6128 results
Cited 10 times since 2021 (2.5 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 5, 22 4 2021, Pages e018565
Clinical Course Long After Atrial Switch: A Novel Risk Score for Major Clinical Events.
Woudstra OI, Zandstra TE, Vogel RF, van Dijk APJ, Vliegen HW, Kiès P, Jongbloed MRM, Egorova AD, Doevendans PAFM, Konings TC, Mulder BJM, Tanck MWT, Meijboom FJ, Bouma BJ
Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on the emerging risks remain scarce. We assessed the risk for events during the clinical course in adulthood, and provided a novel risk score for event-free survival. Methods and Results This multicenter study observed 167 patients with transposition of the great arteries corrected by an atrial...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
European journal of applied physiology,
Volume 121, Issue 5, 22 4 2021, Pages 1405-1418
Biventricular function in exercise during autonomic (thoracic epidural) block.
Wink J, Steendijk P, Tsonaka R, de Wilde RBP, Friedericy HJ, Braun J, Veering BT, Aarts LPHJ, Wouters PF
Background: Blockade of cardiac sympathetic fibers by thoracic epidural anesthesia (TEA) was previously shown to reduce right and left ventricular systolic function and effective pulmonary arterial elastance. At conditions of constant paced heart rate, cardiac output and systemic hemodynamics were unchanged. In this study, we further investigated the effect of cardiac sympathicolysis during physical stress and increased oxygen demand. Methods: In a cross-over design, 12 patients scheduled to und...
Abstract
Cited 17 times since 2021 (4.2 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 2, 22 4 2021, Pages 1541-1551
Clinical and economic impact of HeartLogic™ compared with standard care in heart failure patients.
Treskes RW, Beles M, Caputo ML, Cordon A, Biundo E, Maes E, Egorova AD, Schalij MJ, Van Bockstal K, Grazioli-Gauthier L, Vanderheyden M, Bartunek J, Auricchio A, Beeres SLMA, Heggermont WA
Aims: The implantable cardiac defibrillator/cardiac resynchronization therapy with defibrillator-based HeartLogic™ algorithm has recently been developed for early detection of impending decompensation in heart failure (HF) patients; but whether this novel algorithm can reduce HF hospitalizations has not been evaluated. We investigated if activation of the HeartLogic algorithm reduces the number of hospital admissions for decompensated HF in a 1 year post-activation period as compared with a 1 ye...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
European heart journal. Digital health,
Volume 2, Issue 2, 22 4 2021, Pages 215-223
Potential of eHealth smart technology in optimization and monitoring of heart failure treatment in adults with systemic right ventricular failure.
Nederend M, Zandstra TE, Kiès P, Jongbloed MRM, Vliegen HW, Treskes RW, Schalij MJ, Atsma DE, Egorova AD
Aims: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA are prone to heart failure and arrhythmias. This study evaluated feasibility, patient adherence, and satisfaction of a smart technology-based care pathway for heart failure treatment optimization in these patients. Methods and results: Patients with symptomatic sRV failure eligible for initiation of sacubitril/valsartan were provided w...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation,
Volume 30, Issue 6, 19 3 2021, Pages 1605-1617
The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial.
Timal RJ, de Gucht V, Rotmans JI, Hensen LCR, Buiten MS, de Bie MK, Putter H, Schalij MJ, Rabelink TJ, Jukema JW
Rationale: The impact of prophylactic implantable cardioverter-defibrillator (ICD) implantation on the psychological well-being of patients on dialysis is unknown. Objective: We aimed to identify the effect of primary ICD implantation on quality of life (QoL), mood and dispositional optimism in patients undergoing dialysis. Methods and results: We performed a prespecified subanalysis of the randomized controlled ICD2 trial. In total, 177 patients on chronic dialysis, with an age of 55-81 years,...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 4, 18 3 2021, Pages 2010
BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice.
Bakker W, Dingenouts CKE, Lodder K, Wiesmeijer KC, de Jong A, Kurakula K, Mager HJ, Smits AM, de Vries MR, Quax PHA, Goumans MJTH
Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor endoglin. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1 patients display an impaired immune response. To date it is not fully understood how endoglin haploinsufficient immune cells contribute to HHT1 pathology. Therefore, we investigated the immune response during tissue repair in Eng+/- mice, a model for...
