8616 results
Cited 15 times since 2010 (1 per year)
source: EuropePMC
Cardiovascular research,
Volume 88, Issue 2, 17 3 2010, Pages 367-375
A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease.
Eefting D, Seghers L, Grimbergen JM, de Vries MR, de Boer HC, Lardenoye JW, Jukema JW, van Bockel JH, Quax PH
Aims: Matrix metalloproteinases (MMP) and plasminogen activator (PA)/plasmin-mediated proteolysis, especially at the cell surface, play important roles in matrix degeneration and smooth muscle cell migration, which largely contributes to vein graft failure. In this study, a novel hybrid protein was designed to inhibit both protease systems simultaneously. MMP and plasmin activity were inhibited at the cell surface by this hybrid protein, consisting of the receptor-binding amino-terminal fragment...
Abstract
Cited 8 times since 2010 (0.5 per year)
source: EuropePMC
Cardiovascular therapeutics,
Volume 29, Issue 6, 14 2 2010, Pages e43-53
Coronary artery calcium scoring in cardiovascular risk assessment.
Nucifora G, Bax JJ, van Werkhoven JM, Boogers MJ, Schuijf JD
Identification of patients at risk of future coronary artery disease (CAD) events traditionally relies on scoring tools that take demographic and clinical characteristics into account (e.g., the Framingham risk score in the United States and the Heart Score in Europe). Although these scoring tools have been shown to have a good predictive value, they may still fail to recognize a proportion of patients with coronary atherosclerosis at risk for future CAD events. In order to improve risk stratifi...
Abstract
Cited 16 times since 2010 (1.1 per year)
source: EuropePMC
Journal of neuroimmunology,
Volume 226, Issue 1-2, 12 2 2010, Pages 147-149
HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.
de Graaf MT, de Beukelaar JW, Haasnoot GW, Levering WH, Rogemond V, Didelot A, Honnorat J, Gratama JW, Smitt PA
Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in...
Abstract
Cited 36 times since 2010 (2.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 106, Issue 2, 9 2 2010, Pages 198-203
Predictive value of total atrial conduction time estimated with tissue Doppler imaging for the development of new-onset atrial fibrillation after acute myocardial infarction.
Antoni ML, Bertini M, Atary JZ, Delgado V, ten Brinke EA, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, van de Veire NR
Patients who develop new-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) show an increased risk for adverse events and mortality during follow-up. Recently, a novel noninvasive echocardiographic method has been validated for the estimation of total atrial activation time using tissue Doppler imaging of the atria (PA-TDI duration). PA-TDI duration has shown to be independently predictive of new-onset AF. However, whether PA-TDI duration provides predictive value for new-ons...
Abstract
Cited 8 times since 2010 (0.5 per year)
source: EuropePMC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Volume 48, Issue 8-9, 9 2 2010, Pages 2443-2447
Evaluation of genotoxicity from Nilufer Stream (Bursa/Turkey) water using piscine micronucleus test.
Summak S, Aydemir NC, Vatan O, Yilmaz D, Zorlu T, Bilaloğlu R
In the present study, the in vivo micronucleus (MN) test in fish erythrocytes was used to evaluate the genotoxic potentials of water samples collected from four different sites along the Nilufer Stream which empties into the Marmara Sea on the north-west of Turkey. Nilufer Stream receives discharges of industrial and domestic wastes resulting from industrialization and urbanization activities in Bursa city. Nile tilapias (Oreochromis niloticus) were exposed to collected water samples under labor...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
The Journal of infection,
Volume 61, Issue 2, 9 2 2010, Pages 192-195
Clindamycin-resistant Staphylococcus aureus in foot ulcers of patients with diabetes.
Regeer MV, van Bon AC, Spanjaard L, Busch-Westbroek TE, van Schie CH, Geerlings SE, Devries JH
Abstract
Cited 97 times since 2010 (6.6 per year)
source: EuropePMC
Mediators of inflammation,
Volume 2010, 9 2 2010, Pages 704202
TLR2 and TLR4 in ischemia reperfusion injury.
Arslan F, Keogh B, McGuirk P, Parker AE
Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia and is associated with trauma, stroke, myocardial infarction, and solid organ transplantation. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important role for the innate immune system in initiating the inflammatory cascade leading to detrimental/deleterious changes. The Toll-like Receptors (TLRs) play a cent...
