Research

Publications

Below you can find a list of our published research.

6205 results

Cited 99 times since 2016 (11.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 68, Issue 9, 1 1 2016, Pages 934-945 Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study. van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, Zabaneh D, van Setten J, Isgum I, Galesloot TE, Arpegård J, Amouyel P, Trompet S, Waldenberger M, Dörr M, Magnusson PK, Giedraitis V, Larsson A, Morris AP, Felix JF, Morrison AC, Franceschini N, Bis JC, Kavousi M, O'Donnell C, Drenos F, Tragante V, Munroe PB, Malik R, Dichgans M, Worrall BB, Erdmann J, Nelson CP, Samani NJ, Schunkert H, Marchini J, Patel RS, Hingorani AD, Lind L, Pedersen NL, de Graaf J, Kiemeney LA, Baumeister SE, Franco OH, Hofman A, Uitterlinden AG, Koenig W, Meisinger C, Peters A, Thorand B, Jukema JW, Eriksen BO, Toft I, Wilsgaard T, Onland-Moret NC, van der Schouw YT, Debette S, Kumari M, Svensson P, van der Harst P, Kivimaki M, Keating BJ, Sattar N, Dehghan A, Reiner AP, Ingelsson E, den Ruijter HM, de Bakker PI, Pasterkamp G, Ärnlöv J, Holmes MV, Asselbergs FW

Background: Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. Objectives: The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population. Methods: We incorpor... Abstract

Cited 7 times since 2016 (0.8 per year) source: EuropePMC

The American journal of cardiology, Volume 118, Issue 8, 29 5 2016, Pages 1217-1224 Long-Term Echocardiographic Outcome in Super-Responders to Cardiac Resynchronization Therapy and the Association With Mortality and Defibrillator Therapy. van der Heijden AC, Höke U, Thijssen J, Willem Borleffs CJ, Wolterbeek R, Schalij MJ, van Erven L

Super-response to cardiac resynchronization therapy (CRT) is associated with significant left ventricular (LV) reverse remodeling and improved clinical outcome. The study aimed to: (1) evaluate whether LV reverse remodeling remains sustained during long-term follow-up in super-responders and (2) analyze the association between the course of LV reverse remodeling and ventricular arrhythmias. Of all, primary prevention super-responders to CRT were selected. Super-response was defined as LV end-sys... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 6, 29 5 2016, Pages 1399-1410 Diagnostic and prognostic roles of echocardiography and cardiac magnetic resonance. Delgado V, Bucciarelli-Ducci C, Bax JJ

Accurate prediction of sudden cardiac death due to ventricular arrhythmia remains challenging. Left ventricular ejection fraction has shown an association with increased risk of ventricular arrhythmias and is included in the recommendations for implantable cardioverter defibrillator as primary prevention. However, left ventricular ejection fraction may be normal in a large number of patients who are at risk of ventricular arrhythmias. Echocardiography remains the imaging technique of first choic... Abstract

Cited 30 times since 2016 (3.4 per year) source: EuropePMC

Scientific reports, Volume 6, 27 4 2016, Pages 30439 Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model. Wong C, Bezhaeva T, Rothuizen TC, Metselaar JM, de Vries MR, Verbeek FP, Vahrmeijer AL, Wezel A, van Zonneveld AJ, Rabelink TJ, Quax PH, Rotmans JI

Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulat... Abstract

Cited 19 times since 2016 (2.1 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 102, Issue 6, 22 4 2016, Pages 1981-1987 Effect of Aortic Valve Replacement on Aortic Root Dilatation Rate in Patients With Bicuspid and Tricuspid Aortic Valves. Regeer MV, Versteegh MI, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Background: It remains unclear whether aortic valve replacement (AVR) has an effect on the aortic root dilatation rate in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). The present study evaluated the pre- and postoperative annual aortic root dilatation rates in BAV and TAV. Methods: A total of 93 patients (67 ± 11 years; 71% men) who underwent AVR between 2003 and 2013 and had at least 2 pre- and postoperative echocardiographic studies 1 year or more apart were incl... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

Nuklearmedizin. Nuclear medicine, Volume 55, Issue 5, 20 3 2016, Pages 196-202 Sex differences in absolute myocardial perfusion. Non-invasive H2(15)O-PET in young healthy adults. Range FT, Kies P, Schäfers KP, Breithardt G, Schober O, Wichter T, Schäfers MA

Aim: To investigate sex differences in myocardial perfusion especially in healthy individuals since former studies are rare and findings are controversial. Participants, methods: 26 subjects were enrolled: 16 healthy women (age: 34 ±7 years) were compared with 10 healthy men (age: 34 ± 3 years; p = ns). Myocardial blood flow (MBF) and coronary vascular resistance (CVR) were quantified at rest, during adenosine infusion and cold-pressor-testing, using positron emission tomography and radioactive-... Abstract

