Research

Publications

Below you can find a list of our published research.

7971 results

International journal of nursing education scholarship, Volume 16, Issue 1, 3 1 2019 Evaluation of Bachelor's Degree Nursing Program Assessment by Nurses Working at A University Hospital: A Cross-Sectional Study from Turkey. Yılmaz D, Düzgün F, Yılmaz DU, Dikmen Y

The aim of this study was to examine the evaluation of integrated program, traditional and problem based programs in nursing by nurses working in a university hospital. The population of the study consisted of the 288 nurses. In the collection of research data, use was made of a Nurses' Description Form and the Bachelor's Degree Nursing Program Assessment Scale (BNPAS). It was found that the total mean BNPAS scores of nurses graduating from the integrated educational program were highe... Abstract

Cited 1 times since 2019 (0.2 per year) source: EuropePMC

European journal of hybrid imaging, Volume 3, Issue 1, 2 1 2019, Pages 14 Characterization of the left ventricular arrhythmogenic substrate with multimodality imaging: role of innervation imaging and left ventricular global longitudinal strain. El Mahdiui M, Smit JM, van Rosendael AR, Delgado V, Ajmone Marsan N, Jukema JW, Scholte AJHA, Bax JJ

Background: Even though implantable cardioverter defibrillator (ICD) implantation for primary prevention has shown to reduce the risk of sudden cardiac death in chronic heart failure patients with reduced left ventricular ejection fraction (LVEF), a significant portion of these patients will never receive appropriate ICD therapy. We aimed to functionally characterize the arrhythmogenic substrate using left ventricular (LV) global longitudinal strain (GLS) and heart-to-mediastinum (H/M) ratio on... Abstract

Cited 149 times since 2019 (25.5 per year) source: EuropePMC

The Lancet. Planetary health, Volume 3, Issue 8, 1 1 2019, Pages e357-e369 Attributable sources of community-acquired carriage of Escherichia coli containing β-lactam antibiotic resistance genes: a population-based modelling study. Mughini-Gras L, Dorado-García A, van Duijkeren E, van den Bunt G, Dierikx CM, Bonten MJM, Bootsma MCJ, Schmitt H, Hald T, Evers EG, de Koeijer A, van Pelt W, Franz E, Mevius DJ, Heederik DJJ, ESBL Attribution Consortium

Background: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC), plasmid-mediated AmpC-producing E coli (pAmpC-EC), and other bacteria are resistant to important β-lactam antibiotics. ESBL-EC and pAmpC-EC are increasingly reported in animals, food, the environment, and community-acquired and health-care-associated human infections. These infections are usually preceded by asymptomatic carriage, for which attributions to animal, food, environmental, and human sources remain unquant... Abstract

Der Urologe. Ausg. A, Volume 58, Issue 8, 1 1 2019, Pages 858-863 [The affiliated physician in Germany: the end of a cross-sector form of care?] Schneider AW

In the classic affiliated physician system, patients are typically guaranteed cross-sectoral surgical and nonsurgical care. For years, neutral experts have been confirming the resource-efficient use of the increasing demand for medical services due to changing demographics. Nevertheless, due to lack of support, this form of care is increasingly being replaced by structures that substitute affiliated physicians. Only by returning to this cross-sectoral form of care, which was a leading form of ca... Abstract

Cited 73 times since 2019 (12.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 74, Issue 7, 1 1 2019, Pages 905-927 Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease: JACC Scientific Expert Panel. Desai MY, Windecker S, Lancellotti P, Bax JJ, Griffin BP, Cahlon O, Johnston DR

Radiation-associated cardiac disease, a heterogeneous and complex disease, manifests years or even decades following radiation exposure to the chest. It is associated with a significantly higher morbidity and mortality. Often, the presentation is vague and overlaps with many diseases, presenting unique diagnostic and management issues. As a result, a high index of suspicion followed by multimodality imaging is crucial, along with comprehensive screening to enable early detection. Timing of inter... Abstract

Cited 35 times since 2019 (6 per year) source: EuropePMC

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Volume 34, Issue 11, 1 1 2019, Pages 1993-2000 The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial. Merlijn T, Swart KM, van Schoor NM, Heymans MW, van der Zwaard BC, van der Heijden AA, Rutters F, Lips P, van der Horst HE, Niemeijer C, Netelenbos JC, Elders PJ

