7971 results
Cited 22 times since 2020 (4.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 11, 1 1 2020, Pages 1248-1258
Incremental value of left ventricular global longitudinal strain in a newly proposed staging classification based on cardiac damage in patients with severe aortic stenosis.
Vollema EM, Amanullah MR, Prihadi EA, Ng ACT, van der Bijl P, Sin YK, Ajmone Marsan N, Ding ZP, Généreux P, Leon MB, Ewe SH, Delgado V, Bax JJ
Aims: Cardiac damage in severe aortic stenosis (AS) can be classified according to a recently proposed staging classification. The present study investigated the incremental prognostic value of left ventricular (LV) global longitudinal strain (GLS) over stages of cardiac damage in patients with severe AS. Methods and results: From an ongoing registry, a total of 616 severe symptomatic AS patients with available LV GLS by speckle tracking echocardiography were selected and retrospectively analyse...
Abstract
Cited 18 times since 2020 (3.9 per year)
source: EuropePMC
The Journal of experimental medicine,
Volume 217, Issue 10, 1 1 2020, Pages e20200318
Liver X receptors are required for thymic resilience and T cell output.
Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity-critically contribute to thymic integrity and function. LXRαβ-deficient mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoire. LXRαβ's functions are cell specific, and the resulting phen...
Abstract
Alcohol and alcoholism (Oxford, Oxfordshire),
Volume 55, Issue 6, 1 1 2020, Pages 705
Corrigendum to: L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety.
Eriksson CJP, Metsälä M, Möykkynen T, Mäkisalo H, Kärkkäinen O, Palmén M, Salminen JE, Kauhanen J
Abstract
Cited 25 times since 2020 (5.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 107, Issue 5, 1 1 2020, Pages 411-418
Parameters associated with ventricular arrhythmias in mitral valve prolapse with significant regurgitation.
van Wijngaarden AL, de Riva M, Hiemstra YL, van der Bijl P, Fortuni F, Bax JJ, Delgado V, Ajmone Marsan N
Objective: Mitral valve prolapse (MVP) has been associated with ventricular arrhythmias (VA), but little is known about VA in patients with significant primary mitral regurgitation (MR). Our aim was to describe the prevalence of symptomatic VA in patients with MVP (fibro-elastic deficiency or Barlow's disease) referred for mitral valve (MV) surgery because of moderate-to-severe MR, and to identify clinical, electrocardiographic, standard and advanced echocardiographic parameters associated...
Abstract
Cited 12 times since 2020 (2.6 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 13, Issue 11, 1 1 2020, Pages e008484
Long-Term Outcome of the Randomized DAPA Trial.
Haanschoten DM, Elvan A, Ramdat Misier AR, Delnoy PPHM, Smit JJJ, Adiyaman A, Demirel F, Wellens HJJ, Verheugt FWA, Ottervanger JP, DAPA Investigators
Background: The randomized DAPA trial (Defibrillator After Primary Angioplasty) aimed to evaluate the survival benefit of prophylactic implantable cardioverter defibrillator (ICD) implantation in early selected high-risk patients after primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction. Methods: A randomized, multicenter, controlled trial compared ICD versus conventional medical therapy in high-risk patients with primary percutaneous coronary intervention,...
Abstract
Cited 9 times since 2020 (1.9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 11, 1 1 2020, Pages 1227-1234
Left ventricular mechanical dispersion in ischaemic cardiomyopathy: association with myocardial scar burden and prognostic implications.
Abou R, Prihadi EA, Goedemans L, van der Geest R, El Mahdiui M, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Left ventricular (LV) mechanical dispersion (MD) may result from heterogeneous electrical conduction and is associated with adverse events. The present study investigated (i) the association between LV MD and the extent of LV scar as assessed with contrast-enhanced cardiac magnetic resonance (CMR) and (ii) the prognostic implications of LV MD in patients after ST-segment elevation myocardial infarction. Methods and results: LV MD was calculated by echocardiography and myocardial scar was a...
