9618 results
Pharmacogenomics,
Volume 20, Issue 18, 6 1 2019, Pages 1247-1249
Circulating biomarkers of response to immunotherapy in cancer treatment.
Del Re M, Gianfilippo G, Crucitta S, Addeo A, van Schaik RH, Danesi R
Abstract
Cited 34 times since 2019 (5.9 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 107, Issue 1, 6 1 2019, Pages 57-61
Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.
Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF
Abstract
Frontiers in veterinary science,
Volume 6, 6 1 2019, Pages 375
Assessing the Adoption of Recommended Standards, Novel Approaches, and Best Practices for Animal Health Surveillance by Decision Makers in Europe.
Häsler B, Garza M, Bisdorff B, Léger A, Tavornpanich S, Peyre M, Lindberg A, van Schaik G, Alban L, Stärk KDC
Animal health surveillance is an important tool for disease mitigation and helps to promote animal health and welfare, protect human health, support efficient animal production, and enable trade. This study aimed to assess adoption of recommended standards and best practice for surveillance (including risk-based approaches) in Europe. It included scoping interviews with surveillance experts in Denmark, the Netherlands, Norway, and Switzerland to gather information on knowledge acquisition, decis...
Abstract
Cited 19 times since 2019 (3.3 per year)
source: EuropePMC
Urologic oncology,
Volume 38, Issue 5, 5 1 2019, Pages 440-448
Papillary urothelial neoplasm of low malignant potential (PUN-LMP): Still a meaningful histo-pathological grade category for Ta, noninvasive bladder tumors in 2019?
Hentschel AE, van Rhijn BWG, Bründl J, Compérat EM, Plass K, Rodríguez O, Henríquez JDS, Hernández V, de la Peña E, Alemany I, Turturica D, Pisano F, Soria F, Čapoun O, Bauerová L, Pešl M, Bruins HM, Runneboom W, Herdegen S, Breyer J, Brisuda A, Scavarda-Lamberti A, Calatrava A, Rubio-Briones J, Seles M, Mannweiler S, Bosschieter J, Kusuma VRM, Ashabere D, Huebner N, Cotte J, Mertens LS, Cohen D, Lunelli L, Cussenot O, Sheikh SE, Volanis D, Coté JF, Rouprêt M, Haitel A, Shariat SF, Mostafid AH, Nieuwenhuijzen JA, Zigeuner R, Dominguez-Escrig JL, Hacek J, Zlotta AR, Burger M, Evert M, Hulsbergen-van de Kaa CA, van der Heijden AG, Kiemeney LALM, Soukup V, Molinaro L, Gontero P, Llorente C, Algaba F, Palou J, N'Dow J, Babjuk M, van der Kwast TH, Sylvester RJ
Background: Papillary urothelial neoplasm of low malignant potential (PUN-LMP) was introduced as a noninvasive, noncancerous lesion and a separate grade category in 1998. Subsequently, PUN-LMP was reconfirmed by World Health Organization (WHO) 2004 and WHO 2016 classifications for urothelial bladder tumors. Objectives: To analyze the proportion of PUN-LMP diagnosis over time and to determine its prognostic value compared to Ta-LG (low-grade) and Ta-HG (high-grade) carcinomas. To assess the intra...
Abstract
Cited 14 times since 2019 (2.4 per year)
source: EuropePMC
BMC neurology,
Volume 19, Issue 1, 4 1 2019, Pages 265
Determinants of extended door-to-needle time in acute ischemic stroke and its influence on in-hospital mortality: results of a nationwide Dutch clinical audit.
Kuhrij LS, Marang-van de Mheen PJ, van den Berg-Vos RM, de Leeuw FE, Nederkoorn PJ, Dutch Acute Stroke Audit consortium
Background: Intravenous thrombolysis (IVT) plays a prominent role in the treatment of acute ischemic stroke (AIS). The sooner IVT is administered, the higher the odds of a good outcome. Therefore, registering the in-hospital time to treatment with IVT, i.e. the door-to-needle time (DNT), is a powerful way to measure quality improvement. The aim of this study was to identify determinants that are associated with extended DNT. Methods: Patients receiving IVT in 2015 and 2016 registered in the Dutc...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 161, Issue 1, 2 1 2019, Pages 66-75.e4
Antithrombotic therapy and bleeding events after aortic valve replacement with a novel bioprosthesis.
Klautz RJM, Vriesendorp MD, Dagenais F, Labrousse L, Bapat V, Moront MG, Misfeld M, Gearhart E, Kappetein AP, Sabik JF
Objective: Several recent-generation surgical tissue valves have been found to have bleeding rates exceeding rates recommended by regulatory bodies. We explored bleeding events using data from the Pericardial Surgical Aortic Valve Replacement (PERIGON) Pivotal Trial for the Avalus valve (Medtronic, Minneapolis, Minn) to examine whether this end point remains relevant for the evaluation of bioprostheses. Methods: Patients (n = 1115) underwent aortic valve replacement. Bleeding and thromboembolic...
