Research

Publications

Below you can find a list of our published research.

7971 results

Journal of the peripheral nervous system : JPNS, Volume 30, Issue 2, 1 1 2025, Pages e70031 Validity and Responsiveness of Balance Measurements Using Posturography in Patients With Immune-Mediated Neuropathies. Michael MR, van Veen R, Wieske L, Merkies ISJ, van Schaik IN, Eftimov F

Background and aims: Validated objective measures for balance in immune mediated neuropathies are lacking. In this study, we investigated the clinimetric properties of posturography using a force platform, a quantitative assessment of postural control. Methods: We assessed patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and IgM-related polyneuropathy (IgM-PNP) using sway parameters (path, area and amplitude) measured at multiple time points. Validity was investigated by as... Abstract

The clinical teacher, Volume 22, Issue 3, 1 1 2025, Pages e70073 Faculty Development for the People: Workplace-Based Solutions for Busy Clinicians. Brode EC, Bernal JM, Cornes SB, Santhosh L, Rivera JA, Kulkarni SA, Mandal JR, Henry DM, Bartz KS, Van Schaik SM

Background: Across clinical learning environments (CLEs), learners often encounter supervising clinicians who do not self-identify as educators and, therefore, may not seek out faculty development to augment their teaching skills. To reach those faculty, we conducted a proof-of-concept project framed by Billet's theory on workplace learning, bringing tailored faculty development to the clinical workplace. Approach: We recruited 22 faculty champions from 8 clinical departments at our institu... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 27 4 2025 Comparison of Procedural and Clinical Outcomes of Angiography- Versus Imaging-Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy. Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is an innovative treatment for coronary artery calcification (CAC). Aims: This study aimed to compare procedural and clinical outcomes of intracoronary imaging (ICI)-guided percutaneous coronary intervention (PCI) versus angiography-guided PCI with IVL in patients with CAC. Methods: A total of 509 patients were analyzed from the BENELUX-IVL registry (May 2019 to September 2024). Angiography-guided PCI with IVL was defined as therapy under solely fluoro... Abstract

The Journal of dermatological treatment, Volume 36, Issue 1, 27 4 2025, Pages 2503273 Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers. van der Rijst LP, de Bruin-Weller MS, Zuithoff NPA, Spillekom-van Koulil S, Seyger MMB, de Graaf M

Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups. Materials and methods: A web-based survey was conducted among children (6-11 years), adolescents (12-17 years), and young adults (18-30 years) with AD and caregivers of AD patients. Survey questions included multiple-choice, four-po... Abstract

Journal of cardiac failure, 23 4 2025, Pages S1071-9164(25)00236-2 The Association between Serially Measured Circulating Biomarker Patterns and Pulmonary Artery Pressures measured by Invasive Hemodynamic Monitoring. de Jong MBL, Allach Y, Kamar SA, Clephas PRD, Brunner-La Rocca HP, Handoko ML, van de Halm VP, Kok WEM, Asselbergs FW, van Kimmenade R, Beeres SLMA, Rienstra M, Szymanski MK, de Boer RA, Kardys I, Brugts JJ

Aims: Invasive hemodynamic monitoring devices provide relevant insights into the remote hemodynamic status of heart failure (HF) patients. Additionally, circulating biomarkers have been advocated as additive in HF management by offering prognostic information and therapeutic targets. However, limited data exist correlating serially measured biomarkers to hemodynamic pressures provided by invasive sensors. This study aims to investigate the association between serial biomarker patterns and pulmon... Abstract

Bone research, Volume 13, Issue 1, 23 4 2025, Pages 55 Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging. Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R

Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss. Our study uses the prematurely aged PolgD257A/D257A (PolgA) mouse... Abstract

The international journal of cardiovascular imaging, 22 4 2025 Evolution and prognostic implications of cardiac damage in women after transcatheter aortic valve implantation. Myagmardorj R, Fortuni F, Galloo X, Nabeta T, Meucci MC, Butcher SC, van der Kley F, Ajmone Marsan N, Bax JJ

Recently, a cardiac damage staging system has been proposed in patients with severe AS to improve risk stratification, but there is still paucity of data in women. Accordingly, we aimed to characterize the change in cardiac damage after transcatheter aortic valve implantation (TAVI), and to assess the prognostic value of cardiac damage staging in women. A total of 334 women (mean age 81 ± 7 years) with severe AS undergoing TAVI were included and retrospectively analyzed. Echocardiography was per... Abstract

BMC medical education, Volume 25, Issue 1, 22 4 2025, Pages 757 The effect of three different techniques used to improve vein prominence on the first peripheral venous catheterization experience in nursing students: a randomized controlled study. Yılmaz H, Yılmaz D, Çinar HG

Background: Peripheral venous catheterization (PVC) insertion is a complex sensory-motor skill that can be difficult for nursing students to acquire. Objectives: The authors aimed to examine the effect of three techniques used to improve vein prominence on achievement, knowledge, and psychomotor skills in the first PVC experience in nursing students. Methods: A single-center, parallel-group, randomized control study. Near-infrared light visualization (n = 49) and isometric exercise (n = 50) tech... Abstract