Abstract
Cited 10 times since 2020 (2.1 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 3, 1 1 2020, Pages 232-239
Impact of age on coronary artery plaque progression and clinical outcome: A PARADIGM substudy.
Kim M, Lee SP, Kwak S, Yang S, Kim YJ, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Lin FY, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ
Background: The association of age with coronary plaque dynamics is not well characterized by coronary computed tomography angiography (CCTA). Methods: From a multinational registry of patients who underwent serial CCTA, 1153 subjects (61 ± 5 years old, 61.1% male) were analyzed. Annualized volume changes of total, fibrous, fibrofatty, necrotic core, and dense calcification plaque components of the whole heart were compared by age quartile groups. Clinical events, a composite of all-cause death,...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
International journal of stroke : official journal of the International Stroke Society,
Volume 16, Issue 5, 30 5 2020, Pages 534-541
The association between computed tomography angiography timing and workflow times in patients with acute ischemic stroke.
Dessens FM, Groot AE, van der Veen B, Treurniet KM, Majoie CB, Driessen-Waaijer A, Weinstein HC, Roos YB, Van den Berg-Vos RM, Coutinho JM, van Schaik SM
Background: In most hospitals, computed tomography angiography (CTA) is nowadays routinely performed in patients with acute ischemic stroke. However, it is unclear whether CTA is best performed before or after start of intravenous thrombolysis (IVT), since acquisition of CTA before IVT may prolong door-to-needle times, while acquisition after IVT may prolong door-to-groin times in patients undergoing endovascular treatment. Methods: We performed a before-versus-after study (CTA following IVT, pe...
Abstract
Cited 5 times since 2020 (1.1 per year)
source: EuropePMC
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,
Volume 29, Issue 12, 30 5 2020, Pages 105326
CT Angiography of the Heart and Aorta in TIA and Ischaemic Stroke: Cardioembolic Risk Sources and Clinical Implications.
Holswilder G, Wermer MJ, Holman ER, Kruyt ND, Kroft LJ, van Walderveen MA
Background: Cardiac emboli are important causes of (recurrent) ischaemic stroke. Aorta atherosclerosis might also be associated with an increased risk of stroke recurrence. This study aimed to evaluate the yield and clinical implications of CT-angiography (CTA) of the heart and aorta in the diagnostic workup of transient ischaemic attack (TIA) or ischaemic stroke. Methods: CTA of the heart and aortic arch was performed in TIA/ischaemic stroke patients, in addition to routine diagnostic workup. O...
Abstract
Cited 49 times since 2020 (10.5 per year)
source: EuropePMC
The American journal of medicine,
Volume 134, Issue 4, 30 5 2020, Pages 482-489
Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe.
Sokolski M, Gajewski P, Zymliński R, Biegus J, Berg JMT, Bor W, Braunschweig F, Caldeira D, Cuculi F, D'Elia E, Edes IF, Garus M, Greenwood JP, Halfwerk FR, Hindricks G, Knuuti J, Kristensen SD, Landmesser U, Lund LH, Lyon A, Mebazaa A, Merkely B, Nawrocka-Millward S, Pinto FJ, Ruschitzka F, Semedo E, Senni M, Sepehri Shamloo A, Sorensen J, Stengaard C, Thiele H, Toggweiler S, Tukiendorf A, Verhorst PM, Wright DJ, Zamorano P, Zuber M, Narula J, Bax JJ, Ponikowski P
Purpose: We evaluated whether the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic was associated with changes in the pattern of acute cardiovascular admissions across European centers. Methods: We set-up a multicenter, multinational, pan-European observational registry in 15 centers from 12 countries. All consecutive acute admissions to emergency departments and cardiology departments throughout a 1-month period during the COVID-19 outbreak were compared with an equivalent...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Cardiology in the young,
Volume 30, Issue 12, 29 5 2020, Pages 1960-1963
Dealing with kinked and swirled pulmonary vessels: surgical treatment of arterial tortuosity syndrome: a case report.
