7313 results
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 31, Issue 7-8, 28 4 2023, Pages 315-323
The arrhythmogenic cardiomyopathy phenotype associated with PKP2 c.1211dup variant.
Bos TA, Piers SRD, Wessels MW, Houweling AC, Bökenkamp R, Bootsma M, Bosman LP, Evertz R, Hellebrekers DMEI, Hoedemaekers YM, Knijnenburg J, Lekanne Deprez R, van Mil AM, Te Riele ASJM, van Slegtenhorst MA, Wilde AAM, Yap SC, Dooijes D, Koopmann TT, van Tintelen JP, Barge-Schaapveld DQCM, European Reference Network for rare, low prevalence and complex diseases of the heart: ERN GUARD-Heart
Background: The arrhythmogenic cardiomyopathy (ACM) phenotype, with life-threatening ventricular arrhythmias and heart failure, varies according to genetic aetiology. We aimed to characterise the phenotype associated with the variant c.1211dup (p.Val406Serfs*4) in the plakophilin‑2 gene (PKP2) and compare it with previously reported Dutch PKP2 founder variants. Methods: Clinical data were collected retrospectively from medical records of 106 PKP2 c.1211dup heterozygous carriers. Using data from...
Abstract
Cited 12 times since 2023 (5.6 per year)
source: EuropePMC
Annals of surgery,
Volume 278, Issue 5, 27 4 2023, Pages 772-780
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.
Greijdanus NG, Wienholts K, Ubels S, Talboom K, Hannink G, Wolthuis A, de Lacy FB, Lefevre JH, Solomon M, Frasson M, Rotholtz N, Denost Q, Perez RO, Konishi T, Panis Y, Rutegård M, Hompes R, Rosman C, van Workum F, Tanis PJ, de Wilt JHW, TENTACLE-Rectum Collaborative Group
Objective: To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL). Background: AL after RC resection often results in a permanent stoma. Methods: This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were include...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Annals of surgery,
Volume 278, Issue 5, 27 4 2023, Pages 815-822
Persistent High Long-term Excess Mortality After Elective AAA Repair Especially in Women: A Large Population-based Study.
Bulder RMA, van der Vorst JR, van Schaik J, Bedene A, Lijfering WM, Bastiaannet E, Hamming JF, Lindeman JHN
Objective: The aim of this time-trend analysis is to estimate long-term excess mortality and associated cardiovascular risk for abdominal aortic aneurysm (AAA) patients after elective repair while addressing the changes in AAA management and patient selection over time. Background: Despite the intensification of endovascular aneurysm repair and cardiovascular risk management, Swedish population data suggest that AAA patients retain a persistently high long-term mortality after elective repair. T...
Abstract
Journal of clinical medicine,
Volume 12, Issue 15, 26 4 2023, Pages 4921
Increased Aortic Exclusion in Endovascular Treatment of Complex Aortic Aneurysms.
Verhagen M, Eefting D, van Rijswijk C, van der Meer R, Hamming J, van der Vorst J, van Schaik J
Purpose: Perioperative risk assessments for complex aneurysms are based on the anatomical extent of the aneurysm and do not take the length of the aortic exclusion into account, as it was developed for open repair. Nevertheless, in the endovascular repair (ER) of complex aortic aneurysms, additional segments of healthy aorta are excluded compared with open repair (OR). The aim of this study was to assess differences in aortic exclusion between the ER and OR of complex aortic aneurysms, to subseq...
Abstract
Cited 15 times since 2023 (6.9 per year)
source: EuropePMC
Clinical chemistry and laboratory medicine,
Volume 62, Issue 1, 25 4 2023, Pages 118-127
Determination of cortisone and cortisol in human scalp hair using an improved LC-MS/MS-based method.
Mirzaian M, van Zundert SKM, Schilleman WF, Mohseni M, Kuckuck S, van Rossum EFC, van Schaik RHN, van den Berg SAA
Objectives: Human scalp hair is an easily available but complex matrix for determination of cortisone and cortisol, and has been shown to reflect long-term glucocorticoid exposure. Hair glucocorticoid analysis has been used to detect hypo- and hypercortisolism. In this study, we describe the development and validation of a LC-MS/MS method for quantification of cortisone and cortisol in human scalp hair, and provide a novel approach for analysis and interpretation of the results. Methods: Improve...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Pediatric cardiology,
Volume 45, Issue 8, 24 4 2023, Pages 1627-1635
Comparison of Four-Dimensional Flow MRI, Two-Dimensional Phase-Contrast MRI and Echocardiography in Transposition of the Great Arteries.