Cited 15 times since 2016 (1.7 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 29, Issue 9, 19 3 2016, Pages 871-878 Prevalence and Correlates of Early Right Ventricular Dysfunction in Sarcoidosis and Its Association with Outcome. Joyce E, Kamperidis V, Ninaber MK, Katsanos S, Debonnaire P, Schalij MJ, Taube C, Bax JJ, Delgado V, Ajmone Marsan N

Background: Right ventricular (RV) function has not been systematically assessed in sarcoidosis. The aim of this study was to assess the prevalence and associates of RV dysfunction in sarcoidosis using global longitudinal peak systolic strain (GLS). Furthermore, whether RV dysfunction was associated with clinical outcomes was investigated. Methods: A total of 88 patients with sarcoidosis (mean age, 54 ± 13 years; 51% men) without known sarcoid-related or other structural heart disease or alterna... Abstract

Cited 5 times since 2016 (0.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 3, 19 3 2016, Pages 476-481 Valve-sparing root replacement in children. Kluin J, Koolbergen DR, Sojak V, Hazekamp MG

Objectives: In children, words of caution have been raised about valve-sparing procedures especially regarding the valve-remodelling technique. This study reviewed our experience with the valve-sparing reimplantation technique in children. Methods: All consecutive paediatric ( Abstract

Cited 12 times since 2016 (1.4 per year) source: EuropePMC

Congenital heart disease, Volume 12, Issue 1, 18 3 2016, Pages 40-48 Comparative Evaluation of Flow Quantification across the Atrioventricular Valve in Patients with Functional Univentricular Heart after Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization. She HL, Roest AA, Calkoen EE, van den Boogaard PJ, van der Geest RJ, Hazekamp MG, de Roos A, Westenberg JJ

Purpose: To evaluate the inflow pattern and flow quantification in patients with functional univentricular heart after Fontan's operation using 4D flow magnetic resonance imaging (MRI) with streamline visualization when compared with the conventional 2D flow approach. Method: Seven patients with functional univentricular heart after Fontan's operation and twenty-three healthy controls underwent 4D flow MRI. In two orthogonal two-chamber planes, streamline visualization was applied, and... Abstract

Cited 12 times since 2016 (1.4 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 32, Issue 10, 12 2 2016, Pages 1567-1575 Incidence of persistent renal dysfunction after contrast enhanced coronary CT angiography in patients with suspected coronary artery disease. Maaniitty T, Stenström I, Uusitalo V, Ukkonen H, Kajander S, Bax JJ, Saraste A, Knuuti J

Contrast-induced nephropathy (CIN) is a potentially serious complication of contrast agents used in computed tomography angiography (CTA). The aim of this study was to evaluate whether persistent renal dysfunction occurs in patients undergoing coronary CTA for suspected stable coronary artery disease (CAD). From a cohort of 957 patients undergone coronary CTA, we identified 402 patients with plasma creatinine levels collected before and within 6 months after CTA. According to the definition of C... Abstract

International journal of cardiology, Volume 221, 9 2 2016, Pages 682-687 Haptoglobin polymorphism in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and near-infrared spectroscopy in patients with coronary artery disease. Buljubasic N, Oemrawsingh RM, Smeets MB, Cheng JM, Regar E, van Geuns RJ, Serruys PW, Boersma E, Akkerhuis KM, Kardys I, Arslan F

Background: Conflicting results exist regarding the association between a common Haptoglobin (Hp) polymorphism and risk of coronary artery disease. We investigated the association of three functionally different anti-oxidant and anti-inflammatory Hp phenotypes (Hp1-1, Hp2-1, Hp2-2) with invasively measured degree and composition of coronary atherosclerosis as determined by intravascular ultrasound (-virtual histology) (IVUS(-VH)) as well as near-infrared spectroscopy (NIRS). Methods: Non-culprit... Abstract

Cited 2 times since 2016 (0.2 per year) source: EuropePMC

African journal of traditional, complementary, and alternative medicines : AJTCAM, Volume 13, Issue 4, 3 1 2016, Pages 191-198 EFFECT OF HARVEST DATE AND STALK SECTION ON SELECTED STRENGTH CHARACTERISTICS OF TURKISH OREGANO (<i>Origanum onites</i> L). Yilmaz D, Jasinskas A

Background: The time required to harvest plant crops is important to the plant properties. It is affected by design of the harvest equipment and the desire for high-quality products with low energy usage. Materials and methods: Strength characteristics of Origanum onites L., an important medicinal aromatic plant, harvested on 2, 9, 16 and 23 July, 2012-2014 (H1, H2, H3 and H4, respectively) were measured at the bottom and top sections of the stalk. Measurements included maximum force, bio-yield... Abstract

Cited 82 times since 2016 (9.2 per year) source: EuropePMC

Lab on a chip, Volume 16, Issue 14, 1 1 2016, Pages 2644-2653 Engineering a perfusable 3D human liver platform from iPS cells. Schepers A, Li C, Chhabra A, Seney BT, Bhatia S

