Research

Publications

Below you can find a list of our published research.

7503 results

Nederlands tijdschrift voor geneeskunde, Volume 169, 18 3 2025, Pages D8577 [The role of clinical practice guidelines in the assessment by the disciplinary board]. Weller FS, van Bodegom-Vos L, Repping S, Hamming JF

Objective: To examine how often disciplinary complaints against physicians are upheld explicitly on the grounds of deviation from clinical practice guidelines. Design: Retrospective document analysis of publicly available medical disciplinary rulings in the Netherlands between January 1, 2019, and December 31, 2023. Methods: We analysed rulings from the official Dutch disciplinary law database (tuchtrecht.nl). All upheld complaints were reviewed to determine whether the disciplinary board explic... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 18 3 2025 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Full version. Peijster AJL, van Nieuwkoop C, Keunen RWM, Felix S, van Welzen BJ, Kouijzer IJE, Boel CHE, Verkaik NJ, Lam KY, Klautz RJM, Glaudemans AWJM, Budde RPJ, Maass AH, Knops RE, Kamp O, Tanis W

This review evaluates the 2023 European Society of Cardiology (ESC) guidelines for the management of infective endocarditis (IE) and offers insights into topics particularly relevant to clinical practice in the Netherlands. The multidisciplinary IE Working Group assessed all ESC recommendations and concluded that the majority could be endorsed, albeit with certain modifications. The IE Working Group presents a refined (and simplified) antibiotic prophylactic regimen and an updated table to guide... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 18 3 2025 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Short version. Peijster AJL, van Nieuwkoop C, Keunen RWM, Felix S, van Welzen BJ, Kouijzer IJE, Boel CHE, Verkaik NJ, Lam KY, Klautz RJM, Glaudemans AWJM, Budde RPJ, Maass AH, Knops RE, Kamp O, Tanis W

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 17 3 2025, Pages ezaf461 Mitral annular disjunction: a roadmap for the surgeon. Bonaros N, Gollmann-Tepeköylü C, Palmen M, Ajmone N, Delgado V, Garbi M, Mayr A, Pölzl L, Marin-Cuartas M, Ascione G, Azzola Guicciardi N, Troger F, Pereda D, Klautz R, De Bonis M, Borger MA, Perier P

Objectives: Mitral annular disjunction (MAD) is a structural abnormality of the mitral annulus fibrosus, associated with myxomatous leaflet degeneration, mitral valve prolapse (MVP), and ventricular arrhythmias. The combination of annular dilatation and abnormal annular motion increases mechanical stress on the mitral leaflets, triggering the degenerative process. Methods: This review summarizes the major pathophysiologic, diagnostic and therapeutic measures for the treatment of patients with MA... Abstract

Nature, 17 3 2025 An integrated view of the structure and function of the human 4D nucleome. Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Andréa W, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepińska T, Chiliński M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park PJ, Alver BH, Schroeder AJ, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit AD, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F

The dynamic three-dimensional (3D) organization of the human genome (the 4D nucleome) is linked to genome function. Here we describe efforts by the 4D Nucleome Project1 to map and analyse the 4D nucleome in widely used H1 human embryonic stem cells and immortalized fibroblasts (HFFc6). We produced and integrated diverse genomic datasets of the 4D nucleome, each contributing unique observations, which enabled us to assemble extensive catalogues of more than 140,000 looping interactions per cell t... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 16 3 2025 Left atrial appendage occlusion vs standard of care in high stroke risk atrial fibrillation patients ineligible for anticoagulation: COMPARE-LAAO. Aarnink EW, Huijboom MFM, van der Kley F, Folkeringa R, de Groot JR, van der Voort PH, Blaauw Y, Chaldoupi M, Stevenhagen J, Vlachojannis GJ, van Mieghem NM, Swaans MJ, van Dijk VF, Dijkgraaf MG, van Dijk EJ, Tijssen JGP, Boersma LVA

Introduction: The left atrial appendage is the dominant source of cardioembolic stroke in patients with atrial fibrillation (AF). Contemporary guidelines recommend considering left atrial appendage occlusion (LAAO) in AF patients contraindicated to oral anticoagulation therapy (OAC), but randomized controlled trial (RCT) data for this subpopulation are lacking. Methods: COMPARE LAAO was designed as an event-driven, multicenter, prospective, randomized, open, blinded endpoint (PROBE) trial that r... Abstract

JACC. Advances, Volume 5, Issue 1, 11 2 2025, Pages 102415 Prognostic Value of NT-proBNP in Patients Treated With Allogeneic Stem Cell Transplantation. Polomski EAS, von dem Borne PA, Veelken H, Heemelaar JC, Jukema JW, Antoni ML

Background: As survival rates after allogeneic stem cell transplantation (alloSCT) continue to grow, cardiovascular disease is becoming a major complication after alloSCT. However, the prognostic value of cardiac biomarkers has not been widely investigated. Objectives: This study aims to investigate the association between baseline N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in patients treated with alloSCT and mortality. Methods: Patients who were referred for alloSCT between... Abstract