Warmerdam EG, Westenberg JJM, Voskuil M, Rijnberg FM, Roest AAW, Lamb HJ, van Wijk B, Sieswerda GT, Doevendans PA, Ter Heide H, Krings GJ, Leiner T, Grotenhuis HB
Pulmonary artery (PA) stenosis is a common complication after the arterial switch operation (ASO) for transposition of the great arteries (TGA). Four-dimensional flow (4D flow) CMR provides the ability to quantify flow within an entire volume instead of a single plane. The aim of this study was to compare PA maximum velocities and stroke volumes between 4D flow CMR, two-dimensional phase-contrast (2D PCMR) and echocardiography. A prospective study including TGA patients after ASO was performed b...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
International journal of medical informatics,
Volume 177, 22 4 2023, Pages 105160
An overview of facilitators and barriers in the development of eHealth interventions for people of low socioeconomic position: A Delphi study.
Al-Dhahir I, Breeman LD, Faber JS, Reijnders T, van den Berg-Emons HJG, van der Vaart R, Janssen VR, Kraaijenhagen R, Visch VT, Chavannes NH, Evers AWM, Medical Delta program eHealth and self-management
Objective: eHealth interventions can improve the health outcomes of people with a low socioeconomic position (SEP) by promoting healthy lifestyle behaviours. However, developing and implementing these interventions among the target group can be challenging for professionals. To facilitate the uptake of effective interventions, this study aimed to identify the barriers and facilitators anticipated or experienced by professionals in the development, reach, adherence, implementation and evaluation...
Abstract
Cited 6 times since 2023 (2.8 per year)
source: EuropePMC
Virus research,
Volume 334, 21 3 2023, Pages 199175
Establishing immunogenicity and safety of needle-free intradermal delivery by nanoporous ceramic skin patch of mRNA SARS-CoV-2 vaccine as a revaccination strategy in healthy volunteers.
Prins MLM, Prins C, de Vries JJC, Visser LG, Roukens AHE
Introduction: Nanoporous microneedle arrays (npMNA) are being developed as skin patches for vaccine delivery. As alternative for needle-based immunisation, they may potentially result in higher vaccine acceptance, which is important for future mass vaccination campaigns to control outbreaks, such as COVID-19, and for public vaccination in general. In this study we investigated the safety and immunogenicity of needle-free intradermal delivery of a fractional third or fourth dose of mRNA-1273 vacc...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Annals of cardiothoracic surgery,
Volume 12, Issue 4, 20 3 2023, Pages 350-357
Valve-sparing operations after Ross procedure: a single-center experience.
Jahanyar J, Arabkhani B, Zanella L, de Kerchove L, Tsai PI, Aphram G, Mastrobuoni S, El Khoury G
Background: The Ross procedure has demonstrated excellent long-term results, with restoration of life-expectancy in patients with severe aortic valve dysfunction. However, reintervention after Ross can occur, and herein we describe our center's experience with redo surgery after previous Ross procedures. Methods: We searched our prospective database for aortic valve-repair and recruited all adult (≥18 years) patients who have undergone valve-sparing root replacements (VSRRs) and/or aortic v...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
American journal of primatology,
Volume 85, Issue 9, 20 3 2023, Pages e23535
Alternative reproductive tactics of unflanged and flanged male orangutans revisited.
Kunz JA, Duvot GJ, Ashbury AM, Willems EP, Spillmann B, Dunkel LP, Bin Abdullah M, Schuppli C, Vogel ER, Utami Atmoko SS, van Noordwijk MA, van Schaik CP
In many slowly developing mammal species, males reach sexual maturity well before they develop secondary sexual characteristics. Sexually mature male orangutans have exceptionally long periods of developmental arrest. The two male morphs have been associated with behavioral alternative reproductive tactics, but this interpretation is based on cross-sectional analyses predominantly of Northwest Sumatran populations. Here we present the first longitudinal analyses of behavioral changes of 10 adult...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 12, Issue 14, 20 3 2023, Pages 4798
Catheter-Based Techniques for Addressing Atrioventricular Valve Regurgitation in Adult Congenital Heart Disease Patients: A Descriptive Cohort.
