Research

Publications

Below you can find a list of our published research.

9618 results

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 71, Issue 15, 1 1 2018, Pages 1661-1662 Machine Learning for Electrocardiographic Diagnosis of Left Ventricular Early Diastolic Dysfunction. Bax JJ, van der Bijl P, Delgado V

Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 11, Issue 4, 1 1 2018, Pages e007117 Cardiac Rotational Mechanics As a Predictor of Myocardial Recovery in Heart Failure Patients Undergoing Chronic Mechanical Circulatory Support: A Pilot Study. Bonios MJ, Koliopoulou A, Wever-Pinzon O, Taleb I, Stehlik J, Xu W, Wever-Pinzon J, Catino A, Kfoury AG, Horne BD, Nativi-Nicolau J, Adamopoulos SN, Fang JC, Selzman CH, Bax JJ, Drakos SG

Background: Impaired qualitative and quantitative left ventricular (LV) rotational mechanics predict cardiac remodeling progression and prognosis after myocardial infarction. We investigated whether cardiac rotational mechanics can predict cardiac recovery in chronic advanced cardiomyopathy patients. Methods and results: Sixty-three patients with advanced and chronic dilated cardiomyopathy undergoing implantation of LV assist device (LVAD) were prospectively investigated using speckle tracking e... Abstract

Cited 103 times since 2018 (13.9 per year) source: EuropePMC

European heart journal, Volume 39, Issue 14, 1 1 2018, Pages 1131-1143 2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia. Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J, Farnier M, Ference BA, Gielen S, Graham I, Grobbee DE, Hovingh GK, Lüscher TF, Piepoli MF, Ray KK, Ray KK, Stroes ES, Wiklund O, Windecker S, Zamorano JL, Pinto F, Tokgözoglu L, Bax JJ, Catapano AL

Abstract

Cited 22 times since 2018 (3 per year) source: EuropePMC

International journal of epidemiology, Volume 47, Issue 2, 1 1 2018, Pages 396-396j Cohort Profile: The Hoorn Studies. Rutters F, Nijpels G, Elders P, Stehouwer CDA, van der Heijden AA, Groeneveld L, 't Hart LM, Dekker JM, Beulens JWJ

Abstract

Cited 47 times since 2018 (6.4 per year) source: EuropePMC

Clinical pharmacokinetics, Volume 57, Issue 4, 1 1 2018, Pages 475-489 A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation. Andrews LM, Hesselink DA, van Gelder T, Koch BCP, Cornelissen EAM, Brüggemann RJM, van Schaik RHN, de Wildt SN, Cransberg K, de Winter BCM

Background: Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based starting dose is used. It can take weeks to reach the target tacrolimus pre-dose concentration. Objectives: The objectives of this study were to determine the pharmacokinetics of tacrolimus immediately after kidney transplantation and to find relevant parameters for dose individualization using a population pharmacokinetic analy... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Annals of translational medicine, Volume 6, Issue 7, 1 1 2018, Pages 115 No association between systemic complement activation and intensive care unit-acquired weakness. Witteveen E, Wieske L, de Beer FM, Juffermans NP, Verhamme C, Schultz MJ, van Schaik IN, Horn J, BASIC study group

Background: The main risk factors for intensive care unit-acquired weakness (ICU-AW) are sepsis, the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction. These risk factors are associated with systemic complement activation. We hypothesized that critically ill patients who develop ICU-AW have increased systemic complement activation compared to critically ill patients who do not develop ICU-AW. Methods: Complement activation products C3b/c, C4b/c and C5a were measured i... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 566-572 Outcome reporting for surgical treatment of degenerative mitral valve disease: a systematic review and critical appraisal. Tomšic A, Arabkhani B, Schoones JW, van Brakel TJ, Takkenberg JJM, Palmen M, Klautz RJM

Objectives: Standardized outcome reporting is of critical importance for performance monitoring, improvement of existing techniques and introduction of novel technologies. Whether outcome reporting for surgical treatment of degenerative mitral valve disease complies with the guidelines has not been assessed to date. Methods: A systematic review of PubMed, EMBASE, Web of Science and the Cochrane Library was conducted for articles published between 1 January 2009 and 7 March 2016. Inclusion criter... Abstract

