Research

Publications

Below you can find a list of our published research.

6139 results

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 19, Issue 4, 1 1 2017, Pages 560-567 Limited left atrial surgical ablation effectively treats atrial fibrillation but decreases left atrial function. Compier MG, Tops LF, Braun J, Zeppenfeld K, Klautz RJ, Schalij MJ, Trines SA

Aims: Limited left atrial (LA) surgical ablation with bipolar radiofrequency is considered to be an effective procedure for treatment of atrial fibrillation (AF). We studied whether limited LA surgical ablation concomitant to cardiac surgery is able to maintain LA function. Methods and results: Thirty-six consecutive patients (age 66 ± 12 years, 53% male, 78% persistent AF) scheduled for valve surgery and/or coronary revascularization and concomitant LA surgical ablation were included. Epicardia... Abstract

Cited 15 times since 2017 (1.9 per year) source: EuropePMC

Oncotarget, Volume 8, Issue 17, 1 1 2017, Pages 28650-28659 Expression of HIF-1α in medullary thyroid cancer identifies a subgroup with poor prognosis. Lodewijk L, van Diest P, van der Groep P, Ter Hoeve N, Schepers A, Morreau J, Bonenkamp J, van Engen-van Grunsven A, Kruijff S, van Hemel B, Links T, Nieveen van Dijkum E, van Eeden S, Valk G, Borel Rinkes I, Vriens M

Background: Medullary thyroid cancer (MTC) comprises only 4% of all thyroid cancers and originates from the parafollicular C-cells. HIF-1α expression has been implied as an indicator of worse prognosis in various solid tumors. However, whether expression of HIF-1α is a prognosticator in MTC remained unclear. Our aim was to evaluate the prognostic value of HIF-1α in patients with MTC. Methods: All patients with MTC who were operated on between 1988 and 2014 in five tertiary referral centers in Th... Abstract

Cited 22 times since 2017 (2.8 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 114, Issue 15, 27 4 2017, Pages E3022-E3031 High-throughput identification of small molecules that affect human embryonic vascular development. Vazão H, Rosa S, Barata T, Costa R, Pitrez PR, Honório I, de Vries MR, Papatsenko D, Benedito R, Saris D, Khademhosseini A, Quax PH, Pereira CF, Mercader N, Fernandes H, Ferreira L

Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and limited mechanistic information regarding the biological pathways and potential adverse consequences in humans. To develop a screening platform for molecules that affect hum... Abstract

Heart rhythm, Volume 14, Issue 7, 23 4 2017, Pages 1051-1052 The right timing for the left lead: Now or later? Yilmaz D, van Erven L, Borleffs CJW, Thijssen J

Abstract

Cited 2 times since 2017 (0.3 per year) source: EuropePMC

Minerva cardioangiologica, Volume 65, Issue 5, 23 4 2017, Pages 516-530 Multimodality imaging to plan and guide transcatheter tricuspid valve interventions. Prihadi EA, Delgado V, Bax JJ

Tricuspid regurgitation (TR) is a highly prevalent valvular heart disease. The natural history of untreated significant TR portends an unfavorable outcome, but only a minority of patients is currently referred for surgical treatment. Organic TR (caused by primary abnormality of the leaflets) is relatively infrequent whereas secondary or functional TR (caused by dilatation of the tricuspid annulus, right ventricle [RV] and right atrium) is the predominant mechanism. The success of transcatheter t... Abstract

Cited 6 times since 2017 (0.8 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 40, Issue 5, 23 4 2017, Pages 504-513 Effects of Spinal Cord Stimulation on Cardiac Sympathetic Nerve Activity in Patients with Heart Failure. Naar J, Jaye D, Linde C, Neužil P, Doškář P, Málek F, Braunschweig F, Lund LH, Mortensen L, Linderoth B, Lind G, Bone D, Scholte AJ, Kueffer F, Koehler J, Shahgaldi K, Lang O, Ståhlberg M