JACC. Case reports, 10 2 2025, Pages 106227 Severe Aortic Stenosis and Dual Valve Vegetations: An Uncommon Presentation of Primary Antiphospholipid Syndrome. van der Woude SFS, Valentijn FA, Antoni ML, Huisman SJ, van Vliet M

Background: Primary antiphospholipid syndrome (PAPS) may cause thromboembolic events and valvular heart disease. Case summary: A 42-year-old woman with a history of pre-eclampsia, epilepsy, and thrombocytopenia presented with acute chest pain and shortness of breath. Investigations revealed vegetation on both the aortic and mitral valves, severe aortic stenosis, and a non-ST-segment elevation myocardial infarction. Autoimmune testing confirmed antiphospholipid antibodies, which led to a diagnosi... Abstract

Scientific reports, 10 2 2025 Sex-based differences in biomarker trajectories in acute coronary syndrome patients from the BIOMArCS study. Gärtner C, Haaf MET, Akkerhuis KM, Oemrawsingh RM, van Schaik RH, de Rijke YB, Kardys I, Appelman Y, Boersma E

Acute coronary syndrome (ACS) presents sex-based differences in pathophysiology. Variations in biomarker patterns post-ACS, reflecting myocardial injury, vascular inflammation, and remodeling, may indicate critical differences in cardiovascular disease mechanisms and outcomes. We analyzed biomarker patterns in 787 patients (22% females) from the BIOMArCS study, all without re-ACS during the study period. We tracked levels of hs-cTnT, NT-proBNP, hs-CRP, GDF-15, and additional biomarkers in a subc... Abstract

Allergy, 9 2 2025 Drug Survival in Atopic Dermatitis: Comparison of Biologics and JAK Inhibitors in the BioDay Registry. van der Gang LF, Boesjes CM, Zuithoff NPA, Haeck I, Bacoş-Cosma O, Loman L, Atash K, Harbers V, Stadhouders S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynski A, Christoffers WA, Garritsen FM, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, Galimont-Collen AFS, Schuttelaar MA, de Graaf M, de Bruin-Weller MS

Abstract

The New England journal of medicine, 9 2 2025 Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. Casey JD, Seitz KP, Driver BE, Gibbs KW, Ginde AA, Trent SA, Russell DW, Muhs AL, Prekker ME, Gaillard JP, Resnick-Ault D, Stewart LJ, Whitson MR, DeMasi SC, Robinson AE, Palakshappa JA, Aggarwal NR, Brainard JC, Douin DJ, Marvi TK, Scott BK, Alber SM, Lyle C, Gandotra S, Van Schaik GW, Lacy AJ, Sherlin KC, Erickson HL, Cain JM, Redman B, Beach LL, Gould B, McIntosh J, Lewis AA, Lloyd BD, Israel TL, Imhoff B, Wang L, Spicer AB, Churpek MM, Rice TW, Self WH, Han JH, Semler MW, RSI Investigators and the Pragmatic Critical Care Research Group

Background: For critically ill adults undergoing tracheal intubation, observational studies suggest that the use of etomidate to induce anesthesia may increase the risk of death. Whether the use of ketamine rather than etomidate decreases the risk of death is uncertain. Methods: In a randomized trial conducted in 14 emergency departments and intensive care units in the United States, we randomly assigned critically ill adults who were undergoing tracheal intubation to receive ketamine or etomida... Abstract

European heart journal. Cardiovascular Imaging, 8 2 2025, Pages jeaf336 Pitfalls and Solutions in the Imaging Follow-up of Valvular Heart Disease Devices. Ternacle J, Turgeon PY, Hahn RT, Marsan NA, Pibarot P

Doppler-echocardiography is the primary imaging modality for the evaluation and follow-up of valvular heart devices. This article highlights the unique pitfalls associated with these devices, including imaging challenges and flow dynamics, which often push echocardiography to its limits. The use of a multimodality imaging approach including cardiac computed tomography (CT) and magnetic resonance, and positron emission tomography-CT is recommended to confirm the diagnosis of prosthetic valve dysf... Abstract

Expert opinion on biological therapy, 7 1 2025, Pages 1-22 Current treatment landscape of atopic dermatitis focusing on real-world evidence of dupilumab treatment. Boesjes CM, van der Gang LF, Achten RE, Bakker DS, van der Rijst LP, Dekkers CC, van Wijk F, Haeck IM, de Bruin-Weller MS, de Graaf M

Introduction: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder and has a considerable impact on patients' quality of life. Dupilumab, the first biologic approved for moderate-to-severe AD, is a human monoclonal antibody targeting the interleukin (IL)-4 receptor α, thereby blocking both IL-4 and IL-13 signaling, key drivers of type 2 inflammation in AD. Its introduction has marked a paradigm shift in the management of AD and paved the way for future therapies. As real... Abstract

ESMO open, Volume 10, Issue 12, 5 1 2025, Pages 105923 Pathological complete response and survival after neoadjuvant chemotherapy in patients with stage I TNBC: a registry-based study. de Graaf M, Gielen RCAM, Balduzzi S, Siesling S, Linn SC, Kok M

