8892 results
Circulation,
Volume 140, Issue 18, 28 4 2019, Pages e744-e745
Response by Timal and Jukema to Letter Regarding Article, "Random Controlled Trials of Sudden Cardiac Death: Use of Autopsy to Refine Sudden Cardiac Death Outcomes".
Timal RJ, Jukema JW
Abstract
Cited 2133 times since 2019 (355.9 per year)
source: EuropePMC
Nature,
Volume 575, Issue 7784, 21 3 2019, Pages 693-698
FSP1 is a glutathione-independent ferroptosis suppressor.
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4)3,4 and radical-trapping antioxidants5,6. However, elucidation of the factors that underlie the sensitivity of a given cell type to ferroptosis7 is crucial to understand the pathophysiological role of ferroptosis and how it may be exploited for the t...
Abstract
Cited 62 times since 2019 (10.3 per year)
source: EuropePMC
Nature communications,
Volume 10, Issue 1, 18 3 2019, Pages 4755
Identification of atrial fibrillation associated genes and functional non-coding variants.
van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori LE, Scholman KT, Liu J, de Vries AAF, Boukens BJ, Ellinor PT, Goumans MJTH, Efimov IR, Nobrega MA, Barnett P, Martin JF, Christoffels VM
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized....
Abstract
Cited 25 times since 2019 (4.2 per year)
source: EuropePMC
Frontiers in microbiology,
Volume 10, 17 3 2019, Pages 2394
Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters.
Strubbia S, Schaeffer J, Oude Munnink BB, Besnard A, Phan MVT, Nieuwenhuijse DF, de Graaf M, Schapendonk CME, Wacrenier C, Cotten M, Koopmans MPG, Le Guyader FS
Metagenomic sequencing is a promising method to determine the virus diversity in environmental samples such as sewage or shellfish. However, to identify the short RNA genomes of human enteric viruses among the large diversity of nucleic acids present in such complex matrices, method optimization is still needed. This work presents methodological developments focused on norovirus, a small ssRNA non-enveloped virus known as the major cause of human gastroenteritis worldwide and frequently present...
Abstract
Cited 6 times since 2019 (1 per year)
source: EuropePMC
Cardiology and therapy,
Volume 8, Issue 2, 16 3 2019, Pages 345-356
Electrocardiographic Detection of Left Ventricular Hypertrophy; Adding Body Mass Index and Spatial QRS-T Angle: A Cross-Sectional Study.
Elffers TW, Trompet S, de Mutsert R, Maan AC, Lamb HJ, Macfarlane PW, Rosendaal FR, Jukema JW
Introduction: We investigated improvement of electrocardiographic LVH detection by adding measures of adiposity and/or novel electrocardiographic measures. Left ventricular hypertrophy (LVH) is an important risk factor for adverse cardiovascular outcomes. Improvement of electrocardiographic criteria for LVH is desirable, since electrocardiography is widely used. Methods: We included 1091 participants of the Netherlands Epidemiology of Obesity Study (NEO) who underwent cardiac magnetic resonance...
Abstract
Cited 15 times since 2019 (2.5 per year)
source: EuropePMC
Brain research,
Volume 1726, 16 3 2019, Pages 146510
Artificial Intelligence and the detection of pediatric concussion using epigenomic analysis.
Bahado-Singh RO, Vishweswaraiah S, Er A, Aydas B, Turkoglu O, Taskin BD, Duman M, Yilmaz D, Radhakrishna U
Concussion, also referred to as mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury. Currently concussion is an area ofintensescientific interest to better understand the biological mechanisms and for biomarker development. We evaluated whole genome-wide blood DNA cytosine ('CpG') methylation in 17 pediatric concussion isolated cases and 18 unaffected controls using Illumina Infinium MethylationEPIC assay. Pathway analysis was performed using Ingenuity...
Abstract
Cited 5 times since 2019 (0.8 per year)
source: EuropePMC
Nanomedicine (London, England),
Volume 14, Issue 21, 16 3 2019, Pages 2783-2798
Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.
Khan A, Al-Harrasi A, Rehman NU, Sarwar R, Ahmad T, Ghaffar R, Khan H, Al-Amri I, Csuk R, Al-Rawahi A
Aim: Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound limited by its low water solubility and bioavailability. To load AKBA on silver nanoparticles (AgNPs) to improve bioavailability and water solubility of the compound. Materials & methods: AKBA-AgNPs were chemically synthesized and characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. AKBA and AKBA-Ag were studied f...
Abstract
Cited 13 times since 2019 (2.2 per year)
source: EuropePMC
BMC cardiovascular disorders,
Volume 19, Issue 1, 15 3 2019, Pages 217
Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs.