Background: Spinal cord stimulation (SCS) reduces sympathetic activity in animal models of heart failure with reduced ejection fraction (HF) but limited data exist of SCS in patients with HF. The aim of the present study was to test the primary hypothesis that SCS reduces cardiac sympathetic nerve activity in HF patients. Secondary hypotheses were that SCS improves left ventricular function and dimension, exercise capacity, and clinical variables relevant to HF. Methods: HF patients with a SCS d... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

Environmental management, Volume 62, Issue 1, 21 3 2017, Pages 170-181 Participatory Planning, Monitoring and Evaluation of Multi-Stakeholder Platforms in Integrated Landscape Initiatives. Kusters K, Buck L, de Graaf M, Minang P, van Oosten C, Zagt R

Integrated landscape initiatives typically aim to strengthen landscape governance by developing and facilitating multi-stakeholder platforms. These are institutional coordination mechanisms that enable discussions, negotiations, and joint planning between stakeholders from various sectors in a given landscape. Multi-stakeholder platforms tend to involve complex processes with diverse actors, whose objectives and focus may be subjected to periodic re-evaluation, revision or reform. In this articl... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

BMJ open, Volume 7, Issue 3, 20 3 2017, Pages e014360 Design and reliability of a specific instrument to evaluate patient safety for patients with acute myocardial infarction treated in a predefined care track: a retrospective patient record review study in a single tertiary hospital in the Netherlands. Eindhoven DC, Borleffs CJ, Dietz MF, Schalij MJ, Brouwers C, de Bruijne MC

Objective: Numerous studies have shown that a substantial number of patients suffer from adverse events (AEs) as a result of hospital care. However, specific data on AEs in acute cardiac care are scarce. The current manuscript describes the development and validation of a specific instrument to evaluate patient safety of a predefined care track for patients with acute myocardial infarction (AMI). Design: Retrospective patient record review study. Setting and participants: A total of 879 hospital... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

Lancet (London, England), Volume 389, Issue 10087, 19 3 2017, Pages 2352-2354 Bioprosthetic surgical and transcatheter heart valve thrombosis. Bax JJ, Stone GW

Abstract

Cited 158 times since 2017 (19.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 69, Issue 21, 18 3 2017, Pages 2579-2589 Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis. Yoon SH, Bleiziffer S, De Backer O, Delgado V, Arai T, Ziegelmueller J, Barbanti M, Sharma R, Perlman GY, Khalique OK, Holy EW, Saraf S, Deuschl F, Fujita B, Ruile P, Neumann FJ, Pache G, Takahashi M, Kaneko H, Schmidt T, Ohno Y, Schofer N, Kong WKF, Tay E, Sugiyama D, Kawamori H, Maeno Y, Abramowitz Y, Chakravarty T, Nakamura M, Kuwata S, Yong G, Kao HL, Lee M, Kim HS, Modine T, Wong SC, Bedgoni F, Testa L, Teiger E, Butter C, Ensminger SM, Schaefer U, Dvir D, Blanke P, Leipsic J, Nietlispach F, Abdel-Wahab M, Chevalier B, Tamburino C, Hildick-Smith D, Whisenant BK, Park SJ, Colombo A, Latib A, Kodali SK, Bax JJ, Søndergaard L, Webb JG, Lefèvre T, Leon MB, Makkar R

Background: Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid aortic valve stenosis (AS). Objectives: This study sought to compare the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS from the Bicuspid AS TAVR multicenter registry. Methods: Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity score matching, assembling 546 pairs of patients with similar bas... Abstract

Cited 312 times since 2017 (39 per year) source: EuropePMC

The New England journal of medicine, Volume 376, Issue 16, 17 3 2017, Pages 1527-1539 Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC, SPIRE Cardiovascular Outcome Investigators

Background: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. Methods: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) sub... Abstract