El Bouziani A, Witte LS, Bouma BJ, Jongbloed MRM, Robbers-Visser D, Straver B, Beijk MAM, Kiès P, Koolbergen DR, van der Kley F, Schalij MJ, de Winter RJ, Egorova AD
Introduction: Increasing survival of adult congenital heart disease (ACHD) patients comes at the price of a range of late complications-arrhythmias, heart failure, and valvular dysfunction. Transcatheter valve interventions have become a legitimate alternative to conventional surgical treatment in selected acquired heart disease patients. However, literature on technical aspects, hemodynamic effects, and clinical outcomes of percutaneous atrioventricular (AV) valve interventions in ACHD patients...
Abstract
Pediatric emergency care,
Volume 39, Issue 9, 19 3 2023, Pages 661-665
Parental Attitudes About Lumbar Puncture in Children With Suspected Central Nervous System Infection.
Sahin A, Kara-Aksay A, Demir G, Ekemen-Keles Y, Ustundag G, Berksoy E, Karadag-Oncel E, Yilmaz D
Objectives: This study aimed to evaluate parents' attitudes toward lumbar puncture (LP) for their children with suspected central nervous system infection to determine the reasons for rejection and related factors. Methods: The survey was provided to parents of children (1 month to 18 years old) for whom LP was recommended because of a concern for central nervous system infection. Sociodemographic characteristics and other related factors of parents who did and did not approve of LP were co...
Abstract
Cited 4 times since 2023 (1.8 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 9, Issue 8 Pt 3, 19 3 2023, Pages 1652-1664
Quantification of Large Transmural Biopsies Reveals Heterogeneity in Innervation Patterns in Chronic Myocardial Infarction.
Chen HS, Voortman LM, van Munsteren JC, Wisse LJ, Tofig BJ, Kristiansen SB, Glashan CA, DeRuiter MC, Zeppenfeld K, Jongbloed MRM
Background: Abnormal cardiac innervation plays an important role in arrhythmogenicity after myocardial infarction (MI). Data regarding reperfusion models and innervation abnormalities in the medium to long term after MI are sparse. Histologic quantification of the small-sized cardiac nerves is challenging, and transmural analysis has not been performed. Objectives: This study sought to assess cardiac innervation patterns in transmural biopsy sections in a porcine reperfusion model of MI (MI-R) u...
Abstract
Cited 4 times since 2023 (1.8 per year)
source: EuropePMC
Crystal growth & design,
Volume 23, Issue 8, 19 3 2023, Pages 6067-6080
Design and Validation of a Droplet-based Microfluidic System To Study Non-Photochemical Laser-Induced Nucleation of Potassium Chloride Solutions.
Korede V, Penha FM, de Munck V, Stam L, Dubbelman T, Nagalingam N, Gutta M, Cui P, Irimia D, van der Heijden AEDM, Kramer HJM, Eral HB
Non-photochemical laser-induced nucleation (NPLIN) has emerged as a promising primary nucleation control technique offering spatiotemporal control over crystallization with potential for polymorph control. So far, NPLIN was mostly investigated in milliliter vials, through laborious manual counting of the crystallized vials by visual inspection. Microfluidics represents an alternative to acquiring automated and statistically reliable data. Thus we designed a droplet-based microfluidic platform ca...
Abstract
Cited 7 times since 2023 (3.2 per year)
source: EuropePMC
Anatolian journal of cardiology,
Volume 27, Issue 11, 19 3 2023, Pages 628-638
The Definition of Sarcomeric and Non-Sarcomeric Gene Mutations in Hypertrophic Cardiomyopathy Patients: A Multicenter Diagnostic Study Across Türkiye.
