, Sels JW, Stubbs A, Jukema JW, Doevendans PA, Waltenberger J, van Zonneveld AJ, Pasterkamp G, De Groot PG, Hoefer IE
Monocyte recruitment to damaged endothelium is enhanced by platelet binding to monocytes and contributes to vascular repair. Therefore, we studied whether the number of platelets per monocyte affects the recurrence of adverse events in patients after percutaneous coronary intervention (PCI). Platelet-monocytes complexes with high and low median fluorescence intensities (MFI) of the platelet marker CD42b were isolated using cell sorting. Microscopic analysis revealed that a high platelet marker M...
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 22, Issue 5, 1 1 2015, Pages 866-873
Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.
Kitsiou A, Dorbala S, Scholte AJ
Abstract
Cited 36 times since 2015 (3.8 per year)
source: EuropePMC
Expert opinion on therapeutic targets,
Volume 20, Issue 2, 30 5 2015, Pages 223-239
Targeting danger-associated molecular patterns after myocardial infarction.
van Hout GP, Arslan F, Pasterkamp G, Hoefer IE
Introduction: Myocardial infarction (MI) provokes an intense inflammatory response that can lead to left ventricular adverse remodeling and heart failure (HF). The prognosis of HF patients is poor and related to a decreased quality of life and considerable health care costs. Hence, targeting the early inflammatory response after MI provides an interesting target to attenuate left ventricular remodeling and prevent HF. Areas covered: In the current review, we discuss the theory that our immune sy...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 28 4 2015, Pages 571-572
Reduction of healthcare utilization after bone marrow cell therapy for refractory angina pectoris.
Rodrigo SF, Mann I, van Ramshorst J, Beeres SL, Zwaginga JJ, Fibbe WE, Bax JJ, Schalij MJ, Atsma DE
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 11, 26 4 2015, Pages 1043
The "De Winter Pattern" Can Progress to ST-segment Elevation Acute Coronary Syndrome. Response.
Montero-Cabezas JM, van der Kley F, Karalis I, Schalij MJ
Abstract
Cited 38 times since 2015 (4 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 26 4 2015, Pages 784-795
Atrioventricular septal defect: From embryonic development to long-term follow-up.
Calkoen EE, Hazekamp MG, Blom NA, Elders BB, Gittenberger-de Groot AC, Haak MC, Bartelings MM, Roest AA, Jongbloed MR
Atrioventricular septal defect (AVSD) covers a spectrum of heart anomalies with a common atrioventricular connection and has an incidence of 4-5.3 per 10.000 live births. About half of the AVSDs occur in patient with Down syndrome. This review provides a bench to bedside overview of AVSD. Developmental aspects, nomenclature, anatomy, and classification of AVSD are discussed. Furthermore an overview of genetic and maternal risk factors for AVSD is provided, and available literature on (fetal) dia...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 49, Issue 1, 26 4 2015, Pages 60-68
Electrocardiographic detection of pulmonary hypertension in patients with systemic sclerosis using the ventricular gradient.
Couperus LE, Vliegen HW, Henkens IR, Maan AC, Treskes RW, de Vries JK, Schouffoer AA, Swenne CA, Schalij MJ, Scherptong RW
Background: Pulmonary hypertension (PH) is a leading cause of death in systemic sclerosis (SSc) patients. The current study assessed the ability of the ECG-derived ventricular gradient (VG-RVPO) to detect PH and predict all-cause mortality in PH patients with subtypes of SSc differing in the extent of multi-organ involvement. Methods: ECGs were obtained from 196 patients with limited and 77 patients with diffuse SSc included from our screening programme on cardiac complications. The association...
Abstract
Cited 8 times since 2015 (0.8 per year)
source: EuropePMC
Clinical journal of the American Society of Nephrology : CJASN,
Volume 10, Issue 10, 25 4 2015, Pages 1740-1748
Cardiac Resynchronization Therapy in CKD Stage 4 Patients.
Höke U, Khidir MJ, van der Velde ET, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Background and objectives: Cardiac resynchronization therapy (CRT) is a well established heart failure treatment that has shown to improve renal function. However, landmark CRT trials excluded patients with severe renal dysfunction. Therefore, this study evaluated the effect of CRT on renal function and long-term prognosis in patients with stage 4 CKD. Design, setting, participants, & measurements: This study evaluated 73 consecutive CRT patients (71±10 years) with stage 4 CKD who underwent...
Abstract
Cited 232 times since 2015 (24.1 per year)
source: EuropePMC
Nature genetics,
Volume 47, Issue 11, 21 3 2015, Pages 1282-1293
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Yu Mok Z, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Scannell Bryan M, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husem
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the reg...
Abstract
