6136 results
Cited 72 times since 2016 (8.2 per year)
source: EuropePMC
Science translational medicine,
Volume 8, Issue 341, 1 1 2016, Pages 341ra76
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M, CVD50 consortium, Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sa
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and f...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 27, Issue 3, 1 1 2016, Pages 288-294
The multifaceted interplay between lipids and epigenetics.
Dekkers KF, Slagboom PE, Jukema JW, Heijmans BT
Purpose of review: The interplay between lipids and epigenetic mechanisms has recently gained increased interest because of its relevance for common diseases and most notably atherosclerosis. This review discusses recent advances in unravelling this interplay with a particular focus on promising approaches and methods that will be able to establish causal relationships. Recent findings: Complementary approaches uncovered close links between circulating lipids and epigenetic mechanisms at multipl...
Abstract
Cited 16 times since 2016 (1.8 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 63, Issue 6, 1 1 2016, Pages 1451-1457
Experience with the GORE EXCLUDER iliac branch endoprosthesis for common iliac artery aneurysms.
van Sterkenburg SM, Heyligers JM, van Bladel M, Verhagen HJ, Eefting D, van Sambeek MR, Zeebregts CJ, Reijnen MM, Dutch IBE Collaboration
Objective: In this study, we analyzed the procedural success and early outcome of endovascular treatment of a multicenter cohort of patients with common iliac artery (CIA) aneurysms treated with the new GORE EXCLUDER (W. L. Gore & Associates, Flagstaff, Ariz) iliac branch endoprosthesis (IBE). Methods: A retrospective cohort analysis was performed in 13 sites in The Netherlands. Anatomic, demographic, procedural, and follow-up data were assessed from hospital records. Results: From November...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 9, Issue 6, 1 1 2016, Pages e003924
Effect of Gender on Outcomes After Cardiac Resynchronization Therapy in Patients With a Narrow QRS Complex: A Subgroup Analysis of the EchoCRT Trial.
Steffel J, Varma N, Robertson M, Singh JP, Bax JJ, Borer JS, Dickstein K, Ford I, Gorcsan J, Gras D, Krum H, Sogaard P, Holzmeister J, Brugada J, Abraham WT, Ruschitzka F
Background: In EchoCRT, a randomized controlled trial evaluating the effect of cardiac resynchronization therapy (CRT) in patients with a QRS duration of
Abstract
Cited 122 times since 2016 (13.9 per year)
source: EuropePMC
JAMA cardiology,
Volume 1, Issue 3, 1 1 2016, Pages 335-340
Differences in the Clinical Profile and Outcomes of Typical and Atypical Takotsubo Syndrome: Data From the International Takotsubo Registry.
Ghadri JR, Cammann VL, Napp LC, Jurisic S, Diekmann J, Bataiosu DR, Seifert B, Jaguszewski M, Sarcon A, Neumann CA, Geyer V, Prasad A, Bax JJ, Ruschitzka F, Lüscher TF, Templin C, International Takotsubo (InterTAK) Registry
Importance: Apical ballooning is broadly recognized as the classic form of takotsubo syndrome (TTS). Atypical subtypes of TTS also exist, which constitute about 20% of all cases. To date, clinical profile and course of atypical TTS types have rarely been studied. Objective: To characterize the clinical profile and outcomes of typical vs atypical types of TTS in a large patient cohort. Design, setting, and participants: Records of 1750 patients from the International Takotsubo Registry, comprisin...
Abstract
Cited 14 times since 2016 (1.6 per year)
source: EuropePMC
Laboratory investigation; a journal of technical methods and pathology,
Volume 96, Issue 7, 30 5 2016, Pages 784-790
Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in the abdominal aortic aneurysm.
Nieuwland AJ, Kokje VB, Koning OH, Hamming JF, Szuhai K, Claas FH, Lindeman JH
In vitro and in vivo studies attribute potent immune regulatory properties to the vitamin D receptor (VDR). Yet, it is unclear to what extend these observations translate to the clinical context of (vascular) inflammation. This clinical study evaluates the potential of a VDR agonist to quench vascular inflammation. Patients scheduled for open abdominal aneurysm repair received paricalcitol 1 μg daily during 2-4 weeks before repair. Results were compared with matched controls. Evaluation in a par...
Abstract
Cited 11 times since 2016 (1.3 per year)
source: Scopus
The American journal of cardiology,
Volume 118, Issue 4, 29 5 2016, Pages 567-571
Impact of Different Iterations of Devices and Degree of Aortic Valve Calcium on Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation.