European urology oncology, 20 3 2025, Pages S2588-9311(25)00104-X Towards Defining Follow-up Strategies for Patients with Primary Intermediate-risk Non-muscle-invasive Bladder Cancer. Contieri R, Martini A, Beijert IJ, Mertens LS, Hentschel AE, Bründl J, Compérat EM, Plass K, Rodríguez O, Subiela Henríquez JD, Hernández V, de la Peña E, Alemany I, Turturica D, Pisano F, Soria F, Čapoun O, Bauerová L, Pešl M, Maxim Bruins H, Runneboom W, Herdegen S, Breyer J, Brisuda A, Calatrava A, Rubio-Briones J, Seles M, Mannweiler S, Bosschieter J, Kusuma VRM, Ashabere D, Huebner N, Seisen T, Claps F, Masson-Lecomte A, Liedberg F, Cohen D, Lunelli L, Cussenot O, Sheikh SE, Volanis D, Côté JF, Rouprêt M, Haitel A, Shariat SF, Mostafid AH, Nieuwenhuijzen JA, Zigeuner R, Dominguez-Escrig JL, Hacek J, Zlotta AR, Burger M, Evert M, de Kaa CAH, van der Heijden AG, Kiemeney LALM, Soukup V, Molinaro L, Hurle R, Paciotti M, Moschini M, Pradere B, Perdonà S, Gontero P, Llorente C, Algaba F, Palou J, N'Dow J, Ribal MJ, van der Kwast TH, Babjuk M, Sylvester RJ, van Rhijn BWG

Background and objective: The current European Association of Urology (EAU) guidelines on non-muscle-invasive bladder cancer (NMIBC) categorize patients into four risk groups. In 2024, a specific follow-up schedule was introduced for intermediate-risk (IR) disease. However, recommendations are based on expert opinion and restricted to patients with IR-NMIBC who have primary low-grade or high-grade/grade 2 disease. Our aim was to identify a subgroup of patients with IR-NMIBC who may require more... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 19 3 2025 Efficacy and Safety of Intravascular Lithotripsy in the Management of Underexpanded Stents: A Systematic Review and Meta-Analysis. Sagris M, Soulaidopoulos S, Papanikolaou A, Ktenopoulos N, van Oort MJH, Montero-Cabezas JM, Patsourakos N, Honton B, Tousoulis D, Tsioufis K

Background: Stent underexpansion significantly heightens the risk of major adverse cardiac events (MACE), and available treatment options for this condition remain limited. Intravascular Lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, emerges as a promising tool for underexpanded stents. Aims: This study examines the overall efficacy and safety of IVL, an until-now off-label modality, in the management of underexpanded stents.... Abstract

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 15 3 2025 Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum. van der Rijst LP, Knol EF, Zuithoff NPA, den Hartog Jager CF, van Wijk F, de Bruin-Weller MS, de Graaf M

Objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods: Twenty paediatric AD patients ( Abstract

Arthritis & rheumatology (Hoboken, N.J.), 12 2 2025 Differences in dynamics of specific anti-nuclear antibodies and their susceptibility to B cell targeting treatment in Systemic Lupus Erythematosus. van Dooren HJ, van Schaik M, Dorjée AL, Arends EJ, Mackay M, Laura C, Fox DA, Wofsy D, Smilek D, Aranow C, Dall'Era M, Huizinga TWJ, van Kooten C, Toes REM, Diamond B, Teng YKO, Suurmond J

Objective: The presence of anti-nuclear antibodies (ANAs) is characteristic for systemic lupus erythematosus (SLE). Antibody dynamics over time are thought to reflect the cellular source of ANAs and their therapeutic targetability. Anti-dsDNA is the most prevalent and well-studied of all ANAs, and fluctuations in anti-dsDNA serum levels are associated with disease activity. Antibody dynamics of other ANAs, such as antibodies targeting RNA-binding proteins (RBPs), are often considered more stable... Abstract

Heart & lung : the journal of critical care, Volume 73, 12 2 2025, Pages 108-113 Intravascular lithotripsy and temporary mechanical circulatory support for the treatment of heavily calcified coronary artery disease: insights from the BENELUX-IVL registry. Oliveri F, Merino I, van Oort MJH, Al Amri I, Bingen BO, Arslan F, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Kley F, Jukema JW, Montero-Cabezas J

Background: Intravascular lithotripsy (IVL) is increasingly utilized for the treatment of heavily calcified coronary lesions. However its use in conjunction with temporary mechanical circulatory support (tMCS) remains underexplored. Objective: This study aims to evaluate the current use of tMCS and IVL for the treatment of heavily calcified coronary lesions. Method: From the BENELUX-IVL prospective registry, patients who underwent IVL during PCI and required tMCS during the procedure were select... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 12 2 2025, Pages ezaf161 Sex difference in aortic root replacement with a stentless bioprosthesis. Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J

Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centers were included. Survival analyses were performed using the Kaplan-Meier method or Aahlen-Johansen with death as competing risk as relevant. Results were quantified using uni- a... Abstract