Abawi D, Faragli A, Schwarzl M, Manninger M, Zweiker D, Kresoja KP, Verderber J, Zirngast B, Maechler H, Steendijk P, Pieske B, Post H, Alogna A
Background: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 und...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 163, 11 2 2019, Pages D3963
[Suspected traumatic posterior shoulder luxation].
Keulen MHF, de Joode SGCJ, Klemann-Harings SEJM, Samijo SK
BACKGROUND An obstetric brachial plexus lesion arises during childbirth as a consequence of excessive lateral traction of the neonate's head during shoulder dystocia. A small number of patients do not experience spontaneous recovery and secondary glenohumeral deformities can arise due to rotator cuff imbalance. CASE DESCRIPTION A 34-year-old man of Syrian descent with a history of a conservatively treated right-sided obstetric brachial plexus lesion went to the accident and emergency depart...
Abstract
Cited 49 times since 2019 (8.1 per year)
source: EuropePMC
Journal of pineal research,
Volume 68, Issue 1, 10 2 2019, Pages e12614
Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice.
Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbée JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S
Disruption of circadian rhythm by means of shift work has been associated with cardiovascular disease in humans. However, causality and underlying mechanisms have not yet been established. In this study, we exposed hyperlipidemic APOE*3-Leiden.CETP mice to either regular light-dark cycles, weekly 6 hours phase advances or delays, or weekly alternating light-dark cycles (12 hours shifts), as a well-established model for shift work. We found that mice exposed to 15 weeks of alternating light-dark...
Abstract
Cited 37 times since 2019 (6.1 per year)
source: EuropePMC
The British journal of surgery,
Volume 107, Issue 2, 9 2 2019, Pages e161-e169
Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery.
EuroSurg Collaborative
Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary ou...
Abstract
Cited 10 times since 2019 (1.7 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 51, Issue 4, 7 1 2019, Pages 1105-1116
Altered Ascending Aorta Hemodynamics in Patients After Arterial Switch Operation for Transposition of the Great Arteries.
van der Palen RLF, Deurvorst QS, Kroft LJM, van den Boogaard PJ, Hazekamp MG, Blom NA, Lamb HJ, Westenberg JJM, Roest AAW
Background: Patients with transposition of the great arteries (TGA) have an altered aortic geometry after an arterial switch operation (ASO), with neo-aortic root dilatation as an important complication. Geometry-related aortic hemodynamics have been assumed to contribute to pathology of the ascending aorta (AAo). Purpose: To evaluate aortic flow displacement (FD) and regional wall shear stress (WSS) in relation to ascending neo-aortic geometry in children after ASO. Study type: Prospective. Pop...
Abstract
Cited 55 times since 2019 (9.1 per year)
source: EuropePMC
Molecular therapy : the journal of the American Society of Gene Therapy,
Volume 28, Issue 1, 7 1 2019, Pages 157-170
MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia.
van der Kwast RVCT, Woudenberg T, Quax PHA, Nossent AY
MicroRNAs are posttranscriptional regulators of gene expression. As microRNAs can target many genes simultaneously, microRNAs can regulate complex multifactorial processes, including post-ischemic neovascularization, a major recovery pathway in cardiovascular disease. MicroRNAs select their target mRNAs via full complementary binding with their seed sequence, i.e., nucleotides 2-8 from the 5' end of a microRNA. The exact sequence of a mature microRNA, and thus of its 5' and 3' end...
Abstract
Cited 28 times since 2019 (4.6 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 109, Issue 6, 5 1 2019, Pages 1858-1863
Total Endovascular Repair of the Aortic Arch: Initial Experience in the Netherlands.
van der Weijde E, Heijmen RH, van Schaik PM, Hazenberg CEVB, van Herwaarden JA
Background: We report procedural and early results in the Netherlands of the Relay Branch device (Terumo Aortic, Sunrise, FL) for total endovascular repair of the aortic arch. Methods: Between 2014 and 2018, all consecutive patients who received the Aortic Relay double-branched stent graft in the Netherlands were included in a multicenter, retrospective registry. Results: The Relay Branch device was used in 11 patients to treat saccular (n = 4), fusiform (n = 5), or false aneurysms (n = 2) in th...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 155, 4 1 2019, Pages 108926
Mean atomic number analysis by the coherent to backscattering intensity ratios at 59.54 and 661.62 photon energies.
Akkuş T, Yılmaz D
In this work, the qualitative analysis has been performed by using ratio of coherent to backscattering intensity ratios. The samples in the mean atomic number range 4.268≤Z‾≤5.786 and 9.743≤Z‾≤83.00 were prepared by using dilution technique. 59.54 and 661.62 keV photon energies are obtained from the radioactive point sources of 241Am and 137Cs an activity of 0.43-0.20 MBq, respectively. The scattered gamma rays were counted by a HPGe detector with a resolution of 182 eV at 5.9 keV. The obtained...