Cited 38 times since 2018 (5.1 per year) source: EuropePMC

Endocrine reviews, Volume 39, Issue 2, 1 1 2018, Pages 154-191 Diagnostic Utility of Molecular and Imaging Biomarkers in Cytological Indeterminate Thyroid Nodules. de Koster EJ, de Geus-Oei LF, Dekkers OM, van Engen-van Grunsven I, Hamming J, Corssmit EPM, Morreau H, Schepers A, Smit J, Oyen WJG, Vriens D

Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As ~25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a preoperative clinical setting, includi... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Journal of hypertension, Volume 36, Issue 4, 1 1 2018, Pages 773-778 Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history. Wijsman LW, Muller M, de Craen AJM, Jukema JW, Westendorp RGJ, Mooijaart SP

Background: In older age, a low DBP has been associated with increased risk of cardiovascular events, especially in frail older people. We tested the hypothesis that low DBP is associated with a high risk of cardiovascular events in people with a previous history of cardiovascular disease, as a proxy of vascular impairment. Methods: We included 5804 participants (mean age 75 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) who as part of the trial were intensivel... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 610-616 Early and late results of surgical treatment for isolated active native mitral valve infective endocarditis. Tomšic A, Versteegh MIM, Ajmone Marsan N, van Brakel TJ, Klautz RJM, Palmen M

Objectives: Native mitral valve infective endocarditis (IE) is a complicated disease with high mortality and morbidity rates. Mitral valve repair (MVRep) is feasible when limited valve destruction is present. However, recurrent valve dysfunction and reintervention are common. Methods: Between January 2000 and March 2016, 83 patients underwent surgery for isolated active native mitral valve IE. We applied an early surgery, MVRep-oriented approach with progressive utilization of patch techniques t... Abstract

Cited 9 times since 2018 (1.2 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 559-565 Mitral valve repair in Barlow's disease with bileaflet prolapse: the effect of annular stabilization on functional mitral valve leaflet prolapse. Tomšic A, Hiemstra YL, Bissessar DD, van Brakel TJ, Versteegh MIM, Ajmone Marsan N, Klautz RJM, Palmen M

Objectives: Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal mitral annular dynamics is typically present and results in functional prolapse of the mitral leaflets that may be addressed with annular stabilization alone. Methods: Between January 2001 and December 2015, 128 patients with Barlow's disease and bileaflet prolapse underwent valve repair. This included anterior mitral valve leaflet (AMVL) rep... Abstract

Cited 34 times since 2018 (4.6 per year) source: EuropePMC

European heart journal, Volume 39, Issue 15, 1 1 2018, Pages 1308-1313 Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve. Kong WKF, Regeer MV, Poh KK, Yip JW, van Rosendael PJ, Yeo TC, Tay E, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may... Abstract

Cited 66 times since 2018 (8.9 per year) source: EuropePMC

European heart journal, Volume 39, Issue 16, 1 1 2018, Pages 1416-1425 Left atrial function to identify patients with atrial fibrillation at high risk of stroke: new insights from a large registry. Leung M, van Rosendael PJ, Abou R, Ajmone Marsan N, Leung DY, Delgado V, Bax JJ

Aims: Atrial fibrillation (AF) is an independent risk factor for ischaemic stroke. The CHA2DS2-VASc is the most widely used risk stratification model; however, echocardiographic refinement may be useful, particularly in low risk AF patients. The present study examined the association between advanced echocardiographic parameters and ischaemic stroke, independent of CHA2DS2-VASc score. Methods and results: One thousand, three hundred and sixty-one patients (mean age 65±12 years, 74% males) with f... Abstract

Cited 60 times since 2018 (8.1 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 103, Issue 5, 30 5 2018, Pages 795-801 Pharmacogenetic Information in Clinical Guidelines: The European Perspective. Swen JJ, Nijenhuis M, van Rhenen M, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GA, van Schaik RHN, van der Weide J, Wilffert B, Deneer VHM, Guchelaar HJ, Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Pharmacists Association (KNMP)

Surveys among pharmacists and physicians show that these healthcare professionals have successfully adopted the concept of pharmacogenomics (PGx).1-3 In addition, patients are willing to consent to participate in PGx implementation studies.4 However, the surveys also show that healthcare professionals do not frequently order or recommend a PGx test.1,2 Among others, a frequently perceived hurdle for clinical uptake of PGx is the availability of guidelines translating PGx test results into clinic... Abstract