Annals of surgery, 8 2 2025 Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn's Disease after Ileocolic Resection: Results from A Prospective Multicenter Cohort Study. Bak MTJ, Oudijk L, Ooms AHAG, Beelen EMJ, van der Bilt JDW, Romberg-Camps M, Dijkstra G, Duijvestein M, van der Marel S, Stassen LPS, Maljaars PWJ, Buskens CJ, Lange JFM, Kats-Ugurlu G, Jansen SV, Jharap BJH, Horjus CS, van Schaik FDM, West RL, de Boer NKH, Janneke van der Woude C, Parikh K, van Ruler O, Doukas M, de Vries AC, RAP-CD study group; on behalf of the Dutch Initiative on Crohn and Colitis (ICC) & Dutch Initiative on Crohn and Colitis – Surgery (ICC-S)

Objective: This study assessed the association of histopathological features in the resection specimen of CD patients with (severe) endoscopic postoperative recurrence (ePOR) in a large prospective, multicenter cohort study. Summary background data: The predictive value of histopathologic features of the intestinal resection specimen for the risk of Crohn's disease (CD) recurrence after ileocolic (re-)resection (ICR) remains a matter of debate. Methods: CD patients (≥16 y) scheduled for ICR... Abstract

Psychological research, Volume 89, Issue 3, 8 2 2025, Pages 98 Moral decision-making 'on the fly'. Kusev P, Martin R, van Schaik P, Teal J

Over a century of research has focused on the consistency and inconsistency of human moral decision preferences. We proposed and found that moral decision preferences are flexible and shift towards newly learned moral rules when their application leads to utilitarian choices. Hence, decision-makers' psychological concept of morality is continually under construction (on the fly); based on learning, informed by changes in moral rules and specific moral contexts. Accordingly, in two experimen... Abstract

The Journal of hospital infection, 6 1 2025, Pages S0195-6701(25)00128-8 The use of a Poisson hidden Markov model for automated detection of hospital outbreaks with vancomycin-resistant enterococci in routine surveillance data. van Kessel SAM, Wielders CCH, van de Kassteele J, Verbon A, Schoffelen AF, ISIS-AR study group, SO-ZI/AMR study group

Background: Despite the low prevalence of infections due to vancomycin-resistant enterococci (VRE) in the Netherlands, VRE is a frequent source of hospital outbreaks. We investigated whether a Poisson hidden Markov model (PHMM) can detect in-hospital VRE outbreaks in routine data from the Dutch Infectious Diseases Surveillance Information System for Antimicrobial Resistance (ISIS-AR). Methods: We performed a retrospective data linkage study from 2013 up to 2023, including data from 89 hospitals... Abstract

Developmental psychology, 5 1 2025 Psychological needs and well-being through the eyes of vocational students in Aruba, Dutch Caribbean. Proveyer Llopiz MR, van Schaik SDM, Harkness S, Super CM, Denessen EJPG

Well-being has been thoroughly studied worldwide mostly using questionnaires. Still, it is unclear what well-being means in specific contexts, as studies found that both well-being and underlying psychological needs may vary across cultures. In Aruba, concerns were raised regarding youth well-being. Therefore, this project used a mixed-method approach to explore the development of young people's well-being in Aruba. By taking a culture and human development approach, this project aims to co... Abstract

Cancers, Volume 17, Issue 9, 3 1 2025, Pages 1557 Patterns of Recurrence After Postoperative Stereotactic Radiotherapy for Brain Metastases. Crouzen JA, Petoukhova AL, Hakstege M, van Schaik EEMW, Nandoe Tewarie RDS, Nabuurs RJA, Vos MJ, Kerkhof M, van der Vaart T, Koekkoek JAF, Hagenbeek RE, Yildirim FM, Wiltink LM, van der Voort van Zyp NCMG, Kiderlen M, Broekman MLD, Mast ME, Zindler JD

Background/objectives: Neurosurgical resection is the standard treatment for large brain metastases (BMs). Postoperative stereotactic radiotherapy (SRT) is used to reduce local recurrence (LR) but does not always prevent leptomeningeal disease (LMD). This study aims to analyze patterns of tumor recurrence and to identify opportunities for the further improvement of treatment efficacy. Methods: We included 147 patients who underwent resection and SRT for BMs. The distance between the resection ca... Abstract

The Science of the total environment, Volume 980, 3 1 2025, Pages 179386 Towards a European sustainable beneficiation of rare earth elements bearing minerals: a review. Gajendra N, Yilmaz D, Vila MC, de Lurdes Dinis M, Levei EA, Török AI, Avsar D, Kladis A, Preveniou A, Hansen AM, Aaen SB, Ferrando-Climent L

This review explores the multifaceted aspects of sustainable extraction of rare earth elements (REEs) bearing minerals within Europe, stressing the exploitation of local deposits, that together with the integration of cleaner and greener approaches (including circular economy approaches) might help to reduce dependency on imports and contribute to a greener economy. The mineralogical characteristics and distribution of REEs in European deposits are examined, alongside current and emerging benefi... Abstract