In vitro models of human tissue are crucial to our ability to study human disease as well as develop safe and effective drug therapies. Models of single organs in static and microfluidic culture have been established and shown utility for modeling some aspects of health and disease; however, these systems lack multi-organ interactions that are critical to some aspects of drug metabolism and toxicity. Thus, as part of a consortium of researchers, we have developed a liver chip that meets the foll... Abstract

Cited 54 times since 2016 (6.1 per year) source: EuropePMC

Circulation, Volume 134, Issue 3, 1 1 2016, Pages 212-221 Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects. Smit RA, Trompet S, Sabayan B, le Cessie S, van der Grond J, van Buchem MA, de Craen AJ, Jukema JW

Background: Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. Methods: We investigated the association between LDL-C variability and 4 cognitive domains at month 30 in 4428 participants of PROSPER (PROspective Study of Pravastatin in the Elderly at Risk... Abstract

Cited 5 times since 2016 (0.6 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 24, Issue 7, 1 1 2016, Pages 1096 Genome-wide association studies identify genetic loci for low von Willebrand factor levels. van Loon J, Dehghan A, Weihong T, Trompet S, McArdle WL, Asselbergs FW, Chen MH, Lopez LM, Huffman JE, Leebeek FW, Basu S, Stott DJ, Rumley A, Gansevoort RT, Davies G, Wilson JJ, Witteman JC, Cao X, de Craen AJ, Bakker SJ, Psaty BM, Starr JM, Hofman A, Jukema JW, Deary IJ, Hayward C, van der Harst P, Lowe GD, Folsom AR, Strachan DP, Smith N, de Maat MP, O'Donnell C

Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

Archives of medical science : AMS, Volume 12, Issue 4, 1 1 2016, Pages 697-703 Serum paraoxonase 1 activity in patients with iron deficiency anemia. Okuturlar Y, Gedikbasi A, Akalin N, Gunaldi M, Yilmaz D, Mert M, Harmankaya O, Soylu A, Karakaya P, Kumbasar A

Introduction: In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy. Material and methods: In this study, 50 adult patients with IDA and 40 healthy subjects were enrolled. All patients were analyzed at the beginning and after treatment according to laboratory assessments. Results: Mean paraoxonase and arylesterase activities in the iron deficiency anemia group were signifi... Abstract

Cited 7 times since 2016 (0.8 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 7-8, 1 1 2016, Pages 441-446 Redesigning healthcare: The 2.4 billion euro question? : Connecting smart technology to improve outcome of patients. Treskes RW, Van Der Velde ET, Atsma DE, Schalij MJ

Although it has been possible to transfer electrocardiograms via a phone line for more than 100 years, use of internet-based patient monitoring and communication systems in daily care is uncommon. Despite the introduction of numerous health-monitoring devices, and despite most patients having internet access, the implementation of individualised healthcare services is still limited. On the other hand, hospitals have invested heavily in massive information systems offering limited value for money... Abstract

Cited 19 times since 2016 (2.1 per year) source: EuropePMC

The Journal of general virology, Volume 97, Issue 9, 30 5 2016, Pages 2255-2264 Comparison of norovirus genogroup I, II and IV seroprevalence among children in the Netherlands, 1963, 1983 and 2006. van Beek J, de Graaf M, Xia M, Jiang X, Vinjé J, Beersma M, de Bruin E, van de Vijver D, Holwerda M, van Houten M, Buisman AM, van Binnendijk R, Osterhaus ADME, van der Klis F, Vennema H, Koopmans MPG

Noroviruses are a major cause of acute gastroenteritis worldwide and are a genetically diverse group of viruses. Since 2002, an increasing number of norovirus outbreaks have been reported globally, but it is not clear whether this increase has been caused by a higher awareness or reflects the emergence of new genogroup II genotype 4 (GII.4) variants. The hypothesis that norovirus prevalence has increased post-2002 and is related to the emergence of GII.4 is tested in this study. Sera collected f... Abstract

Cited 9 times since 2016 (1 per year) source: EuropePMC

PLoS genetics, Volume 12, Issue 6, 29 5 2016, Pages e1006166 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Sc

[This corrects the article DOI: 10.1371/journal.pgen.1005378.]. Abstract

Cited 122 times since 2016 (13.7 per year) source: EuropePMC

Genome biology, Volume 17, Issue 1, 27 4 2016, Pages 138 Blood lipids influence DNA methylation in circulating cells. Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei H, Zhernakova DV, van den Berg LH, Deelen J, van Dongen J, van Heemst D, Hofman A, Hottenga JJ, van der Kallen CJ, Schalkwijk CG, Stehouwer CD, Tigchelaar EF, Uitterlinden AG, Willemsen G, Zhernakova A, Franke L, 't Hoen PA, Jansen R, van Meurs J, Boomsma DI, van Duijn CM, van Greevenbroek MM, Veldink JH, Wijmenga C, BIOS Consortium, van Zwet EW, Slagboom PE, Jukema JW, Heijmans BT

Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To interrogate the causal relationship between triglyceride, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels and genome-wide DNA methylation while excludi... Abstract