Abstract
Cited 9 times since 2021 (2.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue 4, 18 3 2021, Pages 224-229
Emergency medical services evaluations for chest pain during first COVID-19 lockdown in Hollands-Midden, the Netherlands.
de Koning ER, Boogers MJ, Bosch J, de Visser M, Schalij MJ, Beeres SLMA
Objective: To assess whether the COVID-19 lockdown in 2020 had negative indirect health effects, as people seem to have been reluctant to seek medical care. Methods: All emergency medical services (EMS) transports for chest pain or out-of-hospital cardiac arrest (OHCA) in the Dutch region Hollands-Midden (population served > 800,000) were evaluated during the initial 6 weeks of the COVID-19 lockdown and during the same time period in 2019. The primary endpoint was the number of evaluated ches...
Abstract
JACC. Case reports,
Volume 3, Issue 2, 17 3 2021, Pages 217-219
Björk-Fontan and the Restoration of Right-Sided Conduits.
de Winter RJ, Koolbergen DR
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Sensors (Basel, Switzerland),
Volume 21, Issue 4, 15 3 2021, Pages 1361
Early Detection of Fluid Retention in Patients with Advanced Heart Failure: A Review of a Novel Multisensory Algorithm, HeartLogic<sup>TM</sup>.
Feijen M, Egorova AD, Beeres SLMA, Treskes RW
Heart failure (HF) hospitalisations due to decompensation are associated with shorter life expectancy and lower quality of life. These hospitalisations pose a significant burden on the patients, doctors and healthcare resources. Early detection of an upcoming episode of decompensation may facilitate timely optimisation of the ambulatory medical treatment and thereby prevent heart-failure-related hospitalisations. The HeartLogicTM algorithm combines data from five sensors of cardiac implantable e...
Abstract
Cited 13 times since 2021 (3.2 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 12 2 2021, Pages 631985
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem.
Meerman M, Bracco Gartner TCL, Buikema JW, Wu SM, Siddiqi S, Bouten CVC, Grande-Allen KJ, Suyker WJL, Hjortnaes J
Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibro...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
BMJ open,
Volume 11, Issue 2, 12 2 2021, Pages e041553
Prehospital triage of patients with acute cardiac complaints: study protocol of HART-c, a multicentre prospective study.
de Koning E, Biersteker TE, Beeres S, Bosch J, Backus BE, Kirchhof CJ, Alizadeh Dehnavi R, Silvius HA, Schalij M, Boogers MJ
Introduction: Emergency department (ED) overcrowding is a major healthcare problem associated with worse patient outcomes and increased costs. Attempts to reduce ED overcrowding of patients with cardiac complaints have so far focused on in-hospital triage and rapid risk stratification of patients with chest pain at the ED. The Hollands-Midden Acute Regional Triage-Cardiology (HART-c) study aimed to assess the amount of patients left at home in usual ambulance care as compared with the new prehos...
Abstract
Cited 9 times since 2021 (2.2 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 54, Issue 2, 10 2 2021, Pages 411-420
Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.
Bakermans AJ, Boekholdt SM, de Vries DK, Reckman YJ, Farag ES, de Heer P, Uthman L, Denis SW, Zuurbier CJ, Houtkooper RH, Koolbergen DR, Kluin J, Planken RN, Lamb HJ, Webb AG, Strijkers GJ, Beard DA, Jeneson JAL, Nederveen AJ
Background: Proton magnetic resonance spectroscopy (1 H-MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking. Purpose: To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized 1 H-MRS. Study type: Test-retest repeatability and measurement validation study. Subjects: Sixteen v...
Abstract
Cited 21 times since 2021 (5.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 6, 10 2 2021, Pages 1085-1095
Prognostic Implications of a Novel Algorithm to Grade Secondary Tricuspid Regurgitation.
Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, De Ferrari GM, Knuuti J, Bax JJ, Delgado V, Marsan NA
Objectives: A novel tricuspid regurgitation (TR) grading system, using vena contracta (VC) width and effective regurgitant orifice area (EROA), was proposed and validated based on its prognostic usefulness. Background: The clinical need of a new grading system for TR has recently been emphasized to depict the whole spectrum of TR severity, particularly beyond severe TR (massive or torrential). Methods: TR severity was characterized in 1,129 patients with moderate or severe secondary TR (STR). Re...
Abstract
Cited 6 times since 2021 (1.5 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 9 2 2021, Pages 638487
Multi-Modality Imaging for Interventions in Tricuspid Valve Disease.