Abstract
JACC. Cardiovascular imaging,
Volume 12, Issue 11 Pt 1, 1 1 2019, Pages 2282
Is Older Age Truly a Predictor of SVD?
Vriesendorp MD, de Lind van Wijngaarden RAF, Klautz RJM
Abstract
Cited 14 times since 2019 (2.4 per year)
source: EuropePMC
American journal of hypertension,
Volume 32, Issue 12, 1 1 2019, Pages 1146-1153
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group.
Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, Sun F, Liu CT, Xu H, Cupples AL, Tanner RM, Rossing P, Smith A, Zilhão NR, Launer LJ, Noordam R, Rotter JI, Yao J, Li X, Guo X, Limdi N, Sundaresan A, Lange L, Correa A, Stott DJ, Ford I, Jukema JW, Gudnason V, Mook-Kanamori DO, Trompet S, Palmas W, Warren HR, Hellwege JN, Giri A, O'donnell C, Hung AM, Edwards TL, Ahluwalia TS, Arnett DK, Avery CL
Background: Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. Methods: We conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP ≥ 140 mm Hg and/or diastolic BP ≥ 90 mm...
Abstract
Cited 62 times since 2019 (10.7 per year)
source: EuropePMC
JAMA,
Volume 322, Issue 20, 1 1 2019, Pages 1977-1986
Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism.
Mooijaart SP, Du Puy RS, Stott DJ, Kearney PM, Rodondi N, Westendorp RGJ, den Elzen WPJ, Postmus I, Poortvliet RKE, van Heemst D, van Munster BC, Peeters RP, Ford I, Kean S, Messow CM, Blum MR, Collet TH, Watt T, Dekkers OM, Jukema JW, Smit JWA, Langhorne P, Gussekloo J
Importance: It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism. Objective: To determine the association of levothyroxine treatment for subclinical hypothyroidism with thyroid-related quality of life in adults aged 80 years and older. Design, setting, and participants: Prospectively planned combined analysis of data involving community-dwelling adults aged 80 years and older with subclinical hypoth...
Abstract
Cited 57 times since 2019 (9.8 per year)
source: EuropePMC
Epidemiology (Cambridge, Mass.),
Volume 30, Issue 6, 1 1 2019, Pages 813-816
Survival Bias in Mendelian Randomization Studies: A Threat to Causal Inference.
Smit RAJ, Trompet S, Dekkers OM, Jukema JW, le Cessie S
It has been argued that survival bias may distort results in Mendelian randomization studies in older populations. Through simulations of a simple causal structure we investigate the degree to which instrumental variable (IV)-estimators may become biased in the context of exposures that affect survival. We observed that selecting on survival decreased instrument strength and, for exposures with directionally concordant effects on survival (and outcome), introduced downward bias of the IV-estimat...
Abstract
Cited 9 times since 2019 (1.6 per year)
source: EuropePMC
Academic medicine :, journal of the Association of American Medical Colleges..,
Volume 94, Issue 11, 1 1 2019, Pages 1728-1732
Jump-Starting Faculty Development in Quality Improvement and Patient Safety Education: A Team-Based Approach.
van Schaik SM, Chang A, Fogh S, Haehn M, Lyndon A, O'Brien B, O'Sullivan P, Ranji S, Rosenbluth G, Sehgal N, Tabas J, Baron RB
Problem: Quality improvement (QI) and patient safety (PS) are cornerstones of health care delivery. Accreditation organizations increasingly require that learners engage in QIPS. For many faculty, these are new domains. Additional faculty development is needed for them to teach and mentor trainees. Existing programs, such as the Association of American Medical Colleges Teaching for Quality (Te4Q) program, target individual faculty and thus accommodate only limited participants at a time, which i...
Abstract
Cited 23 times since 2019 (4 per year)
source: EuropePMC
FEMS microbiology letters,
Volume 366, Issue 22, 1 1 2019, Pages fnz256
CRISPR-Cas9-mediated genome editing in vancomycin-resistant Enterococcus faecium.
de Maat V, Stege PB, Dedden M, Hamer M, van Pijkeren JP, Willems RJL, van Schaik W
The Gram-positive bacterium Enterococcus faecium is becoming increasingly prevalent as a cause of hospital-acquired, antibiotic-resistant infections. A fundamental part of research into E. faecium biology relies on the ability to generate targeted mutants but this process is currently labour-intensive and time-consuming, taking 4 to 5 weeks per mutant. In this report, we describe a method relying on the high recombination rates of E. faecium and the application of the Clustered Regularly Intersp...
Abstract
Cited 16 times since 2019 (2.8 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 94, Issue 11S Association of American Medical Colleges Learn Serv, 1 1 2019, Pages S42-S47
Effect of Professional Background and Gender on Residents' Perceptions of Leadership.