Population screening for fracture risk may reduce the fracture incidence. In this randomized pragmatic trial, the SALT Osteoporosis Study (SOS), we studied whether screening for fracture risk and subsequent treatment in primary care can reduce fractures compared with usual care. A total of 11,032 women aged 65 to 90 years with ≥1 clinical risk factor for fractures were individually randomized to screening (n = 5575) or usual care (n = 5457). Participants in the screening group underwent a screen... Abstract

Cited 17 times since 2019 (2.9 per year) source: EuropePMC

Aims: Age-induced changes and electrical remodelling are important components of the atrial fibrillation (AF) substrate. To study regional distribution and age-dependent changes in gene expression that may promote AF in human atria. Methods and results: Human left atrial (LA) and right atrial (RA) tissue samples were obtained from donor hearts unsuitable for transplantation and from patients undergoing mitral valve repair. Atrial fibrillation was mimicked in vitro by tachypacing of human atrial... Abstract

Cited 7 times since 2019 (1.2 per year) source: EuropePMC

World journal of surgery, Volume 43, Issue 8, 1 1 2019, Pages 1972-1980 Timing of Parathyroidectomy Does Not Influence Renal Function After Kidney Transplantation. van der Plas WY, El Moumni M, von Forstner PJ, Koh EY, Dulfer RR, van Ginhoven TM, Rotmans JI, Appelman-Dijkstra NM, Schepers A, Hoorn EJ, Plukker JTM, Vogt L, Engelsman AF, Nieveen van Dijkum EJM, Kruijff S, Pol RA, de Borst MH, Dutch Hyperparathyroidism Study Group

Background: Parathyroidectomy (PTx) is the treatment of choice for end-stage renal disease (ESRD) patients with therapy-resistant hyperparathyroidism (HPT). The optimal timing of PTx for ESRD-related HPT-before or after kidney transplantation (KTx)-is subject of debate. Methods: Patients with ESRD-related HPT who underwent both PTx and KTx between 1994 and 2015 were included in a multicenter retrospective study in four university hospitals. Two groups were formed according to treatment sequence:... Abstract

Cited 25 times since 2019 (4.3 per year) source: EuropePMC

Cardiovascular research, Volume 115, Issue 10, 1 1 2019, Pages 1519-1532 Genetic associations and regulation of expression indicate an independent role for 14q32 snoRNAs in human cardiovascular disease. Håkansson KEJ, Goossens EAC, Trompet S, van Ingen E, de Vries MR, van der Kwast RVCT, Ripa RS, Kastrup J, Hohensinner PJ, Kaun C, Wojta J, Böhringer S, Le Cessie S, Jukema JW, Quax PHA, Nossent AY

Aims: We have shown that 14q32 microRNAs are highly involved in vascular remodelling and cardiovascular disease. However, the 14q32 locus also encodes 41 'orphan' small nucleolar RNAs (snoRNAs). We aimed to gather evidence for an independent role for 14q32 snoRNAs in human cardiovascular disease. Methods and results: We performed a lookup of the 14q32 region within the dataset of a genome wide association scan in 5244 participants of the PROspective Study of Pravastatin in the Elderly... Abstract

Cited 186 times since 2019 (31.9 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 21, Issue 8, 1 1 2019, Pages 1143-1144 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Della Bella P, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Kay GN, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Sáenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K, ESC Scientific Document Group

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. There... Abstract

Cited 6 times since 2019 (1 per year) source: EuropePMC

Physical chemistry chemical physics : PCCP, Volume 21, Issue 33, 1 1 2019, Pages 18240-18249 Understanding the influence of defects and surface chemistry on ferroelectric switching: a ReaxFF investigation of BaTiO<sub>3</sub>. Akbarian D, Yilmaz DE, Cao Y, Ganesh P, Dabo I, Munro J, Van Ginhoven R, van Duin ACT

Ferroelectric materials such as barium titanate (BaTiO3) have a wide range of applications in nano scale electronic devices due to their outstanding properties. In this study, we developed an easily extendable atomistic ReaxFF reactive force field for BaTiO3 that can capture both its field- and temperature-induced ferroelectric hysteresis and corresponding changes due to surface chemistry and bulk defects. Using our force field, we were able to reproduce and explain a number of experimental obse... Abstract