Abstract
Cited 18 times since 2010 (1.2 per year)
source: EuropePMC
Clinical orthopaedics and related research,
Volume 468, Issue 9, 8 2 2010, Pages 2485-2494
Developmental dysplasia of the hip: open reduction as a risk factor for substantial osteonecrosis.
Firth GB, Robertson AJ, Schepers A, Fatti L
Background: Kalamchi and MacEwen (K&M) described a four-group scheme for classifying osteonecrosis (ON) following treatment for developmental dysplasia of the hip (DDH). However, the four groups can overlap in radiographic appearance, making assessment difficult. Questions/purposes: We (1) describe a simplified K&M classification; (2) determined whether the simplified classification was reliable; and (3) assessed whether differences in the type of reduction or age at reduction resulted i...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 8, 8 2 2010, Pages 893-896
Gated myocardial SPECT imaging; true additional value in AMI?
van der Wall EE, Scholte AJ, Bax JJ
Abstract
Cited 9 times since 2010 (0.6 per year)
source: EuropePMC
PloS one,
Volume 5, Issue 6, 3 1 2010, Pages e10954
Rapid and sensitive lentivirus vector-based conditional gene expression assay to monitor and quantify cell fusion activity.
Gonçalves MA, Janssen JM, Holkers M, de Vries AA
Cell-to-cell fusion is involved in multiple fundamental biological processes. Prominent examples include osteoclast and giant cell formation, fertilization and skeletal myogenesis which involve macrophage, sperm-egg and myoblast fusion, respectively. Indeed, the importance of cell fusion is underscored by the wide range of homeostatic as well as pathologic processes in which it plays a key role. Therefore, rapid and sensitive systems to trace and measure cell fusion events in various experimenta...
Abstract
Cited 9 times since 2010 (0.6 per year)
source: EuropePMC
American heart journal,
Volume 159, Issue 6, 1 1 2010, Pages 1108-1115
Risk factors and outcome of new-onset cardiac arrhythmias in vascular surgery patients.
Winkel TA, Schouten O, Hoeks SE, Flu WJ, Hampton D, Kirchhof P, van Kuijk JP, Lindemans J, Verhagen HJ, Bax JJ, Poldermans D
Background: The pathophysiology of new-onset cardiac arrhythmias is complex and may bring about severe cardiovascular complications. The relevance of perioperative arrhythmias during vascular surgery has not been investigated. The aim of this study was to assess risk factors and prognosis of new-onset arrhythmias during vascular surgery. Methods: A total of 513 vascular surgery patients, without a history of arrhythmias, were included. Cardiac risk factors, inflammatory status, and left ventricu...
Abstract
Cited 179 times since 2010 (12.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 55, Issue 24, 1 1 2010, Pages 2769-2777
Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients.
Boogers MJ, Borleffs CJ, Henneman MM, van Bommel RJ, van Ramshorst J, Boersma E, Dibbets-Schneider P, Stokkel MP, van der Wall EE, Schalij MJ, Bax JJ
Objectives: The purpose of this study was to evaluate whether 123-iodine metaiodobenzylguanidine (123-I MIBG) imaging predicts ventricular arrhythmias causing appropriate implantable cardioverter-defibrillator (ICD) therapy (primary end point) and the composite of appropriate ICD therapy or cardiac death (secondary end point). Background: Although cardiac sympathetic denervation is associated with ventricular arrhythmias, limited data are available on the predictive value of sympathetic nerve im...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 17, Issue 3, 1 1 2010, Pages 354-358
Should mechanical dyssynchrony be assessed in patients with implantable cardioverter-defibrillators?
Boogers MJ, Schalij MJ, Bax JJ
Abstract
Cited 4 times since 2010 (0.3 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 5, 1 1 2010, Pages 537-540
Echocardiography in Takotsubo cardiomyopathy; a useful approach?
van der Wall EE, Holman ER, Scholte AJ, Bax JJ
Abstract
Cited 225 times since 2010 (15.2 per year)
source: EuropePMC
Archives of internal medicine,
Volume 170, Issue 12, 1 1 2010, Pages 1024-1031
Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants.