Ricciardi G, Sojak V, Hazekamp MG
We present the case of a child with arterial tortuosity syndrome, describing the operative findings and our surgical technique to address pulmonary arteries stenosis.
Abstract
Cited 22 times since 2020 (4.7 per year)
source: EuropePMC
Arthritis & rheumatology (Hoboken, N.J.),
Volume 72, Issue 11, 29 5 2020, Pages 1897-1904
Association of Anti-Topoisomerase I Antibodies of the IgM Isotype With Disease Progression in Anti-Topoisomerase I-Positive Systemic Sclerosis.
Boonstra M, Bakker JA, Grummels A, Ninaber MK, Ajmone Marsan N, Wortel CM, Huizinga TWJ, Jordan S, Hoffman-Vold AM, Distler O, Toes REM, Scherer HU, de Vries-Bouwstra JK
Objective: Anti-topoisomerase I (anti-topo I) autoantibodies in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the relationship between anti-topo I antibody response and disease course has not yet been fully evaluated. This study was undertaken to gain insight into the association between characteristics of the anti-topo I antibody response and clinical disease course in SSc patients positive for anti-topo I antibodies. Me...
Abstract
Cited 12 times since 2020 (2.6 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 29 5 2020, Pages 15968
bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice.
Parma L, Peters HAB, Sluiter TJ, Simons KH, Lazzari P, de Vries MR, Quax PHA
Intraplaque angiogenesis increases the chance of unstable atherosclerotic plaque rupture and thrombus formation leading to myocardial infarction. Basic Fibroblast Growth Factor (bFGF) plays a key role in angiogenesis and inflammation and is involved in the pathogenesis of atherosclerosis. Therefore, we aim to test K5, a small molecule bFGF-inhibitor, on remodelling of accelerated atherosclerotic vein grafts lesions in ApoE3*Leiden mice. K5-mediated bFGF-signalling blockade strongly decreased int...
Abstract
Cited 10 times since 2020 (2.1 per year)
source: EuropePMC
Disease models & mechanisms,
Volume 13, Issue 9, 28 4 2020, Pages dmm044990
Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy.
Peterson JC, Wisse LJ, Wirokromo V, van Herwaarden T, Smits AM, Gittenberger-de Groot AC, Goumans MTH, VanMunsteren JC, Jongbloed MRM, DeRuiter MC
Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The mechanisms underlying BAV-associated aortopathy are poorly understood. This study examined BAV-associated aortopathy in Nos3-/- mice, a model with congenital BAV formation. A combination of histological examination and in vivo ultrasound imaging was used to investigate aortic dilation and dissections in Nos3-...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Journal of vascular surgery cases and innovative techniques,
Volume 6, Issue 4, 25 4 2020, Pages 633-636
Giant true hepatic aneurysm mimicking Mirizzi syndrome.
Corion CLS, Vriens PWHE, Alwayn IPJ, Hamming JF, van Schaik J
Giant true aneurysms of the hepatic arteries are rare. Pseudoaneurysms of the hepatic arteries are more common and are mostly caused by intra-abdominal infection, iatrogenic injury, or trauma. Hepatic or cystic pseudoaneurysms are often successfully treated by embolization owing to their saccular nature as opposed to true aneurysms. We present a case of a patient with a giant true aneurysm of the proper hepatic artery, mimicking Mirizzi syndrome. Open reconstruction was successfully preformed, a...
Abstract
Cited 60 times since 2020 (12.8 per year)
source: EuropePMC
Journal of medical Internet research,
Volume 22, Issue 9, 25 4 2020, Pages e17831
Internet and Computer-Based Cognitive Behavioral Therapy for Anxiety and Depression in Adolescents and Young Adults: Systematic Review and Meta-Analysis.
Christ C, Schouten MJ, Blankers M, van Schaik DJ, Beekman AT, Wisman MA, Stikkelbroek YA, Dekker JJ
Background: Anxiety and depressive disorders are prevalent in adolescents and young adults. However, most young people with mental health problems do not receive treatment. Computerized cognitive behavior therapy (cCBT) may provide an accessible alternative to face-to-face treatment, but the evidence base in young people is limited. Objective: The objective was to perform an up-to-date comprehensive systematic review and meta-analysis of the effectiveness of cCBT in treating anxiety and depressi...