Cited 154 times since 2017 (19.2 per year) source: EuropePMC

The New England journal of medicine, Volume 376, Issue 16, 17 3 2017, Pages 1517-1526 Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab. Ridker PM, Tardif JC, Amarenco P, Duggan W, Glynn RJ, Jukema JW, Kastelein JJP, Kim AM, Koenig W, Nissen S, Revkin J, Rose LM, Santos RD, Schwartz PF, Shear CL, Yunis C, SPIRE Investigators

Background: Bococizumab, a humanized monoclonal antibody targeting proprotein convertase subtilisin-kexin type 9 (PCSK9), reduces levels of low-density lipoprotein (LDL) cholesterol. However, the variability and durability of this effect are uncertain. Methods: We conducted six parallel, multinational lipid-lowering trials enrolling 4300 patients with hyperlipidemia who were randomly assigned to receive 150 mg of bococizumab or placebo subcutaneously every 2 weeks and who were followed for up to... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

Open heart, Volume 4, Issue 1, 15 3 2017, Pages e000541 Prognosis of complete versus incomplete revascularisation of patients with STEMI with multivessel coronary artery disease: an observational study. Dimitriu-Leen AC, Hermans MP, Veltman CE, van der Hoeven BL, van Rosendael AR, van Zwet EW, Schalij MJ, Delgado V, Bax JJ, Scholte AJ

Objective: The best strategy in patients with acute ST-segment elevation myocardial infarction (STEMI) with multivessel coronary artery disease (CAD) regarding completeness of revascularisation of the non-culprit lesion(s) is still unclear. To establish which strategy should be followed, survival rates over a longer period should be evaluated. The aim of this study was to investigate whether complete revascularisation, compared with incomplete revascularisation, is associated with reduced short-... Abstract

Cited 11 times since 2017 (1.4 per year) source: EuropePMC

Molecular therapy. Nucleic acids, Volume 7, 14 2 2017, Pages 61-70 Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494. Welten SMJ, de Vries MR, Peters EAB, Agrawal S, Quax PHA, Nossent AY

Improving the efficacy of neovascularization is a promising strategy to restore perfusion of ischemic tissues in patients with peripheral arterial disease. The 14q32 microRNA cluster is highly involved in neovascularization. The Mef2a transcription factor has been shown to induce transcription of the microRNAs within this cluster. We inhibited expression of Mef2a using gene-silencing oligonucleotides (GSOs) in an in vivo hind limb ischemia model. Treatment with GSO-Mef2a clearly improved blood f... Abstract

Cited 36 times since 2017 (4.5 per year) source: EuropePMC

Radiology, Volume 284, Issue 1, 14 2 2017, Pages 55-65 Prognostic Value of Combined CT Angiography and Myocardial Perfusion Imaging versus Invasive Coronary Angiography and Nuclear Stress Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events: The CORE320 Multicenter Study. Chen MY, Rochitte CE, Arbab-Zadeh A, Dewey M, George RT, Miller JM, Niinuma H, Yoshioka K, Kitagawa K, Sakuma H, Laham R, Vavere AL, Cerci RJ, Mehra VC, Nomura C, Kofoed KF, Jinzaki M, Kuribayashi S, Scholte AJ, Laule M, Tan SY, Hoe J, Paul N, Rybicki FJ, Brinker JA, Arai AE, Matheson MB, Cox C, Clouse ME, Di Carli MF, Lima JAC

Purpose To compare the prognostic importance (time to major adverse cardiovascular event [MACE]) of combined computed tomography (CT) angiography and CT myocardial stress perfusion imaging with that of combined invasive coronary angiography (ICA) and stress single photon emission CT myocardial perfusion imaging. Materials and Methods This study was approved by all institutional review boards, and written informed consent was obtained. Between November 2009 and July 2011, 381 participants clinica... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

Cardiac electrophysiology clinics, Volume 9, Issue 2, 13 2 2017, Pages 285-294 Clinical Aspects and Ablation of Ventricular Arrhythmias in Tetralogy of Fallot. Zeppenfeld K, Wijnmaalen AP