Ray KK, Seshasai SR, Erqou S, Sever P, Jukema JW, Ford I, Sattar N
Background: Statins have been shown to reduce the risk of all-cause mortality among individuals with clinical history of coronary heart disease. However, it remains uncertain whether statins have similar mortality benefit in a high-risk primary prevention setting. Notably, all systematic reviews to date included trials that in part incorporated participants with prior cardiovascular disease (CVD) at baseline. Our objective was to reliably determine if statin therapy reduces all-cause mortality a...
Abstract
Cited 7 times since 2010 (0.5 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 51, Issue 3, 1 1 2010, Pages 391-398
A comparison of the Doppler-derived maximal systolic acceleration versus the ankle-brachial pressure index or detecting and quantifying peripheral arterial occlusive disease in diabetic patients.
Van Tongeren RB, Bastiaansen AJ, Van Wissen RC, Le Cessie S, Hamming JF, Van Bockel JH
Aim: The aim of this study was to assess the diagnostic accuracy of the Doppler derived maximal systolic acceleration (ACCmax) as a novel technique for evaluating peripheral arterial occlusive disease (PAOD) in patients with diabetes mellitus, who are known for a falsely elevated ankle-brachial index (ABI). Methods: In this retrospective analysis ACCmax was measured at ankle level in a series of 163 consecutive patients referred to the vascular laboratory for initial assessment of PAOD. Patients...
Abstract
Cited 6 times since 2010 (0.4 per year)
source: EuropePMC
Animal science journal = Nihon chikusan Gakkaiho,
Volume 81, Issue 3, 1 1 2010, Pages 352-361
Effects of transportation during the hot season, breed and electrical stimulation on histochemical and meat quality characteristics of goat longissimus muscle.
Kadim IT, Mahgoub O, Al-Marzooqi W, Khalaf S, Al-Sinawi SS, Al-Amri I
The effects of transportation and electrical stimulation (90 V) on physiological, histochemical and meat quality characteristics of two breeds of Omani goats were assessed. Twenty 1-year-old male goats from each breed (Batina and Dhofari) were divided into two groups: 3 h transported during the hot season (42 degrees C day time temperature) and non-transported. Animals were blood-sampled before loading and prior to slaughter. Electrical stimulation was applied 20 min postmortem to 50% randomly s...
Abstract
Cited 6 times since 2010 (0.4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 12, Issue 6, 1 1 2010, Pages 766-767
Imaging modalities for measurements of left atrial volume in patients with atrial fibrillation: what do we choose?
de Groot NM, Schalij MJ
Abstract
Cited 53 times since 2010 (3.6 per year)
source: EuropePMC
Investigative radiology,
Volume 45, Issue 6, 1 1 2010, Pages 331-340
Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography to noninvasively assess in-stent restenosis.
de Graaf FR, Schuijf JD, van Velzen JE, Boogers MJ, Kroft LJ, de Roos A, Reiber JH, Sieders A, Spanó F, Jukema JW, Schalij MJ, van der Wall EE, Bax JJ
Objectives: Percutaneous coronary intervention with stent implantation is routinely performed to treat patients with obstructive coronary artery disease. However, thus far, noninvasive assessment of in-stent restenosis has been challenging. Recently, 320-row multidetector computed tomography coronary angiography (CTA) was introduced, allowing volumetric image acquisition of the heart in a single heart beat or gantry rotation. The aim of this study was to evaluate the diagnostic performance of 32...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 58, Issue 3, 1 1 2010, Pages 313-332
Echocardiography and non-invasive imaging in cardiac resynchronization therapy.
Delgado V, Mooyaart EA, Ct Ng A, Auger D, Bertini M, van Bommel RJ, Yiu KH, Ewe SH, Witkowski TG, Ajmone Marsan N, Schuijf JD, van der Wall EE, Schalij MJ, Bax JJ
The beneficial effects of cardiac resynchronization therapy (CRT) on morbidity and mortality in advanced heart failure patients have been extensively demonstrated. However, previous single- and multicenter studies demonstrated that approximately 30-40% of CRT patients do not show significant clinical improvement or LV reverse remodeling despite fulfilling current inclusion criteria. In search of novel indices that may help to improve the selection of responders to CRT, non-invasive multimodality...
Abstract