Abstract
Cited 286 times since 2019 (47.3 per year)
source: EuropePMC
Nature,
Volume 574, Issue 7777, 2 1 2019, Pages 268-272
Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, Te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R
Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatocellular carcinoma3. The induction of senescence may represent a strategy for the treatment of cancer, especially when combined with a second drug that selectively eliminates senescent cancer cells (senolysis)4,5. Here, using a kinome-focused genetic screen, we show that pharmacological i...
Abstract
Cited 29 times since 2019 (4.8 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 12, Issue 10, 1 1 2019, Pages 2029-2048
Transcatheter Interventions for Mitral Regurgitation: Multimodality Imaging for Patient Selection and Procedural Guidance.
Bax JJ, Debonnaire P, Lancellotti P, Ajmone Marsan N, Tops LF, Min JK, Piazza N, Leipsic J, Hahn RT, Delgado V
Transcatheter therapies to treat mitral regurgitation are rapidly developing. Currently, there are several devices commercially available to treat mitral regurgitation. The underlying cause of mitral regurgitation and specific anatomical aspects of the mitral valve and surrounding structures are considered when patients with symptomatic severe mitral regurgitation for transcatheter mitral valve therapies are selected. Multimodality imaging plays an important central role in the selection of pati...
Abstract
Cited 83 times since 2019 (13.7 per year)
source: EuropePMC
Human molecular genetics,
Volume 28, Issue 19, 1 1 2019, Pages 3327-3338
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.
Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson
Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (≥95th percentile of body mass index (BMI) achieved 2-18 years old)...
Abstract
Cited 138 times since 2019 (22.8 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 366, Issue 6464, 1 1 2019, Pages 480-485
Global distribution of earthworm diversity.
Phillips HRP, Guerra CA, Bartz MLC, Briones MJI, Brown G, Crowther TW, Ferlian O, Gongalsky KB, van den Hoogen J, Krebs J, Orgiazzi A, Routh D, Schwarz B, Bach EM, Bennett J, Brose U, Decaëns T, König-Ries B, Loreau M, Mathieu J, Mulder C, van der Putten WH, Ramirez KS, Rillig MC, Russell D, Rutgers M, Thakur MP, de Vries FT, Wall DH, Wardle DA, Arai M, Ayuke FO, Baker GH, Beauséjour R, Bedano JC, Birkhofer K, Blanchart E, Blossey B, Bolger T, Bradley RL, Callaham MA, Capowiez Y, Caulfield ME, Choi A, Crotty FV, Dávalos A, Cosin DJD, Dominguez A, Duhour AE, van Eekeren N, Emmerling C, Falco LB, Fernández R, Fonte SJ, Fragoso C, Franco ALC, Fugère M, Fusilero AT, Gholami S, Gundale MJ, López MG, Hackenberger DK, Hernández LM, Hishi T, Holdsworth AR, Holmstrup M, Hopfensperger KN, Lwanga EH, Huhta V, Hurisso TT, Iannone BV, Iordache M, Joschko M, Kaneko N, Kanianska R, Keith AM, Kelly CA, Kernecker ML, Klaminder J, Koné AW, Kooch Y, Kukkonen ST, Lalthanzara H, Lammel DR, Lebedev IM, Li Y, Lidon JBJ, Lincoln NK,
Soil organisms, including earthworms, are a key component of terrestrial ecosystems. However, little is known about their diversity, their distribution, and the threats affecting them. We compiled a global dataset of sampled earthworm communities from 6928 sites in 57 countries as a basis for predicting patterns in earthworm diversity, abundance, and biomass. We found that local species richness and abundance typically peaked at higher latitudes, displaying patterns opposite to those observed in...
Abstract
Cited 33 times since 2019 (5.5 per year)
source: EuropePMC
BJU international,
Volume 124, Issue 4, 1 1 2019, Pages 693-700
Androgen receptor (AR) splice variant 7 and full-length AR expression is associated with clinical outcome: a translational study in patients with castrate-resistant prostate cancer.
Del Re M, Crucitta S, Sbrana A, Rofi E, Paolieri F, Gianfilippo G, Galli L, Falcone A, Morganti R, Porta C, Efstathiou E, van Schaik R, Jenster G, Danesi R
Objectives: To investigate if full-length androgen receptor (AR-FL) is associated with resistance to androgen receptor (AR)-directed therapy independently and/or combined with AR splice variant 7 (AR-V7). Patients and methods: Plasma samples were prospectively collected from 73 patients with castrate-resistant prostate cancer before first- or second-line AR-directed therapy. mRNA was isolated from exosomes and AR-FL and AR-V7 were analysed by droplet digital PCR. Results: AR-FL was detected in a...
Abstract