Fortuni F, Hirasawa K, Bax JJ, Delgado V, Ajmone Marsan N
Several studies have demonstrated that severe tricuspid regurgitation (TR) has a significant negative impact on morbidity and mortality. Nowadays, several therapeutic options to treat TR are available and patients at high surgical risk can also be treated with transcatheter procedures. For the management of patients with TR, an accurate assessment of the tricuspid valve and its surrounding structures is therefore of crucial importance and has gained significant interest in the medical community....
Abstract
Cited 21 times since 2021 (5.2 per year)
source: EuropePMC
STAR protocols,
Volume 2, Issue 1, 9 2 2021, Pages 100334
Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes.
Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW
Since the discovery of human induced pluripotent stem cells (hiPSCs), numerous strategies have been established to efficiently derive cardiomyocytes from hiPSCs (hiPSC-CMs). Here, we describe a cost-effective strategy for the subsequent massive expansion (>250-fold) of high-purity hiPSC-CMs relying on two aspects: removal of cell-cell contacts and small-molecule inhibition with CHIR99021. The protocol maintains CM functionality, allows cryopreservation, and the cells can be used in downstream...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Der Urologe. Ausg. A,
Volume 60, Issue 3, 9 2 2021, Pages 318-330
[Urological care in practices and clinics during the corona virus pandemic in Germany].
Kriegmair MC, Speck T, Schneider AW, Volkmer B, Michel MS
The coronavirus pandemic has had an immediate and far-reaching effect on the care of urological patients. The pandemic monitor of the German Society for Urology was able to record the restrictions on patient care in urological practices and clinics by means of regular surveys of the members. A total of 689 responses at four survey time points were included. In April there was a reduction in urological inpatients to 44% and the number of patients in practices dropped to 50%. Available operating t...
Abstract
Journal of clinical medicine,
Volume 10, Issue 4, 8 2 2021, Pages 649
Mitral Valve Annulus Dimensions Assessment with Three-Dimensional Echocardiography Versus Computed Tomography: Implications for Transcatheter Interventions.
Hirasawa K, Vo NM, Gegenava T, Pio SM, van Wijngaarden SE, Ajmone Marsan N, Bax JJ, Delgado V
The aim of this study is to evaluate the agreement between three-dimensional (3D) transesophageal echocardiography (TEE) and multidetector computed tomography (MDCT) for assessing mitral annular (MA) dimensions. A total of 105 patients (79 ± 9 years old, 52% male) who underwent clinically indicated 3D TEE and MDCT feasible for MA geometrical assessment were included. Using dedicated semi-automated postprocessing software, MA geometry, including mitral annular area (MAA), perimeter, septal-latera...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Nature communications,
Volume 12, Issue 1, 8 2 2021, Pages 995
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A,
Abstract
Cited 13 times since 2021 (3.2 per year)
source: EuropePMC
Angiogenesis,
Volume 24, Issue 3, 7 1 2021, Pages 567-581
Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization.
Baganha F, de Jong RCM, Peters EA, Voorham W, Jukema JW, Delibegovic M, de Vries MR, Quax PHA
Objective: Statins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and hemorrhage (IPH) remain unclear. Therefore, we discriminated statin's lipid-lowering dependent and independent effects on IPA and IPH. Approach and results: ApoE3*Leiden mice are statin-responsive due to ApoE and LDLR presence, but also allow to titrate plasma cholesterol levels by diet. Therefore, ApoE3*Leiden mice were fed a high-cholesterol-i...
Abstract
Cited 18 times since 2021 (4.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 331, 3 1 2021, Pages 316-321
Standard and emerging CMR methods for mitral regurgitation quantification.
Fidock B, Archer G, Barker N, Elhawaz A, Al-Mohammad A, Rothman A, Hose R, Hall IR, Grech E, Briffa N, Lewis N, van der Geest RJ, Zhang JM, Zhong L, Swift AJ, Wild JM, De Gárate E, Bucciarelli-Ducci C, Bax JJ, Plein S, Myerson S, Garg P
Background: There are several methods to quantify mitral regurgitation (MR) by cardiovascular magnetic resonance (CMR). The interoperability of these methods and their reproducibility remains undetermined. Objective: To determine the agreement and reproducibility of different MR quantification methods by CMR across all aetiologies. Methods: Thirty-five patients with MR were recruited (primary MR = 12, secondary MR = 10 and MVR = 13). Patients underwent CMR, including cines and four-dimensional f...
Abstract