Cited 14 times since 2018 (1.9 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 10, 29 5 2018, Pages 1533-1539 Prognostic value of global longitudinal strain in heart failure patients treated with cardiac resynchronization therapy. Khidir MJH, Abou R, Yilmaz D, Ajmone Marsan N, Delgado V, Bax JJ

Background: Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. Objective: The purpose of this study was to evaluate the prognostic value of LV GLS in HF patients treated with cardiac resynchronization therapy (CRT). Methods: The study included 829 HF patients (mean age 64.6 ± 10.4 years; 72% men) treated with CRT. Before CRT implantation, LV GLS was asses... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Turkish journal of haematology : official journal of Turkish Society of Haematology, Volume 35, Issue 2, 28 4 2018, Pages 122-128 Acute Traumatic Coagulopathy: The Value of Histone in Pediatric Trauma Patients. Ulusoy E, Duman M, Çağlar A, Küme T, Er A, Akgül F, Çitlenbik H, Yılmaz D, Ören H

Objective: Acute traumatic coagulopathy occurs after trauma with impairment of hemostasis and activation of fibrinolysis. Some endogenous substances may play roles in this failure of the coagulation system. Extracellular histone is one such molecule that has recently attracted attention. This study investigated the association between plasma histone-complexed DNA (hcDNA) fragments and coagulation abnormalities in pediatric trauma patients. Materials and methods: This prospective case-control stu... Abstract

Cited 12 times since 2018 (1.6 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 4, Issue 6, 28 4 2018, Pages 781-793 Slow Conducting Electroanatomic Isthmuses: An Important Link Between QRS Duration and Ventricular Tachycardia in Tetralogy of Fallot. Kapel GFL, Brouwer C, Jalal Z, Sacher F, Venlet J, Schalij MJ, Thambo JB, Jongbloed MRM, Blom NA, de Riva M, Zeppenfeld K

Objectives: This study sought to evaluate the influence of slow conducting anatomic isthmuses (SCAI) as dominant ventricular tachycardia (VT) substrate on QRS duration. Background: QRS prolongation has been associated with VT in repaired tetralogy of Fallot. Methods: Seventy-eight repaired tetralogy of Fallot patients (age 37 ± 15 years, 52 male, QRS duration 153 ± 29 ms, 67 right bundle branch blocks [RBBB]) underwent programmed stimulation and electroanatomic activation mapping during sinus rh... Abstract

Cited 12 times since 2018 (1.6 per year) source: EuropePMC

Cytokine, Volume 108, 26 4 2018, Pages 96-104 CXCL8 hyper-signaling in the aortic abdominal aneurysm. Kokje VBC, Gäbel G, Dalman RL, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN

There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an evaluation of a role for CXCL8 in AAA progression relevant. ELISA's, real time PCR and array analysis were used to explore CXCL8 signaling in AAA wall samples. A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist... Abstract

Cited 18 times since 2018 (2.4 per year) source: EuropePMC

Applied biochemistry and biotechnology, Volume 186, Issue 1, 24 4 2018, Pages 245-255 MicroRNA-499a-5p Promotes Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells to Cardiomyocytes. Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AAF, Mojarrad M, Naderi-Meshkin H, Neshati Z, Mirahmadi M, Kerachian MA

Since the adult mammalian heart has limited regenerative capacity, cardiac trauma, disease, and aging cause permanent loss of contractile tissue. This has fueled the development of stem cell-based strategies to provide the damaged heart with new cardiomyocytes. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are capable of self-renewal and differentiation into cardiomyocytes, albeit inefficiently. MicroRNAs (miRNAs, miRs) are non-coding RNAs that have the potential to control stem cell fate... Abstract

Cited 21 times since 2018 (2.8 per year) source: EuropePMC

Behavioural processes, Volume 161, 23 4 2018, Pages 17-30 Zoon politikon: The evolutionary origins of human socio-political systems. Gintis H, van Schaik C, Boehm C

We deploy the most up-to-date evidence available in various behavioral fields in support of the following hypothesis: The emergence of bipedalism and cooperative breeding in the hominin line, together with environmental developments that made a diet of meat from large animals adaptive, as well as cultural innovations in the form of fire, cooking, and lethal weapons, created a niche for hominins in which there was a significant advantage to individuals with the ability to communicate and persuade... Abstract