Kong WK, van Rosendael PJ, van der Kley F, de Weger A, Kamperidis V, Regeer MV, Marsan NA, Bax JJ, Delgado V
The iterations of the SAPIEN prosthesis might impact the incidence and grade of paravalvular regurgitation (PVR). The aim of this study was to assess the impact of iterations of balloon-expandable valves (SAPIEN, SAPIEN XT, and SAPIEN 3) and degree of aortic valve calcification (AVC) on the severity of PVR after transcatheter aortic valve implantation (TAVI). Comprehensive echocardiographic examinations and multidetector computed tomography (MDCT) were performed in 272 patients (127 men, 81 ± 7 ...
Abstract
Cited 40 times since 2016 (4.6 per year)
source: EuropePMC
American heart journal,
Volume 178, 28 4 2016, Pages 135-144
Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Lipid Lowering and SPIRE Cardiovascular Outcomes Trials.
Ridker PM, Amarenco P, Brunell R, Glynn RJ, Jukema JW, Kastelein JJ, Koenig W, Nissen S, Revkin J, Santos RD, Schwartz PF, Yunis C, Tardif JC, Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Investigators
Background: Although statins significantly reduce vascular event rates, residual cholesterol risk remains high in many patient groups, including those with known vascular disease as well as in the setting of high-risk primary prevention. Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), prolongs the half-life of hepatic low-density lipoprotein (LDL) receptors, and reduces circulating atherogenic cholesterol levels. Design: The SPI...
Abstract
Cited 217 times since 2016 (24.7 per year)
source: EuropePMC
Nature reviews. Microbiology,
Volume 14, Issue 7, 23 4 2016, Pages 421-433
Human norovirus transmission and evolution in a changing world.
de Graaf M, van Beek J, Koopmans MP
Norovirus infections are a major cause of gastroenteritis, and outbreaks occur frequently. Several factors are currently increasing the challenge posed by norovirus infections to global health, notably the increasing number of infections in immunocompromised individuals, who are more susceptible to disease, and the globalization of the food industry, which enables large norovirus outbreaks to occur on an international scale. Furthermore, the rapid rate of the genetic and antigenic evolution of c...
Abstract
Cited 5 times since 2016 (0.6 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 32, Issue 8, 21 3 2016, Pages 1311-1322
Automatic detection of aorto-femoral vessel trajectory from whole-body computed tomography angiography data sets.
Gao X, Kitslaar PH, Budde RP, Tu S, de Graaf MA, Xu L, Xu B, Scholte AJ, Dijkstra J, Reiber JH
Extraction of the aorto-femoral vessel trajectory is important to utilize computed tomography angiography (CTA) in an integrated workflow of the image-guided work-up prior to trans-catheter aortic valve replacement (TAVR). The aim of this study was to develop a new, fully-automated technique for the extraction of the entire arterial access route from the femoral artery to the aortic root. An automatic vessel tracking algorithm was first used to find the centerline that connected the femoral acce...
Abstract
Cited 142 times since 2016 (16.1 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 13, Issue 8, 19 3 2016, Pages 451-470
Vein graft failure: from pathophysiology to clinical outcomes.
de Vries MR, Simons KH, Jukema JW, Braun J, Quax PH
Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside from balloon angioplasty, bypass graft surgery is the most commonly performed revascularization technique for occlusive arterial disease. Coronary artery bypass graft surgery is performed in patients with left main coronary artery disease and three-vessel coronary disease, whereas peripheral artery bypass graft surgery is used to treat patients with late-stage peripheral artery occlusive disease. The great...
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
Herzschrittmachertherapie & Elektrophysiologie,
Volume 27, Issue 2, 19 3 2016, Pages 131-136
Ventricular tachycardia in repaired congenital heart disease.
Zeppenfeld K
Ventricular arrhythmias are an important cause of late morbidity and sudden cardiac death in the growing population of adults with repaired congenital heart disease. Risk stratification remains challenging because of the heterogeneity of the malformations and the surgical approaches. Therapeutic interventions depend on the type of ventricular arrhythmia, which can be polymorphic ventricular tachycardia (VT) or ventricular fibrillation in patients without ventricular scars, but also potentially f...
Abstract
Cited 4 times since 2016 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 118, Issue 3, 14 2 2016, Pages 326-331
Prognostic Implications of Elevated Pulmonary Artery Pressure After ST-Segment Elevation Myocardial Infarction.
Haeck ML, Hoogslag GE, Boden H, Velders MA, Katsanos S, Al Amri I, Debonnaire P, Schalij MJ, Vliegen HW, Bax JJ, Marsan NA, Delgado V
Elevated systolic pulmonary artery pressure (SPAP) after ST-segment elevation myocardial infarction (STEMI) has been associated with adverse outcome. However, little is known about the development of increased SPAP after STEMI treated with primary percutaneous coronary intervention. The aims of this study were to investigate the incidence and determinants of elevated SPAP (SPAP ≥36 mm Hg at 12 months) after first STEMI and to analyze its prognostic implications. A total of 705 patients (60 ± 12 ...