Ju M, van Schaik SM
Purpose: To examine the impact of professional background and gender of a resuscitation team leader on residents' perceptions of leadership skills. Method: The authors video-recorded a scripted, simulated resuscitation scenario twice, with either a male or a female team leader. They copied each video and labeled the leader as physician (MD) or nurse practitioner (NP), creating 4 conditions: female NP, female MD, male NP, or male MD. The authors recruited resident participants from 5 special...
Abstract
Cited 9 times since 2019 (1.6 per year)
source: EuropePMC
Journal of clinical psychopharmacology,
Volume 39, Issue 6, 1 1 2019, Pages 583-590
Effects of Pharmacogenetic Screening for CYP2D6 Among Elderly Starting Therapy With Nortriptyline or Venlafaxine: A Pragmatic Randomized Controlled Trial (CYSCE Trial).
van der Schans J, Hak E, Postma M, Breuning L, Brouwers JRBJ, Ditters K, Jansen PAF, Kok RM, Maring JG, van Marum R, Mulder H, Nanninga J, Oude Voshaar RC, Risselada AJ, Vleugel L, Stek M, van Schaik RHN, Berm EJJ, Wilffert B
Purpose/background: The duration of untreated depression is a predictor for poor future prognosis, making rapid dose finding essential. Genetic variation of the CYP2D6 isoenzyme can influence the optimal dosage needed for individual patients. The aim of this study was to determine the effectiveness of CYP2D6 pharmacogenetic screening to accelerate drug dosing in older patients with depression initiating nortriptyline or venlafaxine. Methods/procedures: In this randomized controlled trial, patien...
Abstract
Cited 42 times since 2019 (7.2 per year)
source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology,
Volume 30, Issue 11, 1 1 2019, Pages 1697-1727
EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†.
Horwich A, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Van Der Kwast T, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, DeBlok W, De Visschere PJL, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Carmen Mir M, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, Oyen WJG, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR,
Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Del...
Abstract
Cited 29 times since 2019 (5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1187-1197
Imaging in ESC clinical guidelines: chronic coronary syndromes.
Saraste A, Barbato E, Capodanno D, Edvardsen T, Prescott E, Achenbach S, Bax JJ, Wijns W, Knuuti J
The European Society of Cardiology (ESC) has recently published new guidelines on the diagnosis and management of chronic coronary syndromes (CCS). The 2019 guideline identified six common clinical scenarios of CCS defined by the different evolutionary phases of coronary artery disease (CAD), excluding the situations in which an acute coronary event, often with coronary thrombus formation, dominates the clinical presentation. This review aims at providing a summary of novel or revised concepts i...
Abstract
Cited 10 times since 2019 (1.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1279-1286
Long-term prognostic utility of computed tomography coronary angiography in older populations.
Gnanenthiran SR, Naoum C, Leipsic JA, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufman PA, Kim YJ, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Kritharides L, Min JK
Aims: The long-term prognostic value of coronary computed tomography angiography (CCTA)-identified coronary artery disease (CAD) has not been evaluated in elderly patients (≥70 years). We compared the ability of coronary CCTA to predict 5-year mortality in older vs. younger populations. Methods and results: From the prospective CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry, we analysed CCTA results according to age 50%); (ii) segment in...
Abstract
Cited 6 times since 2019 (1 per year)
source: EuropePMC
European heart journal,
Volume 40, Issue 41, 1 1 2019, Pages e20-e22
Assessment of coronary artery plaque with non-contrast and T1-weighted magnetic resonance: promise for clinical use?
Schindler TH, Bax JJ
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 27, Issue 11, 1 1 2019, Pages 550-558
Myocardial infarction patients referred to the primary care physician after 1‑year treatment according to a guideline-based protocol have a good prognosis.
Bodde MC, van Hattem NE, Abou R, Mertens BJA, van Duijn HJ, Numans ME, Bax JJ, Schalij MJ, Jukema JW
Introduction: Identifying ST-elevation myocardial infarction (STEMI) patients who can be referred back to the general practitioner (GP) can improve patient-tailored care. However, the long-term prognosis of patients who are returned to the care of their GP is unknown. Therefore, the aim of this study was to assess the long-term prognosis of patients referred back to the GP after treatment in accordance with a 1-year institutional guideline-based protocol. Methods: All consecutive patients treate...
Abstract
Cited 102 times since 2019 (17.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 11, 1 1 2019, Pages 1198-1207
Impact of a decreasing pre-test probability on the performance of diagnostic tests for coronary artery disease.
Juarez-Orozco LE, Saraste A, Capodanno D, Prescott E, Ballo H, Bax JJ, Wijns W, Knuuti J
Aims: To provide a pooled estimation of contemporary pre-test probabilities (PTPs) of significant coronary artery disease (CAD) across clinical patient categories, re-evaluate the utility of the application of diagnostic techniques according to such estimates, and propose a comprehensive diagnostic technique selection tool for suspected CAD. Methods and results: Estimates of significant CAD prevalence across sex, age, and type of chest pain categories from three large-scale studies were pooled (...
Abstract