Cited 5 times since 2019 (0.9 per year) source: EuropePMC

BMJ open, Volume 9, Issue 8, 1 1 2019, Pages e028858 Design and protocol of a comprehensive multicentre biobank for abdominal aortic aneurysms. Jalalzadeh H, Indrakusuma R, Blankensteijn JD, Wisselink W, Yeung KK, Lindeman JHN, Hamming JF, Koelemay MJW, Legemate DA, Balm R

Introduction: The pathophysiology and natural course of abdominal aortic aneurysms (AAAs) are insufficiently understood. In order to improve our understanding, it is imperative to carry out longitudinal research that combines biomarkers with clinical and imaging data measured over multiple time points. Therefore, a multicentre biobank, databank and imagebank has been established in the Netherlands: the 'Pearl Abdominal Aortic Aneurysm' (AAA bank). Methods and analysis: The AAA bank is... Abstract

Cited 15 times since 2019 (2.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 20, Issue 8, 1 1 2019, Pages 897-905 Characterization of functionally significant coronary artery disease by a coronary computed tomography angiography-based index: a comparison with positron emission tomography. Anagnostopoulos CD, Siogkas PK, Liga R, Benetos G, Maaniitty T, Sakellarios AI, Koutagiar I, Karakitsios I, Papafaklis MI, Berti V, Sciagrà R, Scholte AJHA, Michalis LK, Gaemperli O, Kaufmann PA, Pelosi G, Parodi O, Knuuti J, Fotiadis DI, Neglia D

Aims: To test the hypothesis that virtual functional assessment index (vFAI) is related with regional flow parameters derived by quantitative positron emission tomography (PET) and can be used to assess abnormal vasodilating capability in coronary vessels with stenotic lesions at coronary computed tomography angiography (CCTA). Methods and results: vFAI, stress myocardial blood flow (MBF), and myocardial flow reserve (MFR) were assessed in 78 patients (mean age 62.2 ± 7.7 years) with intermediat... Abstract

Cited 19 times since 2019 (3.3 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 5, Issue 10, 31 5 2019, Pages 1130-1140 Multisize Electrodes for Substrate Identification in Ischemic Cardiomyopathy: Validation by Integration of Whole Heart Histology. Glashan CA, Tofig BJ, Tao Q, Blom SA, Jongbloed MRM, Nielsen JC, Lukac P, Kristiansen SB, Zeppenfeld K

Objectives: This study sought to evaluate the value of combined electrogram (EGM) information provided by simultaneous mapping using micro- and conventional electrodes in the identification of post-myocardial infarction ventricular tachycardia substrate. Background: Ventricular tachycardias after myocardial infarction are related to scars with complex geometry. Scar delineation and ventricular tachycardia substrate identification relies on bipolar voltages (BV) and EGM characteristics. Early rep... Abstract

Cited 9 times since 2019 (1.5 per year) source: Scopus

The American journal of cardiology, Volume 124, Issue 8, 30 5 2019, Pages 1239-1245 One-Year Follow-Up of Conduction Abnormalities After Transcatheter Aortic Valve Implantation With the SAPIEN 3 Valve. Dolci G, Vollema EM, van der Kley F, de Weger A, Ajmone Marsan N, Delgado V, Bax JJ

Long-term evolution of new-onset conduction abnormalities and need of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) have not been extensively evaluated. We describe the incidence and time course of new conduction abnormalities and the rate of PPI with the new-generation transcatheter aortic valve prosthesis Edwards SAPIEN 3 (S3). In total, 266 patients with severe aortic stenosis who underwent TAVI were retrospectively analyzed. Twelve-lead electroca... Abstract

Cited 47 times since 2019 (8 per year) source: EuropePMC

International journal of molecular sciences, Volume 20, Issue 15, 29 5 2019, Pages E3704 Variations in Surgical Procedures for Inducing Hind Limb Ischemia in Mice and the Impact of These Variations on Neovascularization Assessment. Aref Z, de Vries MR, Quax PHA

Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial disease and critical limb ischemia. This model is used to investigate the mechanisms of neovascularization and to develop new therapeutic agents. The literature shows many variations in the model, including the method of occlusion, the number of occlusions, and the position at which the occlusions are made to induce hind limb ischemia. Furthermore, predefined end points and the histopathological and radiol... Abstract

Cited 7 times since 2019 (1.2 per year) source: EuropePMC

JBMR plus, Volume 3, Issue 9, 26 4 2019, Pages e10206 Despite Genetic Iron Overload, <i>Hfe</i>-Hemochromatosis Mice Do Not Show Bone Loss. Wagner A, Alan B, Yilmaz D, Ahmad M, Liu P, Tangudu NK, Tuckermann JP, Vujic Spasic M

One of the most prevalent genetic iron overload disorders in Caucasians is caused by mutations in the HFE gene. Both HFE patients and Hfe-mouse models develop a progressive accumulation of iron in the parenchymal cells of various tissues, eventually resulting in liver cirrhosis, hepatocellular carcinoma, cardiomyopathies, hypogonadism, and other pathologies. Clinical data and preclinical models have brought considerable attention to the correlation between iron overload and the development of os... Abstract

Cited 3 times since 2019 (0.5 per year) source: EuropePMC

BMJ open, Volume 9, Issue 7, 26 4 2019, Pages e029716 Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies. Wildisen L, Moutzouri E, Beglinger S, Syrogiannouli L, Cappola AR, Åsvold BO, Bakker SJL, Ceresini G, Dullaart R, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp RGJ, Gussekloo J, Peeters RP, Klöppel S, Aujesky D, Bauer DC, Rodondi N, Del Giovane C, Feller M, Thyroid Studies Collaboration

Introduction: Prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating hormone cut-off levels or degree of baseline depressive symptoms. Analysis of individual participant data (IPD) may help clarify this association. Methods and analysis: We will conduct a systematic review and IPD meta-analysis of prospective studies on the association between... Abstract

Cited 38 times since 2019 (6.5 per year) source: EuropePMC

American journal of human genetics, Volume 105, Issue 2, 25 4 2019, Pages 283-301 De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia. Haijes HA, Koster MJE, Rehmann H, Li D, Hakonarson H, Cappuccio G, Hancarova M, Lehalle D, Reardon W, Schaefer GB, Lehman A, van de Laar IMBH, Tesselaar CD, Turner C, Goldenberg A, Patrier S, Thevenon J, Pinelli M, Brunetti-Pierri N, Prchalová D, Havlovicová M, Vlckova M, Sedláček Z, Lopez E, Ragoussis V, Pagnamenta AT, Kini U, Vos HR, van Es RM, van Schaik RFMA, van Essen TAJ, Kibaek M, Taylor JC, Sullivan J, Shashi V, Petrovski S, Fagerberg C, Martin DM, van Gassen KLI, Pfundt R, Falk MJ, McCormick EM, Timmers HTM, van Hasselt PM

The RNA polymerase II complex (pol II) is responsible for transcription of all ∼21,000 human protein-encoding genes. Here, we describe sixteen individuals harboring de novo heterozygous variants in POLR2A, encoding RPB1, the largest subunit of pol II. An iterative approach combining structural evaluation and mass spectrometry analyses, the use of S. cerevisiae as a model system, and the assessment of cell viability in HeLa cells allowed us to classify eleven variants as probably disease-causing... Abstract

Cited 18 times since 2019 (3.1 per year) source: EuropePMC

JMIR mental health, Volume 6, Issue 7, 25 4 2019, Pages e12707 Unraveling the Black Box: Exploring Usage Patterns of a Blended Treatment for Depression in a Multicenter Study. Kemmeren LL, van Schaik A, Smit JH, Ruwaard J, Rocha A, Henriques M, Ebert DD, Titzler I, Hazo JB, Dorsey M, Zukowska K, Riper H

Background: Blended treatments, combining digital components with face-to-face (FTF) therapy, are starting to find their way into mental health care. Knowledge on how blended treatments should be set up is, however, still limited. To further explore and optimize blended treatment protocols, it is important to obtain a full picture of what actually happens during treatments when applied in routine mental health care. Objective: The aims of this study were to gain insight into the usage of the dif... Abstract

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Research

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