Background: Pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is a strong prognostic factor in patients with early-stage triple-negative breast cancer (TNBC). One-third of all patients with early-stage TNBC have stage I disease. Chemotherapy is recommended for most patients with stage I TNBC with an increasing use in the neoadjuvant setting supported by recent guidelines. However, little is known on the chemotherapy benefit for stage I TNBC, in particular the likelihood... Abstract

JAC-antimicrobial resistance, Volume 7, Issue 6, 5 1 2025, Pages dlaf229 Increasing trend in fusidic acid resistance among MRSA isolates in the Netherlands, 2016-23. Velthuis F, Nauta IM, Altorf-van der Kuil W, Notermans DW, Zwittink RD, Schoffelen AF, de Greeff SC, Infectious Diseases Surveillance Information System–Antimicrobial Resistance (ISIS–AR) Study Group

Objectives: Recently, several MRSA community outbreaks occurred in the Netherlands, including one caused by an impetigo-causing MRSA strain resistant to fusidic acid. Since fusidic acid and flucloxacillin are the main treatment options for impetigo, increasing resistance limits treatment possibilities. We examined trends in fusidic acid resistance percentages among MRSA isolates in the Netherlands. Materials and methods: Data on routine bacteriological cultures between 2016 and 2023 from 30 labo... Abstract

United European gastroenterology journal, 5 1 2025 Filgotinib Is an Effective and Safe Treatment Option for Difficult-To-Treat Ulcerative Colitis: Real-World Evidence of the Dutch Initiative on Crohn and Colitis (ICC) Registry. Naber MR, van der Meulen AE, Voorneveld PW, Veltkamp SHC, van Bodegraven AA, Bodelier A, Mujagic Z, Pierik M, Verleye LMM, Duijvestein M, Bouwknegt DG, Visschedijk MC, Srivastava N, West RL, Oldenburg B, Löwenberg M, van Schaik FDM, Dutch ICC Registry

Background: Filgotinib is a preferential Janus kinase 1 (JAK-1) inhibitor registered for the treatment of ulcerative colitis (UC). Real-world effectiveness of filgotinib, especially for difficult-to-treat (DTT, failure of ≥ 2 prior advanced therapies) patients, has been scarcely reported. Objective: This study aimed to assess the effectiveness and safety of filgotinib for UC patients in routine care. Methods: The Dutch ICC registry enrolled UC patients initiating filgotinib and prospectively eva... Abstract

Circulation. Cardiovascular imaging, 4 1 2025, Pages e018862 Global Longitudinal Strain for Prognostic Staging in Wild-Type Transthyretin Cardiac Amyloidosis. Debonnaire P, L'Hoyes W, Donal E, Verheyen N, Vervloet D, Dujardin K, Pouleur AC, Dulgheru R, Sarli Issa V, Droogmans S, Jurcut R, Regeer M, Dupont M, Bondue A, Timmermans P, Bohyn A, Christiaen E, Wyseure N, Bezard M, Zach D, Schwegel N, Knapen R, Buytaert L, de Marneffe N, Adam R, Ajmone Marsan N, Tavernier R, Buysschaert I, Trenson S

Background: A formal prognostic staging system in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), based on echocardiographic imaging, is lacking. We evaluated the prognostic performance of global longitudinal strain (GLS) staging in a large ATTRwt-CM patient cohort, including under tafamidis treatment and relative to National Amyloidosis Center (NAC) biomarker staging. Methods: A multicentric, international ATTRwt-CM patient cohort with baseline GLS (distribution quartiles), evaluate... Abstract

Journal of the American Heart Association, 3 1 2025, Pages e046283 Anrep Effect in the Right Ventricle: Evidence From Systolic Duration Analysis. Reil JC, Sequeira V, Wink J, Federspiel JM, Reil GH, Steendijk P

Abstract

Annals of hepatology, 3 1 2025, Pages 102170 Genetic risk factors for MASLD/MASH and cardiovascular disease in elderly individuals. Theel WB, de Jong VD, Grobbee DE, Jukema JW, Trompet S, Cabezas MC

Introduction and objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, MASH, are closely related to obesity and lifestyle. From previous studies, MASLD is also known for its strong genetic background. This study aimed to investigate the association between previously reported genetic polymorphisms of MASLD/MASH and clinical outcomes in an elderly Western European population. Patients and methods: We performed an analysis of 5,244 participants (mea... Abstract

Cardiovascular diabetology, Volume 24, Issue 1, 2 1 2025, Pages 453 Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes. Mäenpää M, Jukema RA, van Diemen P, Bär S, Raijmakers PG, Sprengers R, Driessen RS, Bax JJ, Knaapen P, Knuuti J, Danad I, Saraste A, Maaniitty T

Background: Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary computed tomography angiography (CTA) whereas positron emission tomography (PET) enables quantitative assessment of myocardial perfusion. We studied the prognostic implications of quantitatively measured coronary plaque burden and myocardial perfusion in diabetic vs. non-diabetic patients with suspe... Abstract