Oktay V, Tüfekçioğlu O, Yılmaz DÇ, Onrat E, Karabulut D, Çelik M, Balcıoğlu AS, Sucu MM, Özdemir G, Kaya H, Kış M, Güven B, Bağdatoğlu O, Turhan Çağlar FN, Yüksel UÇ, Düzen İV, Barutçu A, Şimşir ÖS, Başarıcı İ, Parspur A, Dalgıç O, Arıcan Özlük FÖ, Evlice M, Sağ S, Deniz MF, Öcal A, Gazi E, Şen T, Özdabakoğlu O, Bayar Çakıcı N, Bakır EO, Ülgen Kunak A, Çaylı G, Gül Taşdelen A, Akşit E, Uslu Çil Ş, Onay H
Background: Hypertrophic cardiomyopathy is a common genetic heart disease and up to 40%-60% of patients have mutations in cardiac sarcomere protein genes. This genetic diagnosis study aimed to detect pathogenic or likely pathogenic sarcomeric and non-sarcomeric gene mutations and to confirm a final molecular diagnosis in patients diagnosed with hypertrophic cardiomyopathy. Methods: A total of 392 patients with hypertrophic cardiomyopathy were included in this nationwide multicenter study conduct...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
BMC cardiovascular disorders,
Volume 23, Issue 1, 19 3 2023, Pages 363
Thoracic aortic atherosclerosis in patients with a bicuspid aortic valve; a case-control study.
Dolmaci OB, Klautz RJM, Poelmann RE, Lindeman JHN, Sprengers R, Kroft L, Grewal N
Introduction: Bicuspid aortic valve (BAV) patients have an increased risk to develop thoracic aortic complications. Little is known about the prevalence and severity of atherosclerosis in the BAV ascending aortic wall. This study evaluates and compares the prevalence of thoracic aortic atherosclerosis in BAV and tricuspid aortic valve (TAV) patients. Methods: Atherosclerosis was objectified using three diagnostic modalities in two separate BAV patient cohorts (with and without an aortic dilatati...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Learning health systems,
Volume 8, Issue 1, 15 3 2023, Pages e10379
Learning healthcare systems in cardiology: A qualitative interview study on ethical dilemmas of a learning healthcare system.
Laurijssen S, van der Graaf R, Schuit E, den Haan M, van Dijk W, Groenwold R, le Sessie S, Grobbee D, de Vries M
Background: Implementation of an LHS in cardiology departments presents itself with ethical challenges, including ethical review and informed consent. In this qualitative study, we investigated stakeholders' attitudes toward ethical issues regarding the implementation of an LHS in the cardiology department. Methods: We conducted a qualitative study using 35 semi-structured interviews and 5 focus group interviews with 34 individuals. We interviewed cardiologists, research nurses, cardiovascu...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Journal of neuroendocrinology,
Volume 35, Issue 8, 13 2 2023, Pages e13317
Elevated IGF-1 concentrations in children with low grade glioma: A descriptive analysis in a retrospective national cohort.
van Schaik J, van Roessel IMAA, Bos ID, Claashen-van der Grinten HL, Clement SC, van Iersel L, Bakker B, Meijer L, Kremer L, Schouten-van Meeteren AYN, van Santen HM
Children with low grade glioma (LGG) may present with, or develop, elevated concentrations of insulin-like growth factor 1 (IGF-1). The prevalence, pathophysiology, or its possible clinical effects are poorly understood. Our aim was to evaluate the prevalence of such elevated IGF-1 concentrations and to describe its association with linear growth, body mass index (BMI), pituitary outcome, and tumor behavior in a large retrospective national cohort. From a nationwide retrospective cohort of pedia...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 182, 11 2 2023, Pages 107294
Feasibility of salvage resection following locoregional failure after chemoradiotherapy and consolidation durvalumab for unresectable stage III non-small cell lung cancer.
Dickhoff C, Unal S, Heineman DJ, Winkelman JA, Braun J, Bahce I, van Dorp M, Senan S, Dahele M
Introduction: In patients with unresectable stage III non-small cell lung cancer, high-dose chemoradiotherapy (CRT) followed by consolidation durvalumab improves the 5-year overall survival compared to CRT alone. The feasibility and safety of salvage surgery for such patients who subsequently develop locoregional failure (LRF) is unclear. We evaluated our institutional experience with radical-intent salvage surgery in this patient population. Materials and methods: Details of patients undergoing...
Abstract
Cited 24 times since 2023 (10.9 per year)
source: EuropePMC
Acta neuropathologica communications,
Volume 11, Issue 1, 11 2 2023, Pages 112
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D
Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~ 45% of patients living with frontotemporal lobar degeneration, but no disease-modifying therapy is available. Antibody therapy targeting other aggregating proteins associated with neurodegenerative disorders has shown beneficial effects in animal models and clinical trials. The most effective epitopes for safe antibody therapy targeting TD...
Abstract