Abstract
Cited 20 times since 2020 (4.3 per year)
source: EuropePMC
Cells,
Volume 9, Issue 10, 24 4 2020, Pages E2164
Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits.
Heuschkel MA, Skenteris NT, Hutcheson JD, van der Valk DD, Bremer J, Goody P, Hjortnaes J, Jansen F, Bouten CVC, van den Bogaerdt A, Matic L, Marx N, Goettsch C
Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in the developed world, yet no pharmacological therapy exists. Here, we hypothesize that the integration of multiple omic data represents an approach towards unveiling novel molecular networks in CAVD. Databases were searched for CAVD omic studies. Differentially expressed molecules from calcified and control samples were retrieved, identifying 32 micro RNAs (miRNA), 596 mRNAs and 80 proteins. Over-representation p...
Abstract
Cited 75 times since 2020 (16 per year)
source: EuropePMC
Surgery,
Volume 169, Issue 2, 24 4 2020, Pages 264-274
Perioperative SARS-CoV-2 infections increase mortality, pulmonary complications, and thromboembolic events: A Dutch, multicenter, matched-cohort clinical study.
Jonker PKC, van der Plas WY, Steinkamp PJ, Poelstra R, Emous M, van der Meij W, Thunnissen F, Bierman WFW, Struys MMRF, de Reuver PR, de Vries JPM, Kruijff S, Dutch Surgical COVID-19 Research Collaborative
Background: A direct comparison of severe acute respiratory syndrome coronavirus 2 positive patients with a severe acute respiratory syndrome coronavirus 2 negative control group undergoing an operative intervention during the current pandemic is lacking, and a reliable estimate of the assumed difference in morbidity and mortality between both patient categories remains unknown. Methods: We included all consecutive patients with a confirmed pre- or postoperative severe acute respiratory syndrome...
Abstract
Cited 15 times since 2020 (3.2 per year)
source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 28, Issue 1, 23 4 2020, Pages 78-92
Image Fusion During Standard and Complex Endovascular Aortic Repair, to Fuse or Not to Fuse? A Meta-analysis and Additional Data From a Single-Center Retrospective Cohort.
Doelare SAN, Smorenburg SPM, van Schaik TG, Blankensteijn JD, Wisselink W, Nederhoed JH, Lely RJ, Hoksbergen AWJ, Yeung KK
Purpose: To determine if image fusion will reduce contrast volume, radiation dose, and fluoroscopy and procedure times in standard and complex (fenestrated/branched) endovascular aneurysm repair (EVAR). Materials and methods: A search of the PubMed, Embase, and Cochrane databases was performed in December 2019 to identify articles describing results of standard and complex EVAR procedures using image fusion compared with a control group. Study selection, data extraction, and assessment of the me...
Abstract
Cited 4 times since 2020 (0.9 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 2, 23 4 2020, Pages 121-128
The clinical utility of FFR<sub>CT</sub> stratified by age.
Anastasius M, Maggiore P, Huang A, Blanke P, Patel MR, Nørgaard BL, Fairbairn TA, Nieman K, Akasaka T, Berman DS, Raff GL, Hurwitz Koweek LM, Pontone G, Kawasaki T, Rønnow Sand NP, Jensen JM, Amano T, Poon M, Øvrehus KA, Sonck J, Rabbat MG, Mullen S, De Bruyne B, Rogers C, Matsuo H, Bax JJ, Leipsic J
Background: CT coronary angiography (CTA) with Fractional Flow Reserve as determined by CT (FFRCT) is a safe alternative to invasive coronary angiography. A negative FFRCT has been shown to have low cardiac event rates compared to those with a positive FFRCT. However, the clinical utility of FFRCT according to age is not known. Methods: Patients' in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry, were stratified into those ≥65 or
Abstract