Abstract
Cited 8 times since 2016 (0.9 per year)
source: Scopus
The Thoracic and cardiovascular surgeon,
Volume 65, Issue 4, 13 2 2016, Pages 338-342
Titanium Plate Fixation versus Conventional Closure for Sternal Dehiscence after Cardiac Surgery.
Vos RJ, Jongbloed L, Sonker U, Kloppenburg GTL
Background Postoperative sternal dehiscence with or without mediastinitis is a complication of cardiac surgery leading to considerable disability. Titanium plate fixation can provide sternal stability in patients with a dehiscent sternum. The aim of this study is to compare clinical outcomes of titanium plate fixation with conventional treatment methods such as steel wire cerclage and pectoralis muscle reconstruction. Patients and Methods A retrospective analysis was performed on 42 patients who...
Abstract
Cited 5 times since 2016 (0.6 per year)
source: EuropePMC
Frontiers in psychology,
Volume 7, 10 2 2016, Pages 685
Varied Practice in Laparoscopy Training: Beneficial Learning Stimulation or Cognitive Overload?
Spruit EN, Kleijweg L, Band GP, Hamming JF
Determining the optimal design for surgical skills training is an ongoing research endeavor. In education literature, varied practice is listed as a positive intervention to improve acquisition of knowledge and motor skills. In the current study we tested the effectiveness of a varied practice intervention during laparoscopy training. Twenty-four trainees (control group) without prior experience received a 3 weeks laparoscopic skills training utilizing four basic and one advanced training task....
Abstract
Cited 24 times since 2016 (2.7 per year)
source: EuropePMC
PLoS genetics,
Volume 12, Issue 5, 5 1 2016, Pages e1006034
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.
Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjögren M, Ngwa J, Brandimarto J, Stott DJ, Aguilar D, Rice KM, Sesso HD, Demissie S, Buckley BM, Taylor KD, Ford I, Yao C, Liu C, CHARGE-SCD consortium, EchoGen consortium, QT-IGC consortium, CHARGE-QRS consortium, Sotoodehnia N, van der Harst P, Stricker BH, Kritchevsky SB, Liu Y, Gaziano JM, Hofman A, Moravec CS, Uitterlinden AG, Kellis M, van Meurs JB, Margulies KB, Dehghan A, Levy D, Olde B, Psaty BM, Cupples LA, Jukema JW, Djousse L, Franco OH, Boerwinkle E, Boyer LA, Newton-Cheh C, Butler J, Vasan RS, Cappola TP, Smith NL
Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% incr...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 49, Issue 5, 1 1 2016, Pages e91-6
Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction.
Bokenkamp R, Aguilar E, van der Palen RL, Sojak V, Bruggemans EF, Hruda J, Kuipers IM, Hazekamp MG
Objectives: Right ventricular outflow tract obstruction (RVOTO) is one of the reasons for late reinterventions after repair of transposition of the great arteries (TGA) with aortic arch obstruction (AAO). The aim of the present study was to identify predictors of reoperation for RVOTO in patients who underwent arterial switch operation (ASO) and arch repair for TGA or Taussig-Bing anomaly with AAO. Methods: Between 1977 and 2015, 45 patients [TGA/intact ventricular septum (IVS) 5, TGA/ventricula...
Abstract
The New England journal of medicine,
Volume 374, Issue 20, 1 1 2016, Pages 1992
Surgery for Severe Ischemic Mitral Regurgitation.
Braun J, Petrus AH, Klautz RJ
Abstract
Journal of clinical and diagnostic research : JCDR,
Volume 10, Issue 5, 1 1 2016, Pages ZL01-2
Antibiotic usage - Ectopic Impacted Lower Third Molar.
Karaca IR, Ulutürk H, Yilmaz D
Abstract
Cited 4 times since 2016 (0.5 per year)
source: EuropePMC
American heart journal,
Volume 178, 30 5 2016, Pages 115-125
Time course, predictors, and prognostic implications of significant mitral regurgitation after ST-segment elevation myocardial infarction.
Abate E, Hoogslag GE, Al Amri I, Debonnaire P, Wolterbeek R, Bax JJ, Delgado V, Marsan NA
Background: Ischemic mitral regurgitation (MR) is a known complication of ST-segment elevation myocardial infarction (STEMI) with important prognostic implications. We evaluated changes over time in ischemic MR after STEMI and the prevalence and predictors of significant (grade ≥2) MR at 12 months. Furthermore, the prognostic additional value of significant MR at 12-month follow-up over acute MR was assessed. Methods: STEMI patients (n = 1,599; 77% male; 60 ± 12 years) treated with primary percu...
Abstract