Life expectancy of patients with rToF has considerably improved due to refined surgical interventions. Monomorphic fast VTs are frequently encountered in adult patients with rToF. The dominant substrate of VT is anatomical isthmuses bordered by surgical incisions, patch material and valve annuli. Substrate based ablation strategies aim to transect all slow conducting anatomical isthmuses (SCAI) as identified by electroanatomical mapping. Procedural success is defined as non-inducibility of VT an... Abstract

Annals of vascular surgery, Volume 42, 11 2 2017, Pages 293-298 PX-18 Protects Human Saphenous Vein Endothelial Cells under Arterial Blood Pressure. Kupreishvili K, Stooker W, Emmens RW, Vonk ABA, Sipkens JA, van Dijk A, Eijsman L, Quax PH, van Hinsbergh VWM, Krijnen PAJ, Niessen HWM

Background: Arterial blood pressure-induced shear stress causes endothelial cell apoptosis and inflammation in vein grafts after coronary artery bypass grafting. As the inflammatory protein type IIA secretory phospholipase A2 (sPLA2-IIA) has been shown to progress atherosclerosis, we hypothesized a role for sPLA2-IIA herein. Methods: The effects of PX-18, an inhibitor of both sPLA2-IIA and apoptosis, on residual endothelium and the presence of sPLA2-IIA were studied in human saphenous vein segme... Abstract

Cited 14 times since 2017 (1.7 per year) source: EuropePMC

European journal of heart failure, Volume 19, Issue 4, 8 2 2017, Pages 449-456 Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases. Filippatos GS, de Graeff P, Bax JJ, Borg JJ, Cleland JG, Dargie HJ, Flather M, Ford I, Friede T, Greenberg B, Henon-Goburdhun C, Holcomb R, Horst B, Lekakis J, Mueller-Velten G, Papavassiliou AG, Prasad K, Rosano GM, Severin T, Sherman W, Stough WG, Swedberg K, Tavazzi L, Tousoulis D, Vardas P, Ruschitzka F, Anker SD

Data Monitoring Committees (DMCs) play a crucial role in the conducting of clinical trials to ensure the safety of study participants and to maintain a trial's scientific integrity. Generally accepted standards exist for DMC composition and operational conduct. However, some relevant issues are not specifically addressed in current guidance documents, resulting in uncertainties regarding optimal approaches for communication between the DMC, steering committee, and sponsors, release of infor... Abstract

Cited 22 times since 2017 (2.7 per year) source: EuropePMC

Journal of the American Heart Association, Volume 6, Issue 3, 8 2 2017, Pages e005281 CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia. Nossent AY, Bastiaansen AJ, Peters EA, de Vries MR, Aref Z, Welten SM, de Jager SC, van der Pouw Kraan TC, Quax PH

Background: In order to identify factors that stimulate arteriogenesis after ischemia, we followed gene expression profiles in two extreme models for collateral artery formation over 28 days after hindlimb ischemia, namely "good-responding" C57BL/6 mice and "poor-responding" BALB/c mice. Methods and results: Although BALB/c mice show very poor blood flow recovery after ischemia, most known proarteriogenic genes were upregulated more excessively and for a longer period than in... Abstract

Cited 9 times since 2017 (1.1 per year) source: EuropePMC

International journal of cardiology, Volume 237, 6 1 2017, Pages 15-18 Sudden cardiac death: The role of imaging. van der Bijl P, Delgado V, Bax JJ

Sudden cardiac death (SCD) is defined as "a non-traumatic, unexpected, fatal event occurring within one hour of the onset of symptoms in an apparently healthy subject", and it causes a fifth of all deaths worldwide. It often occurs in individuals not previously known with cardiac disease, which makes prevention challenging. The mechanism underlying SCD is thought to be a trigger (e.g. ischemia) acting upon a substrate (e.g. scar), causing a lethal arrhythmia. Primary prevention refers... Abstract